Search Result
Results for "
pH
" in MedChemExpress (MCE) Product Catalog:
91
Biochemical Assay Reagents
13
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-112798
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Others
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Neurological Disease
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PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.
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- HY-10499
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- HY-149669
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PI3K
HDAC
Apoptosis
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Cancer
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PH14 is a dual PI3K/HDAC inhibitor with IC50 values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma .
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- HY-144121
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Bacterial
Fungal
Apoptosis
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Infection
Cancer
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Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities .
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- HY-151797
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CaMK
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Neurological Disease
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Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders .
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- HY-10403
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-
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- HY-W096158
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PROTAC Linkers
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Cancer
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Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-153395
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Drug-Linker Conjugates for ADC
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Cancer
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PH-HG-005-5 (compound 16c) is a derivative of SN-38 (HY-13704) and can be used as Drug-Linker Conjugates for ADC. PH-HG-005-5 can conjugate to targeting peptides for ADCs synthesis .
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- HY-D0169A
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pHenolsulfonepHthalein sodium salt
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Fluorescent Dye
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Others
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Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .
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- HY-140337
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PROTAC Linkers
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Cancer
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Ph-Bis(C1-N-(C2-NH-Boc)2) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-163235
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Phenyl phenylcarbamate-CH-5-methoxypicolinamide-CH-CH-Ph-CF3 is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.
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- HY-D0169
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pHenolsulfonepHthalein
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Fluorescent Dye
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Others
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Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .
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- HY-U00017
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- HY-145575
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pH10
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Others
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Neurological Disease
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Itruvone is a intermediate of 17α-ethinylestradiol (EE2) during Fenton oxidation. Itruvone has an antidepressant effect .
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- HY-145567
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pH94B
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Others
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Neurological Disease
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Fasedienol is a neurochemical stimulator of the vomeronasal organ (VON). Fasedienol alleviates the symptoms of PMS and anxiety (extracted from patent WO1998014194A1) .
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- HY-128545
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Nitrazine paper; pHenapHthazine
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Biochemical Assay Reagents
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Others
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Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-12063
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PHT-427
1 Publications Verification
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Akt
Apoptosis
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Cancer
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PHT-247 is an inhibitor of the pleckstrin homology (PH) domain of Akt, and it is also an inhibitor of PDPK1 with Kis of 2.7 µM and 5.2 µM and for Akt and PDPK1, respectively.
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- HY-E70329
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Endogenous Metabolite
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Others
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P-Hydroxybenzoate hydroxylase, native microorganism is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-E70339
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Endogenous Metabolite
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Others
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Phenylethanolamine N-methyl transferase, bovine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-128590
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PHT-7.3
1 Publications Verification
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Ras
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Cancer
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PHT-7.3 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity .
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- HY-W088066
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pHospHoric acid, sodium salt, hydrate (1:3:12)
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Biochemical Assay Reagents
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Others
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Trisodium phosphate dodecahydrate is a corrosion inhibitor for iron in 0.1 M NaClO4, in both aerated and deaerated solutions. Trisodium phosphate dodecahydrate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
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- HY-B1610N
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .
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- HY-B1610J
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .
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- HY-B1610K
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .
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- HY-B1610M
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .
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- HY-B1610L
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Biochemical Assay Reagents
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Others
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Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .
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- HY-B0246S3
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- HY-133463
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133465
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-141808
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Others
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Cancer
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AZD-CO-Ph-PEG4-Ph-CO-AZD is a bis-β-lactam linker can be used for antibody-siRNA conjugate synthesis .
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- HY-140349
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PROTAC Linkers
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Cancer
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AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-141894
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Others
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Others
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5-Ph-IAA-AM is an eggshell-permeable 5-Ph-IAA analog. 5-Ph-IAA-AM affords an enhanced protein degradation in laid embryos. 5-Ph-IAA-AM can be used to disclosure the roles of proteins in C. elegans, in particular those that are involved in embryogenesis and development, through temporally controlled protein degradation .
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- HY-124480
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-10403A
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p38 MAPK
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Inflammation/Immunology
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(aS)-PH-797804 is a selective p38 MAPK inhibitor with IC50 values for p38 α /β of 26 nM and 102 nM, respectively. (aS)-PH-797804 has anti-inflammatory activity .
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- HY-130107
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ADC Linker
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Cancer
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Ald-Ph-NHS ester is a nonclaevable linker for antibody-agent-conjugation (ADC).
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- HY-D1094
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SNARF 1
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Fluorescent Dye
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Others
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Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement of intracellular pH .
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- HY-D1093
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Fluorescent Dye
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Others
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Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
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- HY-126908
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130283
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PROTAC Linkers
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Cancer
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Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130928
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ADC Linker
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Cancer
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Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-147118
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ADC Linker
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Cancer
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NHS-SS-Ph is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
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- HY-D1457
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Fluorescent Dye
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Others
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DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles .
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- HY-D0265
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Fluorescent Dye
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Others
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Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH .
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- HY-134653
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Others
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Cancer
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5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression .
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- HY-133504
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ADC Linker
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Cancer
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Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-D0252
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Fluorescent Dye
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Others
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m-Cresol purple is a pH indicator dye with large cross section and halochromic property in neutral pH range .
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- HY-Y0699
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Fluorescent Dye
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Others
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Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively .
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- HY-130496
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-163146
-
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Fluorescent Dye
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Cancer
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TME-HYM (PH Probe) is a novel fluorescent probe based on acidic tumor microenvironment (TME) activation and organic anion transporting polypeptide (OATPs, overexpressed on cancer cells), and can be selective uptaken. TME-HYM (PH Probe) can selectively lit up cancer cells and tumor tissues, offering dual tumor selectivity for precise visualization of tumor mass .
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- HY-130099
-
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ADC Linker
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Cancer
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Ald-Ph-amido-PEG2 is a noncleavable ADC linker for antibody-drug conjugate .
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- HY-D0219A
-
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Fluorescent Dye
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Others
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Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 .
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- HY-130846
-
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PROTAC Linkers
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Cancer
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Pip-alkyne-Ph-COOCH3 is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC ARD-266 . Pip-alkyne-Ph-COOCH3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-130508
-
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PROTAC Linkers
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Cancer
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Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130551
-
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-126524
-
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ADC Linker
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Cancer
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N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-140628
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140629
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140626
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140624
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG12-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140625
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG24-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140623
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140627
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG6-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140622
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PROTAC Linkers
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Cancer
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Ald-Ph-amido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-D0219
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ThymolsulpHonepHthalein
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Fluorescent Dye
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Others
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Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 . Storage: protect from light.
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- HY-133044
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PROTAC Linkers
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Cancer
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Boc-Pip-alkyne-Ph-COOH is a PROTAC linker, which refers to the alkyl/ether composition. Boc-Pip-alkyne-Ph-COOH can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 effectively induces degradation of androgen receptor (AR) protein in AR-positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0.2-1 nM . Boc-Pip-alkyne-Ph-COOH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-161500
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Thalidomide-NHCH2-Ph-pyrimidine-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and a Linker Boc-NHCH2-Ph-pyrimidine-NH2 (HY-161499). Thalidomide-NHCH2-Ph-pyrimidine-NH2 is utilized for synthesis of PROTAC molecule XYD198 (HY-161498) .
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- HY-Y1269H
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Salmiac, meets analytical specification of pH. Eur. BP USP FCC
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Autophagy
Biochemical Assay Reagents
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Others
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Ammonium chloride, meets analytical specification of Ph. Eur. BP USP FCC (Salmiac, meets analytical specification of Ph. Eur. BP USP FCC) can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.
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- HY-160114
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- HY-133464
-
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-W422359A
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Biochemical Assay Reagents
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Others
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2-Aminopurine-O-Ph-NHCO-C3-COOH hydrochloride is the acid form in the previous step of the final product 2-Aminopurine-O-Ph-NHCO-C3-NHS ester (HY-143336) .
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- HY-133460
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PROTAC Linkers
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Cancer
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Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-133479
-
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PROTAC Linkers
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Cancer
|
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130638
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VH032-O-pH-PEG1-NH-Boc
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc (VH032-O-Ph-PEG1-NH-Boc) is a synthesized E3 ligase ligand-linker conjugate which is used for the EED-targeted PROTAC .
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- HY-126533
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ADC Linker
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Cancer
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PDP-C1-Ph-Val-Cit is a cleavable ADC linker used for antibody-drug conjugates (ADCs).
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- HY-154801
-
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Others
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Others
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Biotin-PEG3-CONH-Ph-CF3-diazirine is a biotin labeled PEG3 derivative. Biotin-PEG3-CONH-Ph-CF3-diazirine can be used for protein labeling .
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- HY-130096
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ADC Linker
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Cancer
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Ald-Ph-amido-C2-nitrate (Example XXIVb) is a thiazolidine derivative, used as a noncleavable ADC linker .
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- HY-130527
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-140636
-
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PROTAC Linkers
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Cancer
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Ald-Ph-PEG2-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-D1677
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Fluorescent Dye
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Others
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5(6)-Carboxynaphthofluorescein is a pH-dependent fluorophore. 5(6)-Carboxynaphthofluorescein shows good sensitivity in an alkaline pH range and it can be exploited in the construction of fiber-optic pH sensors. 5(6)-Carboxynaphthofluorescein can be used as a fluorescent pH indicator (Ex/Em=593/668 nm) .
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- HY-156897
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Drug-Linker Conjugates for ADC
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Cancer
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Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocyte growth factor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
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- HY-149680
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Others
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Others
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CatD-P1is a pH insensitive CatD (Cathepsin D) probe .
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- HY-130816
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VH032-O-pH-PEG1-NH2
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E3 Ligase Ligand-Linker Conjugates
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Cancer
|
(S,R,S)-AHPC-O-Ph-PEG1-NH2 (VH032-O-Ph-PEG1-NH2) is E3 ligase ligand-linker conjugate and incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. (S,R,S)-AHPC-O-Ph-PEG1-NH2 is used in PROTAC EED degrader-1 (HY-130614). PROTAC EED degrader-1 is a PROTAC targeting EED with a pKD of 9.02 .
|
-
- HY-D0870
-
-
- HY-D0870A
-
-
- HY-130098
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG3-C-COOH is a noncleavable linker used for the antibody-drug conjugate (ADC).
|
-
- HY-133545
-
|
ADC Linker
|
Cancer
|
Mal-Ph-CONH-PEG4- NHS ester is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
|
-
- HY-W011271
-
1,4-Piperazinediethanesulfonic acid monosodium
|
Biochemical Assay Reagents
|
Others
|
PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed .
|
-
- HY-133461
-
|
PROTAC Linkers
|
Cancer
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133462
-
|
PROTAC Linkers
|
Cancer
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-Y1968A
-
|
Biochemical Assay Reagents
|
Others
|
Sterile 10 mM Histidine, pH 5.5 buffer is a multi-purpose buffer solution with important applications in many fields such as protein purification, vaccine preparation, drug development, cell culture and electrophoresis. Histidine is an amino acid with good buffering capacity. Sterile 10 mM Histidine, pH 5.5 buffer The sterility and specific pH conditions make it ideal for experiments that require precise control of environmental conditions. The histidine in Sterile 10 mM Histidine, pH 5.5 buffer derivatizes photosensitizers that accumulate and increase greatly upon exposure to light. Histidine-derived photosensitizers are also the primary mediators of tryptophan photooxidation .
|
-
- HY-Y0332L
-
Potassium pHospHate monobasic, meets analytical specification of pH. Eur., NF, E340
|
Biochemical Assay Reagents
|
Others
|
Potassium dihydrogen phosphate (Potassium phosphate monobasic), meets analytical specification of Ph. Eur., NF, E340 is used as a buffer capacity reagent in molecular biology, biochemistry, and chromatography. For the preparation of biological buffers. It is also used to purify antibodies, and in combination with other sodium phosphates, meets analytical specification of Ph. Eur., NF, E340 .
|
-
- HY-B1571
-
|
Fluorescent Dye
|
Others
|
Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6 .
|
-
- HY-D0276
-
Metacresol purple sodium
|
Biochemical Assay Reagents
|
Others
|
m-Cresol purple sodium (Metacresol purple sodium) is a pH indicator. m-Cresol purple sodium solution from yellow to blue in the pH range from 7.5 to 9.0 .
|
-
- HY-130962
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG23-OPSS is a cleavable 23 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-130682
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312) . Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-133579
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG3-NHS ester is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-130097
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG4-C2-acid is a noncleavable linker used for the antibody-drug conjugate (ADC).
|
-
- HY-138519
-
|
PROTAC Linkers
|
Cancer
|
Bis-(Mal-PEG3)-PH-N-succinimidyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W342700
-
|
Biochemical Assay Reagents
|
Others
|
PIPPS is a kind of buffer commonly used in biological and biochemical research to maintain the acidity and alkalinity (pH value) of solutions .
|
-
- HY-134705
-
|
PROTAC Linkers
|
Cancer
|
m-PEG2-amido-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096113
-
|
PROTAC Linkers
|
Cancer
|
m-PEG2-O-Ph-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-161496
-
-
- HY-161499
-
|
PROTAC Linkers
|
Cancer
|
Boc-NHCH2-Ph-pyrimidine-NH2 is the linker for PROTAC molecule XYD198 (HY-161498) .
|
-
- HY-130154
-
|
PROTAC Linkers
|
Cancer
|
Ald-Ph-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141115
-
|
PROTAC Linkers
|
Cancer
|
Mal-NO2-Ph-PEG12-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-D0859A
-
|
Biochemical Assay Reagents
|
Others
|
MOPS sodium salt is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media .
|
-
- HY-Y0317I
-
Disodium sulfate, meets analytical specification of pH. Eur. BP USP
|
Biochemical Assay Reagents
|
Others
|
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-133572
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG11-NH-Boc is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-130100
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG3-C1-Boc is an ADC linker, which belongs to a polyethylene glycol (PEG) linker.
|
-
- HY-130967
-
|
ADC Linker
|
Cancer
|
Ald-Ph-PEG4-bis-PEG4-propargyl is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-Y0344I
-
Halite, meets analytical specification of pH. Eur. BP USP
|
Biochemical Assay Reagents
|
Others
|
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-D1563
-
|
Fluorescent Dye
|
Others
|
CypHer 5 is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. CypHer 5 has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. CypHer 5 has been used as a pH sensor of lysosomal compartments .
|
-
- HY-130102
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG3-C2-Pfp ester is an noncleavable ADC linker, which belongs to a polyethylene glycol (PEG) linker.
|
-
- HY-130202
-
|
PROTAC Linkers
|
Cancer
|
Ald-Ph-amido-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-140632
-
|
PROTAC Linkers
|
Cancer
|
Ald-Ph-amido-C2-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130974
-
|
ADC Linker
|
Cancer
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130105
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG1-C2-Pfp ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130106
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG1-C2-NHS ester is a nonclaevable 1-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130101
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG4-C2-NHS ester is a nonclaevable 4-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130103
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG2-C2-Pfp ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-130104
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG2-C2-NHS ester is a nonclaevable 2-unit PEG linker for antibody-agent-conjugation (ADC).
|
-
- HY-W096118
-
|
PROTAC Linkers
|
Cancer
|
m-PEG2-O-Ph-3-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-131086
-
-
- HY-101850
-
|
Biochemical Assay Reagents
|
Others
|
MOPSO is a biological zwitterionic buffer with the useful pH range from 6.2 to 7.6. MOPSO has been employed as a buffer component of charcoal yeast extract medium .
|
-
- HY-130637
-
|
PROTAC Linkers
|
Cancer
|
Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC Linker which is used for the EED-targeted PROTAC .
|
-
- HY-130667
-
|
PROTAC Linkers
|
Cancer
|
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-D0015A
-
|
Fluorescent Dye
|
Others
|
Cresol Red sodium is a triarylmethane dye. Cresol Red sodium can be used for indicating pH, temperatures and salinities .
|
-
- HY-128369
-
Metanil Yellow
|
Cytochrome P450
|
Others
|
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes .
|
-
- HY-130669
-
|
PROTAC Linkers
|
Cancer
|
Ald-Ph-amido-C2-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-125907
-
PROTAC Linker 34
|
PROTAC Linkers
|
Cancer
|
Dox-Ph-PEG1-Cl (PROTAC Linker 34) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-130174
-
|
PROTAC Linkers
|
Cancer
|
Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W087913
-
|
Biochemical Assay Reagents
|
Others
|
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .
|
-
- HY-W009245
-
|
HIV
|
Infection
|
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation .
|
-
- HY-158118
-
|
DNA-PK
|
Cancer
|
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-131087
-
|
ADC Linker
|
Cancer
|
Me-triacetyl-β-D-glucopyranuronate-Ph-CH2OH-Fmoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-158122
-
|
DNA-PK
|
Cancer
|
Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-Y0317E
-
Disodium sulfate (pHarmaceutical primary standard, USP)
|
Biochemical Assay Reagents
|
Others
|
Sodium sulfate anhydrous (Disodium sulfate), can be widely used as a desiccant, pH regulator, etc. in biochemical experiments. It is a reference standard grade of the United States Pharmacopeia (USP), pharmaceutical primary standard.
|
-
- HY-133426
-
Ald-benzyl-amide-PEG4-propargyl
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D1687
-
|
Fluorescent Dye
|
Others
|
Flubi-2 is a fluorescein-biotin based pH-ratio dye (Ex=480 nm, Em= 520-560 nm) with a pK value of 6.7. Flubi-2 is a hydrolysis product of Flubida-2 (non-fluorescent, membrane permeable). Flubi-2 can be used for pH determination of organelles of the secretory pathway (such as golgi apparatus and endoplasmic reticulum) in living cells .
|
-
- HY-D0140
-
ETH 5294
|
Fluorescent Dye
|
Others
|
Chromoionophore I (ETH 5294) is a hydrophobic pH indicator. Chromoionophore I is used as a transmissive or fluorescent probe molecule in many types of hydrophobic sensor membranes. Chromoionophore I is oil-soluble .
|
-
- HY-133546
-
|
ADC Linker
|
Cancer
|
Ald-Ph-amido-PEG11-C2-NH2 is a non-cleavable 11 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
|
-
- HY-D0023
-
HPTS; Solvent Green 7
|
Fluorescent Dye
|
Others
|
Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu + ion(λex=450 nm, λem=510 nm) .
|
-
- HY-118320
-
Mordant orange 1
|
Fluorescent Dye
|
Others
|
Alizarine Yellow R (Mordant orange 1), a salicylic acid derivative, is a azo dye. Alizarine Yellow R is mostly used as a pH indicator, as a biological stain in chemical examinations and also in dyeing industries .
|
-
- HY-P5172
-
|
Sodium Channel
|
Neurological Disease
|
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .
|
-
- HY-D1069
-
DBCO-Sulfo-Cy3
|
Fluorescent Dye
|
Others
|
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-W094475D
-
Epsom salts, meets analytical specification of pH. Eur. BP USP FCC
|
Biochemical Assay Reagents
|
Cardiovascular Disease
Cancer
|
Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC is currently the anticonvulsant of choice for the prevention and control of eclamptic fits. Magnesium sulfate is also widely used as a tocolytic agent .
|
-
- HY-153195
-
|
Others
|
Cancer
|
Tetra-O-acetyl-β-D-galactopyranosyl-Ph-CH2OH-Fmoc can be used as conjugates to prepare antibody drug conjugates (ADCs) .
