2. Anti-infection
  3. Bacterial
  4. TAM-16

TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel.

For research use only. We do not sell to patients.

TAM-16 Chemical Structure

TAM-16 Chemical Structure

CAS No. : 2030241-59-7

Size Price Stock Quantity
5 mg USD 180 In-stock
10 mg USD 290 In-stock
25 mg USD 580 In-stock
50 mg USD 930 In-stock
100 mg USD 1490 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

TAM-16 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TAM-16 is a potent and orally active polyketide synthase 13 (Pks13) inhibitor with an IC50 value of 0.32 μM. TAM-16 has promising activity against Mycobacterium tuberculosis. TAM-16 inhibits hERG cardiac ion channel[1][2].

In Vitro

TAM-16 (compound 1) inhibits the growth of M. tuberculosis strain H37Rv with an IC50 value of 0.08 μM[1].
TAM-16 (0-10 μM) inhibits Mycobacterium tuberculosis by targeting Pks13[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TAM-16 Related Antibodies
In Vivo

TAM-16 (compound 1; 200 mg/kg; p.o.; daily, for 14 days) prevents the development of characteristic lung lesions in murine TB infection models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with tuberculosis (TB) model[2]
Dosage: 200 mg/kg
Administration: oral administration; daily, for 14 days
Result: Had a significant reduction in lung CFU counts by ∼0.9 log10 compared with the untreated control mice
Molecular Weight

380.44

Formula

C22H24N2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C2=CC=C(O)C=C2)OC3=CC=C(O)C(CN4CCCCC4)=C13)NC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (328.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6285 mL 13.1427 mL 26.2854 mL
5 mM 0.5257 mL 2.6285 mL 5.2571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6285 mL 13.1427 mL 26.2854 mL 65.7134 mL
5 mM 0.5257 mL 2.6285 mL 5.2571 mL 13.1427 mL
10 mM 0.2629 mL 1.3143 mL 2.6285 mL 6.5713 mL
15 mM 0.1752 mL 0.8762 mL 1.7524 mL 4.3809 mL
20 mM 0.1314 mL 0.6571 mL 1.3143 mL 3.2857 mL
25 mM 0.1051 mL 0.5257 mL 1.0514 mL 2.6285 mL
30 mM 0.0876 mL 0.4381 mL 0.8762 mL 2.1904 mL
40 mM 0.0657 mL 0.3286 mL 0.6571 mL 1.6428 mL
50 mM 0.0526 mL 0.2629 mL 0.5257 mL 1.3143 mL
60 mM 0.0438 mL 0.2190 mL 0.4381 mL 1.0952 mL
80 mM 0.0329 mL 0.1643 mL 0.3286 mL 0.8214 mL
100 mM 0.0263 mL 0.1314 mL 0.2629 mL 0.6571 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TAM-16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TAM-162030241-59-7TAM16TAM 16BacterialInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TAM-16
Cat. No.:
HY-116838
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.