Search Result
Results for "
minor
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
12
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N4262
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Others
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Others
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Ginsenoside Rh7 is a minor saponin isolated from the leaves of Panax ginseng .
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-
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- HY-133787
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Drug Metabolite
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Infection
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Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .
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- HY-144336
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DNA Alkylator/Crosslinker
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Cancer
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DNA crosslinker 3 (dihydrochloride) (compound 1) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.4 °C. DNA crosslinker 3 (dihydrochloride) can be used for researching anticancer .
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- HY-144333
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DNA Alkylator/Crosslinker
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Cancer
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DNA crosslinker 1 dihydrochloride (Compound 4) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.1 °C. DNA crosslinker 1 dihydrochloride can be used for researching anticancer .
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- HY-N9695
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Fungal
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Infection
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2,6-Dihydroxy-4-methoxyacetophenone is a phytoalexin, that can be isolated from the root tissue of Sanguisorba minor. 2,6-Dihydroxy-4-methoxyacetophenone exhibits antifungal activity. 2,6-Dihydroxy-4-methoxyacetophenone is a strong germination inhibitor on B. cinerea .
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- HY-119663
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Fungal
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Infection
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Averantin is the minor metabolite of the fungus Cercospora arachidicola . Averantin is an aflatoxin B1 precursor that can be used in the biosynthetic pathway .
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- HY-144337
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DNA Alkylator/Crosslinker
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Cancer
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DNA crosslinker 4 (dihydrochloride) is a potent DNA minor groove binder. DNA crosslinker 4 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 4 (dihydrochloride) can be used for researching anticancer .
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- HY-112058
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NSC-82150
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Antibiotic
Apoptosis
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Infection
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Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis .
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- HY-144335
-
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DNA Alkylator/Crosslinker
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Cancer
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DNA crosslinker 2 (dihydrochloride) is a potent DNA minor groove binder with DNA binding affinity (ΔTm) of 1.2 °C. DNA crosslinker 2 (dihydrochloride) has certain inhibitory activity against cancer cells NCI-H460, A2780 and MCF-7. DNA crosslinker 2 (dihydrochloride) can be used for researching anticancer .
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- HY-145287
-
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DNA/RNA Synthesis
Parasite
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Infection
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S-MGB-234 is a minor groove binder of Animal African Trypanosomiasis (AAT). S-MGB-234 displays excellent in vitro activities against the principal causative organisms of AAT; Trypanosoma congolense, and Trypanosoma vivax. S-MGB-234 does not show cross-resistance with the current diamidine agents and are not internalized via the transporters used by diamidines .
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-
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- HY-113367
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-
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- HY-N8853
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Others
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Others
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Victoxinine is a metabolite of Bipolaris sp. Victoxinine has minor phytotoxic .
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-
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- HY-W701936
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-
-
- HY-I0177
-
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Drug Metabolite
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Others
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Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor) .
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-
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- HY-N8484
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Parasite
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Infection
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Eprinomectin B1b is a minor component and belongs to the avermectin family of insecticides and anthelmintics.
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-
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- HY-113085
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-
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- HY-N6832
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Others
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Others
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Rebaudioside N is a minor steviol glycoside isolated from the leaves of Stevia rebaudiana Bertoni .
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- HY-17478A
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-
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- HY-N11064
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Others
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Others
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Rebaudioside S is a minor steviol glycoside that can be isolated from the leaves of Stevia rebaudiana .
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- HY-N0818
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Calenduloside F
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Others
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Others
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Chikusetsusaponin IVa a major active ingredient of triterpenoid saponins, exerts antithrombotic effects, including minor hemorrhagic events.
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- HY-N2291
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Others
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Others
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Rebaudioside G is the minor constituent isolated from the leaves of Stevia rebaudiana Bertoni, used for sweeteners research .
