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Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM.

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Tumulosic acid Chemical Structure

Tumulosic acid Chemical Structure

CAS No. : 508-24-7

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1 mg USD 210 In-stock
5 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Tumulosic acid Related Antibodies

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Description

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

In Vitro

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes[1].
Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tumulosic acid Related Antibodies

Western Blot Analysis[1]

Cell Line: Normal human epidermal keratinocytes (NHEKs)
Concentration: 1 μM and 10 μM
Incubation Time: 23 h in the presence of 10 μM cycloheximide
Result: Decreased LL-37 production in epidermal keratinocytes.
Molecular Weight

486.73

Formula

C31H50O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@](C(CC[C@](C(C)1C)([H])[C@@]2(CC[C@@H]1O)C)=C2CC3)(C[C@H]4O)[C@]3([C@@]4([H])[C@H](C(O)=O)CCC(C(C)C)=C)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (51.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0545 mL 10.2726 mL 20.5453 mL
5 mM 0.4109 mL 2.0545 mL 4.1091 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0545 mL 10.2726 mL 20.5453 mL 51.3632 mL
5 mM 0.4109 mL 2.0545 mL 4.1091 mL 10.2726 mL
10 mM 0.2055 mL 1.0273 mL 2.0545 mL 5.1363 mL
15 mM 0.1370 mL 0.6848 mL 1.3697 mL 3.4242 mL
20 mM 0.1027 mL 0.5136 mL 1.0273 mL 2.5682 mL
25 mM 0.0822 mL 0.4109 mL 0.8218 mL 2.0545 mL
30 mM 0.0685 mL 0.3424 mL 0.6848 mL 1.7121 mL
40 mM 0.0514 mL 0.2568 mL 0.5136 mL 1.2841 mL
50 mM 0.0411 mL 0.2055 mL 0.4109 mL 1.0273 mL
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Tumulosic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tumulosic acid508-24-7OtherstriterpenoidKLK5proteaseproteolyticLL-37keratinocytesInhibitorinhibitorinhibit

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