|
-
- HY-130969
-
|
ADC Linker
|
Cancer
|
Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-W110898
-
|
Fluorescent Dye
|
Others
|
Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics .
|
-
- HY-D0227
-
Tris; Tris(hydroxymethyl)aminomethane
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
THAM (Tris) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM is an effective amine compound for pH control in the physiological range .
|
-
- HY-D0227B
-
Tris acetate; Tris(hydroxymethyl)aminomethane acetate
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Trometamol acetate (Tromethamine acetate) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. Trometamol acetate is an effective amine compound for pH control in the physiological range .
|
-
- HY-D0227A
-
Tris HCl; Tris(hydroxymethyl)aminomethane hydrochloride
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range .
|
-
- HY-D0859
-
|
Biochemical Assay Reagents
|
Others
|
MOPS are commonly used as buffers in biology. MOPS buffer maintains the pH of mammalian cell culture media. MOPS and Tris buffer also have inhibitory effects on TfCut2 and LCC hydrolases, inhibiting the rate of hydrolyzing PET films. MOPS may also interfere with calcium binding, translocation, and utilization in vascular smooth muscle cells .
|
-
- HY-161652
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is the conjugate of a linker and a ligand for E3 ligase. Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione can be used for synthesis of PROTAC BRD4 Degrader-26 (HY-161650) .
|
-
- HY-Y1269I
-
Salmiac (pHarmaceutical primary standard, USP)
|
Biochemical Assay Reagents
Autophagy
|
Others
|
Ammonium chloride United States Pharmacopeia (USP) Reference Standard (Salmiac, Pharmaceutical primary standard, USP) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.
|
-
- HY-D0009
-
|
Fluorescent Dye
|
Others
|
Bromocresol green sodium is an anionic dye. Bromocresol green sodium can be used for pH indication and DNA agarose gel electrophoresis. Bromocresol green sodium is also used in mammalian albumin measurement. Bromocresol green sodium deprotonates and produces the monoanionic form of yellow colour at lower pH (acidic condition), and produces dianionic blue colour at the basic condition .
|
-
- HY-W133967
-
-
- HY-D1463
-
-
- HY-D0874
-
|
Biochemical Assay Reagents
|
Others
|
HEPPSO is a zwitterionic buffer. The working pH range of HEPPSO buffer is 7.1-8.5. HEPPSO displays relatively high ability to bind copper(II), has a pKa of 7.84 at 2.0 mM buffer concentration .
|
-
- HY-128931
-
PROTAC Linker 31
|
PROTAC Linkers
|
Cancer
|
NH2-Ph-C4-acid-NH2-Me (PROTAC Linker 31) is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs .
|
-
- HY-118155
-
|
Fluorescent Dye
|
Others
|
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system .
|
-
- HY-153196
-
|
ADC Linker
|
Others
|
Tetra-O-acetyl-β-D-galactopyranosyl-Ph-CH2-(4-nitrophenyl)carbonate-Fmoc (Example 2.28.6) is an ADC linker that can be used to synthesize antibody-conjugated active molecules (ADCs) .
|
-
- HY-D0878
-
|
Biochemical Assay Reagents
|
Others
|
TAPSO is a common biological buffer, a pH stabilization reagent, with effective pH ranging from 7-8, and pKa values ranging from 7.5–9.0. TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides .
|
-
- HY-D0227AR
-
|
Biochemical Assay Reagents
|
Metabolic Disease
Cancer
|
THAM (hydrochloride) (Standard) is the analytical standard of THAM (hydrochloride). This product is intended for research and analytical applications. THAM hydrochloride (Tris HCl) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM hydrochloride is an effective amine compound for pH control in the physiological range .
|
-
- HY-W411215
-
|
Fluorescent Dye
|
Others
|
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .
|
-
- HY-108535
-
|
Biochemical Assay Reagents
|
Others
|
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis .
|
-
- HY-W100209
-
|
Potassium Channel
|
Others
|
5Me3F4AP is a potent blocker of potassium channel, with the IC50 of 220 μM to 693 μM when the pH is increased from 6.4 to 9.1. 5Me3F4AP has the potential to cross the blood-brain barrier and potential application in positron emission tomography (PET) .
|
-
- HY-161653
-
|
PROTAC Linkers
|
Cancer
|
Boc-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is a linker of PROTAC BRD4 Degrader-26 (HY-161650), and can be used for synthesis of PROTACs .
|
-
- HY-D1200
-
Solvent Green 1
|
Fungal
Parasite
|
Others
|
Malachite Green Carbinol base (MGOH, MGCB) is a derivative of Malachite green (MG) with not fluorescence. Malachite green carbinol base (MGOH, MGCB), as a pH regulation reagent,MGCB molecule could release OH - under UV light irradiation and generate a progressive shift in pH values. MGCB solution turns from colorless to deep green rapidly when exposed to a high-pressure UV lamp (500 W, 50 W/cm) .
|
-
- HY-145576
-
|
Others
|
Others
|
2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
|
-
- HY-W440988
-
|
Liposome
|
Others
|
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner .
|
-
- HY-D1591
-
|
Fluorescent Dye
|
Others
|
BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic research, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis .
|
-
- HY-105033
-
Pirfloxacin
|
Bacterial
|
Infection
|
Irloxacin (Pirfloxacin) is a quinolone antibacterial agent. Irloxacin shows greater activity with an acid pH. Irloxacin has a good in vitro antimicrobial spectrum against both gram-positive and gram-negative bacteria. Orally active .
|
-
- HY-D0142
-
|
Fluorescent Dye
|
Others
|
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release .
|
-
- HY-B1422
-
Aminacrine
|
Bacterial
HIV
|
Infection
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-D0872
-
|
Biochemical Assay Reagents
|
Others
|
DIPSO is a biological zwitterionic buffer with the useful pH range from 7.0 to 8.2. DIPSO can interfere meiotic regulation in mouse oocytes. DIPSO also has surfactant activity at 10 mM .
|
-
- HY-113697
-
Mal-PEG2-AZD
|
PROTAC Linkers
|
Cancer
|
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-148825
-
-
- HY-Y1269
-
|
Autophagy
|
Cancer
|
Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor .
|
-
- HY-P10469
-
|
NF-κB
|
Inflammation/Immunology
Cancer
|
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .
|
-
- HY-D1694
-
|
Fluorescent Dye
|
Others
|
LysoTracker Yellow HCK 123 is a potent yellow membrane-permeable fluorescent probe. LysoTracker Yellow HCK 123 is a weakly basic amine that selectively accumulates in cellular compartments with low luminal pH. (λex=465 nm, λem=535 nm) .
|
-
- HY-B1422R
-
|
Bacterial
HIV
|
Infection
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-W129456
-
|
Others
|
Neurological Disease
|
Isaxonine acts as a modifier of the surface pH of the bilayer . Isaxonine accelerates the rate of peripheral nerve regeneration, stimulate axonal sprouting and promote motor and sensory function recovery . Isaxonine is a neurotrophic agent .
|
-
- HY-145576B
-
|
Others
|
Others
|
2-Amino-8-oxononanoic acid (hydrochloride) is the hydrochloride form of 2-Amino-8-oxononanoic acid. 2-Amino-8-oxononanoic acid is an amino acid, incorporation into proteins in E.coli in genetic. 2-Amino-8-oxononanoic acid is efficient in labeling of proteins with different probes with a site-specific manner under a mild condition close to the physiological pH .
|
-
- HY-41549
-
Cereblon Ligand-Linker Conjugates 9; E3 Ligase Ligand-Linker Conjugates 2
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.
|
-
- HY-Y1269C
-
Salmiac, for cell culture
|
Biochemical Assay Reagents
Autophagy
|
Others
|
Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor.
|
-
- HY-D1445
-
|
Fluorescent Dye
|
Metabolic Disease
|
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes (Abs=329 nm; Em=440 nm) .
|
-
- HY-B1329
-
Nebramycin II sulfate
|
Bacterial
Antibiotic
|
Infection
|
Apramycin (EBL 1003) is an orally active, acidic pH tolerant and aminoglycoside-modifying-enzymes-tolerant aminoglycoside antibiotic which inhibits protein biosynthesis by targeting the bacterial ribosome. Apramycin is a potential anti-drug-resistance antibiotic .
|
-
- HY-P10105
-
|
Akt
Apoptosis
|
Cancer
|
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo .
|
-
- HY-17507
-
BY1023; SKF96022
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-17507A
-
BY1023 sodium; SKF96022 sodium
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-17507B
-
BY1023 sodium hydrate; SKF96022 sodium hydrate
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
Pantoprazole sodium hydrate (BY10232 sodium hydrate) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium hydrate, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium hydrate improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium hydrate significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-116033
-
|
Ser/Thr Protease
|
Inflammation/Immunology
|
BMS-363131 is a selective inhibitor for tryptase, with an IC50 <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model .
|
-
- HY-W025785
-
Solvent Yellow 2; Dimethyl yellow
|
Others
|
Others
|
Methyl yellow (Solvent Yellow 2) is a pH indicator. Methyl yellow appears red at low pH, and becomes yellow above pH 4.0 .
|
-
- HY-17507R
-
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
Pantoprazole (Standard) is the analytical standard of Pantoprazole. This product is intended for research and analytical applications. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-125457
-
p-NapHtolbenzein
|
Fluorescent Dye
|
Others
|
α-Naphtholbenzein (p-Naphtolbenzein) is a dye. α-Naphtholbenzein can be used as a pH indicator. α-Naphtholbenzein has a visual transition from yellow (pH0-8.2) to turquoise (pH10). α-Naphtholbenzein is often used during sequential injection analysis technique done for acid-base titrations .
|
-
- HY-D0011
-
|
Biochemical Assay Reagents
|
Others
|
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis .
|
-
- HY-D0856
-
|
Biochemical Assay Reagents
|
Others
|
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .
|
-
- HY-113377
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Glyceric acid is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid excretion to distinguish PH1 from PH2 .
|
-
- HY-113377A
-
|
Endogenous Metabolite
|
Metabolic Disease
|
L-Glyceric acid sodium is a mainly urinary metabolite accumulating in rare inherited metabolic disease L-glyceric aciduria. L-Glyceric acid sodium can be used to diagnose primary hyperoxaluria type 2 (PH2). L-Glyceric acid sodium excretion to distinguish PH1 from PH2 .
|
-
- HY-19548A
-
|
Arginase
|
Metabolic Disease
|
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively .
|
-
- HY-100230A
-
|
Potassium Channel
|
Others
|
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 .
|
-
- HY-D0075
-
|
Fluorescent Dye
|
Others
|
DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver .
|
-
- HY-D0012
-
-
- HY-101882
-
BCECF
1 Publications Verification
2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein
|
Fluorescent Dye
|
Others
|
BCECF is a pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0–8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
|
-
- HY-W331502
-
-
- HY-N2383
-
(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol
|
Glucosidase
|
Metabolic Disease
|
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme .
|
-
- HY-148530
-
|
PROTACs
CDK
|
Cancer
|
YX-2-107 is a PROTAC (IC50= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph + ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph +) acute lymphoblastic leukemia (ALL) .
|
-
- HY-D2119
-
|
Fluorescent Dye
|
Cancer
|
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes .
|
-
- HY-135226
-
|
Others
|
Others
|
PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.
|
-
- HY-W040144
-
|
Fluorescent Dye
|
Others
|
Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells .
|
-
- HY-145616
-
-
- HY-124348
-
3,5-Dimethyl PIT-1
|
PI3K
|
Cancer
|
DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor . DM-PIT-1 has the potential for the research of ovarian cancer .
|
-
- HY-D0305
-
|
Fluorescent Dye
|
Others
|
Tropaeolin O is an acidic monoazo dye that undergoes a coupling reaction under pH=10.5 conditions to form a blue disazo dye. Tropaeolin O can be used for the determination of palladium(II), osmium(IV), albumin, and casein .
|
-
- HY-D1111
-
|
Fluorescent Dye
|
Others
|
TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) .
|
-
- HY-D0228
-
Azo Violet; Magneson I
|
Fluorescent Dye
|
|
4-(4-Nitrophenylazo)resorcinol is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used.
|
-
- HY-D1110
-
|
Fluorescent Dye
|
Others
|
TFAX 594,SE is a red fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 594,SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) .
|
-
- HY-107757
-
|
Sodium Channel
|
Neurological Disease
|
GMQ is a ASIC (acid-sensing ion) channel activator with an EC50 value of 1.83 mM for ASIC3 at pH 7.4. GMQ opens only ASIC3 but no other ASICs at pH 7.4. GMQ can be used for neurological disease research .
|
-
- HY-D1113
-
|
Fluorescent Dye
|
Others
|
TFAX 488,TFP is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,TFP yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) .
|
-
- HY-W008865
-
|
Biochemical Assay Reagents
|
Others
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 .
|
-
- HY-D0858B
-
2-MorpHolinoethanesulpHonic acid sodium salt
|
Biochemical Assay Reagents
|
Others
|
MES (2-Morpholinoethanesulphonic acid) sodium salt is a buffering agent in biology and biochemistry. MES sodium salt is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES sodium salt is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858
-
2-MorpHolinoethanesulpHonic acid
|
Biochemical Assay Reagents
|
Others
|
MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. MES is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858A
-
2-MorpHolinoethanesulpHonic acid monohydrate
|
Biochemical Assay Reagents
|
Others
|
MES (2-Morpholinoethanesulphonic acid) monohydrate is a buffering agent in biology and biochemistry. MES monohydrate is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES monohydrate is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858E
-
2-MorpHolinoethanesulpHonic acid potassium
|
Biochemical Assay Reagents
|
Others
|
MES (2-Morpholinoethanesulphonic acid) potassium is a buffering agent in biology and biochemistry. MES potassium is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES potassium is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-W250149
-
|
Biochemical Assay Reagents
|
Others
|
Chlorophosphonazo III is a sensitive reagent for both calcium and magnesium. It is possible to determine calcium alone at pH 2.2 and calcium and magnesium at pH 7.0. Chlorophosphonazo III can also be used for the spectrophotometric determination of titanium, zirconium, thorium, and scandium, quinquevalent actinide elements, and protactinium .
|
-
- HY-D0858C
-
2-MorpHolinoethanesulpHonic acid hydrate
|
Biochemical Assay Reagents
|
Others
|
MES (2-Morpholinoethanesulphonic acid) hydrate is a buffering agent in biology and biochemistry. MES hydrate is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES hydrate is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858D
-
2-MorpHolinoethanesulpHonic acid hemisodium
|
Others
|
Others
|
MES (2-Morpholinoethanesulphonic acid) sodium is a buffering agent in biology and biochemistry. MES sodium is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES sodium is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D1401
-
|
Fluorescent Dye
|
Others
|
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences .
|
-
- HY-148949A
-
|
Kallikrein
|
Others
|
Kallikrein 5-IN-2 TFA is the TFA salt form of Kallikrein 5-IN-2 (HY-148949). Kallikrein 5-IN-2 TFA is a selective inhibitor for kallikrein 5 (KLK5) with pIC50 of 7.1. Kallikrein 5-IN-2 TFA is non-phototoxic (100 μg/mL) and non-irritant. Kallikrein 5-IN-2 is stable at pH 4-pH 8 under non-oxidative condition. Kallikrein 5-IN-2 is potent in ameliorating the Netherton syndrome .
|
-
- HY-D1114
-
|
Fluorescent Dye
|
Others
|
TFAX 488,SE dilithium is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,SE dilithium yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) .
|
-
- HY-131007
-
|
Adrenergic Receptor
|
Metabolic Disease
|
FFN270 hydrochloride, a fluorescent tracer of norepinephrine, is a fluorescent substrate of the norepinephrine and vesicular monoamine transporters. FFN270 hydrochloride exhibits two resolved absorption/excitation maxima depending on solvent pH (FFN270 ex: 320 nm or 365 nm, em: 475 nm) and can function as ratiometric fluorescent pH-sensors .
|
-
- HY-D0050
-
|
Fluorescent Dye
|
Others
|
5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester (cDCFDASE) is a fluorescent probe. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate N-succinimidyl ester can be used to evaluate the intracellular pH (pHin) of living cells at a medium pH (pHex) .
|
-
- HY-160764
-
|
Others
|
Others
|
N6-Carboxymethyl-ATP is the alkylation product of ATP with iodoacetic acid at pH 6.5, where alkylation of ATP with iodoacetic acid at pH 6.5 yielded 1-carboxymethyl-ATP which, after alkaline rearrangement gave N6-carboxymethyl-ATP .
|
-
- HY-101883
-
|
Fluorescent Dye
|
Others
|
BCECF-AM is a cell membrane permeable compound widely used as a fluorescent indicator for intracellular pH.
|
-
- HY-110337
-
|
Others
|
Others
|
FFN 102 mesylate is a synthetic biogenic neurotransmitter analogue with PH-dependent fluorescence and electrical activity .
|
-
- HY-W739302
-
Sodium α-oxyhyponitrite
|
Others
|
Others
|
Sodium Oxyhyponitrite Angeli (Angeli) is a nitroxyl (NO-) donor, but under certain conditions NO release has also been observed. Sodium Oxyhyponitrite Angeli spontaneously dissociates in a pH-dependent first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4), releasing 0.54 mol NO per mole.
|
-
- HY-144768
-
|
Liposome
|
Others
|
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .
|
-
- HY-118643
-
BMS-986231; CXL-1427
|
Others
|
Cardiovascular Disease
|
Cimlanod (BMS-986231) is a second-generation Nitroxyl (HNO) donor for heart failure. Cimlanod (BMS-986231) delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream. Cimlanod (BMS-986231) possesses positive lusitropic and inotropic as well as vasodilatory effects .
|
-
- HY-120742
-
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
MMG-0358 is a potent IDO1 inhibitor. MMG-0358 shows IC50 values of 2 nM in a cellular assay on mIDO1, 80 nM in a cellular assay on hIDO1, 330 nM in an enzymatic assay on hIDO1 at pH 6.5, and 71 nM in an enzymatic assay on hIDO1 at pH 7.4 .
|
-
- HY-D1482
-
|
Fluorescent Dye
|
Others
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-144025
-
|
Liposome
|
Others
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery .
|
-
- HY-157379
-
-
- HY-126774
-
|
Fluorescent Dye
|
Others
|
DAF-FM is a diaminofluorescein, which can be used as fluorescent indicator for nitric oxide (NO) with good pH tolerance .
|
-
- HY-P1748
-
EC 3.4.24.27; TML
|
Endogenous Metabolite
|
Infection
|
Thermolysin, Bacillus thermoproteolyticus rokko (EC 3.4.24.27) (TML) is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues .
Optimal pH: 8.0. Considerably stable from pH 5 to 9.5.