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- HY-101127
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PBD dimer
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ADC Cytotoxin
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Cancer
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SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
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- HY-B1183
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-
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- HY-Y0069
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Aceturic acid; Acetamidoacetic acid
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Endogenous Metabolite
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Others
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N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
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- HY-N0311
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Others
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Cancer
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Emodin-8-glucoside is an anthraquinone derivative isolated from Aloe vera, binds to minor groove of DNA .
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- HY-W011239
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Oxfendazole sulfone; FBZ-SO2
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Parasite
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Infection
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Fenbendazole sulfone (Oxfendazole sulfone;FBZ-SO2) is a minor metabolite of Fenbendazole in plasma and is a benzimidazole anthelmintic agent .
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- HY-133794
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Drug Metabolite
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Cancer
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Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor .
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- HY-N0356
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(-)-Catechin 3-gallate; (-)-Catechin 3-O-gallate
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COX
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Cancer
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(-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
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- HY-N6583
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Bacterial
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Infection
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Licoflavonol, a minor flavone from the roots of Glycyrrhiza uralensis, is an inhibitor of the Salmonella type III secretion system (T3SS) .
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- HY-126047A
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Others
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Inflammation/Immunology
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(R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .
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- HY-113367S1
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Endogenous Metabolite
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Metabolic Disease
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Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-113367S
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Endogenous Metabolite
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Metabolic Disease
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Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-N6808
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Others
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Others
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Rebaudioside B is the minor constituent isolated from the leaves of Stevia rebaudiana Bertoni. Rebaudioside B tastes about 150 times sweeter than sucrose .
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- HY-N9460
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DNA Alkylator/Crosslinker
Antibiotic
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Cancer
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Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine .
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- HY-P1635
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EC 3.4.23.1
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Endogenous Metabolite
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Endocrinology
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Pepsin is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin contributes to proteolysis of food proteins in the vertebrate stomach .
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- HY-125729
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Parasite
SARS-CoV
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Infection
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Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture .
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-
-
- HY-101161
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SG3199
2 Publications Verification
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
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- HY-139105
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Microtubule/Tubulin
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Infection
Cancer
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20-O-Demethyl-AP3 is a minor metabolite of Ansamitocin P-3. Ansamitocin P-3, a microtubule inhibitor, is a macrocyclic antitumor antibiotic .
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- HY-112899
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
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- HY-128873
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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Duocarmycin GA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin GA can be used against multi-agent resistant cell lines.
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- HY-107770
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.
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- HY-18987
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ADC Cytotoxin
DNA Alkylator/Crosslinker
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Cancer
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Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.
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- HY-E70198
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EC 3.4.23.1 (MS Grade)
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Endogenous Metabolite
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Others
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Pepsin (MS Grade) is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin (MS Grade) contributes to proteolysis of food proteins in the vertebrate stomach .
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- HY-136289
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Drug-Linker Conjugates for ADC
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Cancer
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MB-VC-MGBA is a agent-linker conjugate for ADC with potent antitumor activity by using MGBA (minor-groove-binding DNA-alkylating agent), linked via the ADC linker MB-VC .
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-
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- HY-W009731
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Keap1-Nrf2
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Metabolic Disease
Cancer
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Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2 .
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- HY-Y0069S
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Aceturic acid-d5; Acetamidoacetic acid-d5
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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N-Acetylglycine-d5 is the deuterium labeled N-Acetylglycine. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
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- HY-B0961
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Mercury dibromofluorescein disodium salt; ZP1
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Flavivirus
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Others
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Merbromin acts as a topical antiseptic for minor cuts and scrapes and as a biological dye. Merbromin is a potent inhibitor against Zika virus (ZIKV) replication. Merbromin shows anti-ZIKV potency through ZIKVpro inhibition .
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- HY-16293
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PM01183; LY-01017
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DNA Alkylator/Crosslinker
DNA/RNA Synthesis
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Cancer
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Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively.
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- HY-130978
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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Duocarmycin DM, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity .
