Search Result
Results for "
sulfonylurea
" in MedChemExpress (MCE) Product Catalog:
10
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-W020020
-
|
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Others
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Others
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Thifensulfuron-methyl is a sulfonylurea herbicide and mainly used for control of broadleaved weeds in wheat, corn, and soybean fields .
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-
-
- HY-121079
-
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DPX-A8947
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Others
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Others
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Azimsulfuron (DPX-A8947) is a sulfonylurea herbicide useful in controlling weeds in paddy fields .
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-
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- HY-B0870
-
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Others
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Others
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Bensulfuron-methyl is a kind of sulfonylurea herbicide widely used to control broad-leaf weeds in rice paddies .
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-
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- HY-W011651
-
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BZ-55
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Others
|
Metabolic Disease
|
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Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .
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-
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- HY-115962
-
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Others
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Cancer
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Anticancer agent 37 (compound 18), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 37 inhibits HePG2 cell growth with an IC50 of 17.2 µg/mL .
|
-
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- HY-115963
-
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Others
|
Cancer
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Anticancer agent 38 (compound 19), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 38 inhibits A431 cell growth with an IC50 of 5.2 µg/mL .
|
-
-
- HY-137245
-
|
MCC7840
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
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Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast can be used for the research of inflammatory diseases .
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-
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- HY-137245A
-
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MCC7840 sodium
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
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Emlenoflast (MCC7840) sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. Emlenoflast sodium can be used for the research of inflammatory diseases .
|
-
-
- HY-B1876
-
|
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Acetolactate Synthase (ALS)
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Others
|
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Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .
|
-
-
- HY-W011651R
-
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Others
|
Metabolic Disease
|
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Carbutamide (Standard) is the analytical standard of Carbutamide. This product is intended for research and analytical applications. Carbutamide (BZ-55) is an orally active and first-generation sulfonylurea with hypoglycemic activity .
|
-
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- HY-115960
-
|
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Others
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Cancer
|
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Anticancer agent 35 (compound 10), a sulfonylurea derivative, is a potent anticancer agent. Anticancer agent 35 inhibits A549, A431, PACA2 cell growth with IC50s of 18.1 µg/mL, 4.0 µg/mL, 18.9 µg/mL, respectively .
|
-
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- HY-100641
-
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Hydroxytolbutamide
|
Potassium Channel
Autophagy
|
Metabolic Disease
Cancer
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4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic .
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-
-
- HY-B1869
-
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Others
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Others
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Metsulfuron-methyl is a systemic sulfonylurea herbicide and has been widely used to control broad-leaved weeds and annual grasses in rice, maize, wheat, and barley. Metsulfuron-methyl has highly efficient herbicidal activity and low mammalian toxicity .
|
-
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- HY-B0254
-
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CP 28720; K 4024
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Potassium Channel
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Metabolic Disease
|
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Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans .
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- HY-115959
-
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Bacterial
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Inflammation/Immunology
Cancer
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Anticancer agent 34 (compound 9), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 34 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/ml. Anticancer agent 34 inhibits A549, PC3 cell growth with IC50s of 8.4 µg/ml, 7.8 µg/ml, respectively .
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- HY-115961
-
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Bacterial
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Inflammation/Immunology
Cancer
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Anticancer agent 36 (compound 11), a sulfonylurea derivative, is a potent antimicrobial and anticancer agent. Anticancer agent 36 inhibits the microbial growth of B. mycoides, E. coli, and C. albicans with a MIC between 0.156 and 0.039 mg/L. Anticancer agent 36 inhibits A549, PC3 cell growth with IC50s of 19.7 µg/mL, 11.9 µg/mL, respectively .
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- HY-B0254R
-
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Potassium Channel
|
Metabolic Disease
|
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Glipizide (Standard) is the analytical standard of Glipizide. This product is intended for research and analytical applications. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans .
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- HY-B1850
-
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Inpool; MON 12000; Manage
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Others
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Others
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Halosulfuron-methyl is a pyrazole sulfonylurea herbicide .
|
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- HY-126150
-
|
LGC-42153
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Others
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Others
|
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LGC-42153 is a new sulfonylurea herbicide .
|
-
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- HY-136357
-
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Others
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Others
|
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Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed .
|
-
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- HY-B0104
-
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Glimperide; HOE-490
|
Amyloid-β
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Metabolic Disease
|
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Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
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- HY-15383
-
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Others
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Others
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Glyparamide is an orally active chlorophenyl-containing sulfonylurea. Glyparamide shows hypoglycemic activity and rarely causes hepatic injury .
