κ-Bungarotoxin  (Synonyms: κ-Bgt)

κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC₅₀ of 2.30 nM^[1].

IC50: 2.30 nM (recombinantly expressed in P. pastoris against α3β2)^[1]

7265.22

C₃₀₃H₄₇₅N₉₁O₉₇S₁₀

124511-67-7

Arg-Thr-Cys-Leu-Ile-Ser-Pro-Ser-Ser-Thr-Pro-Gln-Thr-Cys-Pro-Asn-Gly-Gln-Asp-Ile-Cys-Phe-Leu-Lys-Ala-Gln-Cys-Asp-Lys-Phe-Cys-Ser-Ile-Arg-Gly-Pro-Val-Ile-Glu-Gln-Gly-Cys-Val-Ala-Thr-Cys-Pro-Gln-Phe-Arg-Ser-Asn-Tyr-Arg-Ser-Leu-Leu-Cys-Cys-Thr-Thr-Asp-Asn-Cys-Asn-His (Disulfide bridge:Cys3-Cys21, Cys14-Cys42, Cys27-Cys31, Cys46-Cys58, Cys59-Cys64)

RTCLISPSSTPQTCPNGQDICFLKAQCDKFCSIRGPVIEQGCVATCPQFRSNYRSLLCCTTDNCNH (Disulfide bridge:Cys3-Cys21, Cys14-Cys42, Cys27-Cys31, Cys46-Cys58, Cys59-Cys64)

O=C([C@@H](N)CCCNC(N)=N)N[C@H](C(NC(C(NC(C(N[C@H](C(NC(C(N1C(C(NC(C(NC(C(N[C@H](C(N2C(C(NC(C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]4[C@H](CC)C)=O)CC(O)=O)=O)CCC(N)=O)=O)=O)CC(N)=O)=O)CCC3)=O)CSSCC(N5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CC(C)C)=O)CC(C)C)=O)CO)=O)CCCNC(N)=N)=O)CC8=CC=C(O)C=C8)=O)CC(N)=O)=O)CO)=O)CCCNC(N)=N)=O)CC9=CC=CC=C9)=O)CCC(N)=O)=O)CCC6)=O)CSSC[C@H](NC7=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]%10CC(N)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)[C@@H](C)O)=O)CSSC[C@H](NC%10=O)C(N[C@H](C(N[C@H](C(O)=O)CC%11=CNC=N%11)=O)CC(N)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)C(C)C)=O)=O)[C@@H](C)O)=O)CCC(N)=O)=O)CCC2)=O)[C@@H](C)O)=O)CO)=O)CO)=O)CCC1)=O)CO)=O)[C@H](CC)C)=O)CC(C)C)=O)CSSC[C@H](NC4=O)C(NC(C(NC(C(NC(C(NC(C(NC(C(N[C@H](C(NC(C(NC(C(NC%12CC%13=CC=CC=C%13)=O)CCCCN)=O)CC(O)=O)=O)CSSC[C@H](NC%12=O)C(NC(C(N[C@H](C(NC(C(NCC(N%14C(C(NC(C(N[C@H](C(NC(C(NC(C(NCC5=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CCC%14)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CO)=O)=O)CCC(N)=O)=O)C)=O)CCCCN)=O)CC(C)C)=O)CC%15=CC=CC=C%15)=O)=O)[C@@H](C)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Grant GA, et al. Differential roles for disulfide bonds in the structural integrity and biological activity of kappa-Bungarotoxin, a neuronal nicotinic acetylcholine receptor antagonist. Biochemistry. 1998 Sep 1;37(35):12166-71.  [Content Brief]