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- HY-128904
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Drug-Linker Conjugates for ADC
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Cancer
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MC-Val-Cit-PAB-duocarmycin chloride is a agent-linker conjugate for ADC with potent antitumor activity by using Duocarmycin (a DNA minor groove binding alkylating agent), linked via the ADC linker MC-Val-Cit-PAB.
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- HY-130803
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Others
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Cancer
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5-Methyl-5,6-dihydrouridine is a minor constituent in the chromosomal RNA of the rat ascites tumor. 5-Methyl-5,6-dihydrouridine can be used for nucleic acid modification .
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- HY-B1953
-
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Parasite
DNA Stain
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Infection
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Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables . Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions .
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- HY-N11485
-
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Drug Metabolite
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Others
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(25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite produced by the action of Nocardia globerula on Hecogenin (HY-N1422) .
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- HY-133794S
-
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Drug Metabolite
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Cancer
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Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].
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- HY-N0356S
-
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Isotope-Labeled Compounds
COX
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Cancer
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(+/-)-Catechin Gallate- 13C3 is the 13C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
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- HY-N6800A
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- HY-W612269S
-
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Isotope-Labeled Compounds
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Others
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Isonicotinoyl chloride-d4 is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
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- HY-128915
-
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity .
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- HY-N2307A
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(+)-Lirinidine
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Others
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Cancer
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Lirinidine ((+)-Lirinidine) is an alkaloid isolated from the leaves of L. tulipifera and has antioxidant and anticancer activities. Lirinidine exhibits medium ferric reducing power activity and minor radical scavenging activity in vitro. Lirinidine can be used for cosmetic research .
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- HY-134433
-
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Endogenous Metabolite
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Metabolic Disease
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GDP-L-fucose is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides, providing the fucose moiety for the oligosaccharides.The formation of GDP-L-fucose occurs through two pathways, the major ab initio metabolic pathway and the minor remedial metabolic pathway .
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- HY-101160
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DRG16
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DNA Alkylator/Crosslinker
ADC Cytotoxin
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Cancer
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SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .
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- HY-P4885
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AβpE3-40
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Amyloid-β
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Neurological Disease
|
Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .
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- HY-126047AS
-
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Isotope-Labeled Compounds
Others
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Inflammation/Immunology
|
(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine . (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .
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- HY-137158
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16-Phenoxy tetranor PGE2
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Prostaglandin Receptor
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Metabolic Disease
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16-phenoxy tetranor PGE2 is the free acid form of sulprostone formed by the hydrolysis of the methylsulfonamide bond.1 16-phenoxy tetranor PGE2 is a minor metabolite of sulprostone found in human plasma after parenteral administration of the drug.
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- HY-126047AR
-
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Others
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Inflammation/Immunology
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(R,S)-Anatabine (Standard) is the analytical standard of (R,S)-Anatabine. This product is intended for research and analytical applications. (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .
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- HY-12457
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CC-1065; NSC 298223
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Antibiotic
DNA/RNA Synthesis
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Infection
Cancer
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Rachelmycin (CC-1065) is an antitumor antibiotic and a DNA-alkylating agent. Rachelmycin has cytotoxic potency that can be used as a cytotoxin to synthesis ADC. Rachelmycin effectively inhibits DNA synthesis. Rachelmycin can be used for cancer and infection research .
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- HY-145548
-
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Others
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Others
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cis-4,10,13,16-Docosatetraenoic acid is a long chain polyunsaturated fatty acid derived from the lipids of rat testis .
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- HY-N0600
-
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Interleukin Related
IFNAR
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Inflammation/Immunology
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Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .
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- HY-16293S
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PM01183-d3; LY-01017-d3
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DNA Alkylator/Crosslinker
DNA/RNA Synthesis
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Cancer
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Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].
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- HY-134433A
-
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Endogenous Metabolite
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Metabolic Disease
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GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .