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- HY-B0881
-
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Others
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Metabolic Disease
Cancer
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Acetohexamide is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2; stimulate the pancreas to secrete insulin.
|
-
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- HY-B1114
-
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AR-DF 26
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Others
|
Metabolic Disease
|
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Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
|
-
-
- HY-B0401S
-
-
-
- HY-B0401S1
-
-
-
- HY-133085
-
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DPX-E9636
|
Others
|
Others
|
|
Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds .
|
-
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- HY-B0104S
-
-
-
- HY-B0104S1
-
-
-
- HY-111912
-
|
|
Fungal
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Infection
|
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Tribenuron-methyl, a sulfonylurea herbicide agent, can be used as the fungicide agent. Tribenuron-methyl plays an important role in controlling the weeds and diseases in wheat field .
|
-
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- HY-P5290
-
|
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PSMA
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Cancer
|
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HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research .
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- HY-P5292
-
|
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PSMA
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Cancer
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HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity .
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- HY-P5292A
-
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PSMA
|
Cancer
|
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HYNIC-iPSMA TFA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA TFA has excellent specificity and sensitivity .
|
-
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- HY-126987
-
|
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Acetolactate Synthase (ALS)
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Others
|
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Mesosulfuron-methyl is a sulfonylurea herbicide that inhibits acetolactate synthase (ALS) and is used in research for post-emergence control of ryegrass and Avena spp. (wild oat) in wheat fields .
|
-
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- HY-B1114S
-
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AR-DF 26-d6
|
Isotope-Labeled Compounds
|
Metabolic Disease
|
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Gliquidone-d6 is deuterium labeled Gliquidone. Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
|
-
-
- HY-133085S
-
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DPX-E9636-d6
|
Isotope-Labeled Compounds
|
Others
|
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Rimsulfuron-d6 is deuterium labeled Rimsulfuron. Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds[1][2].
|
-
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- HY-B1114R
-
|
|
Others
|
Metabolic Disease
|
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Gliquidone (Standard) is the analytical standard of Gliquidone. This product is intended for research and analytical applications. Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
|
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- HY-145490
-
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Others
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Metabolic Disease
|
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trans-hydroxy Glimepiride is an active metabolite of the sulfonylurea Glimepiride (HY-B0104). It is formed from glimepiride primarily in the liver by the cytochrome P450 (CYP) isoform CYP2C9.
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-
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- HY-B0089
-
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BAY g 5421
|
Glucosidase
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Metabolic Disease
|
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Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .
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-
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- HY-133085R
-
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DPX-E9636 (Standard)
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Others
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Others
|
|
Rimsulfuron (Standard) is the analytical standard of Rimsulfuron. This product is intended for research and analytical applications. Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds .
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- HY-136690
-
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Others
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Others
|
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Triasulfuron is a sulfonylurea herbicide. Triasulfuron degrades slowly, with most of the residues remaining in the first 20 cm of the soil surface, but small amounts have been observed to penetrate deeper into the soil (up to 1 m deep) .
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-
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- HY-B0089A
-
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Bay-g 5421 sulfate
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Glucosidase
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Metabolic Disease
|
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Acarbose (BAY g 5421) sulfate, antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose sulfate can potentiate the hypoglycemic effects of sulfonylureas or insulin .
|
-
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- HY-B0870S
-
-
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- HY-124150
-
|
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Prostaglandin Receptor
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Cardiovascular Disease
|
|
BM567 is a sulfonylurea compound (compound 1), which exhibits antithrombogenic efficacy as thromboxane A2 receptor (TXR) antagonists and thromboxane A2 synthase (TXS) inhibitors, with IC50s of 1.1 and 12 nM, respectively .
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-
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- HY-W422402
-
|
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Acetolactate Synthase (ALS)
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Others
|
|
Foramsulfuron is a postemergence herbicide used for selective control of grass and some broadleaved weeds in maize (Zea mays L.). Foramsulfuron is a sulfonylurea herbicide that exerts its herbicidal activity by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched chain amino acids .
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-
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- HY-B1876S
-
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Acetolactate Synthase (ALS)
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Others
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Nicosulfuron-d6 is the deuterium labeled Nicosulfuron[1]. Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity[2].
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-
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- HY-B1876R
-
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Acetolactate Synthase (ALS)
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Others
|
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Nicosulfuron (Standard) is the analytical standard of Nicosulfuron. This product is intended for research and analytical applications. Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity .
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-
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- HY-118742
-
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HPPD
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Others
|
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Benzobicyclon is a 4-HPPD inhibitor and herbicide that reacts with water to form a hydrolysate of the active herbicide benzobicycline, causing bleaching and death of weeds. Benzobicyclon is effective against grass, sedge and broadleaf weeds. Benzobicyclon effectively targets sulfonylurea herbicide-resistant biotypes as well as wild-type weeds .
