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  2. Isotope-Labeled Compounds
  3. β-Carotene-d8

β-Carotene-d8  (Synonyms: Provitamin A-d8; beta-Carotene-d8)

Cat. No.: HY-N0411S1 Purity: 96.42%
COA Handling Instructions

β-Carotene-d8 is the deuterium labeled β-Carotene (HY-N0411)[1].

For research use only. We do not sell to patients.

β-Carotene-d<sub>8</sub> Chemical Structure

β-Carotene-d8 Chemical Structure

CAS No. : 53163-44-3

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Based on 1 publication(s) in Google Scholar

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Description

β-Carotene-d8 is the deuterium labeled β-Carotene (HY-N0411)[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells[4].
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner[4].
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner[4].
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner[4].
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187)[4].
β-Carotene induces cytochrome C release[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

544.92

Formula

C40H48D8

CAS No.
Unlabeled CAS

7235-40-7

Appearance

Solid

Color

Light brown to brown

SMILES

CC1(C)C(/C=C/C(C([2H])([2H])[2H])=C([2H])/C=C/C(C)=C/C=C/C=C(C)/C=C/C([2H])=C(C([2H])([2H])[2H])/C=C/C2=C(C)CCCC2(C)C)=C(C)CCC1

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Purity & Documentation

Purity: 96.42%

References
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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β-Carotene-d8
Cat. No.:
HY-N0411S1
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