Optimal temperature : 70 °C
|
-
- HY-155717
-
|
Autophagy
Pim
|
Cancer
|
NDBM is a probe and binds to tumor-specific Pim-1 kinase, releases strong fluorescence, and produces cytotoxicity, thus achieving cell screening and killing effects. NDBM can specifically target lysosomes and sensitively respond to pH. NDBM can be used to track the pH changes in the intracellular environment under conditions of autophagy and external stimulation .
|
-
- HY-W102681
-
|
Biochemical Assay Reagents
|
Others
|
Caps sodium salt, a polyanion, is a surfactant. Caps sodium salt can be used as biological buffer (0.05 M, pH 11) for dialysis .
|
-
- HY-136283
-
|
Others
|
Neurological Disease
|
DMNPE-4 AM-caged-calcium, photolabile analogues of EGTA, is an extremely effective Ca 2+ selective cage, with a Kd for Ca 2+ of 48 nM and 19 nM at pH 7.2 and pH 7.4, respectively. DMNPE-4 AM-caged-calcium has a lower affinity for Ca 2+ (Kd=~2 nM) after photolysis .
|
-
- HY-E70063
-
|
Endogenous Metabolite
|
Metabolic Disease
|
alpha-2,3-Sialyltransferase (Phα2,3SiaT) is a beta-galactoside. alpha-2,3-Sialyltransferase (Phα2,3SiaT) catalyzes the transfer of sialic acid to carbohydrate groups of glycoproteins and glycolipids .
|
-
- HY-D0858S
-
|
Isotope-Labeled Compounds
|
Others
|
MES-d13 is the deuterium labeled MES[1]. MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. MES is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments[2][3].
|
-
- HY-133527
-
Oregon green 488 succinimidyl ester
|
Fluorescent Dye
|
Neurological Disease
|
OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences .
|
-
- HY-P1315
-
Glycylglycyl-L-tyrosyl-L-arginine
|
Cathepsin
|
Others
|
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a Ki of 9 μM at pH 6.2 .
|
-
- HY-D0227F
-
Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)
|
Biochemical Assay Reagents
|
Others
|
THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.
|
-
- HY-158082C
-
Tetramethyl rhodamine isothiocyanate glucan, MW 70000
|
Fluorescent Dye
|
Others
|
TRITC-dextran, MW 70000 (Tetramethyl rhodamine isothiocyanate glucan, MW 70000) is a fluorescent dye, with the molecular weight of 70 kD. TRITC-dextran, MW 70000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 70000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-D1366
-
|
Fluorescent Dye
|
|
Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
|
-
- HY-D0166
-
|
Fluorescent Dye
|
Others
|
Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red .
|
-
- HY-D0869
-
N-Cyclohexyl-3-aminopropanesulfonic acid
|
Biochemical Assay Reagents
|
Others
|
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis .
|
-
- HY-D1477
-
|
Fluorescent Dye
|
Others
|
5(6)-Carboxyfluorescein diisobutyrate is a protected 5(6)-carboxyfluorescein. 5(6)-carboxyfluorescein is a fluorescence pH indicator .
|
-
- HY-155667
-
|
Others
|
Others
|
Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
|
-
- HY-155667A
-
|
Cathepsin
|
Others
|
Z-Nle-Lys-Arg-AMC acetate is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range .
|
-
- HY-W105704
-
|
Biochemical Assay Reagents
|
Others
|
HEPBS is a zwitterionic buffering agent with a pH range (7.6-9.0) similar to that of biological systems. HEPBS can be used in the culture of cells .
|
-
- HY-P2729
-
EC 3.4.21.14
|
Others
|
Others
|
Subtilisin, or rubinase, is a bacterial serine protease. Subtilisin can be used as a detergent additive with thermal stability, pH tolerance, and calcium dependent stability .
|
-
- HY-109541S6
-
(Rac)-DMPC-d72
|
Isotope-Labeled Compounds
|
Others
|
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph
|
-
- HY-125066
-
|
Bacterial
|
Infection
|
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC50=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.
|
-
- HY-P99965
-
SKY59; RO7112689
|
Complement System
|
Cardiovascular Disease
Metabolic Disease
|
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
|
-
- HY-17608
-
GSK1278863
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
|
-
- HY-D0867
-
|
Biochemical Assay Reagents
|
Others
|
BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES is used in the diagnostic testing area.
|
-
- HY-D0867A
-
|
Biochemical Assay Reagents
|
Others
|
BES sodium is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES sodium is used in the diagnostic testing area.
|
-
- HY-D1556
-
|
Fluorescent Dye
|
Others
|
DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids .
|
-
- HY-15923
-
|
Reactive Oxygen Species
|
Others
|
MAOS is a modified Trinder’s reagent that can be used as a chromogenic probe for the determination of H2O2. MAOS is strongly dependent on the pH of the reaction medium .
|
-
- HY-158082D
-
Tetramethyl rhodamine isothiocyanate glucan, MW 150000
|
Fluorescent Dye
|
Others
|
TRITC-dextran, MW 150000 (Tetramethyl rhodamine isothiocyanate glucan, MW 150000) is a fluorescent dye, with the molecular weight of 150 kD. TRITC-dextran, MW 150000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 150000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 150000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-158082E
-
Tetramethyl rhodamine isothiocyanate glucan, MW 500000
|
Fluorescent Dye
|
Others
|
TRITC-dextran, MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye, with the molecular weight of 500 kD. TRITC-dextran, MW 500000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 500000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 500000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-158082H
-
Tetramethyl rhodamine isothiocyanate glucan, MW 2000000
|
Fluorescent Dye
|
Others
|
TRITC-dextran, MW 2000000 (Tetramethyl rhodamine isothiocyanate glucan, MW 2000000) is a fluorescent dye, with the molecular weight of 2000 kD. TRITC-dextran, MW 2000000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 2000000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 2000000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-W747507
-
|
Bacterial
|
Infection
|
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC50s=1.6 and 1.3 μg/mL, respectively).
|
-
- HY-128476
-
|
Others
|
Others
|
Sodium Tartrate is a pH-Regulating agent with antioxidant activity. Sodium Tartrate is particularly effective retarding hydrolysis while heating at high temperatures, resulting in increase of acid values (AVs) of vegetable oils .
|
-
- HY-W002110
-
3-Hydroxy-4-methoxypHenylacetic acid; iso-HVA; Homoisovanillic acid
|
Endogenous Metabolite
|
Cancer
|
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is extracted from urine at pH 2 by ethyl acetate. Isohomovanillic acid is not found in appreciable values in many normal human urines .
|
-
- HY-D0866
-
N-(2-Acetamido)-2-aminoethanesulfonic acid
|
Biochemical Assay Reagents
|
Others
|
ACES (N-(2-Acetamido)-2-aminoethanesulfonic acid) is a zwitterionic buffer. The working pH range of ACES buffer is 6.8-7.2 .
|
-
- HY-N11071
-
|
Bacterial
|
Infection
|
Monascorubramine is a microbial colorant. Monascorubramine is capable of producing by the Monascus, which is from the bacteria Talaromyces. Under the condition of different pH value, the hue and chromaticity value of the colorant are also different .
|
-
- HY-137873
-
4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside; 4-MU-α-D-Glucopyranoside
|
Fluorescent Dye
|
Others
|
4-Methylumbelliferyl-α-D-Glucopyranoside (4-Methylumbelliferyl-α-D-Glucose; 4-Methylumbelliferyl-α-D-Glucoside) is a fluorogenic substrate for α-glucosidase. 4-Methylumbelliferyl-α-D-glucopyranoside is cleaved by α-glucosidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high pH (7.12-10.3), respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-α-D-glucopyranoside has been used to quantify α-glucosidase activity in infant blood spot samples as a biomarker of Fabry and Pompe diseases, lysosomal storage disorders characterized by a deficiency in the enzyme.
|
-
- HY-W460471
-
|
Biochemical Assay Reagents
|
Others
|
Tris Buffered Saline is a common buffer reagent in molecular biology, consisting of Tris and NaCl. Tris Buffered Saline can adjust pH and ionic strength and is widely used in DNA/RNA extraction, PCR and protein electrophoresis. Tris Buffered Saline can purify and protect nucleic acid materials and improve reaction efficiency and concentration. In protein electrophoresis, Tris Buffered Saline stabilizes gels and maintains pH. Overall, Tris Buffered Saline offers versatility, good solubility, and low toxicity in molecular biology applications.
|
-
- HY-158082
-
Tetramethyl rhodamine isothiocyanate glucan, MW 4000
|
Fluorescent Dye
|
Others
|
TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-158082A
-
Tetramethyl rhodamine isothiocyanate glucan, MW 20000
|
Fluorescent Dye
|
Others
|
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-158082B
-
Tetramethyl rhodamine isothiocyanate glucan, MW 40000
|
Fluorescent Dye
|
Others
|
TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
-
- HY-15942
-
5-TAMRA
1 Publications Verification
|
Fluorescent Dye
|
Others
|
5-TAMRA (5-Carboxytetramethylrhodamine), SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
|
-
- HY-100718
-
|
Others
|
Cardiovascular Disease
|
SCH00013 is a cardiotonic agent that primarily acts via an increase in myofibrillar Ca++ sensitivity, have a significant Ca(2+)sensitizing effect at pH 7.2 to 7.4.
|
-
- HY-23430
-
-
- HY-W127770
-
|
Fluorescent Dye
|
Others
|
Pararosaniline hydrochloride is a pH-responsive basic dye, as a biological stain to track certain proteins. Pararosaniline hydrochloride has been used in the analysis of SO2 and formaldehyde and staining of bacteria or other organisms .
|
-
- HY-23430A
-
|
Biochemical Assay Reagents
|
Others
|
TES sodium is a buffering agent (pKa=7.550 at 25°C). TES sodium is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2 .
|
-
- HY-D0112
-
|
Fluorescent Dye
|
Others
|
7-Hydroxycoumarin-4-acetic acid, a pH-indicator dye, is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm) .
|
-
- HY-155754
-
|
ATP Synthase
|
Others
|
3’-Acetate-ATP, an ATP analogue, is ATP acetylation product with an maxima uv absorption at 259 nm in water at neutral pH. 3’-Acetate-ATP exerts a blocking effect on nucleic acid polymerization .
|
-
- HY-45545
-
|
Others
|
Others
|
Fmoc-gly-gly-ph-gly-nh-ch2-o-ch2cooh can be used to synthesize the ADC Linker, LND1067 .
|
-
- HY-12654
-
BAY 85-3934
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
Molidustat (BAY 85-3934) is a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with mean IC50 values of 480 nM for PHD1, 280 nM for PHD2, and 450 nM for PHD3.
|
-
- HY-D0048
-
5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester
|
Fluorescent Dye
|
Others
|
5-TAMRA-SE is an amine-reactive fluorescent agent, its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
|
-
- HY-18749
-
SC79
Maximum Cited Publications
164 Publications Verification
|
Akt
|
Neurological Disease
Inflammation/Immunology
Cancer
|
SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt .
|
-
- HY-126193
-
|
NO Synthase
Apoptosis
|
Cancer
|
JS-K is a NO donor that reacts with glutathione to generate NO at physiological pH . JS-K inhibits proliferation, induces apoptosis, and disrupts the cell cycle of Jurkat T acute lymphoblastic leukemia cells .
|
-
- HY-D2254
-
|
Fluorescent Dye
|
Others
|
CTB probe-1 (probe 1) a lysosome-targeting fluorogenic small-molecule probe for fluorescence imaging in living cells .
|
-
- HY-123633
-
|
Glucosidase
|
Others
|
4-Methylumbelliferyl β-D-Glucopyranoside, a β-D-glucoside, is a fluorogenic substrate for β-glucosidase, utilizes to assay β-glucosidase activity . 4-Methylumbelliferyl β-D-Glucopyranoside releases the highly fluorescent 4-methylumbelliferyl (4-MU), which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively .
|
-
- HY-B2227B
-
Lactic acid sodium
|
Bacterial
|
Metabolic Disease
|
Lactate (Lactic acid) sodium is the product of glycogenolysis and glycolysis . Lactate (Lactic acid) sodium is an organic salt that is mainly used as a buffer and pH adjuster for injection solutions. Lactate sodium can be metabolized by the body into sodium bicarbonate, which in turn acts to increase the pH of the blood. Lactate sodium is used to improve metabolic acidosis and hypovolemic states. In terms of pharmaceutical preparations, Lactate sodium is often used in combination with sodium chloride, glucose, etc. to form normal saline or compound liquid intravenous injection . Lactate sodium also has antimicrobial activity, which can be used as a food preservative .
|
-
- HY-Y0836
-
Diethyl Butanedioate
|
Biochemical Assay Reagents
|
Metabolic Disease
|
Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring .
|
-
- HY-D0857
-
HEPES
3 Publications Verification
|
Biochemical Assay Reagents
|
Others
|
HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis .
|
-
- HY-147104
-
|
Fluorescent Dye
|
Others
|
Fmoc-Lys(5-FITC)-OH is a marker for polypeptides or proteins. FITC is a fluorescence probe for the labeling of amines. FITC is a pH- and Cu 2+-sensitive fluorescence dye .
|
-
- HY-W040291
-
|
Fluorescent Dye
|
Cancer
|
7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.
|
-
- HY-131510
-
SNARF-DE
|
Fluorescent Dye
|
Others
|
Chromoionophore XIII (SNARF-DE) is a pH senor that enables excitation with red light. Chromoionophore XIII functionality renders the indicator molecule lipophilic and water-insoluble but also prevents lactonization of the dye in an apolar environment .
|
-
- HY-138547
-
Diaminopropanoltetraacetic acid
|
Biochemical Assay Reagents
|
Others
|
DHPTA (compound 3) can directly combine with lanthanide elements (Tb 3+, Ho 3+, Lu 3+) to form a strong chelating effect,in aqueous solution with a pH of 2.0-7.0 .
|
-
- HY-145391
-
|
Influenza Virus
|
Infection
|
Triperiden is an inhibitor of influenza virus multiplication. Triperiden targets the haemagglutinin of fowl plague virus (FPV) for antiviral activity and acts by inhibiting the conformational change in the haemagglutinin at acid pH. Triperiden is also anticholinergic anti-parkinsonism agent .
|
-
- HY-D1082
-
|
Fluorescent Dye
|
Others
|
5-DTAF is a isomeric fluorescein derivative that directly react with polysaccharides and other alcohols in aqueous solution at pH > 9. The maximum of the 5-DTAF emission profile is at a wavelength of 518 nm after excitation at 488 nm .
|
-
- HY-D0859S
-
|
Isotope-Labeled Compounds
|
Others
|
MOPS-d15 is the deuterium labeled MOPS[1]. MOPS is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media[2][3].
|
-
- HY-P0224
-
fMLP; N-Formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
|
-
- HY-101677
-
|
Drug Metabolite
|
Infection
|
cPrPMEDAP is an intermediate metabolite of GS-9219. cpr-PMEDAP functions as a proagent of the guanine nucleotide analog PMEG and has antiproliferative activity. cPrPMEDAP is negatively charged at physiologic pH and has poor permeability into the skin .
|
-
- HY-141475
-
|
Endogenous Metabolite
|
Others
|
Acetoacetyl coenzyme A sodium is a central endogenous metabolite. The Km at pH 7.5 for Acetoacetyl coenzyme A sodium is 1.10 mM. Acetoacetyl coenzyme A sodium can be used for the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) .
|
-
- HY-P99853
-
CR6261
|
Influenza Virus
|
Infection
|
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus .
|
-
- HY-101277
-
PG-1016548; AKB-6548
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
Vadadustat (PG-1016548) is a titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor . Vadadustat is an erythropoiesis-stimulating agent and has the potential for anemia treatment in chronic kidney disease in vivo .
|
-
- HY-129457
-
FINO2
2 Publications Verification
|
Ferroptosis
|
Cancer
|
FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .
|
-
- HY-D1593
-
|
Fluorescent Dye
|
Others
|
BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
|
-
- HY-P2863
-
DNase II
|
Endonuclease
|
Others
|
Deoxyribonuclease II (DNase II) is an endonuclease that hydrolyzes the phosphodiester bonds of deoxyribonucleotides in native and denatured DNA, producing 3' phosphate and 5'-hydroxyl termini. Deoxyribonuclease II works best at acidic pH and is commonly used in biochemical research .
|
-
- HY-116284A
-
Methyl β-D-glucoside hemihydrate
|
Others
|
Others
|
Methyl β-D-glucopyranoside (Methyl β-D-glucoside) hemihydrate is a hemihydrate compound. Methyl β-D-glucopyranoside hemihydrate less reactive at higher PH. The formation of Methyl β-D-glucopyranoside hemihydrate is stereospecific .
|
-
- HY-W110798
-
|
Biochemical Assay Reagents
|
Others
|
Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.
|
-
- HY-148610
-
|
Others
|
Metabolic Disease
|
LDH-IN-2, a salicylic acid derivative, is an inhibitor of glycolate oxidase (GO). LDH-IN-2 decreases oxalate output in hyperoxaluric hepatocytes. LDH-IN-2 can be used for research of primary hyperoxaluria type 1 (PH1) .
|
-
- HY-D0860
-
|
Biochemical Assay Reagents
|
Others
|
Tricine is widely used as a buffer in protein electrophoresis, nucleic acid analysis, and immunology, which can help adjust pH and stabilize chemical reactions. In addition, the compound can also be used in research in certain medical fields, such as in antibody detection and drug screening.
|
-
- HY-132606
-
DCR-pHXC
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate .
|
-
- HY-139305
-
|
Liposome
|
Cancer
|
CL4H6 is a pH-sensitive cationic lipid. CL4H6 is the main component of lipid nanoparticles (LNPs), which can be used to target and deliver siRNA, and induces a potent gene-silencing response .
|
-
- HY-138540
-
N-Dodecylimidazole
|
Fungal
|
Cancer
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .
|
-
- HY-125374A
-
XRP9881 dihydrate
|
Others
|
Cancer
|
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors .
|
-
- HY-132613
-
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .
|
-
- HY-Y1242
-
|
Biochemical Assay Reagents
|
Others
|
Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .
|
-
- HY-P4773
-
|
HSV
|
Infection
|
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M -1 s -1 .
|
-
- HY-17608R
-
|
HIF/HIF Prolyl-Hydroxylase
|
Cardiovascular Disease
|
Daprodustat (Standard) is the analytical standard of Daprodustat. This product is intended for research and analytical applications. Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
|
-
- HY-D0952
-
|
Parasite
|
Others
|
Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .
|
-
- HY-15529
-
|
Na+/HCO3- Cotransporter
|
Cardiovascular Disease
|
S0859 is a selective, high-affinity generic Na +/HCO3 - transporter (NBC) inhibitor. S0859 reversibly inhibits NBC-mediated intracellular pH (pHi) recovery (Ki=1.7 μM, full inhibition at approximately 30 μM).
|
-
- HY-15369
-
|
Akt
Apoptosis
|
Cancer
|
FPA-124, a cell-permeable copper complex, is a selective Akt inhibitor with an IC50 of 0.1 μM. FPA-124 interacts with both the pleckstrin homology (PH) and the kinase domains of Akt. FPA-124 induces apoptosis .
|
-
- HY-D0873
-
EPPS
|
Amyloid-β
|
Neurological Disease
|
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier .
|
-
- HY-D0877
-
|
Biochemical Assay Reagents
|
Others
|
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .
|
-
- HY-114174
-
|
Amyloid-β
|
Neurological Disease
|
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .
|
-
- HY-W250110
-
|
Biochemical Assay Reagents
|
Infection
Others
|
Polyethylenimine (PEI) branched is a organic macromolecule with high cationic-charge-density potential. PEI can ensnare DNA as well as attach to cell membrane, PEI also retains a substantial buffering capacity at virtually any pH. PEI is widely used as transfection reagent .
