TAT-PiET-PROTAC 

TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445). TAT-PiET is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can disrupt the interaction between the breast cancer oncogene BRD4/JMJD6 and inhibit the growth of breast cancer cells. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells and is a potential inhibitor of breast cancer^[1].

BRD4/JMJD6, BRD4 extraterminal (ET) domain^[1]

3316.85

C₁₄₅H₂₃₉N₅₃O₃₅S

Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Asn-Gln-Lys-Phe-Lys-Cys-Gly-Glu-{Ahx}-Tyl-{Hyp}-Tyr-Ile

YGRKKRRQRRRRNQKFKCGE-{Ahx}-Y-{Hyp}-YI

O=C([C@@H](N)CC1=CC=C(O)C=C1)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(O)=O)CCC(NCCCCCC(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@H](C(O)=O)[C@H](CC)C)=O)CC3=CC=C(O)C=C3)=O)CC(O)C2)=O)CC4=CC=C(O)C=C4)=O)=O)=O)=O)CS)=O)CCCCN)=O)CC5=CC=CC=C5)=O)CCCCN)=O)CCC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCC(N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCNC(N)=N)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huang QX, et al. Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both In Vitro and In Vivo. J Med Chem. 2024 Apr 25;67(8):6658-6672.  [Content Brief]