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- HY-129995
-
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TSH Receptor
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Endocrinology
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TSHR antagonist S37b is the less effective enantiomer of TSHR antagonist S37a (HY-129995A). TSHR antagonist S37b shows only a minor effect for thyrotropin receptor (TSHR) inhibition. TSHR antagonist S37b can be used for the research of thyroid function .
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- HY-B1953S
-
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DNA Stain
Parasite
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Infection
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Thiacloprid-d4 is the deuterium labeled Thiacloprid[1]. Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables[1]. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions[2].
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- HY-B1532
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(S)-Anabasine; (+)-Anabasine
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nAChR
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Neurological Disease
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Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM) .
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- HY-W014928
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(S)-Anabasine hydrochloride; (+)-Anabasine hydrochloride
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nAChR
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Neurological Disease
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Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM) .
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- HY-Y0069S1
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Aceturic acid-d2; Acetamidoacetic acid-d2
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Isotope-Labeled Compounds
Endogenous Metabolite
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Others
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N-Acetylglycine-d2 (Aceturic acid-d2; Acetamidoacetic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
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- HY-135900
-
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ADC Cytotoxin
Bacterial
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Cancer
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Aniline-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Aniline-MPB-amino-C3-PBD is a sequence-selective DNA minor-groove binding agent. Aniline-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity .
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- HY-N4298
-
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MMP
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Metabolic Disease
Inflammation/Immunology
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Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .
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- HY-152187
-
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Topoisomerase
Apoptosis
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Others
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Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629) .
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- HY-D1738
-
4',6-Diamidino-2-phenylindole dilactate
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Fluorescent Dye
|
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DAPI (dilactate) is a blue fluorescent dye that preferentially binds dsDNA and binds to minor groove AT clusters. DAPI (dilactate) is combined with dsDNA, and the fluorescence was enhanced about 20-fold. DAPI (dilactate) can be used to identify the cell cycle and specifically stains the nucleus but not the cytoplasm. DAPI (dilactate) form is more soluble in water than DAPI (dihydrochloride) form.
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-
- HY-N6937
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(R,R)-SDG; (R,R)-LGM2605
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Others
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Inflammation/Immunology
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(R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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-
- HY-N10758
-
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Others
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Others
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Petunidin 3-rutinoside is a natural product that can be isolated from Sambucus canadensis .
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-
- HY-50936
-
Ecteinascidin 743; ET-743
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Reactive Oxygen Species
Apoptosis
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Inflammation/Immunology
Cancer
|
Trabectedin (Ecteinascidin 743; ET-743) is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has the potential for soft tissue sarcoma and ovarian cancer research .
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-
- HY-112898
-
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ADC Cytotoxin
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Cancer
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DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.
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-
- HY-128952
-
SG3249
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Drug-Linker Conjugates for ADC
DNA Alkylator/Crosslinker
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Cancer
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Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
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- HY-129379
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ADC Cytotoxin
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Cancer
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DC0-NH2 is an effector moiety for ADC and a simplified analog of DC1 with better stability. DC0-NH2 is about 1000-fold more cytotoxic than commonly used anticancer agents (ex. Doxorubicin). DC0-NH2 can bind to the minor groove of DNA, followed by alkylation of adenine residues by its propabenzindole (CBI) component .
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- HY-108263A
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(S)-CGP52421
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FLT3
Drug Metabolite
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Cancer
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(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
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- HY-50936S
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Ecteinascidin 743-d3; ET-743-d3
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Isotope-Labeled Compounds
Reactive Oxygen Species
Apoptosis
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Inflammation/Immunology
Cancer
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Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .
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- HY-W753927
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C18:2(9E,12Z); C18:2 n-6
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Endogenous Metabolite
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Metabolic Disease
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9(E),12(Z)-Octadecadienoic acid is an ω-6 polyunsaturated fatty acid and an isomer of linoleic acid (HY-N0729) that contains a trans double bond at the C9 position. It has been found as a minor component of bovine milk fat and in partially hydrogenated vegetable oils. 9(E),12(Z)-Octadecadienoic acid levels increase in rabbit meat following supplementation with heated sunflower oil, α-tocopheryl acetate, and zinc.
