TAX2 peptide 

TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment^[1].

1263.44

C₅₁H₈₆N₁₄O₁₉S₂

Cys-Glu-Val-Ser-Gln-Leu-Leu-Lys-Gly-Asp-Ala-Cys (Disulfide bridge: Cys1-Cys12)

CEVSQLLKGDAC (Disulfide bridge: Cys1-Cys12)

O=C([C@@H](N)CSSC[C@H](NC1=O)C(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]1C)=O)CC(O)=O)=O)=O)CCCCN)=O)CC(C)C)=O)CC(C)C)=O)CCC(N)=O)=O)CO)=O)C(C)C)=O)CCC(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jeanne A, et al. Identification of TAX2 peptide as a new unpredicted anti-cancer agent[J]. Oncotarget, 2015, 6(20): 17981.  [Content Brief]