Search Result
Results for "
raw
" in MedChemExpress (MCE) Product Catalog:
20
Biochemical Assay Reagents
4
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N2620
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-
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- HY-34588
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D-(-)-4-Hydroxyphenylglycine; 4-Hydroxy-D-phenylglycine
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Others
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Others
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D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190) .
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-
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- HY-139658
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-
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- HY-N1494
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14-Deoxy-ε-caesalpin
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NO Synthase
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Inflammation/Immunology
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(+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS) .
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-
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- HY-N10297
-
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Others
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Inflammation/Immunology
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Curindolizine, indolizine alkaloid , displays an anti-inflammatory action in lipopolyssacharide (LPS)-induced RAW 264.7 macrophages with an IC50 value of 5.31 μM .
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-
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- HY-N1186
-
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Glucosidase
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Metabolic Disease
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Tachioside inhibits nitric oxide production in lipopolysaccharide (HY-D1056)-stimulated RAW 264.7 cells with IC50 value of 12.14 μM. Tachioside has anti-obesity, antioxidant and α-glucosidase inhibitory activities .
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-
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- HY-149650
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-
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- HY-125531
-
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Others
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Others
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Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effects on NO production effects in RAW 264.7 macrophage cells .
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-
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- HY-149650A
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-
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- HY-N3646
-
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Others
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Others
Neurological Disease
Inflammation/Immunology
Cancer
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Cudratricusxanthone A is isolated from Cudrania tricuspidata, and has anti-inflammatory, hepatoprotective, and anti-proliferative activities. Cudratricusxanthone A inhibits osteoclast differentiation and function in RAW 264.7 cells and mouse bone marrow monocytes .
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- HY-W540926
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Biacetyl dioxime sodium hydrate
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Biochemical Assay Reagents
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Others
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Dimethylglyoxime (sodium hydrate) (Biacetyl dioxime (sodium hydrate)) is a biochemical reagent used for biochemical analysis and as a basic chemical raw material. Dimethylglyoxime (sodium hydrate) is a kind of biological materials or organic compounds that are widely used in life science research .
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-
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- HY-N9891
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-
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- HY-114730
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IKK
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Inflammation/Immunology
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CGA-JK3 is CGA-JK3 is an ATP-competitive inhibitor of IKKβ-catalyzed kinase activity. CGA-JK3 inhibits IκBα phosphorylation in LPS (HY-D1056) - induced RAW 264.7 cells .
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-
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- HY-162425
-
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PGE synthase
COX
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Inflammation/Immunology
Cancer
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Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2, PGE1, COX-2 and COX-1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line .
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-
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- HY-N0569
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-
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- HY-156431
-
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TNF Receptor
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Inflammation/Immunology
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Anti-inflammatory agent 61 (Compound 5b) is a potent anti-inflammatory agent. Anti-inflammatory agent 61 reduces TNF-α expression in LPS-induced inflammation in RAW 264.7 cells. Anti-inflammatory agent 61 alleviates APAP-induced inflammation in HepG2 cells .
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-
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- HY-N8719
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7-Hydroxy-4'-methoxyflavone
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NF-κB
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Inflammation/Immunology
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Pratol is a potent inhibitor of NF-κB. Pratol significantly reduces NO and prostaglandin PGE2 production without any cytotoxic in LPS-stimulated RAW 264.7 cells. Pratol reduces proinflammatory cytokines. Pratol can be used in study inflammatory diseases and cancer .
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-
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- HY-N8160
-
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Keap1-Nrf2
Reactive Oxygen Species
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Inflammation/Immunology
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Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .
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- HY-163355
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COX
Lipoxygenase
NF-κB
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Inflammation/Immunology
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COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities .
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-
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- HY-N10120
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-
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- HY-W573700
-
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Others
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Others
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Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .
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-
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- HY-N10111
-
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IKK
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Inflammation/Immunology
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Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.
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-
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- HY-N2838
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NO Synthase
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Inflammation/Immunology
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Alismol is a natural sesquiterpene. Alismol shows promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells .
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-
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- HY-N10062
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RANKL/RANK
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Others
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Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264.7 cells.
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- HY-130787
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NO Synthase
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Inflammation/Immunology
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Apterin is a natural compound with anti-inflammatory activity. Apterin shows significantly inhibitory activity on NO production in RAW264.7 cells with an IC50 value of 41.8 μM .
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-
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- HY-N2989
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NO Synthase
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Inflammation/Immunology
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3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .
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- HY-161043
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Pyroptosis
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Inflammation/Immunology
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ECDD-S16 is a potent inhibitor of pyroptosis. ECDD-S16 inhibits surface and endosomal TLR ligands activated pyroptosis in Raw264.7 cells .
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- HY-N11544
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NO Synthase
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Inflammation/Immunology
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Inflexuside B, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO Synthase in RAW264.7 macrophages .
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- HY-N11548
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NO Synthase
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Inflammation/Immunology
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Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages .
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-
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- HY-149647
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-
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- HY-N1912
-
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Others
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Cancer
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Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages .
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- HY-N12283
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NF-κB
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Inflammation/Immunology
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NF-κB-IN-13 (compound 12) can significantly inhibit LPS-induced NF-κB activation and NO production in RAW264.7 macrophages. NF-κB-IN-13 has anti-inflammatory effects .
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- HY-N1695
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Regelin acid
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NO Synthase
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Inflammation/Immunology
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Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of iNOS protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .
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-
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- HY-149671
-
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Others
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Inflammation/Immunology
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Anti-inflammatory agent 63 is an anti-inflammatory agent that shows optimal inhibitory activity (EC50 = 5.33±0.57 μM) against the production of nitric oxide (NO) induced by lipopolysaccharide (LPS) in RAW264.7 cells .
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-
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- HY-125495
-
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Others
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Inflammation/Immunology
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Telmesteine is an amucolitic agent. Telmesteine has anti-protease activity. Telmesteine inhibits LPS-induced NO production in RAW264.7 cells. Telmesteine can be used for research of inflammation, such as acute and chronic bronchitis and obstructive airways disease .
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-
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- HY-N12494
-
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NO Synthase
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Inflammation/Immunology
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Diplacol is a geranylated flavanone that can be isolated from paulownia trees (Paulownia coreana UYEKI). Diplacol has anti-inflammatory activity. Diplacol inhibits NO production in LPS-stimulated Raw264.7 cells with an IC50 value of 4.53 μM .
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- HY-N2939
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Others
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Others
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Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC50 value of 48.6 mM .