|
-
- HY-D1549
-
|
Fluorescent Dye
|
Others
|
o-Pah is a BODIPY derivative with an -NH2 and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu 2+ and a specific fluorescence enhancement for Hg 2+ (Ex/Em=483/(495-600) nM) .
|
-
- HY-23430S
-
|
Isotope-Labeled Compounds
|
Others
|
TES-d15 is the deuterium labeled TES[1]. TES is a buffering agent (pKa=7.550 at 25°C). TES is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2[2][3].
|
-
- HY-128945
-
|
ADC Linker
|
Inflammation/Immunology
Cancer
|
CL2A is a claevable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. Labetuzumab govitecan used this linker .
|
-
- HY-130027
-
HKOCl-4
1 Publications Verification
BXY2142
|
Fluorescent Dye
|
Others
|
HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity . HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm.
|
-
- HY-P2818
-
Apase
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
Alkaline phosphatase, Bovine intestine (Apase) is a membrane-bound glycoprotein that catalyzes the hydrolysis of phosphate monoesters at alkaline pH. Alkaline phosphatase can be used in molecular biology and enzyme-free analysis. Inhibition of tissue nonspecific alkaline phosphatase can block intracellular lipid accumulation .
|
-
- HY-110257
-
|
Fluorescent Dye
|
Others
|
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λabs: 504 nm; λem:510 nm .
|
-
- HY-114352
-
|
Fluorescent Dye
|
Others
|
BODIPY FL-X is a green-fluorescent dye. BODIPY FL-X has the succinimidyl ester covalently coupled to proteins. BODIPY FL-X has high fluorescence quantum yield and is relatively insensitive to pH change. (λex=504 nm, λem=510 nm) .
|
-
- HY-D1676
-
|
Phosphatase
|
Others
|
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum .
|
-
- HY-D0869S
-
|
Isotope-Labeled Compounds
|
Others
|
3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
|
-
- HY-W151206
-
|
Fluorescent Dye
|
Others
|
Hydroxy naphthol blue disodium, an azo dye, is a metal indicator for calcium and a colorimetric reagent for alkaline earth metal ions ( λmax = 650 nm). In the pH range between 12 and 13, the solution of the indicator is reddish pink in the presence of calcium ion and to deep blue in the presence of disodium EDTA .
|
-
- HY-142981
-
DODA
|
Liposome
|
Others
|
Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9 .
|
-
- HY-E70325
-
|
Endogenous Metabolite
|
Others
|
Maltogenic amylase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70331
-
|
Endogenous Metabolite
|
Others
|
Acid Stable Protease is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70335
-
|
Endogenous Metabolite
|
Others
|
Colipase, Porcine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70336
-
|
Endogenous Metabolite
|
Others
|
Peroxidase, Lignin is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70338
-
|
Endogenous Metabolite
|
Others
|
Ketoamine oxidase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70345
-
|
Endogenous Metabolite
|
Others
|
Homocysteine methyltransferase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70354
-
|
Endogenous Metabolite
|
Others
|
Protease for flavors is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-14179
-
PPQ-102
3 Publications Verification
CFTR Inhibitor
|
CFTR
|
Others
|
PPQ-102 (CFTR Inhibitor) is a reversible CFTR inhibitor that completely inhibits CFTR chloride currents (IC50 ~90 nM). PPQ-102 is not affected by membrane potential-dependent cell allocation or blocking efficiency (uncharged at physiological pH) and effectively prevents cyst enlargement in polycystic kidney disease .
|
-
- HY-149035
-
|
Others
|
Cancer
|
PAA4 is a methide carbon-centered polynuclear Au(I) clusters. PAA4 shows antiproliferative activity. PAA4 increases the expression of pH2AX in a time dependent manner. PAA4 shows anti-tumor effect in orthotopic bladder cancer mouse model .
|
-
- HY-D0857S
-
|
Isotope-Labeled Compounds
|
Others
|
HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
|
-
- HY-P4522
-
|
Endogenous Metabolite
|
Others
|
Bz-Ala-Arg is a dipeptide. Bz-Ala-Arg is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg can be used to screen competitive inhibitors of these two enzymes .
|
-
- HY-Y1269D
-
Salmiac, for molecular biology
|
Biochemical Assay Reagents
Autophagy
|
Cancer
|
Ammonium chloride, for molecular biology is ammonium chloride that can be used for molecular biology research. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.
|
-
- HY-E70309
-
|
Endogenous Metabolite
|
Others
|
Casein hydrolysate enzymatic is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70326
-
|
Endogenous Metabolite
|
Others
|
Acid Protease, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70327
-
|
Endogenous Metabolite
|
Others
|
Aspartate Aminotransferase, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70332
-
|
Endogenous Metabolite
|
Others
|
Lipase, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70337
-
|
Endogenous Metabolite
|
Others
|
Heparanase 1, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70340
-
|
Endogenous Metabolite
|
Others
|
Lipoamide dehydrogenase, porcine is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70346
-
|
Endogenous Metabolite
|
Others
|
S-Adenosylmethionine synthetase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70347
-
|
Endogenous Metabolite
|
Others
|
Tn5 Transposase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-D0031
-
APTS
|
Fluorescent Dye
|
Others
|
8-Aminopyrene-1,3,6-trisulfonic acid trisodium is a water-soluble anionic fluorescent dye. The fluorescence intensity of 8-Aminopyrene-1,3,6-trisulfonic acid trisodium remains nearly constant over a pH range from 4 to 10 .
|
-
- HY-149036
-
-
- HY-E70328
-
|
Endogenous Metabolite
|
Others
|
Alkalophilic Proteinase, Streptomyces sp is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70330
-
|
Endogenous Metabolite
|
Others
|
Neutral Proteinase, Bacillus sp. is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70342
-
|
Endogenous Metabolite
|
Others
|
Glucose isomerase, streptomyces murinus is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70343
-
|
Endogenous Metabolite
|
Others
|
Human leukocyte esterase (unsonicated) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70344
-
|
Endogenous Metabolite
|
Others
|
Cystathionine γ-lyase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70349
-
|
Endogenous Metabolite
|
Others
|
Betaine homocysteine S-methyltransferase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70351
-
|
Endogenous Metabolite
|
Others
|
Trypsin-Chymotrypsin 1:1 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70352
-
|
Endogenous Metabolite
|
Others
|
Trypsin-Chymotrypsin 1:250 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70353
-
|
Endogenous Metabolite
|
Others
|
Trypsin-Chymotrypsin 6:1 is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-D0234
-
ortho-CresolpHthalein
|
Endogenous Metabolite
|
Others
|
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-D0861
-
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
-
- HY-D0876
-
|
Biochemical Assay Reagents
|
Others
|
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .
|
-
- HY-D1654
-
|
Fluorescent Dye
|
Others
|
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
|
-
- HY-W176012
-
|
Others
|
Metabolic Disease
|
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC50 of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) .
|
-
- HY-P99681
-
IMMU 130; hMN-14-SN-38
|
Antibody-Drug Conjugates (ADCs)
|
Cancer
|
Labetuzumab govitecan (IMMU 130) is an Anti-CEACAM5/SN-38 antibody-drug conjugate (ADC). Labetuzumab govitecan consists of the antibody Labetuzumab, SN-38, and a pH-sensitive Linker. Labetuzumab govitecan can be used for research of cancers, such as colorectal cancer .
|
-
- HY-Y0836S1
-
Diethyl Butanedioate-d4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-E70320
-
Immobilized cefadroxil acylase
|
Endogenous Metabolite
|
Others
|
AMK618 (Immobilized cefadroxil acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70321
-
Immobilized cefradine acylase
|
Endogenous Metabolite
|
Others
|
AMK518 (Immobilized cefradine acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70322
-
Immobilized cefaclor acylase
|
Endogenous Metabolite
|
Others
|
AMK328 (Immobilized cefaclor acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70323
-
Immobilized cepHalexin acylase
|
Endogenous Metabolite
|
Others
|
AMK318 (Immobilized cephalexin acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70324
-
Immobilized amoxicillin acylase
|
Endogenous Metabolite
|
Others
|
AMK218 (Immobilized amoxicillin acylase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70341
-
|
Endogenous Metabolite
|
Others
|
Histamine N-methyl transferase, rat is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70350
-
|
Endogenous Metabolite
|
Others
|
Ribonuclease T2, Aspergillus oryzae is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-111549
-
|
Others
|
Cancer
|
Bragsin1 is a potent, selective and noncompetitive inhibitor of the ArfGEF BRAG2, inhibits Arf GTPase activation, with an IC50 of 3 μM. Bragsin1 binds to PH domain of BRAG2, and is a noncompetitive interfacial inhibitor. Bragsin1 has no effect on the Sec7 domain of human ArfGEFs. Anti-cancer activity .
|
-
- HY-108717
-
Protease K
|
Ser/Thr Protease
|
Others
|
Proteinase K (Protease K) is a nonspecific serine protease that is useful for general digestion of proteins. Proteinase K is active in the presence of SDS or urea and over a wide range of pH (4-12), salt concentrations, and temperatures. Proteinase K can be use for promoting methods of viral nucleic acid extraction, and detection .
|
-
- HY-145413
-
|
Glutathione S-transferase
|
Cancer
|
BRD2889 is an analog of the alkaloid piperlongumine. BRD2889 is a robust modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) . BRD2889 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-151544
-
|
Fluorescent Dye
|
Others
|
PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process .
|
-
- HY-15351
-
NSC 675186
|
HIV
|
Infection
|
UC-781 (NSC 675186) is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1 with an IC50 value of 5 nM. UC-781 is stable under low PH or various temperatures conditions. UC-781 has antiviral activity and resistance .
|
-
- HY-Y0836S
-
1,4-Diethyl butanedioate-1,2,3,4-13C4
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
- HY-N8502
-
|
Fluorescent Dye
|
Cancer
|
Urdamycin A (Compound 3b) is an angucycline antibiotic that can be isolated from Streptomyces fradiae. Urdamycin A is an orange indicator with a change of the color to ultramarine blue at pH 7.7. Urdamycin A has anticancer activity with IC50s of 2.4 and 0.55 μg/mL in proliferation and stem cell assays, respectively .
|
-
- HY-E70283
-
rEGCase II assisted by Activator II
|
Endogenous Metabolite
|
Others
|
Recombinant endoglycoceramidase II assisted by activator II is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70315
-
Fungal Endo- and Exo- chitosanases
|
Endogenous Metabolite
|
Others
|
Chimax-G (Fungal Endo- and Exo- chitosanases) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70317
-
Fungal Endo- and Exo- chitinases
|
Endogenous Metabolite
|
Others
|
Chimax-N (Fungal Endo- and Exo- chitinases) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70334
-
|
Endogenous Metabolite
|
Others
|
Carboxypeptidase Y, Baker's yeast (S. cerevisiae) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-P4522A
-
|
Endogenous Metabolite
|
Others
|
Bz-Ala-Arg TFA is a dipeptide. Bz-Ala-Arg TFA is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg TFA can be used to screen competitive inhibitors of these two enzymes .
|
-
- HY-15940
-
5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers
|
Fluorescent Dye
|
Cancer
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .
|
-
- HY-111550
-
|
Others
|
Cancer
|
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells .
|
-
- HY-D1156
-
|
Reactive Oxygen Species
Fluorescent Dye
|
Others
|
HKSOX-1m (5/6-mixture) is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells .
|
-
- HY-D1156A
-
|
Reactive Oxygen Species
Fluorescent Dye
|
Others
|
HKSOX-1m (5/6-mixture) hydrobromide is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells .
|
-
- HY-D0861A
-
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
-
- HY-D1688
-
|
Fluorescent Dye
|
Others
|
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located .
|
-
- HY-151712
-
|
Fluorescent Dye
|
Others
|
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.
|
-
- HY-108798
-
|
VEGFR
|
Cardiovascular Disease
Cancer
|
Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases .
|
-
- HY-E70312
-
Candida antarctica lipase
|
Endogenous Metabolite
|
Others
|
CalB-10Xup (Candida antarctica lipase) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70333
-
AR2000
|
Endogenous Metabolite
|
Others
|
Rapidase Revelation Aroma (AR2000), Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-E70348
-
|
Endogenous Metabolite
|
Others
|
L-Methionine γ-lyase, pseudomonas putida is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
-
- HY-137798
-
|
Fluorescent Dye
|
Others
|
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated .
|
-
- HY-B1422S
-
Aminacrine-13C6
|
Bacterial
HIV
Isotope-Labeled Compounds
|
Infection
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-132588
-
ALN-G01
|
Small Interfering RNA (siRNA)
|
Metabolic Disease
|
Lumasiran (ALN-G01), a siRNA product, reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1) .
|
-
- HY-113314
-
|
Endogenous Metabolite
|
Cancer
|
AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity . AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway .
|
-
- HY-124473
-
NapHthafluorescein
|
HIF/HIF Prolyl-Hydroxylase
|
Cancer
|
Naphthofluorescein inhibits the interaction between HIF-1 and Mint3.
Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo . Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging .
|
-
- HY-147087
-
|
Liposome
|
Cancer
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
|
-
- HY-146659S
-
3-(pHenylthio)-DL-alanine; H-DL-Cys(pH)-OH-d2
|
Isotope-Labeled Compounds
|
Others
|
S-Phenyl-DL-cysteine-3,3-d2 is the deuterium labeled S-Phenyl-DL-cysteine-3,3[1].
|
-
- HY-128144
-
|
Lipase
|
Metabolic Disease
|
Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .
|
-
- HY-108460
-
|
TRP Channel
|
Neurological Disease
|
A-784168 is a potent and orally active inhibitor of vanilloid receptor type 1 (TRPV1). Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. A-784168 has good CNS penetration .
|
-
- HY-151713
-
|
Fluorescent Dye
|
Others
|
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene .
|
-
- HY-P5780
-
|
Sodium Channel
|
Neurological Disease
|
π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM .
|
-
- HY-D2083
-
|
Fluorescent Dye
|
Cancer
|
BODIPY 540 (purity>98%) is a BODIPY dye.BODIPY dye is a small molecule dye with strong UV absorption ability.Its fluorescence peak is relatively sharp, its quantum yield is high, and it is relatively insensitive to the polarity and pH value of the environment.BODIPY 540 (purity>98%) has a purity higher than 98% and is suitable for cell experiments .
|
-
- HY-15295
-
TAK-438
|
Proton Pump
|
Metabolic Disease
|
Vonoprazan Fumarate (TAK-438), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan Fumarate inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan Fumarate is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease .
|
-
- HY-D0914
-
FD&C Green No. 3; Food green 3; C.I. 42053
|
Fluorescent Dye
|
Others
|
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .
|
-
- HY-D2324
-
|
Fluorescent Dye
|
Others
|
EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 .
|
-
- HY-50868
-
INNO-406; NS-187
|
Bcr-Abl
Src
Apoptosis
|
Cancer
|
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph + leukemia cells. Bafetinib has antitumor activity .
|
-
- HY-127019
-
-
- HY-150086
-
CF4
|
Fluorescent Dye
|
Others
|
Copper Fluor-4 (CF4) is a Cu +-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (Ex: 488 nm) .
|
-
- HY-P10228
-
|
Fungal
Bacterial
|
Infection
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
|
-
- HY-161497
-
|
E3 Ligase Ligand-Linker Conjugates
|
Cancer
|
Thalidomide-benzylamine-Py-NH2 is a conjugate of E3 ligase ligand and linker, which is consisted of a Thalidomide (HY-14658) and the Linker Boc-NHCH2-Ph-Py-NH2 (HY-161496). Thalidomide-benzylamine-Py-NH2 is utilized for synthesis of PROTAC molecule XYD190 (HY-161494) .
|
-
- HY-W440883
-
|
Liposome
|
Others
|
DSPE-PEG-Ald, MW 2000 is a phospholipid polyPEG which can self-assemble to form lipid bilayer in aqueous solution. The polymer can be used to prepare liposome as a drug delivery vehicle for administration of drugs or nutrients, such as mRNA vaccines. The aldehyde is reactive with aminooxy to form a stable oxime linkage or with amine at pH < 7 to form a reversible imine bond. Reagent grade, for research use only.
|
-
- HY-12914
-
|
TRP Channel
|
Neurological Disease
Inflammation/Immunology
|
V116517 is a potent, orally active transient receptor potential vanilloid (TRPV1) antagonist. V116517 shows potent activity in inhibiting both capsaicin (CAP)- and acid (pH 5)-induced currents in rat DRG neurons expressing native TRPV (IC50=423.2 nM for CAP; IC50=180.3 nM for acid). V116517 can be used for the research of pain .
|
-
- HY-110077
-
|
Akt
Apoptosis
|
Cancer
|
API-1, a potent Akt/PKB inhibitor, binds to the PH domain and inhibits Akt membrane translocation. API-1 efficiently reduces the phosphorylation levels of Akt with an IC50 of ∼0.8 μM. API-1 is selective for PKB and does not inhibit the activation of PKC, and PKA. API-1 also induces apoptosis by synergizing with TNF-related apoptosis-inducing ligand (TRAIL) .
|
-
- HY-100007A
-
TAK-438 hydrochloride
|
Proton Pump
Bacterial
|
Infection
Endocrinology
|
Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori .
|
-
- HY-14818
-
R 125489
|
Influenza Virus
|
Infection
|
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively .
|
-
- HY-15558
-
bisBenzimide H 33258; H 33258
|
Fluorescent Dye
|
Cancer
|
Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15559
-
bisBenzimide H 33342; HOE 33342
|
Autophagy
|
Others
|
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15560
-
HOE 34580
|
Amyloid-β
|
Neurological Disease
|
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15619
-
Nuclear yellow
|
Fluorescent Dye
|
Others
|
Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15561
-
meta-Hoechst
|
Fluorescent Dye
|
Cancer
|
HOE-S 785026 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15562
-
|
Fluorescent Dye
|
Others
|
HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15622
-
|
DNA Stain
|
Cancer
|
meta-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15623
-
|
DNA Stain
|
Others
|
Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15626
-
|
Fluorescent Dye
|
Others
|
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15627
-
|
Fluorescent Dye
|
Others
|
Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15629
-
|
DNA Stain
|
Others
|
HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15632
-
|
Fluorescent Dye
|
Others
|
para-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15559A
-
bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
|
Autophagy
|
Others
|
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-100007
-
TAK-438 free base
|
Proton Pump
Bacterial
|
Endocrinology
|
Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .
|
-
- HY-15561B
-
meta-Hoechst trihydrochloride
|
Fluorescent Dye
|
Others
|
HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15560B
-
HOE 34580 tetrahydrochloride
|
Amyloid-β
|
Neurological Disease
|
Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15558A
-
bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
|
Fluorescent Dye
|
Cancer
|
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-106991A
-
S-303 dihydrochloride
|
HIV
Bacterial
|
Infection
|
Amustaline (S-303) dihydrochloride, a nucleic acid-targeted alkylator, is an efficient pathogen inactivation agent for blood components containing red blood cells. Amustaline dihydrochloride has three components: an acridine anchor (an intercalator that targets nucleic acids non-covalently), an effector (a bis-alkylator group that reacts with nucleophiles), and a linker (a small flexible carbon chain containing a labile ester bond that hydrolyzes at neutral pH to yield non-reactive breakdown products) .
