Tylophorine (Synonyms: (+)-(S)-Tylophorine; DCB-3500; NSC-717335)

Cat. No.: HY-122324: FAQs
Data Sheet Handling Instructions

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Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation.

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Tylophorine Chemical Structure

CAS No. : 482-20-2

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MOQ		Minimum order quantity
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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

393.48

Formula

C₂₄H₂₇NO₄

CAS No.

482-20-2

Appearance

Solid

SMILES

COC1=C(C=C2C3=CC(OC)=C(C=C3C4=C(C2=C1)CN5[C@]([H])(C4)CCC5)OC)OC

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 44.46 mg/mL (112.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5414 mL	12.7071 mL	25.4143 mL
5 mM	0.5083 mL	2.5414 mL	5.0829 mL
10 mM	0.2541 mL	1.2707 mL	2.5414 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Novel Mode of Action of Tylophorine Analogs as Antitumor Compounds

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5414 mL	12.7071 mL	25.4143 mL	63.5356 mL
	5 mM	0.5083 mL	2.5414 mL	5.0829 mL	12.7071 mL
	10 mM	0.2541 mL	1.2707 mL	2.5414 mL	6.3536 mL
	15 mM	0.1694 mL	0.8471 mL	1.6943 mL	4.2357 mL
	20 mM	0.1271 mL	0.6354 mL	1.2707 mL	3.1768 mL
	25 mM	0.1017 mL	0.5083 mL	1.0166 mL	2.5414 mL
	30 mM	0.0847 mL	0.4236 mL	0.8471 mL	2.1179 mL
	40 mM	0.0635 mL	0.3177 mL	0.6354 mL	1.5884 mL
	50 mM	0.0508 mL	0.2541 mL	0.5083 mL	1.2707 mL
	60 mM	0.0424 mL	0.2118 mL	0.4236 mL	1.0589 mL
	80 mM	0.0318 mL	0.1588 mL	0.3177 mL	0.7942 mL
	100 mM	0.0254 mL	0.1271 mL	0.2541 mL	0.6354 mL

Tylophorine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tylophorine482-20-2(+)-(S)-Tylophorine DCB-3500 NSC-717335DCB3500DCB 3500DCB-3500NSC717335NSC 717335NSC-717335OthersInhibitorinhibitorinhibit

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