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-
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- HY-N9000
-
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TNF Receptor
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Inflammation/Immunology
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Loganic acid 6′-O-β-D-glucoside, a iridoidal glucoside, is isolated from the whole plant of Gentiana rhodantha (Gentianaceae). Loganic acid 6′-O-β-D-glucoside inhibits LPS-induced NO and TNF-α production in macrophage RAW264.7 cells .
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-
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- HY-N3383
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Ligstroside
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Mitochondrial Metabolism
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Neurological Disease
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Ligustroside (Ligstroside), a secoiridoid derivative, has outstanding performance on mitochondrial bioenergetics in models of early Alzheimer's disease (AD) and brain ageing by mechanisms that may not interfere with Aβ production. Ligustroside significantly inhibits nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages .
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-
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- HY-136930
-
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Others
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Others
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6-Iododiosmin is a impurity of Diosmin (HY-N0178) raw materials .
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-
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- HY-144766
-
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Apoptosis
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Cancer
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ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation .
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-
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- HY-158311
-
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RANKL/RANK
p38 MAPK
NF-κB
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Endocrinology
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Anti-osteoporosis agent-8 (Compound 4aa) is an inhibitor for RANKL, which inhibits RANKL-induced osteoclastogenesis and osteoclast differentiation (IC50 is 2.41 μM) in cells RAW264.7. Anti-osteoporosis agent-8 ameliorates bone loss in an ovariectomized (OVX) mice model .
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-
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- HY-N11657
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Sanggenone A
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NF-κB
Keap1-Nrf2
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Inflammation/Immunology
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Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .
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- HY-N4207
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Others
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Others
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Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .
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-
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- HY-Y1778
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Fluorescent Dye
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Others
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N-(Diphenylmethylene)glycine tert-butyl ester is a dye, also as the raw material and intermediate for organic syntheses .
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-
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- HY-N3392
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-
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- HY-147770
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NF-κB
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Inflammation/Immunology
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NF-κB-IN-6 (Compound 3d) is an anti-inflammatory agent through the mechanism of decreasing the protein expressions of iNOS and COX-2 by suppressing NF-κB signaling pathway. NF-κB-IN-6 inhibits NO production in LPS-induced RAW264.7 cells with an IC50 of 23.1 μM .
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- HY-W015551
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(E)-Dec-2-enal
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Biochemical Assay Reagents
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Others
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trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes.
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-
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- HY-N0634
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Cimitin
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NF-κB
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Inflammation/Immunology
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Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions . Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS .
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-
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- HY-153762
-
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NO Synthase
NF-κB
COX
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Inflammation/Immunology
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COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM) .
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- HY-N12235
-
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Caspase
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Inflammation/Immunology
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Sarglaroids F (compound 6) is an anti-inflammatory agent isolated from the roots of Grass Coral. Sarglaroids F inhibits LPS/ATP-induced IL-1β release by affecting K+ efflux and reducing Caspase-1(P20) levels. Sarglaroids F is not cytotoxic to RAW264.7 cells .
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- HY-N12042
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- HY-N3548
-
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NF-κB
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Inflammation/Immunology
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Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and IFN-β/STAT-1 activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities .
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- HY-N3289A
-
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Others
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Inflammation/Immunology
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(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes .
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- HY-N10114
-
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Others
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Inflammation/Immunology
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Hyperectumine exhibits moderate anti-inflammatory activity via suppression of LPS-activated inflammatory mediators in RAW 264.7 macrophage cells.
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- HY-P1439A
-
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Toll-like Receptor (TLR)
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Inflammation/Immunology
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RS 09 TFA is a TLR4 agonist. RS 09 TFA promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. RS 09 TFA acts as an adjuvant in vivo; RS 09 TFA enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.
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- HY-79722
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trans-4-Aminocyclohexan-1-ol
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Others
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Others
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4-trans-Hydroxycyclohexylamine (trans-4-Aminocyclohexan-1-ol) is a raw material in organic synthesis .
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- HY-N2535
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4-Hydroxy-3-methoxycinnamaldehyde
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Keap1-Nrf2
Apoptosis
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Inflammation/Immunology
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Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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- HY-124482
-
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Others
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Others
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Mesembrenol (Chemotype c) is an alkaloid widely found in plants. Mesembrenol has potential application in quality control of raw materials and products of S.tortuosum .
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- HY-149351
-
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NF-κB
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Cardiovascular Disease
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NF-κB-IN-10 (compound E1) is an NF-κB inhibitor that can improve heart failure by reducing oxidative stress and inflammation by regulating Nrf2/NF-κB signaling pathway. NF-κB-IN-10 inhibits LPS-induced NO production and expression of iNOS and COX-2 in RAW264.7 cells. NF-κB-IN-10 can be used in the research of cardiovascular diseases .
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- HY-W068682
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Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin
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Amylases
Bacterial
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Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
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- HY-129151
-
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Others
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Inflammation/Immunology
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Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .
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- HY-139844
-
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p38 MAPK
NF-κB
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Inflammation/Immunology
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Anti-inflammatory agent 7 inhibits proinflammatory cytokines by blocking the NF-κB/MAPK signaling pathway in LPS-treated RAW 264.7 cells as well as mice.
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-
- HY-N9896
-
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NO Synthase
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Inflammation/Immunology
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Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC50 value of 36.6 μM .
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-
- HY-155751
-
-
- HY-P10329
-
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Fungal
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Infection
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KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
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- HY-W094510
-
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Biochemical Assay Reagents
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Others
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Sodium pyrophosphate decahydrate can be as a buffering agent, a chelator and a hydrated salt nucleating agent. Sodium pyrophosphate decahydrate can also be used to a raw material for synthetic laundry scent additives .
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- HY-155820
-
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NF-κB
NO Synthase
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .
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- HY-155821
-
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NF-κB
NO Synthase
TNF Receptor
Interleukin Related
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Inflammation/Immunology
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Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .
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-
- HY-N10865
-
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NO Synthase
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Inflammation/Immunology
|
Chloranthalactone E (compound 6), a labdane diterpene, can be isolated from the aerial parts of Chloranthus serratus. Chloranthalactone E inhibits NO production in LPS-activated RAW 264.7 macrophages .
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- HY-N1080
-
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Others
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Inflammation/Immunology
|
Vitexdoin A is a nitric oxide scavenging lignin. Vitexdoin A inhibits NO production with an IC50 of 0.38 μM in LPS (HY-D1056)-stimulated RAW 264.7 cells .
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-
- HY-153379
-
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Liposome
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Others
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ALC-0315 analogue-1 (compound P-10) is a cationic lipid. ALC-0315 analogue-1 is the raw material for synthesis of cationic liposome .