|
-
- HY-15563
-
|
Fluorescent Dye
|
Others
|
HOE 33187 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-17507S
-
BY1023-d6; SKF96022-d6
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Apoptosis
|
Inflammation/Immunology
Cancer
|
Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
- HY-17507S1
-
BY1023-d3; SKF96022-d3
|
Isotope-Labeled Compounds
Proton Pump
Autophagy
Apoptosis
|
Inflammation/Immunology
Cancer
|
Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
- HY-P4108
-
|
Influenza Virus
|
Others
|
TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide induces the cellular uptake of macromolecules into endosomes via the TAT moiety and to respond to the acidifying lumen of endosomes to cause membrane leakage and release of macromolecules into cells via the HA2 moiety .
|
-
- HY-15624
-
|
DNA Stain
|
Cancer
|
Hoechst 33258 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15625
-
|
DNA Stain
|
Others
|
Hoechst 33258 analog 3 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15628
-
|
DNA Stain
|
Others
|
Hoechst 33258 analog 5 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15630
-
|
Fluorescent Dye
|
Cancer
|
Hoechst 33342 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15631
-
|
Fluorescent Dye
|
Others
|
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-15893
-
Dimethyloxallyl Glycine
|
HIF/HIF Prolyl-Hydroxylase
Autophagy
|
Cancer
|
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF-PH, which results in HIF-1α stabilisation and accmulation in vitro and in vivo . DMOG is an α-ketoglutarate analogue and inhibits α-KG-dependent hydroxylases. DMOG acts as a pro-angiogenic agent and plays a protective role in experimental model of colitis and diarrhoea via HIF-1 related signal . DMOG induces cell autophagy .
|
-
- HY-15630A
-
|
Fluorescent Dye
|
Others
|
Hoechst 33342 analog 2 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
-
- HY-128943
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma .
|
-
- HY-143285
-
|
Fluorescent Dye
|
Infection
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
|
-
- HY-P5704
-
|
Bacterial
|
Infection
|
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .
|
-
- HY-17507AR
-
BY1023 sodium (Standard); SKF96022 sodium (Standard)
|
Proton Pump
Autophagy
Apoptosis
Bacterial
|
Inflammation/Immunology
Cancer
|
Pantoprazole (sodium) (Standard) is the analytical standard of Pantoprazole (sodium). This product is intended for research and analytical applications. Pantoprazole sodium (BY10232 sodium) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole sodium, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole sodium improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole sodium significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
|
-
- HY-E70311
-
Thermomyces lanuginosus lipase
|
Endogenous Metabolite
|
Others
|
TLL-10X (Thermomyces lanuginosus lipase) is a high-efficiency biocatalyst, a lipase from Thermomyces lanuginosus. TLL-10X can be conjugated to magnetic nanoparticles and coupled to the surface of Fe(3)O(4)-COOH to obtain better temperature resistance and pH resistance. The activity unit (U) of lipase is defined as the amount of enzyme that produces 1 μmol of fatty acid per minute under experimental conditions .
|
-
- HY-E70318
-
Immobilized Penicillin G acylase
|
Endogenous Metabolite
|
Others
|
AMK-GX (Immobilized Penicillin G acylase) is an immobilized penicillin acylase with improved temperature and pH stability. AMK-GX has reusable performance and high recovery rates, retaining much of its original activity after 12 cycles. Among them, AMK-GX can catalyze penicillin G (PG) to generate 6-aminopenicillanic acid (6-APA) and 7-aminodeacetoxycephalosporanic acid, which are key intermediates for β-lactam antibiotics .
|
-
- HY-P10329
-
|
Fungal
|
Infection
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
-
- HY-W412175
-
ZincpHyrin dihydrochloride
|
Bacterial
|
Infection
|
Coproporphyrin III dihydrochloride is a bioactive molecule excreted by nostril- and skin-associated Propionibacterium species that induces aggregation of Staphylococcus aureus (conditions: during early stationary phase growth, low pH: 4-6). Coproporphyrin III dihydrochloride also induces plasma-independent biofilm formation on abiotic surfaces by Staphylococcus aureus. Coproporphyrin III dihydrochloride may be an important mediator of S. aureus accumulation and/or biofilm formation in the nostrils or other sites where Propionibacterium and S. aureus inhabit. .
|
-
- HY-15627A
-
|
Fluorescent Dye
DNA Stain
|
Others
|
Hoechst 33342 analog trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution . Storage: Keep away from light.
|
-
- HY-158255
-
|
Biochemical Assay Reagents
|
Others
|
mPEG-PLGA (2000-80000) (LA/GA 50:50) is a copolymer, which consists of hydrophilic mPEG and biodegradable PLGA (molar ratio is 50:50) with a molecular weight of 2000 (mPEG) + 80000 (PLGA). mPEG-PLGA (2000-80000) (LA/GA 50:50) forms nanoparticles or microparticles, which is stable in aqueous solution at different pH values and elevated temperatures as well as in serum. mPEG-PLGA (2000-80000) (LA/GA 50:50) is utilized as carrier material in drug delivery systems .
|
-
- HY-14818R
-
|
Influenza Virus
|
Infection
|
Laninamivir (Standard) is the analytical standard of Laninamivir. This product is intended for research and analytical applications. Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC50s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively .
|
-
- HY-D1106
-
|
Fluorescent Dye
|
Cancer
|
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions . Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .
|
-
- HY-W019883
-
|
Biochemical Assay Reagents
|
Others
|
Dipotassium hydrogen phosphate is a highly water-soluble salt which is often used as a fertilizer, food additive and buffering agent. Dipotassium hydrogen phosphate can be used as an excipient, such as pH regulator, buffer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
- HY-156514
-
|
Drug-Linker Conjugates for ADC
|
Cancer
|
MC-GGFG-AM-(10NH2-11F-Camptothecin) is an antibody drug conjugates (ADC). MC-GGFG-AM-(10NH2-11F-Camptothecin) binds to the anti-TROp-2 antibody sacituzumab via a hydrolysable pH-sensitive linker and has anti-tumor activity. MC-GGFG-AM-(10NH2-11F-Camptothecin) can be used for cancer research .
|
-
- HY-100007R
-
TAK-438 (Standard)
|
Proton Pump
Bacterial
|
Endocrinology
|
Vonoprazan (Standard) is the analytical standard of Vonoprazan. This product is intended for research and analytical applications. Vonoprazan (TAK-438 free base), a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan inhibits H +,K +-ATPase activity in porcine gastric microsomes with an IC50 of 19 nM at pH 6.5. Vonoprazan is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan can be used for eradication of Helicobacter pylori .
|
-
- HY-18071
-
BI-9627
1 Publications Verification
|
Na+/H+ Exchanger (NHE)
|
Cardiovascular Disease
|
BI-9627 is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .
|
-
- HY-18071A
-
|
Na+/H+ Exchanger (NHE)
|
Cardiovascular Disease
|
BI-9627 hydrochloride is potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI-9627 hydrochloride displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 hydrochloride shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury .
|
-
- HY-W250127
-
TerepHthalic acid disodium salt
|
Biochemical Assay Reagents
|
Others
|
Disodium terephthalate belongs to the class of organic salts. It is commonly used as a catalyst or intermediate in the production of a variety of industrial and consumer products, including polyethylene terephthalate (PET) plastics, polyester fibers and films. Disodium terephthalate has excellent thermal stability, chemical resistance and mechanical properties, making it ideal for high performance applications. Additionally, it is non-toxic, non-flammable and environmentally friendly, making it an attractive alternative to other petroleum-based chemicals. In the food and pharmaceutical industries, Disodium terephthalate is used as a pH regulator and buffer. It is generally considered safe for use in food and pharmaceutical applications by regulatory agencies such as the FDA.
|
-
- HY-125322
-
|
Bacterial
|
Infection
|
Reveromycin C is a polyketide originally isolated from Streptomyces that has antifungal activity against C. albicans (MICs=2.0 and >500 μg/mL at pH 3 and 7.4, respectively). Reveromycin C inhibits EGF-induced mitogenic activity in the Balb/MK mouse epidermal cell line. It also reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells (EC50=1.58 μg/mL) and inhibits proliferation of KB cells and K562 human chronic myelogenous leukemia cells (IC50=2.0 μg/mL for both).
|
-
- HY-135078
-
NSC 270912
|
Others
|
Others
|
2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC50=~1.25 mM).
|
-
- HY-128067
-
Hexamethylene amiloride; HMA
|
Sodium Channel
HIV
Apoptosis
|
Infection
Cancer
|
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na +/H + exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively .
|
-
- HY-N0316
-
|
NF-κB
Reactive Oxygen Species
Apoptosis
VEGFR
c-Myc
|
Cancer
|
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway .
|
-
- HY-W014837
-
3-(1-Pyridinio)-1-propanesulfonate
|
Biochemical Assay Reagents
|
Others
|
NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group. This compound is commonly used as a buffer in biochemical and biological research, especially in electrophoretic applications. It maintains a stable pH in aqueous solutions and has low UV absorption, making it suitable for use in the UV spectrum. Furthermore, due to its ability to form stable complexes with DNA and other biomolecules, 3-(pyridin-1-ium-1-yl)propane-1-sulfonate has been investigated for its potential in drug delivery and genetic research.
|
-
- HY-138660
-
HM-JF526 NHS
|
Fluorescent Dye
|
Others
|
HM Janelia Fluor® 526, SE (HM-JF526 NHS) is a derivative of hydroxymethyl JF526 (HM-JF526). SMLM (single-molecule localization microscopy) imaging in standard phosphate-buffered saline (pH 7.4) revealed that the HM-JF526 label showed spontaneous blinking behavior throughout the imaging session and did not require short-wavelength activation light . Janelia Fluor® products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.
|
-
- HY-D1237
-
|
Fluorescent Dye
|
Metabolic Disease
|
BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 505/515 nm .
|
-
- HY-D1570
-
|
Fluorescent Dye
|
Others
|
BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 480/508 nm .
|
-
- HY-W090090
-
Pyrromethene 546; BDP 493/503 lipid stain
|
Fluorescent Dye
|
Others
|
BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
|
-
- HY-138226
-
|
Fluorescent Dye
|
Others
|
BODIPY 558/568 C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 558/568 nm .
|
-
- HY-D1614
-
|
Fluorescent Dye
|
Others
|
BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
|
-
- HY-D1617
-
|
Fluorescent Dye
|
Others
|
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20℃.
|
-
- HY-125372
-
ABAO
|
Biochemical Assay Reagents
|
Others
|
2-Amino benzamidoxime (ABAO compound 6) can react quickly with aldehydes to form stable 1, 2-dihydroquinazoline 3-oxides in aqueous solutions. The 2-Amino benzamidoxime reaction process consists of the formation of a Schiff base as a rate-determining step, followed by rapid intramolecular cyclization. The reaction rate is dependent on pH, indicating that protonated benzamidoxime is involved in the formation of Schiff bases as an internal generalized acid. Substituents on the aromatic ring can increase the alkalinity of the aromatic amine, thus speeding up the reaction. The reactive properties of 2-Amino benzamidoxime make it a potential platform for the development of new bioconjugated strategies, fluorescent probes, and post-translational diversification of genetic coding libraries .
|
-
- HY-W145516
-
|
Biochemical Assay Reagents
|
Others
|
Guar gum is a versatile polymer for drug delivery applications. Guar gum diaplays thickening, emulsifying, binding and gelling properties, quick solubility in cold water, wide pH stability, film forming ability and biodegradability, it finds applications in large number of industries. Guar gum can be isolated from the powdered endosperm of the seeds of the Cyamopsis tetragonolobus. Guar gum can be used as an excipient, such as thickener, suspending agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
- HY-147414
-
PF-114
|
Bcr-Abl
|
Cancer
|
Vamotinib (PF-114) is a potent, selective and orally active tyrosine kinase inhibitor. Vamotinib inhibits the autophosphorylation of BCR/ABL and BCR/ABL-T315I. Vamotinib induces apoptosis. Vamotinib shows anti-proliferative and anti-tumor activity. Vamotinib has the potential for the research of resistant philadelphia chromosome-positive (Ph+) leukemia. Vamotinib inhibits ABL series kinases with IC50s of 0.49 nM (ABL), 0.78 nM (ABL T315I), 9.5 nM (ABL E255K), 2.0 nM (ABL F317I), 7.4 nM (ABL G250E), 1.0 nM (ABL H396P), 2.8 nM (ABL M351T), 12 nM (ABL Q252H), and 4.1 nM (ABL Y253F), respectively . Vamotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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-
- HY-D1560
-
|
Fluorescent Dye
|
Others
|
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .
|
-
-
-
HY-L0116V
-
|
1,065 compounds
|
Macrocycles are promising scaffolds for the design of novel RNA targeting molecules. This collection of macrocycles for RNA consists of very diverse, drug-like molecules which incorporate certain known RNA-recognition elements (e.g. nucleobase ring systems and analogs) distributed within macrocyclic rings or peripheral fragments. As macrocyclic molecules tend to be larger than traditional screening molecules, it is vital to carefully assess and control their physicochemical properties. All macrocycles have been tested for aqueous and DMSO solubility with cutoffs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4); PAMPA permeability has also been tested for representative set of macrocycles.
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-
-
HY-L0115V
-
|
10,091 compounds
|
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.
Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.
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Cat. No. |
Product Name |
Type |
-
- HY-D0169A
-
pHenolsulfonepHthalein sodium salt
|
Dyes
|
Phenol red (Phenolsulfonephthalein) sodium salt is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .
|
-
- HY-D0169
-
pHenolsulfonepHthalein
|
Dyes
|
Phenol red (Phenolsulfonephthalein) is a pH indicator dye, relying on a distinct color change from pink to yellow in case of a positive reaction .
|
-
- HY-D1094
-
SNARF 1
|
Fluorescent Dyes/Probes
|
Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH. Carboxy-SNARF 1 (5/6-mixture) can be used for measurement of intracellular pH .
|
-
- HY-D1457
-
|
Fluorescent Dyes/Probes
|
DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles .
|
-
- HY-D1093
-
|
Fluorescent Dyes/Probes
|
Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
|
-
- HY-D0219A
-
|
Fluorescent Dyes/Probes
|
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 .
|
-
- HY-D0219
-
ThymolsulpHonepHthalein
|
Fluorescent Dyes/Probes
|
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 . Storage: protect from light.
|
-
- HY-B1571
-
|
Dyes
|
Bromophenol blue is an acid phthalein dye, and it is used as a tracking dye for electrophoresis. Bromophenol blue is also used as a pH indicator, with a transition range of pH 3 to 4.6 .
|
-
- HY-D1563
-
|
Dyes
|
CypHer 5 is a pH-sensitive cyanine derivative and a environmental sensitive fluorophore. CypHer 5 has a pH-sensitive maximal absorption at 644 nm and emission at 664 nm. CypHer 5 has been used as a pH sensor of lysosomal compartments .
|
-
- HY-D0015A
-
|
Dyes
|
Cresol Red sodium is a triarylmethane dye. Cresol Red sodium can be used for indicating pH, temperatures and salinities .
|
-
- HY-128369
-
Metanil Yellow
|
Dyes
|
Acid Yellow 36 (Metanil Yellow) is an azo dye and a pH indicator. Acid Yellow 36 changes its color from red at pH 1.2 to yellow at pH 2.3. Acid Yellow 36 is used in the leather, paper and textile industries. Acid Yellow 36 acts as a bifunctional inducer of specific isozymes of P-450 and cytosolic enzymes .
|
-
- HY-D1687
-
|
Fluorescent Dyes/Probes
|
Flubi-2 is a fluorescein-biotin based pH-ratio dye (Ex=480 nm, Em= 520-560 nm) with a pK value of 6.7. Flubi-2 is a hydrolysis product of Flubida-2 (non-fluorescent, membrane permeable). Flubi-2 can be used for pH determination of organelles of the secretory pathway (such as golgi apparatus and endoplasmic reticulum) in living cells .
|
-
- HY-D0140
-
ETH 5294
|
Fluorescent Dyes/Probes
|
Chromoionophore I (ETH 5294) is a hydrophobic pH indicator. Chromoionophore I is used as a transmissive or fluorescent probe molecule in many types of hydrophobic sensor membranes. Chromoionophore I is oil-soluble .
|
-
- HY-D0023
-
HPTS; Solvent Green 7
|
Fluorescent Dyes/Probes
|
Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine acts as a class of fluorescent chemosensor for the Cu + ion(λex=450 nm, λem=510 nm) .
|
-
- HY-118320
-
Mordant orange 1
|
Fluorescent Dyes/Probes
|
Alizarine Yellow R (Mordant orange 1), a salicylic acid derivative, is a azo dye. Alizarine Yellow R is mostly used as a pH indicator, as a biological stain in chemical examinations and also in dyeing industries .
|
-
- HY-D1069
-
DBCO-Sulfo-Cy3
|
Fluorescent Dyes/Probes
|
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-D0009
-
|
Dyes
|
Bromocresol green sodium is an anionic dye. Bromocresol green sodium can be used for pH indication and DNA agarose gel electrophoresis. Bromocresol green sodium is also used in mammalian albumin measurement. Bromocresol green sodium deprotonates and produces the monoanionic form of yellow colour at lower pH (acidic condition), and produces dianionic blue colour at the basic condition .
|
-
- HY-D1463
-
|
Fluorescent Dyes/Probes
|
Nile Blue Methacrylamide is a Nile Blue-based nanosized pH densor that can be used for simultaneous far-red and near-infrared live bioimaging .
|
-
- HY-118155
-
|
Fluorescent Dyes/Probes
|
9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system .
|
-
- HY-W411215
-
|
Fluorescent Dyes/Probes
|
1,4-Diacetoxy-2,3-dicyanobenzene is a cell-permeable fluorescent probe. 1,4-Diacetoxy-2,3-dicyanobenzene crosses the cell membrane and is cleaved by cytosolic esterases to the fluorescent pH indicator 2,3-dicyano-hydroquinone (DCH). 1,4-Diacetoxy-2,3-dicyanobenzene can be used to monitor intracellular pH .
|
-
- HY-D1591
-
|
Fluorescent Dyes/Probes
|
BODIPY R6G methyl ester (compound 5′-1) is a BODIPY-like fluorescent dye with good light stability and insensitive to pH value. BODIPY R6G methyl ester shows good photostability, high sensitivity and insensitive to pH value. BODIPY R6G methyl ester can be used in research areas such as photodynamic research, PH probes, ion recognition, photocatalysis, protein labeling, cell imaging, and proteomic analysis .
|
-
- HY-D0142
-
|
Fluorescent Dyes/Probes
|
Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium is a fluorescent dye and pH indicator, also as a ligand of multifunctional metal-organic framework. Pyrene-1,3,6,8-tetrasulfonic acid tetrasodium has been used to detect CO2 release .
|
-
- HY-B1422
-
Aminacrine
|
Fluorescent Dyes/Probes
|
9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-B1422R
-
|
Fluorescent Dyes/Probes
|
9-Aminoacridine (Standard) is the analytical standard of 9-Aminoacridine. This product is intended for research and analytical applications. 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
- HY-D1445
-
|
Fluorescent Dyes/Probes
|
PDMPO, a lysosome pH indicator, is an excellent fluorescent acidotropic reagent for fluorescence imaging. PDMPO is a potent tool with which to study acidic organelles of live cells. PDMPO exhibits pH-dependent dual-excitation and dual-emission spectral peaks. PDMPO produces a blue fluorescence in weakly acidic organelles and shifts to yellow in more acidic lysosomes (Abs=329 nm; Em=440 nm) .
