ω-conotoxin MoVIA 

ω-conotoxin MoVIA is a potent and selective Ca_v2.2 inhibitor with an IC₅₀ of 0.33 μM in SH-SY5Y fluorimetric hCa_v2.2 assay^[1].

IC50: 0.33 μM (hCa_v2.2)^[1]

3607.15

C₁₄₇H₂₃₃N₄₅O₄₇S₇

Cys-Lys-Pro-{Hyp}-Gly-Ser-Lys-Cys-Ser-{Hyp}-Ser-Met-Arg-Asp-Cys-Cys-Thr-Thr-Cys-Ile-Ser-Tyr-Thr-Lys-Arg-Cys-Arg-Lys-Tyr-Tyr-Asn (Disulfide bridge: Cys1-Cys16,Cys8-Cys19,Cys15-Cys26)

CKP-{Hyp}-GSKCS-{Hyp}-SMRDCCTTCISYTKRCRKYYN (Disulfide bridge: Cys1-Cys16,Cys8-Cys19,Cys15-Cys26)

O=C(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CSSC[C@H](NC1=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCCN)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)=O)=O)=O)C(N[C@@H](CO)C(N4C[C@H](O)C[C@H]4C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@H](NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CSSC[C@@H]7N)C(N[C@@H]([C@H](O)C)C(N[C@H]1[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H]8C[C@H](CN8C([C@H]9N(C([C@H](CCCCN)NC7=O)=O)CCC9)=O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sousa SR, et al. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Sci Rep. 2018 Sep 7;8(1):13397.  [Content Brief]