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-
- HY-N11570
-
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Others
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Inflammation/Immunology
|
Phaeocaulisin E (Compound 5) is a guaiane-type sesquiterpene that inhibits LPS HY-(HY-D1056)-induced NO production in RAW 264.7 macrophages with an IC50 of 10.3 μM .
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-
- HY-134467
-
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Parasite
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Infection
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Phylloflavan is an antileishmanial agent with an intracellular EC50 of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL) .
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-
- HY-N0617
-
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Phosphatase
ERK
NF-κB
Apoptosis
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Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .
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-
- HY-N6257
-
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ERK
PGE synthase
COX
NF-κB
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Inflammation/Immunology
Cancer
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Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects .
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-
- HY-N2794
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α-Dihydrocaryopterone
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NO Synthase
|
Inflammation/Immunology
|
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC50 of 4.64 µM on LPS-induced NO production in RAW 264.7 cells .
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-
- HY-N3211
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cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-Feruloyltyramine
|
NO Synthase
|
Inflammation/Immunology
|
N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells .
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-
- HY-N1936
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α-Spinasterol glucoside
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Others
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Inflammation/Immunology
|
α-Spinasterol-3-O-β-D-glucoside is a sterol glucoside that can be isolated from the seeds of Momordica cochinchinensis .
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-
- HY-34596
-
|
Biochemical Assay Reagents
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Others
|
4-Hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. 4-Hydroxyindole is an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers .
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- HY-153389
-
|
Liposome
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Others
|
ALC-0315 analogue-3 (compound P-35) is a liposome raw material. ALC-0315 analogue-3 can improve the loading rate and transport rate of nucleic acid drugs .
|
-
- HY-N6893
-
|
NF-κB
|
Inflammation/Immunology
|
Ergolide is a sesquiterpene lactone isolated from the dried flowers of Inula Britannica. Ergolide inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-κB .
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-
- HY-N12429
-
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Others
|
Inflammation/Immunology
|
Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.
|
-
- HY-N11058
-
|
Lipoxygenase
NO Synthase
|
Inflammation/Immunology
|
Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .
|
-
- HY-W250170
-
Octyldecyl glucoside
|
Biochemical Assay Reagents
|
Others
|
Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.
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-
- HY-N4264
-
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Others
|
Inflammation/Immunology
|
Vinaginsenoside R3 is a saponin composition of roots of Panax ginseng. Ginsengs have been not only used as therapeutic agents with tonic, anti-fatigue, and anti-gastric ulcer effect but also marketed as dietary supplements and raw materials of health food .
|
-
- HY-115770
-
|
Bacterial
|
Inflammation/Immunology
|
8-Methylsulfinyloctyl isothiocyanate, an isothiocyanate, has antimicrobial activity and remarkable inhibitory activity against plant growth . 8-Methylsulfinyloctyl isothiocyanate impair COX-2 mediated inflammatory responses in LPS stimulated raw macrophages .
|
-
- HY-N0803S1
-
β-Myrcene-13C3
|
NF-κB
Isotope-Labeled Compounds
|
Others
|
Myrcene- 13C3 is 13C labeled trans-2-Decenal (HY-W015551). trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes.
|
-
- HY-N10156
-
-
- HY-N0223
-
-
- HY-W007437
-
Naphthalene-2-carboxylic acid
|
Biochemical Assay Reagents
|
Others
|
2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
|
-
- HY-147809
-
|
COX
|
Inflammation/Immunology
|
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity .
|
-
- HY-N9969
-
-
- HY-153330
-
-
- HY-162170
-
|
NF-κB
Keap1-Nrf2
p38 MAPK
|
Inflammation/Immunology
|
Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating Nrf2 and inhibiting NF-κB p65/iNOS and MAPKs signaling pathways .
|
-
- HY-N12767
-
-
- HY-158402
-
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
|
-
- HY-N9337
-
|
NO Synthase
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Amaroswerin is a bioactive secoiridoid glucoside from Swertia mussotii. Amaroswerin has anti-inflammatory, antidiabetic, antiviral, anticholinergic and immunomodulatory activities. Amaroswerin inhibits NO release with an IC50 value of 5.42 μg/mL in RAW264.7 cells .
|
-
- HY-W009443
-
Diethyl sebacate
|
Biochemical Assay Reagents
|
Others
|
Diethyl decanedioate is an organic compound commonly used as a raw material for flavors and food additives. It can be used to make fruit and mint flavors, and is widely used in some food processing and cosmetic production. In addition, this compound is also used as a reagent and intermediate in some organic synthesis reactions.
|
-
- HY-128776
-
|
Others
|
Cancer
|
Antitumor agent-19 is an antitomor agent targeting tumor-associated macrophages (TAMs) to serve as an effective TAMs modulator. The EC50 values of Antitumor agent-19 in the RAW 264.7 cells and the BMDM cells are 17.18 μM and 18.87 μM, respectively .
|
-
- HY-N3552
-
|
NF-κB
|
Inflammation/Immunology
|
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages .
|
-
- HY-Y1091
-
|
Endogenous Metabolite
|
Others
|
D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance .
|
-
- HY-W005355
-
|
Biochemical Assay Reagents
|
Others
|
Sodium 2-oxobutanoate is an organic compound commonly used as a food additive and industrial raw material. It can be used as an acidity regulator, leavening agent and preservative, and is often used in the fields of bread, baked goods and canning. In addition, the compound is used in the production of certain industrial products, such as in plastics, textiles and dyes.
|
-
- HY-W008145
-
Sodium tetrachloropalladate(II) trihydrate
|
Biochemical Assay Reagents
|
Others
|
Sodium tetrachloropalladate(II) is an organic compound commonly used as a catalyst and as a raw material for dye production. It can be used to catalyze or promote reactions in certain chemical reactions, and is widely used in the fields of organic synthesis and dye preparation. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
|
-
- HY-N7422
-
ent-Kauran-16β,17-diol
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages .
|
-
- HY-156598
-
|
Others
|
Others
|
1,3-Bis (carboxyphenoxy) propane is one of the monomer raw materials for aromatic polyanhydrides. 1,3-Bis (carboxyphenoxy) propane has been used as biodegradable carriers for drug delivery applications. 1,3-Bis (carboxyphenoxy) can be used for implant related research .
|
-
- HY-W082785A
-
-
- HY-Y0271
-
Urea
1 Publications Verification
Carbonyl diamide
|
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
Urea is a powerful protein denaturant via both direct and indirect mechanisms . A potent emollient and keratolytic agent . Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function . Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
- HY-136741
-
|
IKK
|
Inflammation/Immunology
|
BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC50 of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription .