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- HY-D0814
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4',6-Diamidino-2-phenylindole dihydrochloride
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DNA Stain
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Others
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DAPI dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells .
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- HY-N6937S1
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(R,R)-SDG-d6; (R,R)-LGM2605-d6
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Isotope-Labeled Compounds
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Inflammation/Immunology
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(R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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- HY-D1396
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Br-DAPI
3 Publications Verification
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Fluorescent Dye
DNA Stain
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Others
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Br-DAPI is a marker dye in DAPI series. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells . Storage: Keep away from light.
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- HY-N7864
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all-cis-4,7,10,13,16-Docosapentaenoic acid; Osbond acid
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Biochemical Assay Reagents
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Others
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Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.
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- HY-116889
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Drug Metabolite
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Others
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15-keto Latanoprost is a potential metabolite of latanoprost (HY-B0577) when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.1 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 μg/eye.
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- HY-114773
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Biochemical Assay Reagents
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Others
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Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
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- HY-113778
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15-keto-17-phenyl trinor PGF2α
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Prostaglandin Receptor
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Endocrinology
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Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.
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Product Name |
Type |
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- HY-B0961
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Mercury dibromofluorescein disodium salt; ZP1
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Dyes
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Merbromin acts as a topical antiseptic for minor cuts and scrapes and as a biological dye. Merbromin is a potent inhibitor against Zika virus (ZIKV) replication. Merbromin shows anti-ZIKV potency through ZIKVpro inhibition .
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- HY-D0814
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4',6-Diamidino-2-phenylindole dihydrochloride
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Fluorescent Dyes/Probes
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DAPI dihydrochloride is a DAPI dye. DAPI is a fluorescent dye that binds strongly to DNA. It binds to the AT base pair of the double-stranded DNA minor groove, and one DAPI molecule can occupy three base pair positions. The fluorescence intensity of DAPI molecules bound to double-stranded DNA is increased by about 20 times, and it is commonly observed with fluorescence microscopy, and the amount of DNA can be determined based on the intensity of fluorescence. In addition, because DAPI can pass through intact cell membranes, it can be used to stain both live and fixed cells .
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- HY-D1738
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4',6-Diamidino-2-phenylindole dilactate
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Fluorescent Dyes/Probes
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DAPI (dilactate) is a blue fluorescent dye that preferentially binds dsDNA and binds to minor groove AT clusters. DAPI (dilactate) is combined with dsDNA, and the fluorescence was enhanced about 20-fold. DAPI (dilactate) can be used to identify the cell cycle and specifically stains the nucleus but not the cytoplasm. DAPI (dilactate) form is more soluble in water than DAPI (dihydrochloride) form.
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Cat. No. |
Product Name |
Type |
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- HY-P1635
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EC 3.4.23.1
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Biochemical Assay Reagents
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Pepsin is the major pig and human gastric proteases, it is a pepsin-like minor gastric proteolytic enzymes. Pepsin contributes to proteolysis of food proteins in the vertebrate stomach .
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- HY-N7864
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all-cis-4,7,10,13,16-Docosapentaenoic acid; Osbond acid
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Biochemical Assay Reagents
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Docosapentaenoic acid (DPA) is a 22-carbon fatty acid found in fish oil. It is a minor component of total serum unsaturated fatty acids in humans, ranging from 0.1% to 1%, and increasing with dietary supplementation. all-cis-4,7,10,13,16-DPA, also known as Austrian acid, is an isomer of DPA. It is an omega-6 fatty acid formed by the extension and desaturation of arachidonic acid. During fatty acid desaturase syndrome, levels of this fatty acid may be reduced, which may affect development. Upregulated hepatic elongate expression of very long fatty acid protein 6 and elevated levels of very long chain fatty acids, including all-cis 4,7,10,13,16-DPA, are characteristic of nonalcoholic steatohepatitis, a precancerous disease of hepatocellular carcinoma.
