WP9QY TFA 

WP9QY, TNF-a Antagonist, TNF-a Antagonist is a biological active peptide. (This cyclic peptide is designed to mimic the most critical tumor necrosis factor (TNF) recognition loop on TNF receptor I. It prevents interactions of TNF with its receptor. This TNF antagonist is a useful template for the development of small molecular inhibitors to prevent both inflammatory bone destruction and systemic bone loss in rheumatoid arthritis.)

1340.40

C₆₀H₇₂F₃N₁₁O₁₇S₂

Solid

White to off-white

Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr (Disulfide bridge:Cys2-Cys8)

YCWSQYLCY (Disulfide bridge:Cys2-Cys8)

O=C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CC(C=C2)=CC=C2O)=O)CCC(N)=O)=O)CO)[C@@H](NC([C@H](CSSC[C@H](NC([C@@H]1CC(C)C)=O)C(N[C@H](C(O)=O)CC(C=C3)=CC=C3O)=O)NC([C@@H](N)CC(C=C4)=CC=C4O)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Lin CC, et al. Functional PEG-peptide hydrogels to modulate local inflammation induced by the pro-inflammatory cytokine TNFalpha. Biomaterials. 2009 Oct;30(28):4907-14.  [Content Brief]