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-
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- HY-100641S
-
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Hydroxytolbutamide-d9
|
Potassium Channel
Autophagy
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Metabolic Disease
Cancer
|
|
4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
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-
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- HY-B0254S
-
|
|
Potassium Channel
|
Metabolic Disease
|
|
Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].
|
-
- HY-108573
-
P-1075
1 Publications Verification
|
Potassium Channel
|
Cardiovascular Disease
|
|
P-1075 is a potent activator of sulfonylurea receptor 2-associated ATP-sensitive potassium channels (SUR2-KIR6), with an EC50 value of 45 nM for SUR2B-KIR6 channel activation . P-1075 also P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts .
|
-
- HY-A0176
-
-
- HY-117160
-
|
4-trans-hydroxycyclohexyl Glyburide; 4-trans-hydroxy Glibenclamide
|
Potassium Channel
|
Neurological Disease
|
|
rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
|
-
- HY-153261
-
|
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
|
NLRP3-IN-17 is a potent, selective and orally active NLRP3 inflammasome inhibitor with an IC50 value of 7 nM. NLRP3-IN-17 significantly inhibits NLRP3 dependent IL-1β secretion in mice and can be used for chronic inflammatory diseases research .
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-
- HY-155517
-
|
|
NOD-like Receptor (NLR)
Pyroptosis
|
Inflammation/Immunology
|
|
INF200 (compound 5) is a sulfonylurea-based inhibitor of NLRP3 and NLRP3-mediated pyroptosis. INF200 has beneficial cardiometabolic effects in rat model of high-fat diet (HFD)-induced metaflammation，and shows anti-inflammatory activity to (10 μM) decreases IL-1β release in human macrophages. INF200 improves glucose and lipid profiles，and attenuates systemic inflammation and biomarkers of cardiac dysfunction (particularly BNP). INF200 also improves myocardial damage-dependent ischemia/reperfusion injury (IRI) in hemodynamic evaluation .
|
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- HY-P10386
-
|
|
Bcl-2 Family
|
Cancer
|
|
155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC50 of 18 nM .
|
-
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P5292A
-
|
|
PSMA
|
Cancer
|
|
HYNIC-iPSMA TFA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA TFA has excellent specificity and sensitivity .
|
-
- HY-P5290
-
|
|
PSMA
|
Cancer
|
|
HYNIC-PSMA is a ligand for molecular imaging of tumors. Hynic-psma consists of two components: HYNIC (6-hydrazinonicotinamide) and PSMA (Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules, such as 188Re-HYNIC-PSMA. PSMA is a membrane antigen that is specifically expressed on the surface of prostate cancer cells. HYNIC-PSMA can be used in prostate cancer research .
|
-
- HY-P5292
-
|
|
PSMA
|
Cancer
|
|
HYNIC-iPSMA is a ligand for molecular imaging of tumors. Hynic-ipsma consists of two components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC is a compound used to attach radioactive isotopes to targeted molecules. iPSMA is a specific inhibitor used to inhibit prostate-specific membrane antigen (PSMA). 68GA-labeled iPSMA has been used to detect prostate cancer by PET imaging. The further 99mTc-EDDA/HYNIC-iPSMA has excellent specificity and sensitivity .
|
-
- HY-P10386
-
|
|
Bcl-2 Family
|
Cancer
|
|
155H1 (Compound 11) is a stapled peptide, that covalently binds hMcl1 (172-323) with IC50 of 18 nM .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B0401S
-
|
|
|
Tolbutamide-d9 is the deuterium labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
|
-
-
- HY-B0104S
-
|
|
|
Glimepiride-d5 is the deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
|
-
-
- HY-B0401S1
-
|
|
|
Tolbutamide- 13C is the 13C-labeled Tolbutamide. Tolbutamide is a first generation potassium channel blocker, sulfonylurea oral hypoglycemic agent.
|
-
-
- HY-B0104S1
-
|
|
|
Glimepiride-d4-1 is deuterium labeled Glimepiride. Glimepiride (Glimperide) is a medium-to-long acting sulfonylurea anti-diabetic compound with an ED50 of 182 μg/kg.
|
-
-
- HY-B1114S
-
|
|
|
Gliquidone-d6 is deuterium labeled Gliquidone. Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.
|
-
-
- HY-133085S
-
|
|
|
Rimsulfuron-d6 is deuterium labeled Rimsulfuron. Rimsulfuron (DPX-E9636) is a sulfonylurea herbicide for postemergence use in maize to control grasses and some broadleaf weeds[1][2].
|
-
-
- HY-B0870S
-
|
|
|
Bensulfuron-methyl-d6 is a deuterated Bensulfuron-methyl (HY-B0870) (sulfonylurea pesticides). Bensulfuron-methyl-d6 can be used as an internal standard for the determination of pesticide residues by LC-MS[1].
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-
-
- HY-B1876S
-
|
|
|
Nicosulfuron-d6 is the deuterium labeled Nicosulfuron[1]. Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity[2].
|
-
-
- HY-100641S
-
|
|
|
4-Hydroxytolbutamide-d9 is the deuterium labeled 4-Hydroxytolbutamide. 4-Hydroxytolbutamide (Hydroxytolbutamide) is a metabolite of Tolbutamide. 4-Hydroxytolbutamide is metabolized by CYP2C8 and CYP2C9. Tolbutamide is a first generation potassium channel blocker and a sulfonylurea oral antidiabetic[1][2].
|
-
-
- HY-B0254S
-
|
|
|
Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].
|
-
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