|
-
- HY-157036
-
|
Fluorescent Dyes/Probes
|
INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences .
|
-
- HY-D0075
-
|
Fluorescent Dyes/Probes
|
DHPDS disodium salt is a pH-sensitive fluorescent dye. DHPDS disodium salt is used to measure intracellular pH (pHi) from the surface fluorescence of the isolated perfused rat liver .
|
-
- HY-D0012
-
|
Dyes
|
Bromothymol Blue is a pH indicator.
|
-
- HY-101882
-
BCECF
1 Publications Verification
2′,7′-Bis(2-carboxyethyl)-5(6)-carboxyfluorescein
|
Fluorescent Dyes/Probes
|
BCECF is a pH-sensitive fluorescent dye. BCECF allows measurements in the physiological pH range 6.0–8.0. Excitation ratio: 490/440 nm; Emission intensity: 535 nm.
|
-
- HY-W331502
-
|
Dyes
|
Chlorophenol Red sodium is a pH indicator .
|
-
- HY-D2119
-
|
Fluorescent Dyes/Probes
|
CQ-Lyso is a lysosome-targeting chromenoquinoline. CQ-Lyso is a fluorescent probe for measuring the pH of lysosomes in living cells using only single wavelength excitation. CQ-Lyso can visualize the dynamic pH changes in lysosomes .
|
-
- HY-D1111
-
|
Fluorescent Dyes/Probes
|
TFAX 568, SE is an orange fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 568, SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) .
|
-
- HY-D0228
-
Azo Violet; Magneson I
|
Dyes
|
4-(4-Nitrophenylazo)resorcinol is an azo purple dye used experimentally as a pH indicator, showing yellow when the pH value is lower than 11 and purple when the pH value is higher than 13. In slightly alkaline or alkaline environments, it also turns dark blue in the presence of magnesium salts. Azo Violet can also be used to test for the presence of ammonium ions. The color of the ammonium chloride or ammonium hydroxide solution will change depending on the concentration of azo violet used.
|
-
- HY-D1110
-
|
Fluorescent Dyes/Probes
|
TFAX 594,SE is a red fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 594,SE yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG) .
|
-
- HY-D1113
-
|
Fluorescent Dyes/Probes
|
TFAX 488,TFP is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,TFP yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) .
|
-
- HY-D1401
-
|
Fluorescent Dyes/Probes
|
OG 488, acid, a fluorescent pH indicator, has many applications in biochemistry and neurosciences .
|
-
- HY-D1114
-
|
Fluorescent Dyes/Probes
|
TFAX 488,SE dilithium is a green fluorescent dye and exhibits pH-insensitivity over a very broad range (pH in the 4-10). TFAX 488,SE dilithium yields exceptionally bright, photostable conjugates with proteins or antibodies (such as goat anti-mouse IgG, streptavidin) .
|
-
- HY-101883
-
|
Fluorescent Dyes/Probes
|
BCECF-AM is a cell membrane permeable compound widely used as a fluorescent indicator for intracellular pH.
|
-
- HY-D1482
-
|
Fluorescent Dyes/Probes
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-126774
-
|
Fluorescent Dyes/Probes
|
DAF-FM is a diaminofluorescein, which can be used as fluorescent indicator for nitric oxide (NO) with good pH tolerance .
|
-
- HY-133527
-
Oregon green 488 succinimidyl ester
|
Dyes
|
OG 488, SE (Oregon green 488 succinimidyl ester), a fluorescent pH indicator, has many applications in biochemistry and neurosciences .
|
-
- HY-D1366
-
|
Fluorescent Dyes/Probes
|
Sulfo-Cyanine5.5 carboxylic acidCI Pigment violet 32 is a water-soluble, far-red emitting fluorophore. Due to its four sulfo groups, this dye has a negative charge at neutral pH and is very hydrophilic. As a cyanine dye, sulfo-Cyanine5.5 shows a very low dependence of fluorescence on pH and a very high extinction coefficient.
|
-
- HY-D0166
-
|
Dyes
|
Neutral Red, a nitrogenous pH-indicator with a pKi of 6.8, is an indicator for the internal acidification of thylakoids. Neutral Red stains lysosomes red .
|
-
- HY-D1477
-
|
Fluorescent Dyes/Probes
|
5(6)-Carboxyfluorescein diisobutyrate is a protected 5(6)-carboxyfluorescein. 5(6)-carboxyfluorescein is a fluorescence pH indicator .
|
-
- HY-D1556
-
|
Fluorescent Dyes/Probes
|
DOPE-CF is a pH-sensitive fluorescent membrane labelled probe with a fluorescein moiety that is a weak acid and a conjugated base that is highly fluorescent and can be attached to phospholipid ethanolamine lipids .
|
-
- HY-15923
-
|
Fluorescent Dyes/Probes
|
MAOS is a modified Trinder’s reagent that can be used as a chromogenic probe for the determination of H2O2. MAOS is strongly dependent on the pH of the reaction medium .
|
-
- HY-15942
-
5-TAMRA
1 Publications Verification
|
Fluorescent Dyes/Probes
|
5-TAMRA (5-Carboxytetramethylrhodamine), SE and its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
|
-
- HY-W127770
-
|
Dyes
|
Pararosaniline hydrochloride is a pH-responsive basic dye, as a biological stain to track certain proteins. Pararosaniline hydrochloride has been used in the analysis of SO2 and formaldehyde and staining of bacteria or other organisms .
|
-
- HY-D0112
-
|
Fluorescent Dyes/Probes
|
7-Hydroxycoumarin-4-acetic acid, a pH-indicator dye, is covalently bound to bovine serum albumin (BSA) at the positions of reactive amino groups (λmax=326 nm) .
|
-
- HY-D0048
-
5-TAMRA-NHS ester; 5-Carboxytetramethylrhodamine succinimidyl ester
|
Fluorescent Dyes/Probes
|
5-TAMRA-SE is an amine-reactive fluorescent agent, its conjugates yield bright, pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
|
- HY-D2254
-
|
Fluorescent Dyes/Probes
|
CTB probe-1 (probe 1) a lysosome-targeting fluorogenic small-molecule probe for fluorescence imaging in living cells .
|
- HY-W040291
-
|
Fluorescent Dyes/Probes
|
7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.
|
- HY-131510
-
SNARF-DE
|
Dyes
|
Chromoionophore XIII (SNARF-DE) is a pH senor that enables excitation with red light. Chromoionophore XIII functionality renders the indicator molecule lipophilic and water-insoluble but also prevents lactonization of the dye in an apolar environment .
|
- HY-D1082
-
|
Fluorescent Dyes/Probes
|
5-DTAF is a isomeric fluorescein derivative that directly react with polysaccharides and other alcohols in aqueous solution at pH > 9. The maximum of the 5-DTAF emission profile is at a wavelength of 518 nm after excitation at 488 nm .
|
- HY-D1593
-
|
Fluorescent Dyes/Probes
|
BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
|
- HY-D0952
-
|
Fluorescent Dyes/Probes
|
Acridine Orange base is a cell-permeable fluorescent dye that stains organisms (bacteria, parasites, viruses, etc.) bright orange and, when used under appropriate conditions (pH=3.5, Ex=460 nm), distinguishes human cells in green for detection by fluorescence microscopy. Acridine Orange base fluoresces green when bound to dsDNA (Ex=488, Em=520-524) and red when bound to ssDNA (Ex=457, Em=630-644) or ssRNA (Ex=457, Em=630-644), also can be used in cell cycle assays .
|
- HY-D1549
-
|
Dyes
|
o-Pah is a BODIPY derivative with an -NH2 and -OH substituted meso-Ph group. o-Pah exhibits metal-induced J-aggregation in the presence of Cu 2+ and a specific fluorescence enhancement for Hg 2+ (Ex/Em=483/(495-600) nM) .
|
- HY-130027
-
HKOCl-4
1 Publications Verification
BXY2142
|
Fluorescent Dyes/Probes
|
HKOCl-4 (BXY2142) is a rhodol-based yellow fluorescent probe for the detection of hypochlorous acid with excellent sensitivity and selectivity . HKOCl-4 has longer absorption wavelength and better pH stability compared with fluorescein-based probes. Ex: 530 nm; Em 557 nm.
|
- HY-110257
-
|
Fluorescent Dyes/Probes
|
BODIPY FL-X,SE is a fluorescent greendye for the labeling of amine, shows a high fluorescence quantum yield and is relatively insensitive to pH change. BODIPY FL-X,SE can be used as an alternative for FAM, Cy2 or FITC. λabs: 504 nm; λem:510 nm .
|
- HY-114352
-
|
Fluorescent Dyes/Probes
|
BODIPY FL-X is a green-fluorescent dye. BODIPY FL-X has the succinimidyl ester covalently coupled to proteins. BODIPY FL-X has high fluorescence quantum yield and is relatively insensitive to pH change. (λex=504 nm, λem=510 nm) .
|
- HY-D1676
-
|
Fluorescent Dyes/Probes
|
Thymolphthalein monophosphate disodium hydrate is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. Thymolphthalein is released during the reaction, increases the pH of the medium for easy detection, produces color and stops hydrolysis. Thymolphthalein monophosphate disodium hydrate can be used for the specific detection of prostatic phosphatase in serum .
|
- HY-D1654
-
|
Fluorescent Dyes/Probes
|
BDP 581/591 maleimide is a linker of the BDP 581/591 dye. It has a long fluorescence lifetime and can be used for fluorescence polarization assays. The maleimide group can react with thiol groups to form thioester bonds between pH 6.5 to 7.5, for the labeling of sulfhydryl groups of proteins and peptides.
|
- HY-151544
-
|
Fluorescent Dyes/Probes
|
PNE-Lyso is a activatable fluorescent probe. PNE-Lyso can be used to detect intracellular pH and hexosaminidases with two kinds of fluorescence signals. PNE-Lyso can be used to distinguish apoptosis from necrosis through visualizing lysosome morphology. PNE-Lyso is capable of investigating the agent-induced cell death process .
|
- HY-15940
-
5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers
|
Fluorescent Dyes/Probes
|
5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .
|
- HY-D1156
-
|
Fluorescent Dyes/Probes
|
HKSOX-1m (5/6-mixture) is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells .
|
- HY-D1156A
-
|
Fluorescent Dyes/Probes
|
HKSOX-1m (5/6-mixture) hydrobromide is a O2 fluorescent probe for mitochondria-targeting (Ex/Em=509/534nm; green), exhibiting excellent selectivity and sensitivity toward O2 over a broad range of pH, strong oxidants, and abundant reductants found in cells .
|
- HY-D1688
-
|
Fluorescent Dyes/Probes
|
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located .
|
- HY-151712
-
|
Fluorescent Dyes/Probes
|
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.
|
- HY-151713
-
|
Fluorescent Dyes/Probes
|
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene .
|
- HY-D2083
-
|
Fluorescent Dyes/Probes
|
BODIPY 540 (purity>98%) is a BODIPY dye.BODIPY dye is a small molecule dye with strong UV absorption ability.Its fluorescence peak is relatively sharp, its quantum yield is high, and it is relatively insensitive to the polarity and pH value of the environment.BODIPY 540 (purity>98%) has a purity higher than 98% and is suitable for cell experiments .
|
- HY-D0914
-
FD&C Green No. 3; Food green 3; C.I. 42053
|
Dyes
|
Fast Green FCF is a sea green triarylmethane food dye, with absorption maximum ranging from 622 to 626 nm. Fast Green FCF is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF is carcinogenic and acts as a presynaptic locus by inhibiting the release of neurotransmitters in the nervous system .
|
- HY-D2324
-
|
Fluorescent Dyes/Probes
|
EE-Flipper 33 is a Flipper probe designed to evaluate the mechanism of early endocytosis. EE-Flipper has a pKa value of 10.6 and is capable of tracking approximately 70% of early endosomes (EE) in live cells. Furthermore, EE-Flipper 33 can also label the Golgi apparatus in live cells with an internal pH ranging from 6.0 to 6.7 .
|
- HY-150086
-
CF4
|
Dyes
|
Copper Fluor-4 (CF4) is a Cu +-specific fluorescent probe based on a rhodol dye scaffold. Copper Fluor-4 has high copper selectivity, particularly over zinc and iron, as well as abundant cellular alkali and alkaline earth metals. Copper Fluor-4 is stable in a physiologically relevant pH regime between 6 and 8 (Ex: 488 nm) .
|
- HY-15558
-
bisBenzimide H 33258; H 33258
|
DNA Stain
|
Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15559
-
Hoechst 33342
Maximum Cited Publications
49 Publications Verification
bisBenzimide H 33342; HOE 33342
|
DNA Stain
|
Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15560
-
HOE 34580
|
DNA Stain
|
Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15619
-
Nuclear yellow
|
DNA Stain
|
Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15561
-
meta-Hoechst
|
DNA Stain
|
HOE-S 785026 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15562
-
|
DNA Stain
|
HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15622
-
|
DNA Stain
|
meta-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15623
-
|
DNA Stain
|
Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15626
-
|
DNA Stain
|
ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15627
-
|
DNA Stain
|
Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15629
-
|
DNA Stain
|
HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15632
-
|
DNA Stain
|
para-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15559A
-
bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride
|
DNA Stain
|
Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15561B
-
meta-Hoechst trihydrochloride
|
DNA Stain
|
HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15560B
-
HOE 34580 tetrahydrochloride
|
DNA Stain
|
Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15558A
-
bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride
|
DNA Stain
|
Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15563
-
|
DNA Stain
|
HOE 33187 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15624
-
|
DNA Stain
|
Hoechst 33258 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15625
-
|
DNA Stain
|
Hoechst 33258 analog 3 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15628
-
|
DNA Stain
|
Hoechst 33258 analog 5 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15630
-
|
DNA Stain
|
Hoechst 33342 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15631
-
|
DNA Stain
|
Hoechst 33258 analog 6 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-15630A
-
|
DNA Stain
|
Hoechst 33342 analog 2 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
|
- HY-143285
-
|
Fluorescent Dyes/Probes
|
AMC-GlcNAc (compound 1) is a potent fluorogenic probe for detection and characterization of β-hexosaminidase enzyme activity. AMC-GlcNAc enables continuous monitoring by turn-on fluorescence and fluorescence signal is constant over a wide pH range (Ex=325 nm, Em=390 nm). AMC-GlcNAc enables ratiometric fluorescence detection with high sensitivity and low background, which can be used to screen for recombinant dispersin B activity in E. coli cell lysate .
|
- HY-D1106
-
|
Fluorescent Dyes/Probes
|
BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions . Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells .
|
- HY-D1237
-
|
Fluorescent Dyes/Probes
|
BODIPY505/515 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 505/515 nm .
|
- HY-D1570
-
|
Fluorescent Dyes/Probes
|
BODIPYFL C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 480/508 nm .
|
- HY-W090090
-
Pyrromethene 546; BDP 493/503 lipid stain
|
Fluorescent Dyes/Probes
|
BODIPY493/503 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
|
- HY-138226
-
|
Fluorescent Dyes/Probes
|
BODIPY 558/568 C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 558/568 nm .
|
- HY-D1614
-
|
Fluorescent Dyes/Probes
|
BODIPY493/503 methyl bromide is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 493/503 nm .
|
- HY-D1617
-
|
Fluorescent Dyes/Probes
|
BODIPY 500/510 C1, C12 is a BODIPY dye. BODIPY dye is a small molecule dye with strong ultraviolet absorption ability, its fluorescence peak is relatively sharp, and the quantum yield is high. They are relatively insensitive to the polarity and pH of the environment and are relatively stable under different physiological conditions. Due to its structural asymmetry, BODIPY derives a variety of structural products. BODIPY lipid droplet dyes can well pass through the cell membrane into the cell, and localize the polar lipids in the cell to specifically stain the lipid droplets, which can be used for labeling of live cells and fixed cells . Maximum excitation/emission wavelength: 500/510 nm . Protect from light, stored at -20℃.
|
- HY-D1560
-
|
Fluorescent Dyes/Probes
|
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .
|
Cat. No. |
Product Name |
Type |
-
- HY-B1610N
-
|
Biochemical Assay Reagents
|
Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .
|
-
- HY-B1610J
-
|
Biochemical Assay Reagents
|
Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .
|
-
- HY-128545
-
Nitrazine paper; pHenapHthazine
|
Indicators
|
Nitrazine yellow (Nitrazine paper; Phenaphthazine) is a pH indicator. The color of Nitrazine yellow changes from yellow to blue in the pH range from 6.0 to 7.0. Nitrazine yellow is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-B1610K
-
|
Biochemical Assay Reagents
|
Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .
|
-
- HY-B1610M
-
|
Biochemical Assay Reagents
|
Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .
|
-
- HY-B1610L
-
|
Biochemical Assay Reagents
|
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .
|
-
- HY-D0265
-
|
Biochemical Assay Reagents
|
Thymolphthalein is an electrochemically active dye due to the presence of thymol fragments. Thymolphthalein is a Phthalein dye used as an acid-base indicator. It is colourless in acid pH and is blue in basic pH .
|
-
- HY-D0252
-
|
Biochemical Assay Reagents
|
m-Cresol purple is a pH indicator dye with large cross section and halochromic property in neutral pH range .
|
-
- HY-Y0699
-
|
Biochemical Assay Reagents
|
Methyl red is an azo dye that acts as a pH indicator. Methyl red is red and yellow at pH 4.4 and 6.0 respectively .
|
-
- HY-160113
-
|
Biochemical Assay Reagents
|
Sodium phosphate buffer (pH 6.9 0.02 mol/l) is a water-based salt solution. Sodium phosphate buffer (pH 6.9 0.02 mol/l) can be used in a variety of biochemical studies.
|
-
- HY-Y1269H
-
Salmiac, meets analytical specification of pH. Eur. BP USP FCC
|
Buffer Reagents
|
Ammonium chloride, meets analytical specification of Ph. Eur. BP USP FCC (Salmiac, meets analytical specification of Ph. Eur. BP USP FCC) can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.
|
-
- HY-W579346
-
|
Buffer Reagents
|
POPSO sesquisodium is a water-soluble zwitterionic buffer. POPSO sesquisodium is commonly used in biological and biochemical studies to maintain the acidity or alkalinity (pH value) of solutions, especially within the physiological pH range of 7.0 to 8.5 .
|
-
- HY-160114
-
-
- HY-D0870
-
-
- HY-D0870A
-
|
Buffer Reagents
|
CAPSO sodium is a biological zwitterionic buffer with the useful pH range from 8.9 to 10.3 .
|
-
- HY-W011271
-
1,4-Piperazinediethanesulfonic acid monosodium
|
Buffer Reagents
|
PIPES (1,4-Piperazinediethanesulfonic acid) monosodium is a pH buffer that can be mixed with another disodium salt form of PIPES. By changing the ratio and total amount of the PIPES monosodium and disodium buffers, the pH and ionic strength of the medium can be changed .