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- HY-134433A
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Biochemical Assay Reagents
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GDP-L-fucose disodium is a nucleotide sugar that is a key substrate for the biosynthesis of fucose oligosaccharides. GDP-L-fucose disodium provides the fucose moiety for the oligosaccharides. The formation of GDP-L-fucose disodium occurs through two pathways, the major de novo metabolic pathway and the minor remedial metabolic pathway .
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- HY-114773
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Biochemical Assay Reagents
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Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C11-HSL has a rare odd-numbered acyl carbon chain and may be a minor quorum-sensing signaling molecule in Pseudomonas aeruginosa strains.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P1240
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MOG (35-55)
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Peptides
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Neurological Disease
Inflammation/Immunology
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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .
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- HY-P1240B
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MOG (35-55) (acetate)
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Peptides
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Neurological Disease
Inflammation/Immunology
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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) acetate is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat acetate produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .
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- HY-P1240A
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MOG (35-55) (TFA)
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Peptides
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Neurological Disease
Inflammation/Immunology
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Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) TFA is a minor component of CNS myelin. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA has encephalitogenic activity and induces T cell proliferative. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA induces Th1 cytokine response as well as relatively high levels of IgG antibodies. Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat TFA produces a relapsing-remitting neurological disease with extensive plaque-like demyelination .
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- HY-P4885
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AβpE3-40
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Amyloid-β
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Neurological Disease
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Glp-Amyloid-β (3-40) Peptide (human) (AβpE3-40) is a minor amounts of pyroglutamate-modified Aβ isolated from from 24-month-old Amyloid precursor protein (APP) transgenic Mice .
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Optimized version of product available:
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-113367S
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Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-Y0069S
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N-Acetylglycine-d5 is the deuterium labeled N-Acetylglycine. N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
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- HY-113367S1
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Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-133794S
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Dasatinib N-oxide-d8 is the deuterium labeled Dasatinib N-oxide. Dasatinib N-oxide is a minor metabolite of Dasatinib. Dasatinib is a potent and orally active dual Src/Bcr-Abl inhibitor[1][2].
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- HY-N0356S
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(+/-)-Catechin Gallate- 13C3 is the 13C-labeled (-)-Catechin gallate. (-)-Catechin gallate is a minor constituent in green tea catechins. (-)-Catechin gallate inhibits the activity of COX-1 and COX-2 enzymes.
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- HY-W612269S
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Isonicotinoyl chloride-d4 is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
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- HY-126047AS
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(R,S)-Anatabine-d4 is a deuterated labeled (R,S)-Anatabine . (R,S)-Anatabine is a a minor tobacco alkaloid found in the Solanaceae family of plants that can be used as a specific marker for the detection of tobacco use .
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- HY-16293S
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Lurbinectedin-d3 is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].
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- HY-B1953S
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Thiacloprid-d4 is the deuterium labeled Thiacloprid[1]. Thiacloprid, a chloronicotinyl insecticide, is targeted chiefly to control aphid pest species in orchards and vegetables[1]. Thiacloprid destabilizes DNA. Thiacloprid changes the structure and stability of DNA through binding into the minor groove by hydrophobic or hydrogen interactions[2].
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- HY-Y0069S1
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N-Acetylglycine-d2 (Aceturic acid-d2; Acetamidoacetic acid-d2) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
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- HY-50936S
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Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .
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- HY-N6937S1
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(R,R)-Secoisolariciresinol diglucoside-d6 is deuterated labeled (R,R)-Secoisolariciresinol diglucoside (HY-N6937). (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) is the minor isomer of Secoisolariciresinol diglucoside in flaxseed. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) possesses antioxidant and free radical scavenging activities and DNA-radioprotective properties. (R,R)-Secoisolariciresinol diglucoside ((R,R)-SDG) inhibits myeloperoxidase (MPO) activity by suppressing both the peroxidase and chlorination cyclesin inflammatory cells .
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