2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. UK 357903

UK 357903 is a selective inhibitor for phosphodiesterase 5 (PDE5), with IC50s of 1.7 and 714 nM, for PDE5 and PDE6. UK 357903 exhibits vasodilatory effects on the mesenteric and hindlimb vascular beds, and is potential for ameliorating erectile dysfunction.

For research use only. We do not sell to patients.

UK 357903 Chemical Structure

UK 357903 Chemical Structure

CAS No. : 247580-98-9

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Description

UK 357903 is a selective inhibitor for phosphodiesterase 5 (PDE5), with IC50s of 1.7 and 714 nM, for PDE5 and PDE6. UK 357903 exhibits vasodilatory effects on the mesenteric and hindlimb vascular beds, and is potential for ameliorating erectile dysfunction[1].

IC50 & Target

PDE5

1.7 nM (IC50)

PDE6

714 nM (IC50)

Molecular Weight

582.67

Formula

C27H34N8O5S
CAS No.
SMILES

O=C1N=C(C2=C(OCCOC)N=CC(S(=O)(N3CCN(CC3)CC)=O)=C2)NC4=C(CC)N(CC5=NC=CC=C5)N=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UK 357903 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK 357903247580-98-9UK357903UK-357903Phosphodiesterase (PDE)erectile dysfunctionimpotencesildenafilViagraInhibitorinhibitorinhibit

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