|
-
- HY-Y1968A
-
|
Biochemical Assay Reagents
|
Sterile 10 mM Histidine, pH 5.5 buffer is a multi-purpose buffer solution with important applications in many fields such as protein purification, vaccine preparation, drug development, cell culture and electrophoresis. Histidine is an amino acid with good buffering capacity. Sterile 10 mM Histidine, pH 5.5 buffer The sterility and specific pH conditions make it ideal for experiments that require precise control of environmental conditions. The histidine in Sterile 10 mM Histidine, pH 5.5 buffer derivatizes photosensitizers that accumulate and increase greatly upon exposure to light. Histidine-derived photosensitizers are also the primary mediators of tryptophan photooxidation .
|
-
- HY-Y0332L
-
Potassium pHospHate monobasic, meets analytical specification of pH. Eur., NF, E340
|
Buffer Reagents
|
Potassium dihydrogen phosphate (Potassium phosphate monobasic), meets analytical specification of Ph. Eur., NF, E340 is used as a buffer capacity reagent in molecular biology, biochemistry, and chromatography. For the preparation of biological buffers. It is also used to purify antibodies, and in combination with other sodium phosphates, meets analytical specification of Ph. Eur., NF, E340 .
|
-
- HY-D0276
-
Metacresol purple sodium
|
Biochemical Assay Reagents
|
m-Cresol purple sodium (Metacresol purple sodium) is a pH indicator. m-Cresol purple sodium solution from yellow to blue in the pH range from 7.5 to 9.0 .
|
-
- HY-W094708D
-
Disodium hydrogen pHospHate dihydrate, meets analytical specification of pH. Eur. BP
|
Buffer Reagents
|
Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .
|
-
- HY-W342700
-
|
Buffer Reagents
|
PIPPS is a kind of buffer commonly used in biological and biochemical research to maintain the acidity and alkalinity (pH value) of solutions .
|
-
- HY-D0859A
-
|
Biochemical Assay Reagents
|
MOPS sodium salt is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media .
|
-
- HY-Y0317I
-
Disodium sulfate, meets analytical specification of pH. Eur. BP USP
|
Buffer Reagents
|
Sodium sulfate anhydrous, meets analytical specification of Ph. Eur. BP USP, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-Y0344I
-
Halite, meets analytical specification of pH. Eur. BP USP
|
Buffer Reagents
|
Sodium chloride, meets analytical specification of Ph. Eur. BP USP, ≤0.00002% Al, an inorganic salt, is a biochemical reagent that can be used for life science related research.
|
-
- HY-101850
-
|
Biochemical Assay Reagents
|
MOPSO is a biological zwitterionic buffer with the useful pH range from 6.2 to 7.6. MOPSO has been employed as a buffer component of charcoal yeast extract medium .
|
-
- HY-Y0319B3
-
|
Buffer Reagents
|
Potassium acetate meets analytical specification of Ph. Eur. BP E261, and can be used as food additives, medicine and cosmetics raw materials .
|
-
- HY-W251598I
-
Sodium hydrogen carbonate, meets analytical specification of pH. Eur., BP, USP, FCC, E500
|
Buffer Reagents
|
Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is bicarbonate, can be used for kinds of studies .
|
-
- HY-W087913
-
|
Biochemical Assay Reagents
|
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .
|
-
- HY-ER013I
-
Calcined soda meets analytical specification of pH. Eur., BP, NF, FCC, E500
|
Buffer Reagents
|
Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500 is a biochemical assay reagent suitable for buffer configuration .
|
-
- HY-Y0317E
-
Disodium sulfate (pHarmaceutical primary standard, USP)
|
Buffer Reagents
|
Sodium sulfate anhydrous (Disodium sulfate), can be widely used as a desiccant, pH regulator, etc. in biochemical experiments. It is a reference standard grade of the United States Pharmacopeia (USP), pharmaceutical primary standard.
|
-
- HY-W094475D
-
Epsom salts, meets analytical specification of pH. Eur. BP USP FCC
|
Buffer Reagents
|
Magnesium sulfate heptahydrate, meets analytical specification of Ph. Eur. BP USP FCC is currently the anticonvulsant of choice for the prevention and control of eclamptic fits. Magnesium sulfate is also widely used as a tocolytic agent .
|
-
- HY-Y1269I
-
Salmiac (pHarmaceutical primary standard, USP)
|
Buffer Reagents
|
Ammonium chloride United States Pharmacopeia (USP) Reference Standard (Salmiac, Pharmaceutical primary standard, USP) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.
|
-
- HY-D0874
-
|
Biochemical Assay Reagents
|
HEPPSO is a zwitterionic buffer. The working pH range of HEPPSO buffer is 7.1-8.5. HEPPSO displays relatively high ability to bind copper(II), has a pKa of 7.84 at 2.0 mM buffer concentration .
|
-
- HY-Y1325H
-
|
Buffer Reagents
|
Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al is an inorganic salt that can be used for life science related research .
|
-
- HY-D0878
-
|
Biochemical Assay Reagents
|
TAPSO is a common biological buffer, a pH stabilization reagent, with effective pH ranging from 7-8, and pKa values ranging from 7.5–9.0. TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides .
|
-
- HY-108535
-
|
Biochemical Assay Reagents
|
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis .
|
-
- HY-W440988
-
|
Drug Delivery
|
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner .
|
-
- HY-D0872
-
|
Biochemical Assay Reagents
|
DIPSO is a biological zwitterionic buffer with the useful pH range from 7.0 to 8.2. DIPSO can interfere meiotic regulation in mouse oocytes. DIPSO also has surfactant activity at 10 mM .
|
-
- HY-Y1269
-
|
Biochemical Assay Reagents
|
Ammonium chloride, as a heteropolar compound with pH value regulation, can cause intracellular alkalization and metabolic acidosis thus effecting enzymatic activity and influencing the process of biological system. Ammonium chloride is an autophagy inhibitor. Ammonium chloride is also a lysosome inhibitor .
|
-
- HY-Y1269C
-
Salmiac, for cell culture
|
Buffer Reagents
|
Ammonium chloride, for cell culture (Salmiac, for cell culture) is a reagent that can be used in cell culture to provide a source of nitrogen. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.Ammonium chloride is also a lysosome inhibitor.
|
-
- HY-125457
-
p-NapHtolbenzein
|
Biochemical Assay Reagents
|
α-Naphtholbenzein (p-Naphtolbenzein) is a dye. α-Naphtholbenzein can be used as a pH indicator. α-Naphtholbenzein has a visual transition from yellow (pH0-8.2) to turquoise (pH10). α-Naphtholbenzein is often used during sequential injection analysis technique done for acid-base titrations .
|
-
- HY-D0011
-
|
Biochemical Assay Reagents
|
Bromophenol blue sodium is a pH indicator. It changes from yellow at pH 3.0 to blue at pH 4.6. Bromophenol blue sodium is also used as a tracking dye to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis .
|
-
- HY-D0856
-
|
Buffer Reagents
|
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .
|
-
- HY-W040144
-
|
Biochemical Assay Reagents
|
Bromocresol green is a pH-sensitive triphenylmethane dye commonly used for the determination of protein and albumin in serum. Bromocresol green is a bio-based dye with a yellow-green to blue-green color. Bromocresol green turns yellow (λmax=435 nm, protonated form) when placed in acidic solution (e.g. pH=4.15), and turns blue in basic solution (λmax=615 nm, deprotonated form). Bromocresol green is widely used as a pH indicator in the field of biochemical analysis. In addition, Bromocresol green is also used to detect the concentration of molecules such as creatinine, and to judge the viability of cells .
|
-
- HY-D0305
-
|
Biochemical Assay Reagents
|
Tropaeolin O is an acidic monoazo dye that undergoes a coupling reaction under pH=10.5 conditions to form a blue disazo dye. Tropaeolin O can be used for the determination of palladium(II), osmium(IV), albumin, and casein .
|
-
- HY-W008865
-
|
Buffer Reagents
|
PIPES sesquisodium is a pH buffer. PIPES refers to Piperazine N-N’-bis [2 ethanol sulphonic acid, an organic based buffer. PIPES can be used in the preparation of a variety of marine and mammalian tissues for electron microscopic study, with pH range of 6.1-7.5 .
|
-
- HY-D0858B
-
2-MorpHolinoethanesulpHonic acid sodium salt
|
Biochemical Assay Reagents
|
MES (2-Morpholinoethanesulphonic acid) sodium salt is a buffering agent in biology and biochemistry. MES sodium salt is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES sodium salt is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858
-
2-MorpHolinoethanesulpHonic acid
|
Biochemical Assay Reagents
|
MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. MES is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858A
-
2-MorpHolinoethanesulpHonic acid monohydrate
|
Biochemical Assay Reagents
|
MES (2-Morpholinoethanesulphonic acid) monohydrate is a buffering agent in biology and biochemistry. MES monohydrate is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES monohydrate is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
-
- HY-D0858E
-
2-MorpHolinoethanesulpHonic acid potassium
|
Biochemical Assay Reagents
|
MES (2-Morpholinoethanesulphonic acid) potassium is a buffering agent in biology and biochemistry. MES potassium is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES potassium is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
- HY-W250149
-
|
Biochemical Assay Reagents
|
Chlorophosphonazo III is a sensitive reagent for both calcium and magnesium. It is possible to determine calcium alone at pH 2.2 and calcium and magnesium at pH 7.0. Chlorophosphonazo III can also be used for the spectrophotometric determination of titanium, zirconium, thorium, and scandium, quinquevalent actinide elements, and protactinium .
|
- HY-D0858C
-
2-MorpHolinoethanesulpHonic acid hydrate
|
Buffer Reagents
|
MES (2-Morpholinoethanesulphonic acid) hydrate is a buffering agent in biology and biochemistry. MES hydrate is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES hydrate is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments .
|
- HY-144768
-
|
Drug Delivery
|
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .
|
- HY-144025
-
|
Drug Delivery
|
DOBAQ, a cationic lipid, is a pH-sensitive lipid. DOBAQ can be used for liposomes applied in drug delivery .
|
- HY-157379
-
|
Microbial Culture
|
YM Agar is a low pH growth medium for the cultivation of yeasts, molds and other acid-resistant microorganisms .
|
- HY-W102681
-
|
Biochemical Assay Reagents
|
Caps sodium salt, a polyanion, is a surfactant. Caps sodium salt can be used as biological buffer (0.05 M, pH 11) for dialysis .
|
- HY-D0227F
-
Tris HCl (≥99%, reagent grade); Tris hydrochloride (≥99%, reagent grade)
|
Buffer Reagents
|
THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures.
|
- HY-158082C
-
Tetramethyl rhodamine isothiocyanate glucan, MW 70000
|
Cell Assay Reagents
|
TRITC-dextran, MW 70000 (Tetramethyl rhodamine isothiocyanate glucan, MW 70000) is a fluorescent dye, with the molecular weight of 70 kD. TRITC-dextran, MW 70000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 70000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-Y0308D
-
Disodium hydrogen pHospHate, meets analytical specification of pH. Eur. BP USP FCC E339
|
Buffer Reagents
|
Sodium phosphate dibasic is commonly used as a food additive, buffer and laboratory reagent. Sodium phosphate dibasic has unique chemical properties that make it an important ingredient in the manufacture of fertilizers, detergents and water treatment products. Additionally, it is used in various medical applications such as osmotic laxatives and electrolyte replacement solutions .
|
- HY-D0869
-
N-Cyclohexyl-3-aminopropanesulfonic acid
|
Biochemical Assay Reagents
|
CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis .
|
- HY-W105704
-
|
Biochemical Assay Reagents
|
HEPBS is a zwitterionic buffering agent with a pH range (7.6-9.0) similar to that of biological systems. HEPBS can be used in the culture of cells .
|
- HY-109541S6
-
(Rac)-DMPC-d72
|
Drug Delivery
|
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph
|
- HY-D0867
-
|
Biochemical Assay Reagents
|
BES is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES is used in the diagnostic testing area.
|
- HY-D0867A
-
|
Biochemical Assay Reagents
|
BES sodium is a secondary standard biochemical buffer with effective pH range of 6.4 to 7.8 (pKa: 7.15 at 20 ℃). BES sodium is used in the diagnostic testing area.
|
- HY-158082D
-
Tetramethyl rhodamine isothiocyanate glucan, MW 150000
|
Cell Assay Reagents
|
TRITC-dextran, MW 150000 (Tetramethyl rhodamine isothiocyanate glucan, MW 150000) is a fluorescent dye, with the molecular weight of 150 kD. TRITC-dextran, MW 150000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 150000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 150000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-158082E
-
Tetramethyl rhodamine isothiocyanate glucan, MW 500000
|
Cell Assay Reagents
|
TRITC-dextran, MW 500000 (Tetramethyl rhodamine isothiocyanate glucan, MW 500000) is a fluorescent dye, with the molecular weight of 500 kD. TRITC-dextran, MW 500000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 500000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 500000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-158082H
-
Tetramethyl rhodamine isothiocyanate glucan, MW 2000000
|
Cell Assay Reagents
|
TRITC-dextran, MW 2000000 (Tetramethyl rhodamine isothiocyanate glucan, MW 2000000) is a fluorescent dye, with the molecular weight of 2000 kD. TRITC-dextran, MW 2000000 exhibits an excitation wavelength of 555 nm. TRITC-dextran, MW 2000000 is follicular and vessel penetrate, which is dependent on the molecular weight. TRITC-dextran, MW 2000000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-W460471
-
|
Buffer Reagents
|
Tris Buffered Saline is a common buffer reagent in molecular biology, consisting of Tris and NaCl. Tris Buffered Saline can adjust pH and ionic strength and is widely used in DNA/RNA extraction, PCR and protein electrophoresis. Tris Buffered Saline can purify and protect nucleic acid materials and improve reaction efficiency and concentration. In protein electrophoresis, Tris Buffered Saline stabilizes gels and maintains pH. Overall, Tris Buffered Saline offers versatility, good solubility, and low toxicity in molecular biology applications.
|
- HY-158082
-
Tetramethyl rhodamine isothiocyanate glucan, MW 4000
|
Cell Assay Reagents
|
TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-158082A
-
Tetramethyl rhodamine isothiocyanate glucan, MW 20000
|
Cell Assay Reagents
|
TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-158082B
-
Tetramethyl rhodamine isothiocyanate glucan, MW 40000
|
Cell Assay Reagents
|
TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .
|
- HY-23430
-
|
Biochemical Assay Reagents
|
TES is a buffering agent (pKa=7.550 at 25°C). TES is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2 .
|
- HY-23430A
-
|
Biochemical Assay Reagents
|
TES sodium is a buffering agent (pKa=7.550 at 25°C). TES sodium is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2 .
|
- HY-B2243H
-
Sodium pHospHate monobasic (USP); Monosodium dihydrogen orthopHospHate (USP); Monosodium pHospHate (USP)
|
Buffer Reagents
|
Anhydrous sodium dihydrogen phosphate, meets USP testing specifications is an inorganic salt. It is a chemical compound of sodium with a phosphate counter ion. Anhydrous sodium dihydrogen phosphate, meets USP testing specifications can be used as a pH buffer with other sodium phosphates .
|
- HY-158190
-
Rose Bengal Medium
|
Microbial Culture
|
Rose-Bengal Chloramphenicol Agar is a selective medium for the enumeration of yeasts and moulds from a wide variety of foodstuffs. The medium has a neutral pH and chloramphenicol is used as a selective agent to suppress the growth of bacteria .
|
- HY-D0857
-
HEPES
3 Publications Verification
|
Biochemical Assay Reagents
|
HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis .
|
- HY-Y0537J
-
- HY-W110798
-
|
Biochemical Assay Reagents
|
Bromophenol blue indicator (3.0-4.6) is a synthetic dye commonly used as an acid-base indicator with a transition range of pH 3.0-4.6. Bromophenol blue indicator (3.0-4.6) is water soluble and changes color from yellow to blue as the pH of the solution changes from acidic to basic. Its unique chemical properties make it an important ingredient in a variety of scientific applications, especially in biochemistry and molecular biology. In addition, it can be used as a stain in microbiology and histology. However, Bromophenol blue indicator (3.0-4.6) has potential irritating and staining properties.
|
- HY-D0860
-
|
Biochemical Assay Reagents
|
Tricine is widely used as a buffer in protein electrophoresis, nucleic acid analysis, and immunology, which can help adjust pH and stabilize chemical reactions. In addition, the compound can also be used in research in certain medical fields, such as in antibody detection and drug screening.
|
- HY-138540
-
N-Dodecylimidazole
|
Cell Assay Reagents
|
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .
|
- HY-D0873
-
EPPS
|
Biochemical Assay Reagents
|
HEPPS (EPPS) is a buffering agent with the useful pH range from 7.3 ~ 8.7. HEPPS reduces Aβ-aggregate-induced memory deficits and rescues cognitive deficits in mice. EPPS is orally active and penetrates the blood-brain barrier .
|
- HY-D0877
-
|
Biochemical Assay Reagents
|
TAPS is a biological buffer, remain lysozyme native structure intact and prevents thermal denaturation against high temperatures. TAPS exhibits pKa value of 8.1, while the half-maximum values of connexin channel activity is 8.5 (pH) .
|
- HY-142981
-
DODA
|
Drug Delivery
|
Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9 .
|
- HY-Y1269D
-
Salmiac, for molecular biology
|
Buffer Reagents
|
Ammonium chloride, for molecular biology is ammonium chloride that can be used for molecular biology research. Ammonium chloride can be used as a heteropolar compound to regulate pH value, which can cause intracellular alkalination and metabolic acidosis, thus affecting the activity of enzymes and affecting the process of biological systems. Ammonium chloride acts as an autophagy inhibitor.
|
- HY-D0234
-
ortho-CresolpHthalein
|
Biochemical Assay Reagents
|
o-Cresolphthalein (ortho-Cresolphthalein) is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
|
- HY-D0861
-
EGTA
Maximum Cited Publications
12 Publications Verification
|
Biochemical Assay Reagents
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
- HY-D0876
-
|
Biochemical Assay Reagents
|
POPSO is a zwitterionic buffer, increases osmolality and shows marked inhibition of anion uniport. POPSO inhibits chloride uniport with an IC50 value of 24 mM. POPSO enhances copper uptake and toxicity in alga, impairs mitochondrial inner membrane. The working pH range of POPSO sesquisodium salt is 7.2-8.5 .
|
- HY-D0861A
-
|
Biochemical Assay Reagents
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
- HY-147087
-
|
Drug Delivery
|
YSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo .
|
- HY-W250127
-
TerepHthalic acid disodium salt
|
Biochemical Assay Reagents
|
Disodium terephthalate belongs to the class of organic salts. It is commonly used as a catalyst or intermediate in the production of a variety of industrial and consumer products, including polyethylene terephthalate (PET) plastics, polyester fibers and films. Disodium terephthalate has excellent thermal stability, chemical resistance and mechanical properties, making it ideal for high performance applications. Additionally, it is non-toxic, non-flammable and environmentally friendly, making it an attractive alternative to other petroleum-based chemicals. In the food and pharmaceutical industries, Disodium terephthalate is used as a pH regulator and buffer. It is generally considered safe for use in food and pharmaceutical applications by regulatory agencies such as the FDA.