|
-
- HY-N9971
-
-
- HY-13982
-
JSH-23
Maximum Cited Publications
82 Publications Verification
|
NF-κB
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
JSH-23 is an NF-κB inhibitor which inhibits NF-κB transcriptional activity with an IC50 of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .
|
-
- HY-125911
-
|
NF-κB
|
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Gossypin is a flavone isolated from Hibiscus vitifolius and has antioxidant, antiinflammatory, anticancer, anticataract, antidiabetic, and hepatoprotective activities. Gossypin inhibits NF-κB and NF-κB-regulated gene expression. Gossypin inhibits RANKL-induced osteoclastogenesis both in mouse primary bone marrow cells and RAW 264.7 cells in vitro .
|
-
- HY-W008992
-
8-Hydroxyquinoline sulfate hydrate
|
Biochemical Assay Reagents
|
Others
|
Quinolin-8-ol sulfate hydrate is an organic compound commonly used in dyes and as a raw material for chemical analysis. It can cooperate with metal ions to form dyes, and is widely used in the fields of dyes, printing and textile manufacturing. In addition, the compound also has good toxicity and biocompatibility, and is also used in some medical fields.
|
-
- HY-146066
-
|
nAChR
JAK
STAT
NO Synthase
|
Inflammation/Immunology
|
α7 nAchR-JAK2-STAT3 agonist 1 is a potent α7 nAchR-JAK2-STAT3 agonist, with an IC50 value of 0.32 μM for nitric oxide (NO). α7 nAchR-JAK2-STAT3 agonist 1 effectively suppresses the expression of iNOS, IL-1β, and IL-6 in murine RAW264.7 macrophages. α7 nAchR-JAK2-STAT3 agonist 1 can inhibit LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 can be used for researching sepsis .
|
-
- HY-155759
-
|
Others
|
Inflammation/Immunology
Cancer
|
HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC50 value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC50s of 77.0 μM, and 82.0 μM, respectively .
|
-
- HY-34596R
-
|
Biochemical Assay Reagents
|
Others
|
4-Hydroxyindole (Standard) is the analytical standard of 4-Hydroxyindole. This product is intended for research and analytical applications. 4-Hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. 4-Hydroxyindole is an important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers .
|
-
- HY-129113
-
|
COX
|
Inflammation/Immunology
|
α-Chaconine inhibits the expressions of COX-2, IL-1β, IL-6, and TNF-α at the transcriptional level. α-Chaconine inhibits the LPS-induced expressions of iNOS and COX-2 at the protein and mRNA levels and their promoter activities in RAW 264.7 macrophages. Anti-inflammatory effects .
|
-
- HY-B2225B
-
Edible corn starch (from corn)
|
Biochemical Assay Reagents
Endogenous Metabolite
|
Others
|
Starch (from corn) is a carbohydrate extracted from the kernel of the corn plant. It contains two main components, namely amylose and amylopectin. Starches from corn have various applications in the food industry as thickeners, stabilizers and binders. It is commonly used in the production of products such as baked goods, snacks, sauces and soups. In addition, it can be used as a raw material for the production of biofuels and bioplastics.
|
-
- HY-42935A
-
Enanthate sodium
|
Biochemical Assay Reagents
|
Others
|
Heptanoate sodium is an organic sodium salt compound widely used in various industries and laboratories. It can be used as surfactant, emulsifier, lubricant and preservative, etc., and plays an important role in some electronic devices. In addition, Heptanoate sodium is also used in the preparation of certain chemicals and raw materials such as paints, plastics, fragrances, etc. Although the compound has no direct medical application, it plays an important role in chemical research and industrial production.
|
-
- HY-W099600
-
Bisdodecanoic anhydride
|
Biochemical Assay Reagents
|
Others
|
Lauric anhydride is a white waxy solid used as an intermediate in the production of various chemicals. It is primarily used in the synthesis of surfactants, emulsifiers, and lubricants, and as a raw material for other important industrial chemicals such as plasticizers and flavoring agents. It can be obtained from natural sources such as palm kernel oil and coconut oil, and its unique chemical structure allows it to be used to create compounds with specific surface and interfacial properties.
|
-
- HY-B0386
-
|
COX
|
Inflammation/Immunology
|
Flunixin meglumine is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin meglumine shows anti-inflammatory effects .
|
-
- HY-N0253
-
Kalopanaxsaponin B
|
Bacterial
p38 MAPK
NF-κB
Apoptosis
|
Infection
Inflammation/Immunology
|
Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of MAPK/NF-κB and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity .
|
-
- HY-N6894A
-
Isocoptisine chloride
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
Pseudocoptisine (Isocoptisine) chloride is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects .
|
-
- HY-146727
-
|
JAK
|
Inflammation/Immunology
|
JAK3-IN-11 (Compound 12), a potent, noncytotoxic, irreversible, orally active JAK3 inhibitor with IC50 value of 1.7 nM, has excellent selectivity (>588-fold compared to other JAK isoforms), covalently bind to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T cell proliferation, is a promising tool for study autoimmune diseases .
|
-
- HY-N12394
-
|
Others
|
Inflammation/Immunology
|
Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity .
|
-
- HY-158022
-
|
Cathepsin
|
Infection
Inflammation/Immunology
|
CTSL/CAPN1-IN-1 (compound 14a) is an oral active CTSL and CAPN1 inhibitor with the IC50 values of 3.34 nM and 375.1 nM for CTSL and CAPN1, respectively. CTSL/CAPN1-IN-1 shows anticoronaviral activity and anti-inflammatory effect .
|
-
- HY-161513
-
|
COX
NO Synthase
|
Inflammation/Immunology
|
iNOS/COX-2-IN-1 (Compound 12e) is an inhibitor of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). iNOS/COX-2-IN-1 inhibits the NF-κB and MAPKs signaling pathways and thus exerts anti-inflammatory effects .
|
-
- HY-N0569R
-
|
NO Synthase
COX
TNF Receptor
Interleukin Related
|
Inflammation/Immunology
|
Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells .
|
-
- HY-Y0271S
-
Carbamide-15N2; Carbonyldiamide-15N2
|
Endogenous Metabolite
|
Cardiovascular Disease
Cancer
|
Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
- HY-110247
-
|
TNF Receptor
NF-κB
|
Cardiovascular Disease
Inflammation/Immunology
|
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1 . TRAF-STOP 6877002 prevents the progression of established atherosclerosis in mice, reduces leukocyte recruitment and reduces macrophage activation; reduces macrophage proliferation in atherosclerotic plaques .
