Xaliproden free base (Synonyms: SR57746A free base)

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Xaliproden free base is an orally active and selective 5-HT_1A receptor agonist. Xaliproden free base shows analgesic effect against acute tonic nociceptive pain and has neuroprotective effects. Xaliproden free base has an acute inhibitory effect on paclitaxel (HY-B0015)-induced mechanical allodynia by inhibiting the excessive response of primary afferent neurons.

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Xaliproden free base Chemical Structure

CAS No. : 135354-02-8

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Other In-stock Forms of Xaliproden free base:

Xaliproden hydrochloride

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Description	Xaliproden free base is an orally active and selective 5-HT_1A receptor agonist. Xaliproden free base shows analgesic effect against acute tonic nociceptive pain and has neuroprotective effects. Xaliproden free base has an acute inhibitory effect on paclitaxel (HY-B0015)-induced mechanical allodynia by inhibiting the excessive response of primary afferent neurons^[1].
Molecular Weight	381.43
Formula	C₂₄H₂₂F₃N
CAS No.	135354-02-8
SMILES	FC(F)(F)C1=CC(C2=CCN(CC2)CCC3=CC=C4C=CC=CC4=C3)=CC=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Andoh T, et al. Effects of xaliproden, a 5-HT₁A agonist, on mechanical allodynia caused by chemotherapeutic agents in mice. Eur J Pharmacol. 2013 Dec 5;721(1-3):231-6. [Content Brief]

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Keywords:

Xaliproden135354-02-8SR57746A5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptoranalgesicacute tonic nociceptive painneuroprotectivemechanical allodyniaprimary afferent neuronsInhibitorinhibitorinhibit

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Xaliproden free base (Synonyms: SR57746A free base)

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