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Articles (43)

  • Science | A "new" mechanism for non-ubiquitinated Midnolin-proteasomal degradation pathway

    2024-04-26

    “ubiquitin-mediated protein degradation” won the Nobel Prize in Chemistry in 2004! In fact, proteasomes degrade not only ubiquitinated proteins but also non-ubiquitinated ones. The mechanism remains shrouded in mystery. After reading this piece today, you might have a lightbulb moment!

  • Stunning Debut! SPR Assay Service Powerfully Launched!

    2024-04-18

    SPR, which stands for Surface Plasmon Resonance, essentially works by detecting the interaction between ligands and analytes on a biosensor chip. This in turn allows us to probe the properties and structure of substances. With this technology, we can analyze molecules, proteins, DNA, and various organic and inorganic substances in samples in real-time with precision.

  • Nobel Prize 2023: mRNA vaccine technology to fight COVID-19

    2024-04-12

    Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine in 2023 for their groundbreaking work in nucleoside modification, which paved the way for the creation of successful mRNA vaccines to fight against COVID-19. Let's now delve into the complete process of mRNA vaccine development.

  • AACR | conference announcement: The most noteworthy antitumor drugs!

    2024-04-08

    The 2024 AACR meeting concluded successfully in California, USA. Which antitumor drugs stole the show at this conference?

  • Wnt/β-catenin and tumor EMT

    2024-03-18

    Epithelial-Mesenchymal Transition (EMT) is closely related to the plasticity of tumor cells and is a necessary process for tumor metastasis. Wnt/β-catenin is one of the main actors involved in the EMT process. Today, we’re here to popularize the tumor EMT and Wnt/β-catenin pathway~

  • Compound Screening Guide!

    2024-03-15

    How to use compound library? How to design an experiment if you buy a compound library? Want a specific experimental protocol? This article will introduce popular experimental techniques and provide new ideas for publishing high level literature.

  • What should we know about the "undruggable" target KRAS?

    2024-03-03

    KRAS, a gene we've heard so much about, has quickly risen to fame after shedding its "undruggable" label. After reading numerous articles, it's easy to feel overwhelmed and wonder: What exactly should we know about this often-discussed but previously "undruggable" target KRAS?

  • How to Cryopreserve and Thaw Cells More Effectively?

    2024-02-17

    Are frozen cells always damaged? Is the survival rate of revived cells low? When is it appropriate to freeze cells? What should be considered when reviving them? Today, we're sharing a guide to avoid pitfalls in cell freezing and revival!

  • FDA Annual Review | Record-breaking number of new drug approvals in 2023!

    2024-01-22

    FDA Annual Review | Record-breaking number of new drug approvals in 2023!

  • The Application of Tumor Organoids in Drug Screening

    2023-09-28

    A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening of diseases such as cancer, infectious diseases, and rare diseases.