|
-
- HY-W077279
-
N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine
|
DNA/RNA Synthesis
|
Others
|
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis .
|
-
- HY-W250186
-
Teterdecyl dimethyl amine oxide; Myristyldimethylamine N-oxide
|
Biochemical Assay Reagents
|
Others
|
Myristyl dimethylamine oxide is a cationic surfactant belonging to the family of amine oxides. It is commonly used as a foam booster, thickener and conditioning agent in a variety of personal care and household cleaning products. Myristyl dimethylamine oxide has several properties suitable for these applications, including the ability to reduce surface tension, increase viscosity and provide antistatic properties. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-Y0271S1
-
1,1,3,3-Tetradeuteriourea; Urea-d4
|
Endogenous Metabolite
|
|
Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
- HY-34588R
-
D-(-)-4-Hydroxyphenylglycine (Standard); 4-Hydroxy-D-phenylglycine (Standard)
|
Others
|
Others
|
D-4-Hydroxyphenylglycine (Standard) is the analytical standard of D-4-Hydroxyphenylglycine. This product is intended for research and analytical applications. D-4-Hydroxyphenylglycine (D-(-)-4-Hydroxyphenylglycine) is one of the most important raw materials used in the production of semisynthetic β-lactam antibiotics, such as Amoxicillin (HY-B0467A) and Cefadroxil (HY-B1190) .
|
-
- HY-128922
-
-
- HY-121323
-
-
- HY-163454
-
|
Bacterial
|
Infection
|
NorA-IN-2 (compound DZ-3) is a potent NorA inhibitor. NorA-IN-2 shows NorA efflux pump inhibitors (EPI) activity .
|
-
- HY-146346
-
|
PROTACs
HDAC
|
Inflammation/Immunology
|
HD-TAC7 is a potent PROTAC HDAC degrader with IC50 values of 3.6 μM, 4.2 μM and 1.1 μM for HDAC1, HDAC2 and HDAC3, respectively. HD-TAC7 can decreases NF-κB p65 in RAW 264.7 macrophages. HD-TAC7 can be used for the research of inflammatory diseases like asthma and chronic obstructive pulmonary disease (COPD) .
|
-
- HY-W250166
-
|
Biochemical Assay Reagents
|
Others
|
Poly(ethylene glycol) (12) tridecyl ether is a nonionic surfactant belonging to the family of ethoxylated fatty alcohols. It is commonly used as an emulsifier, solubilizer, and wetting agent in a variety of industrial and personal care products. Poly(ethylene glycol)(12) tridecyl ether has various properties that make it suitable for these applications, including its low toxicity, high solubility in water and organic solvents, and ability to stabilize emulsions. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-Y0271S2
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
Urea- 13C, 15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
|
-
- HY-131626
-
1a,1b-Dihomo PGE2
|
Others
|
Metabolic Disease
|
1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
|
-
- HY-N3364
-
|
Flavivirus
Dengue virus
TNF Receptor
NF-κB
NO Synthase
COX
JNK
p38 MAPK
IKK
|
Infection
Inflammation/Immunology
|
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE2 production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC50=25 μM) .
|
-
- HY-113099
-
Indole-3-lactic acid
|
Endogenous Metabolite
|
Inflammation/Immunology
|
Indolelactic acid (Indole-3-lactic acid) is a tryptophan (Trp) catabolite in Azotobacter vinelandii cultures. Indolelactic acid has anti-inflammation and potential anti-viral activity .
|
-
- HY-N7012
-
5-Hydroxy-3',4',7-trimethoxyflavone
|
TNF Receptor
Interleukin Related
COX
|
Inflammation/Immunology
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 .
|
-
- HY-N4137
-
-
- HY-138989
-
|
Lipoxygenase
|
Inflammation/Immunology
|
15-LOX-1 inhibitor 1 is a potent inhibitor of 15-LOX-1 (15-lipoxygenase-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor 1 protects macrophages from lipopolysaccharide-induced cytotoxicity. 15-LOX-1 inhibitor 1 inhibits NO formation and lipid peroxidation .
|
-
- HY-115927
-
|
NO Synthase
|
Inflammation/Immunology
|
8A8 is a potent proinflammatory factor NO inhibitor with an IC50 of 4.7 μM. 8A8 also significantly inhibits LPS-induced HaCat cell proliferation .
|
-
- HY-145846
-
|
NO Synthase
Interleukin Related
|
Inflammation/Immunology
|
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .
|
-
- HY-N10436
-
-
- HY-N10434
-
-
- HY-N10435
-
-
- HY-150055
-
|
NO Synthase
|
Inflammation/Immunology
|
iNOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 µM). iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research .
|
-
- HY-P2624
-
|
PAK
|
Metabolic Disease
|
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
|
-
- HY-148553
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 36 is an anti-inflammatory agent. Anti-inflammatory agent 36 inhibits LPS-induced macrophage activation .
|
-
- HY-N1546
-
|
Others
|
Inflammation/Immunology
|
Protoplumericin A is a bioactive ingredient of Plumeria obtusa L. attenuates. Protoplumericin A mitigated lipopolysaccharide (LPS) -induced acute lung injury in mice. Protoplumericin A can be used to study the LPS-induced anti-inflammatory effect .
|
-
- HY-157534
-
|
Others
|
Metabolic Disease
|
Pancreatic lipase-IN-2 (compound 7r) is a potent inhibitor of pancreatic lipase (PL), with the IC50 value of 2.67 μM, that has anti-obesity effect .
|
-
- HY-146245C
-
CpG 1826 sodium
|
Toll-like Receptor (TLR)
Apoptosis
|
Cardiovascular Disease
Cancer
|
ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) that is a TLR9 agonist. ODN 1826 sodium is an immunostimulatory agent that induces NO and iNOS production in mouse models. ODN 1826 sodium also enhances apoptosis (apoptosis) and may promote atherosclerosis. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’ .
|
-
- HY-161395
-
|
Bacterial
|
Infection
|
IDD-8E is an effective anti-pseudomonal agent (MIC =4.4 µM ) with no cytotoxicity. IDD-8E shows significant pseudomonal killing and disruption of pseudomonal biofilm. IDD-8E binds to the ATP-binding pocket of WaaP and also inhibits other ESKAPE pathogens.
