BMS-363131

Cat. No.: HY-116033: FAQs
Data Sheet Handling Instructions

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BMS-363131 is a selective inhibitor for tryptase, with an IC₅₀ <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model.

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BMS-363131 Chemical Structure

CAS No. : 384829-65-6

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Description	BMS-363131 is a selective inhibitor for tryptase, with an IC₅₀ <1.7 nM. BMS-363131 is hydrolytic stable at pH=7 and pH=9. BMS-363131 attenuates the astham in a guinea pig model^[1].
Molecular Weight	540.65
Formula	C₂₈H₄₀N₆O₅
CAS No.	384829-65-6
SMILES	O=C(N1CCN(CC1)C(CCCCCC2=CC=CC=C2)=O)N3[C@@H]([C@H](C3=O)C[C@@H]4CN(CCC4)C(N)=N)C(O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Slusarchyk WA, et al., Synthesis of potent and highly selective inhibitors of human tryptase. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3235-8. [Content Brief]

BMS-363131 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-363131384829-65-6BMS363131BMS 363131Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesAsthmaguinea pigselectiveInhibitorinhibitorinhibit

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BMS-363131

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