2. Others Stem Cell/Wnt MAPK/ERK Pathway Apoptosis Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds ERK Caspase Apoptosis Endogenous Metabolite
  4. Tauroursodeoxycholate-d4 sodium

Tauroursodeoxycholate-d4 sodium  (Synonyms: Tauroursodeoxycholic acid-d4 sodium; TUDCA-d4 sodium; UR 906-d4 sodium)

Cat. No.: HY-19696AS Purity: ≥99.0%
COA Handling Instructions

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Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

For research use only. We do not sell to patients.

Tauroursodeoxycholate-d<sub>4</sub> sodium Chemical Structure

Tauroursodeoxycholate-d4 sodium Chemical Structure

CAS No. : 2410279-95-5

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Based on 1 publication(s) in Google Scholar

Other Forms of Tauroursodeoxycholate-d4 sodium:

Tauroursodeoxycholate-d4 sodium Related Antibodies

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Description

Tauroursodeoxycholate-d4 (sodium) is the deuterium labeled Tauroursodeoxycholate sodium. Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tauroursodeoxycholate-d4 sodium Related Antibodies
Molecular Weight

525.71

Formula

C26H40D4NNaO6S
CAS No.
Unlabeled CAS

35807-85-3
Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@]12C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMF : ≥ 25 mg/mL (47.55 mM)

DMF : ≥ 25 mg/mL (47.55 mM)

DMSO : ≥ 20 mg/mL (38.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 20 mg/mL (38.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

PBS (pH 7.2) : ≥ 1 mg/mL (1.90 mM)

Ethanol : ≥ 1 mg/mL (1.90 mM)

Ethanol : ≥ 1 mg/mL (1.90 mM)

PBS : ≥ 1 mg/mL (1.90 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9022 mL 9.5109 mL 19.0219 mL
5 mM 0.3804 mL 1.9022 mL 3.8044 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / Ethanol / Ethanol / PBS / DMSO / DMSO / DMF / DMF 1 mM 1.9022 mL 9.5109 mL 19.0219 mL 47.5547 mL
DMSO / DMSO / DMF / DMF 5 mM 0.3804 mL 1.9022 mL 3.8044 mL 9.5109 mL
10 mM 0.1902 mL 0.9511 mL 1.9022 mL 4.7555 mL
15 mM 0.1268 mL 0.6341 mL 1.2681 mL 3.1703 mL
20 mM 0.0951 mL 0.4755 mL 0.9511 mL 2.3777 mL
25 mM 0.0761 mL 0.3804 mL 0.7609 mL 1.9022 mL
30 mM 0.0634 mL 0.3170 mL 0.6341 mL 1.5852 mL
DMF / DMF 40 mM 0.0476 mL 0.2378 mL 0.4755 mL 1.1889 mL
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Tauroursodeoxycholate-d4 sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tauroursodeoxycholate-d42410279-95-5Tauroursodeoxycholic acid-d4TUDCA-d4UR 906-d4Isotope-Labeled CompoundsERKCaspaseApoptosisEndogenous MetaboliteExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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