|
-
- HY-161342
-
|
Cathepsin
SARS-CoV
|
Infection
Inflammation/Immunology
|
CTSL/CAPN1-IN-2 (Compound 14b) is an orally active inhibitor of both CTSL and CAPN1, with IC50 values of 6.88 nM and 347.6 nM, respectively. CTSL/CAPN1-IN-2 possesses anti-inflammatory properties and favorable pharmacokinetic characteristics. CTSL/CAPN1-IN-2 exhibits broad-spectrum antiviral activity against coronaviruses by blocking viral entry .
|
-
- HY-N12964
-
|
Others
|
Others
|
4-Hydroxycanthin-6-one is a novel quinoline alkaloid isolated from the stem bark of the tree Ailanthus altissima. Five other known compounds were also found in the study. The structures of the new compounds were determined by interpretation of physical and spectroscopic data, and their absolute configurations were determined by electronic circular dichroism spectroscopy and quantum chemical calculations. These compounds showed significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, showing potential anti-inflammatory properties .
|
-
- HY-N7176
-
Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide
|
Interleukin Related
|
Inflammation/Immunology
|
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10 .
|
-
- HY-N7931
-
-
- HY-W013435
-
|
Fluorescent Dye
|
Others
|
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .
|
-
- HY-124240
-
-
- HY-155159
-
|
COX
Lipoxygenase
|
Inflammation/Immunology
|
COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065?μM and 1.86?μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity .
|
-
- HY-118816
-
11-epi PGF2α-EA; 11β-PGF2α-EA; 11β-Prostamide F2α
|
Others
|
Metabolic Disease
|
11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.
|
-
- HY-N8132
-
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside found in the bulbs of Lilium brownie var. viridulum. 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside exhibits weak inhibition of NO production in LPS-stimulated RAW 264.7 cells .
|
-
- HY-N6894
-
Isocoptisine acetate
|
Cholinesterase (ChE)
|
Inflammation/Immunology
|
Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibits acetylcholinesterase (AChE) activity with an IC50 of 12.8 μM. Anti-inflammatory and anti-amnestic effects .
|
-
- HY-151188
-
|
NO Synthase
TNF Receptor
|
Inflammation/Immunology
|
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and TNF-α). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1 .
|
-
- HY-151612
-
|
Parasite
|
Infection
|
Anti-infective agent 6 (compound 28) is a potent anti-infectious agent. Anti-infective agent 6 shows a good activity against P. falciparum F32-ART (IC50=1.4 μM) with a good selectivity index (SI>36). Anti-infective agent 6 also shows a potency against L. donovani (IC50=3.5 μM) .
|
-
- HY-151614
-
|
Bacterial
|
Infection
|
Anti-infective agent 7 is a potent anti-infectious agent. Anti-infective agent 7 has anti-infection activity against P. falciparum (IC50=2.5 μM) and M. tuberculosis (MIC=9 μM) .
|
-
- HY-N3480
-
(+)-Isogospherol; Isogospherol
|
Others
|
Inflammation/Immunology
|
Isogosferol ((+)-Isogospherol; Isogospherol) is a potent anti-inflammatory agent. Isogosferol decreases LPS (HY-D1056)-stimulated NO and IL-1β expression. Isogosferol decreases the LPS (HY-D1056)-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2 .
|
-
- HY-153340
-
|
Keap1-Nrf2
|
Metabolic Disease
|
I-152 is a conjugate containing N-acetyl-cysteine (NAC) and cysteamine (MEA). I-152 activates NRF2 and ATF4 signals. I-152 has anti-proliferative properties .
|
-
- HY-N8477
-
-
- HY-162316
-
|
NF-κB
|
Inflammation/Immunology
|
NF-κB-IN-15 (compound 14r) is a potent NF-κB inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI) .
|
-
- HY-123789
-
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.
|
-
- HY-W042416
-
DMAc
|
Biochemical Assay Reagents
NF-κB
|
Neurological Disease
Metabolic Disease
Inflammation/Immunology
|
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
|
-
- HY-146723
-
|
IKK
|
Inflammation/Immunology
|
IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC50 of 0.20 μM. IKKβ-IN-1 can reduce PGE2 and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality .
|
-
- HY-N3188
-
|
Akt
NF-κB
|
Infection
|
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, MAPK, and NF-κB signaling pathways .
|
-
- HY-147369
-
|
Nuclear Factor of activated T Cells (NFAT)
|
Others
|
NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research .
|
-
- HY-158055
-
|
Keap1-Nrf2
|
Inflammation/Immunology
|
Keap1-Nrf2-IN-20 (Compound ZC9) is an inhibitor for Keap-Nrf2 pathway with KD2 of 51 nM. Keap1-Nrf2-IN-20 exhibits good cell permeability, cell activity, and metabolic stability (serum t1/2 > 24 h) .
|
-
- HY-B1640
-
Etacrynic acid
|
Glutathione S-transferase
NF-κB
Calcium Channel
NO Synthase
|
Inflammation/Immunology
Cancer
|
Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .
|
-
- HY-155031
-
|
Reactive Oxygen Species
COX
|
Inflammation/Immunology
|
MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA) .
|
-
- HY-155133
-
|
COX
|
Inflammation/Immunology
|
COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects .
|
-
- HY-124958
-
|
NF-κB
Dipeptidyl Peptidase
|
Metabolic Disease
Inflammation/Immunology
|
NDMC101 is a potent osteoclastogenesis inhibitor and inhibits osteoclast differentiation via down-regulation of NFATc1-modulated gene expression. NDMC101 is similar to the DPP4 substrate and is a significant inhibitor of early T-cell activation via DPP4 inhibition. NDMC101can be used for study of bone disorders, such as rheumatoid arthritis, and synovial inflammation et al .
|
-
- HY-B0305
-
|
Histamine Receptor
|
Metabolic Disease
Inflammation/Immunology
Cancer
|
Roxatidine acetate is a potent, selective, competitive and orally active histamine H2-receptor antagonist. Roxatidine acetate has antisecretory potency against gastric acid secretion. Roxatidine acetate can also suppress inflammatory responses and can be used for gastric and duodenal ulcers research. Roxatidine acetate has antitumor activity .
|
-
- HY-161476
-
|
Fluorescent Dye
|
Cancer
|
Ir-ImNO is a mitochondria-targeted two-photon probe with excellent cell membrane permeability, capable of detecting both endogenous and exogenous cell membrane permeability. Ir-ImNO can monitor different immune response states of macrophages through various imaging techniques, including one-photon and two-photon phosphorescence imaging as well as phosphorescence lifetime imaging. Ir-ImNO can be utilized in the research to assist in the clinical monitoring of immunotherapy .
