Trimethoprim-d₃

Name: Trimethoprim-d 3
Brand: MedChemExpress
SKU: HY-B0510S2
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0510S2 Purity: 98.24%: FAQs
Data Sheet SDS COA Handling Instructions

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Trimethoprim-d₃is the deuterium labeled Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase inhibitor. Trimethoprim is active against a wide range of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim has the potential for urinary tract infections, Shigellosis and Pneumocystis pneumonia treatment[1][2][3].

For research use only. We do not sell to patients.

Trimethoprim-d<sub>3</sub> Chemical Structure

Trimethoprim-d₃ Chemical Structure

CAS No. : 1189923-38-3

Size	Price	Stock	Quantity
1 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Trimethoprim-d₃:

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

293.34

Formula

C₁₄H₁₅D₃N₄O₃

CAS No.

1189923-38-3

Unlabeled CAS

738-70-5

Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1CC2=CN=C(N)N=C2N)=C(C(OC)=C1)OC([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (170.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 0.67 mg/mL (2.28 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4090 mL	17.0451 mL	34.0901 mL
5 mM	0.6818 mL	3.4090 mL	6.8180 mL
10 mM	0.3409 mL	1.7045 mL	3.4090 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.24%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (250 KB) RP-HPLC (227 KB) MS (198 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Laskowska, E., et al., Trimethoprim induces heat shock proteins and protein aggregation in E. coli cells. Curr Microbiol, 2003. 47(4): p. 286-9.;Brogden, R.N., et al., Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO / DMSO	1 mM	3.4090 mL	17.0451 mL	34.0901 mL	85.2253 mL
DMSO / DMSO	5 mM	0.6818 mL	3.4090 mL	6.8180 mL	17.0451 mL
	10 mM	0.3409 mL	1.7045 mL	3.4090 mL	8.5225 mL
	15 mM	0.2273 mL	1.1363 mL	2.2727 mL	5.6817 mL
	20 mM	0.1705 mL	0.8523 mL	1.7045 mL	4.2613 mL
	25 mM	0.1364 mL	0.6818 mL	1.3636 mL	3.4090 mL
	30 mM	0.1136 mL	0.5682 mL	1.1363 mL	2.8408 mL
	40 mM	0.0852 mL	0.4261 mL	0.8523 mL	2.1306 mL
	50 mM	0.0682 mL	0.3409 mL	0.6818 mL	1.7045 mL
	60 mM	0.0568 mL	0.2841 mL	0.5682 mL	1.4204 mL
	80 mM	0.0426 mL	0.2131 mL	0.4261 mL	1.0653 mL
	100 mM	0.0341 mL	0.1705 mL	0.3409 mL	0.8523 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.