|
- HY-W014837
-
3-(1-Pyridinio)-1-propanesulfonate
|
Biochemical Assay Reagents
|
NDSB-201 consists of a pyridine group attached to a propane chain, which in turn is attached to a sulfonate group. This compound is commonly used as a buffer in biochemical and biological research, especially in electrophoretic applications. It maintains a stable pH in aqueous solutions and has low UV absorption, making it suitable for use in the UV spectrum. Furthermore, due to its ability to form stable complexes with DNA and other biomolecules, 3-(pyridin-1-ium-1-yl)propane-1-sulfonate has been investigated for its potential in drug delivery and genetic research.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P4116
-
pHLIP
|
Peptides
|
Others
|
pH-Low Insertion Peptide (pHLIP) used as a specific ligand to target the tumor acidic microenvironment for tumors at early and metastatic stages .
|
-
- HY-W141932
-
Stearoylglycine; N-Octadecanoylglycine
|
Peptides
|
Others
|
N-stearoylglycine is a lipid and has a small ionizable polar headgroup whose charge is pH dependent and whose amide moiety can form H-bonded network between adjacent molecules in ordered films .
|
-
- HY-P4116A
-
pHLIP TFA
|
Peptides
|
Cancer
|
pH-Low Insertion Peptide TFA is a specific ligand that targets the acidic tumor microenvironment of early- and metastatic-stage tumors .
|
-
- HY-P5172
-
|
Sodium Channel
|
Neurological Disease
|
MitTx-alpha is a subunit of MitTx. MitTx is a potent, persistent, and selective agonist for acid-sensing ion channels (ASICs). MitTx is highly selective for the ASIC1 subtype at neutral pH; under more acidic conditions (pH<6.5), MitTx massively potentiates (>100-fold) proton-evoked activation of ASIC2a channels .
|
-
- HY-P10469
-
|
NF-κB
|
Inflammation/Immunology
Cancer
|
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .
|
-
- HY-P6021
-
|
Peptides
|
Others
|
HBpep-SP is a peptide. HBpep-SP can be used for delivery and release of proteins .
|
-
- HY-P6021A
-
|
Peptides
|
Others
|
HBpep-SP TFA is the TFA salt form of HBpep-SP (HY-P6021). HBpep-SP TFA is utilized for delivery and release of proteins, peptides and mRNA .
|
-
- HY-P4209
-
|
Peptides
|
Others
|
Boc-GRR-AMC is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
-
- HY-P4209A
-
|
Peptides
|
Others
|
Boc-GRR-AMC (TFA) is a tri-peptide Substrate. Boc-GRR-AMC can be used for a fluorogenic West Nile virus (WNV) substrate, profiling the substrate specificity for the NS2B-NS3 proteases or determining the pH optimum of LdMC activity .
|
-
- HY-P10105
-
|
Akt
Apoptosis
|
Cancer
|
TCL1(10-24) is a encompassing the betaA strand of human TCL1. TCL1(10-24) is a Akt inhibitor. TCL1(10-24) interacts with the Akt PH domain prevented phosphoinositide binding and hence inhibits membrane translocation and activation of Akt. TCL1(10-24) inhibits cellular proliferation and anti-apoptosis. TCL1(10-24) has tumor growth in vivo .
|
-
- HY-P4579
-
|
Peptides
|
Others
|
Pyr-Phe-OH is an effective pyrene-based hydrogel. Pyr Phe OH can self-assemble into hydrogels in the range of pH=7.5-14.0, and also shows a very low gel concentration (0.037% (w/v)) in phosphate buffer .
|
-
- HY-P1315
-
Glycylglycyl-L-tyrosyl-L-arginine
|
Cathepsin
|
Others
|
Papain inhibitor (Glycylglycyl-L-tyrosyl-L-arginine) acts as an effective competitive inhibitor to papain, with a Ki of 9 μM at pH 6.2 .
|
-
- HY-P5423
-
|
Peptides
|
Others
|
GALA is a biological active peptide. (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.)
|
-
- HY-P4527
-
|
Peptides
|
Others
|
Ala-Ala-βNA is a dipeptidyl-fl-naphthylamide (βNA). Ala-Ala-βNA is readily hydrolyzed, with optimum hydrolysis pH of 8.5-9.0 .
|
-
- HY-P5405
-
Transducible TAT-HA fusogenic peptide
|
Peptides
|
Others
|
dTAT-HA2 enhances TAT-Cre escape from macropinosomes. dTAT-HA2 is a transfusible, pH-sensitive, fusogenic peptide .
|
-
- HY-P5423A
-
|
Peptides
|
Others
|
GALA (TFA) is a biological active peptide (GALA, a pH-sensitive fusogenic peptide, is a promising method to accelerate this step in order to enhance the expression of the desired proteins.) .
|
-
- HY-P0224
-
fMLP; N-Formyl-MLF
|
TNF Receptor
|
Inflammation/Immunology
|
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.
|
-
- HY-P2530
-
|
Peptides
|
Others
|
KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors .
|
-
- HY-P4773
-
|
HSV
|
Infection
|
HSV-1 Protease substrate is a peptide substrate for HSV-1 (Herpes Simplex Virus Type 1) protease, and the specificity constant (kcat/Km) at pH 7.5 for cleavage is 5.2 M -1 s -1 .
|
-
- HY-114174
-
|
Amyloid-β
|
Neurological Disease
|
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing .
|
-
- HY-P4389
-
|
Peptides
|
Metabolic Disease
|
(Asp28)-Glucagon (1-29) (human, rat, porcine) is an optimized structure of glucagon, the 28th position is replaced by aspartic acid (Asp) which significantly increases the aqueous solubility of glucagon in a physiological pH buffer, has the same activity as glucagon .
|
-
- HY-P10294
-
|
Peptides
|
Others
|
Oligopeptide P11-4 is an α-peptide that can be self-assembled into β-sheet amyloids with a hydrogel appearance at low pH. Oligopeptide P11-4 can be used in biomimetic mineralization, enamel regeneration and oral care agent .
|
-
- HY-P4522
-
|
Endogenous Metabolite
|
Others
|
Bz-Ala-Arg is a dipeptide. Bz-Ala-Arg is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg can be used to screen competitive inhibitors of these two enzymes .
|
-
- HY-P4522A
-
|
Endogenous Metabolite
|
Others
|
Bz-Ala-Arg TFA is a dipeptide. Bz-Ala-Arg TFA is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg TFA can be used to screen competitive inhibitors of these two enzymes .
|
-
- HY-137798
-
|
Fluorescent Dye
|
Others
|
Chromozym PL is a chromogenic substrate for plasmin, and the enzymatic reaction can be carried out in 0.1mL Tris-HCl buffer (50 mM, pH 7.8). 100 μM Chromozym PL was dissolved and prepared. After adding the hydrolase, the generation of p-nitroaniline (pNA) at 405 nm was continuously observed, and the hydrolysis products were calculated .
|
-
- HY-P2435
-
|
Peptides
|
Others
|
Bz-Nle-Lys-Arg-Arg-AMC can be used for protease activity assay. In 0.1mL Tris-HCl buffer (50 mM, pH 7.8), Bz-Nle-Lys-Arg-Arg-AMC was hydrolyzed, and the release rate of AMC was observed and calculated at λex/λem=380 nm/460 nm .
|
-
- HY-P5780
-
|
Sodium Channel
|
Neurological Disease
|
π-TRTX-Hm3a is a 37-amino acid peptide isolated from Togo starburst tarantula (Heteroscodra maculata) venom. π-TRTX-Hm3a pH-dependently inhibits acid-sensing ion channel 1a (ASIC1a) with an IC50 of 1-2 nM and potentiates ASIC1b with an EC50 of 46.5 nM .
|
-
- HY-P10228
-
|
Fungal
Bacterial
|
Infection
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
|
-
- HY-P4108
-
|
Influenza Virus
|
Others
|
TAT-HA2 Fusion Peptide is a peptide-based delivery agent that combines the pH-sensitive HA2 fusion peptide from Influenza and the cell-penetrating peptide TAT from HIV. TAT-HA2 Fusion Peptide induces the cellular uptake of macromolecules into endosomes via the TAT moiety and to respond to the acidifying lumen of endosomes to cause membrane leakage and release of macromolecules into cells via the HA2 moiety .
|
-
- HY-P5704
-
|
Bacterial
|
Infection
|
K11 is an antimicrobial peptide. K11 is active against MDR/XDR K. pneumoniae isolates (MIC: 8-512 μg/mL), and inhibits bacterial biofilm formation. K11 can act synergistically with antibiotics (Chloramphenicol (HY-B0239), Meropenem (HY-13678), Rifampicin (HY-B0272), etc.) against drug-resistant K. pneumoniae. K11 has high thermal and wide pH stability .
|
-
- HY-P10329
-
|
Fungal
|
Infection
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
-
- HY-P6020
-
|
Peptides
|
Others
|
HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines .
|
-
- HY-P6020A
-
|
Peptides
|
Others
|
HBpep-SA is a cell membrane-permeable peptide condensate that phase separates to form stable droplets at pH values below 6.5. HBpep-SA is able to directly and efficiently deliver a variety of macromolecules, ranging from therapeutic peptides as small as 726 Da to large enzymes as large as 430 kDa, and the loaded condensates remain stable under near-physiological and serum conditions until internalized by cells. HBpep-SA can be used for intracellular delivery of large numbers of macromolecules and as a vector for mRNA-based vaccines .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P990025
-
ARGX-117
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
Empasiprubart (ARGX-117) a humanized inhibitory monoclonal antibody against complement C2. Empasiprubart prevents the formation of the C3 proconvertase and inhibits classical and lectin pathway activation upstream of C3 activation through binding to the Sushi-2 domain of C2. Empasiprubart exhibits pH- and calcium-dependent target binding. Empasiprubart prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants .
|
-
- HY-P99037
-
M281
|
Inhibitory Antibodies
|
Inflammation/Immunology
|
Nipocalimab (M281) is a fully human, recombinant, aglycosylated IgG1 monoclonal antibody. Nipocalimab is a human deglycosylated IgG1 anti-FcRn monoclonal antibody that binds with picomolar affinity to Fc receptor (FcRn) at both endosomal pH 6.0 and extracellular pH 7.6 .
|
-
- HY-P99965
-
SKY59; RO7112689
|
Complement System
|
Cardiovascular Disease
Metabolic Disease
|
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0). Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His). Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP). Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research .
|
-
- HY-P99853
-
CR6261
|
Influenza Virus
|
Infection
|
Diridavumab is a monoclonal anti-HA stalk antibody. Diridavumab stabilizes the prefusion HA structure and prevents pH-dependent fusion of cellular and viral membranes in endosomes. Diridavumab can be used in research of H2 influenza virus .
|
-
- HY-108798
-
|
VEGFR
|
Cardiovascular Disease
Cancer
|
Ziv-aflibercept is a soluble inhibitor of vascular endothelial growth factor (VEGF). Ziv-aflibercept is an adaptive variant of Aflibercept (HY-108801), Ziv-aflibercept has a low PH value and high osmotic pressure when compared to Aflibercept. Ziv-aflibercept has potential applications in metastatic colorectal carcinoma and retinal diseases .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-B1329
-
-
-
- HY-113377A
-
-
-
- HY-W002110
-
-
-
- HY-113377
-
-
-
- HY-N2383
-
(1R,2S,3S,4S,6R)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Glucosidase
|
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC50 value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme .
|
-
-
- HY-N11071
-
-
-
- HY-Y0836
-
-
-
- HY-141475
-
-
-
- HY-P2818
-
-
-
- HY-149036
-
-
-
- HY-N8502
-
-
-
- HY-113314
-
-
-
- HY-N0316
-
-
-
- HY-W145516
-
|
Structural Classification
Natural Products
Leguminosae
Source classification
Cyamopsis tetragonoloba (L.) Taub.
Plants
|
Biochemical Assay Reagents
|
Guar gum is a versatile polymer for drug delivery applications. Guar gum diaplays thickening, emulsifying, binding and gelling properties, quick solubility in cold water, wide pH stability, film forming ability and biodegradability, it finds applications in large number of industries. Guar gum can be isolated from the powdered endosperm of the seeds of the Cyamopsis tetragonolobus. Guar gum can be used as an excipient, such as thickener, suspending agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B0246S3
-
|
Carbamazepine-(Ph)d8 (CBZ-(Ph)d8; NSC 169864-(Ph)d8) is the deuterium labeled Carbamazepine-(Ph) (HY-B0246) .
|
-
-
- HY-D0858S
-
|
MES-d13 is the deuterium labeled MES[1]. MES (2-Morpholinoethanesulphonic acid) is a buffering agent in biology and biochemistry. MES is one of the Good's buffers, the buffer capacity ranging pH 5.5-7.0. MES is broadly used to regulate pH value for plants culture medium, reagent solution, and physiological experiments[2][3].
|
-
-
- HY-109541S6
-
|
(Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine-d72 is deuterium labeled (Rac)-1,2-Dimyristoyl-sn-glycero-3-phosphocholine. 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) is a synthetic phospholipid used in liposomes. 1,2-Dimyristoyl-sn-glycero-3-ph
|
-
-
- HY-D0859S
-
|
MOPS-d15 is the deuterium labeled MOPS[1]. MOPS is commonly used as a buffering agent in biology. MOPS buffer can maintain the pH of mammalian cell culture media[2][3].
|
-
-
- HY-23430S
-
|
TES-d15 is the deuterium labeled TES[1]. TES is a buffering agent (pKa=7.550 at 25°C). TES is one of the Good's buffers, the buffer capacity ranging pH 6.8-8.2[2][3].
|
-
-
- HY-D0869S
-
|
3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 is the deuterium labeled CAPS[1]. CAPS, cyclohexylaminopropane sulfonic acid, is a surfactant. CAPS can be used as biological buffer (0.05 M, pH 11) for dialysis[2][3].
|
-
-
- HY-D0857S
-
|
HEPES-d18 is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].
|
-
-
- HY-Y0836S1
-
|
Diethyl succinate-d4 is the deuterium labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
-
- HY-Y0836S
-
|
Diethyl succinate- 13C4 is the 13C labeled Diethyl succinate[1]. Diethyl succinate (Diethyl Butanedioate) is used at physiological pH and crosses biological membranes, incorporates into cells in tissue culture and is metabolized by the TCA cycle. Diethyl succinate is known to be non-toxic and used in fragrances and flavoring[2].
|
-
-
- HY-B1422S
-
|
9-Aminoacridine-13C6 is the 13C-labeled 9-Aminoacridine(HY-B1422). 9-Aminoacridine, a fluorescent probe, acts as an indicator of pH for quantitative determination of transmembrane pH gradients (inside acidic). 9-Aminoacridine is an antimicrobial. 9-Aminoacridine exerts its antimicrobial activity by interacting with specific bacterial DNA and disrupting the proton motive force in K. pneumoniae. 9-Aminoacridine is a HIV-1 inhibitor and inhibits HIV LTR transcription highly dependent on the presence and location of the amino moiety. 9-Aminoacridine inhibits virus replication in HIV-1 infected cell lines. 9-Aminoacridine is used as a Rifampin (RIF; HY-B0272) adjuvant for the multidrug-resistant K. pneumoniae infections .
|
-
-
- HY-146659S
-
|
S-Phenyl-DL-cysteine-3,3-d2 is the deuterium labeled S-Phenyl-DL-cysteine-3,3[1].
|
-
-
- HY-17507S
-
|
Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
-
-
- HY-17507S1
-
|
Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI)[1]. Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142)[3][4].
|
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Cat. No. |
Compare |
Product Name |
Application |
Reactivity |
Compare Products
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Cat. No. |
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Host |
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Reactivity |
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Application |
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Dilution Ratio |
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Molecular Weight |
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Conjugation |
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Clonality |
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Immunogen |
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SwissProt ID |
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Free Sample |
Yes
No
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* This product has been "discontinued".
Optimized version of product available:
|
Cat. No. |
Product Name |
|
Classification |
-
- HY-124480
-
|
|
Tetrazine
PROTAC Synthesis
|
Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-126908
-
|
|
Tetrazine
PROTAC Synthesis
|
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133463
-
|
|
Tetrazine
PROTAC Synthesis
|
Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133465
-
|
|
PROTAC Synthesis
Tetrazine
|
Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-140349
-
|
|
Azide
PROTAC Synthesis
|
AZD-CO-C2-Ph-amido-Ph-azide is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . AZD-CO-C2-Ph-amido-Ph-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-130283
-
|
|
Tetrazine
PROTAC Synthesis
|
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130928
-
|
|
ADC Synthesis
Tetrazine
|
Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133504
-
|
|
Tetrazine
ADC Synthesis
|
Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130508
-
|
|
Tetrazine
PROTAC Synthesis
Azide
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130551
-
|
|
PROTAC Synthesis
Tetrazine
|
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-126524
-
|
|
ADC Synthesis
Azide
|
N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-133464
-
|
|
PROTAC Synthesis
Tetrazine
Alkynes
|
Tetrazine-Ph-NHCO-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-133460
-
|
|
PROTAC Synthesis
Tetrazine
|
Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133479
-
|
|
Tetrazine
PROTAC Synthesis
|
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133461
-
|
|
PROTAC Synthesis
Tetrazine
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133462
-
|
|
PROTAC Synthesis
Tetrazine
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130967
-
|
|
Alkynes
ADC Synthesis
|
Ald-Ph-PEG4-bis-PEG4-propargyl is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-130974
-
|
|
Tetrazine
ADC Synthesis
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130667
-
|
|
Azide
PROTAC Synthesis
|
Ald-Ph-amido-C2-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Ald-Ph-amido-C2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-133426
-
Ald-benzyl-amide-PEG4-propargyl
|
|
ADC Synthesis
Alkynes
|
Ald-Ph-amido-PEG4-propargyl is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-amido-PEG4-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D1069
-
DBCO-Sulfo-Cy3
|
|
DBCO
Labeling and Fluorescence Imaging
|
DBCO-Cy3 (DBCO-Sulfo-Cy3) is the derivative of Cyanine3 fluorophore, a pH insensitive from pH (4-10) orange fluorescent dyewith excitation maximum 555 nm and emission maximum of 580nm. DBCO-Cy3 has fast reaction kinetics and good stability, and is productive to use in many standard fluorescent instrumentations. DBCO-Cy3 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
|
-
- HY-130969
-
|
|
Azide
ADC Synthesis
|
Ald-Ph-PEG4-bis-PEG3-N3 is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
|
-
- HY-131442
-
Alkyne tyramide; Alk-pH
|
|
Alkynes
Labeling and Fluorescence Imaging
|
Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins . Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-D1482
-
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D1593
-
|
|
Alkynes
Labeling and Fluorescence Imaging
|
BODIPY TMR-X alkyne, an orange-fluorescent dye, is an alkyne modified BODIPY TMR-X. BODIPY TMR-X alkyne can react with azides by the copper-catalyzed click reaction. BODIPY TMR-X alkyne is not sensitive to pH.
|
-
- HY-151712
-
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
Sulfo-Cy5-Methyltetrazine is a click chemistry reagent containing a methyltetrazine group. Sulfo-Cy5-Methyltetrazine acts as a fluorophore linker for trans-cyclooctene-based labeling. Sulfo-Cy5-Methyltetrazine shows good stability at physiological pH and is also highly reactive towards cyclooctene.
|
-
- HY-151713
-
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
Sulfo-Cy3-Methyltetrazine (figure 7 compound 5) is a click chemistry reagent containing methyltetrazine and a water-soluble dye. Sulfo-Cy3-Methyltetrazine shows good stability at physiological pH. Sulfo-Cy3-Methyltetrazine can be coupled to trans-cyclooctene and is also highly reactive towards cyclooctene .
|
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