|
-
- HY-N4155
-
|
EBV
HIV Protease
HSV
|
Infection
Cancer
|
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .
|
-
- HY-W027592
-
|
Biochemical Assay Reagents
|
Others
|
1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.
|
-
- HY-146245
-
CpG 1826
|
Toll-like Receptor (TLR)
Apoptosis
|
Inflammation/Immunology
Cancer
|
ODN 1826 (CpG 1826), a class B CpG ODN (oligodeoxynucleotide), is a TLR9 agonist. ODN 1826 promotes Apoptosis. ODN 1826 is an excellent immune stimulator with antitumor activity. ODN 1826 has protective effects on the heart. ODN 1826 sequence: 5’-tccatgacgttcctgacgtt-3’ .
|
-
- HY-A0062
-
HMR3647; RU66647
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma .
|
-
- HY-N0222
-
-
- HY-A0062R
-
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Telithromycin (Standard) is the analytical standard of Telithromycin. This product is intended for research and analytical applications. Telithromycin (HMR3647) is a novel ketolide antibiotic that structurally resembles macrolides. Telithromycin belongs to the ketolide family that is characterized by a keto group at position 3 of the macrolide ring and is active against bacteria causing community-acquired pneumonia, acute exacerbation of chronic bronchitis, and acute sinusitis. Telithromycin also has similar immunomodulatory effects as macrolides. Telithromycin can be used for the research of respiratory infections including bronchial asthma .
|
-
- HY-143456
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .
|
-
- HY-143457
-
|
Others
|
Inflammation/Immunology
|
Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc .
|
-
- HY-147377
-
-
Cat. No. |
Product Name |
Type |
-
- HY-W013435
-
|
Fluorescent Dyes/Probes
|
1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .
|
-
- HY-Y1778
-
|
Dyes
|
N-(Diphenylmethylene)glycine tert-butyl ester is a dye, also as the raw material and intermediate for organic syntheses .
|
Cat. No. |
Product Name |
Type |
-
- HY-W015551
-
(E)-Dec-2-enal
|
Biochemical Assay Reagents
|
trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes.
|
-
- HY-W094510
-
|
Biochemical Assay Reagents
|
Sodium pyrophosphate decahydrate can be as a buffering agent, a chelator and a hydrated salt nucleating agent. Sodium pyrophosphate decahydrate can also be used to a raw material for synthetic laundry scent additives .
|
-
- HY-W540926
-
Biacetyl dioxime sodium hydrate
|
Biochemical Assay Reagents
|
Dimethylglyoxime (sodium hydrate) (Biacetyl dioxime (sodium hydrate)) is a biochemical reagent used for biochemical analysis and as a basic chemical raw material. Dimethylglyoxime (sodium hydrate) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-Y0319B3
-
|
Buffer Reagents
|
Potassium acetate meets analytical specification of Ph. Eur. BP E261, and can be used as food additives, medicine and cosmetics raw materials .
|
-
- HY-153379
-
|
Drug Delivery
|
ALC-0315 analogue-1 (compound P-10) is a cationic lipid. ALC-0315 analogue-1 is the raw material for synthesis of cationic liposome .
|
-
- HY-153389
-
|
Drug Delivery
|
ALC-0315 analogue-3 (compound P-35) is a liposome raw material. ALC-0315 analogue-3 can improve the loading rate and transport rate of nucleic acid drugs .
|
-
- HY-W250170
-
Octyldecyl glucoside
|
Biochemical Assay Reagents
|
Decyl glucoside is a mild nonionic surfactant. Decyl glucoside can be derived from renewable raw materials such as glucose and fatty alcohols from coconut oil or palm kernel oil. Decyl glucoside is known for its excellent foaming and cleaning properties.
|
-
- HY-W007437
-
Naphthalene-2-carboxylic acid
|
Biochemical Assay Reagents
|
2-Naphthoic acid is an organic compound commonly used as a raw material for dyes and the production of other chemicals. It can form dyes with other organic substances and is widely used in textile, printing and manufacturing fields. In addition, the compound is also used as a photosensitive material and a lubricant.
|
-
- HY-W009443
-
Diethyl sebacate
|
Biochemical Assay Reagents
|
Diethyl decanedioate is an organic compound commonly used as a raw material for flavors and food additives. It can be used to make fruit and mint flavors, and is widely used in some food processing and cosmetic production. In addition, this compound is also used as a reagent and intermediate in some organic synthesis reactions.
|
-
- HY-W005355
-
|
Buffer Reagents
|
Sodium 2-oxobutanoate is an organic compound commonly used as a food additive and industrial raw material. It can be used as an acidity regulator, leavening agent and preservative, and is often used in the fields of bread, baked goods and canning. In addition, the compound is used in the production of certain industrial products, such as in plastics, textiles and dyes.
|
-
- HY-W008145
-
Sodium tetrachloropalladate(II) trihydrate
|
Biochemical Assay Reagents
|
Sodium tetrachloropalladate(II) is an organic compound commonly used as a catalyst and as a raw material for dye production. It can be used to catalyze or promote reactions in certain chemical reactions, and is widely used in the fields of organic synthesis and dye preparation. In addition, the compound is also used for metallization, silver plating and electroplating of circuit boards.
|
-
- HY-W008992
-
8-Hydroxyquinoline sulfate hydrate
|
Biochemical Assay Reagents
|
Quinolin-8-ol sulfate hydrate is an organic compound commonly used in dyes and as a raw material for chemical analysis. It can cooperate with metal ions to form dyes, and is widely used in the fields of dyes, printing and textile manufacturing. In addition, the compound also has good toxicity and biocompatibility, and is also used in some medical fields.
|
-
- HY-B2225B
-
Edible corn starch (from corn)
|
Biochemical Assay Reagents
|
Starch (from corn) is a carbohydrate extracted from the kernel of the corn plant. It contains two main components, namely amylose and amylopectin. Starches from corn have various applications in the food industry as thickeners, stabilizers and binders. It is commonly used in the production of products such as baked goods, snacks, sauces and soups. In addition, it can be used as a raw material for the production of biofuels and bioplastics.
|
-
- HY-42935A
-
Enanthate sodium
|
Biochemical Assay Reagents
|
Heptanoate sodium is an organic sodium salt compound widely used in various industries and laboratories. It can be used as surfactant, emulsifier, lubricant and preservative, etc., and plays an important role in some electronic devices. In addition, Heptanoate sodium is also used in the preparation of certain chemicals and raw materials such as paints, plastics, fragrances, etc. Although the compound has no direct medical application, it plays an important role in chemical research and industrial production.
|
-
- HY-W099600
-
Bisdodecanoic anhydride
|
Biochemical Assay Reagents
|
Lauric anhydride is a white waxy solid used as an intermediate in the production of various chemicals. It is primarily used in the synthesis of surfactants, emulsifiers, and lubricants, and as a raw material for other important industrial chemicals such as plasticizers and flavoring agents. It can be obtained from natural sources such as palm kernel oil and coconut oil, and its unique chemical structure allows it to be used to create compounds with specific surface and interfacial properties.
|
-
- HY-W077279
-
N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine
|
Gene Sequencing and Synthesis
|
5'-O-DMT-N4-Ac-dC (N4-Acetyl-2'-deoxy-5'-O-DMT-cytidine, compound 7), a deoxynucleoside, can be used to synthesize of dodecyl phosphoramidite which is the raw material for dod‐DNA (amphiphilic DNA containing an internal hydrophobic region consisting of dodecyl phosphotriester linkages) synthesis .
|
-
- HY-W250186
-
Teterdecyl dimethyl amine oxide; Myristyldimethylamine N-oxide
|
Biochemical Assay Reagents
|
Myristyl dimethylamine oxide is a cationic surfactant belonging to the family of amine oxides. It is commonly used as a foam booster, thickener and conditioning agent in a variety of personal care and household cleaning products. Myristyl dimethylamine oxide has several properties suitable for these applications, including the ability to reduce surface tension, increase viscosity and provide antistatic properties. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-W250166
-
|
Biochemical Assay Reagents
|
Poly(ethylene glycol) (12) tridecyl ether is a nonionic surfactant belonging to the family of ethoxylated fatty alcohols. It is commonly used as an emulsifier, solubilizer, and wetting agent in a variety of industrial and personal care products. Poly(ethylene glycol)(12) tridecyl ether has various properties that make it suitable for these applications, including its low toxicity, high solubility in water and organic solvents, and ability to stabilize emulsions. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-W042416
-
DMAc
|
Co-solvents
|
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease .
|
-
- HY-W027592
-
|
Biochemical Assay Reagents
|
1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-W250166
-
|
Biochemical Assay Reagents
|
Others
|
Poly(ethylene glycol) (12) tridecyl ether is a nonionic surfactant belonging to the family of ethoxylated fatty alcohols. It is commonly used as an emulsifier, solubilizer, and wetting agent in a variety of industrial and personal care products. Poly(ethylene glycol)(12) tridecyl ether has various properties that make it suitable for these applications, including its low toxicity, high solubility in water and organic solvents, and ability to stabilize emulsions. In addition, it can be used as a raw material for the production of other surfactants and specialty chemicals.
|
-
- HY-P10329
-
|
Fungal
|
Infection
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
-
- HY-Y1091
-
|
Endogenous Metabolite
|
Others
|
D-Lysine is a useful raw material employed as an analog of lutenizing-hormone-releasing hormone and as a agent carrier in the form of polylysine. D-Lysine decreases renal uptake of radioactivity during scintigraphy and PRRT with low toxicity. D-Lysine not interferes with the natural amino acid metabolic balance .
|
-
- HY-P2624
-
|
PAK
|
Metabolic Disease
|
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage .
|
-
- HY-158055
-
|
Keap1-Nrf2
|
Inflammation/Immunology
|
Keap1-Nrf2-IN-20 (Compound ZC9) is an inhibitor for Keap-Nrf2 pathway with KD2 of 51 nM. Keap1-Nrf2-IN-20 exhibits good cell permeability, cell activity, and metabolic stability (serum t1/2 > 24 h) .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N4264
-
-
- HY-115770
-
-
- HY-N10156
-
-
- HY-N0223
-
-
- HY-N9969
-
-
- HY-N12767
-
-
- HY-N9337
-
-
- HY-N3552
-
-
- HY-Y1091
-
-
- HY-N7422
-
-
- HY-Y0271
-
-
- HY-N9971
-
-
- HY-125911
-
-
- HY-129113
-
-
- HY-B2225B
-
-
- HY-N0253
-
-
- HY-N6894A
-
-
- HY-N12394
-
-
- HY-N0569R
-
-
- HY-N3364
-
-
- HY-113099
-
-
- HY-N7012
-
5-Hydroxy-3',4',7-trimethoxyflavone
|
Galinsoga parviflora Cav.
Flavonoids
Monophenols
Classification of Application Fields
Flavones
Labiatae
Source classification
Phenols
Plants
Disease Research Fields
Inflammation/Immunology
|
TNF Receptor
Interleukin Related
COX
|
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2 .
|
-
- HY-N4137
-
-
- HY-N10436
-
-
- HY-N10434
-
-
- HY-N10435
-
-
- HY-N1546
-
-
- HY-N12964
-
|
Structural Classification
Alkaloids
Simaroubaceae
Ailanthus altissima (Mill.) Swingle
Source classification
Quinoline Alkaloids
Plants
|
Others
|
4-Hydroxycanthin-6-one is a novel quinoline alkaloid isolated from the stem bark of the tree Ailanthus altissima. Five other known compounds were also found in the study. The structures of the new compounds were determined by interpretation of physical and spectroscopic data, and their absolute configurations were determined by electronic circular dichroism spectroscopy and quantum chemical calculations. These compounds showed significant inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells, showing potential anti-inflammatory properties .
|
-
- HY-N7176
-
-
- HY-N7931
-
-
- HY-N8132
-
-
- HY-N6894
-
-
- HY-N3480
-
-
- HY-N8477
-
-
- HY-N3188
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- HY-N4155
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Rosaceae
Rosa cymosa (L.) Tratt.
Plants
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EBV
HIV Protease
HSV
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2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid, a natural ursane-type triterpene, is a potent inhibitor of HIV protease (HIV Protease). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is also an inhibitor of the activation of Epstein-Barr virus early antigen (EBV-EA). 2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid displays an inhibitory activity against nitric oxide production in Lipopolysaccharide (Lipopolysaccharides)-activated RAW 264.7 cells .
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- HY-N0222
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-Y0271S
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Urea- 15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
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- HY-Y0271S1
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Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
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- HY-Y0271S2
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Urea- 13C, 15N2 is the 13C and 15N labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[1]. A potent emollient and keratolytic agent[2]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[3]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.
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- HY-N0803S1
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Myrcene- 13C3 is 13C labeled trans-2-Decenal (HY-W015551). trans-2-Decenal is an important raw material and intermediate used in organic synthesis, medicine, pesticides and dyes.
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