Search Result
Results for "
fatty acid metabolite
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
6
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W008097
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- HY-135035
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(-)-Decanoylcarnitine
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Others
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Metabolic Disease
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Decanoyl-L-carnitine has stimulatory effect on the formation of desaturated fatty acid metabolites from both [1- 14C]-22:4 (n-6) and [1- 14C]-22:5 (n-3) .
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- HY-113943A
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(±)9-HETE
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Endogenous Metabolite
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Others
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9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
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- HY-113943
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Endogenous Metabolite
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Others
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9(S)-HETE is the S isomer of 9-HETE (HY-113943A). 9-HETE, a monohydroxy fatty acid, is the lipoxygenase metabolite of arachidonic acid (HY-109590) .
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- HY-142105
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2-Ethyl-2-hydroxybutyric acid
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Endogenous Metabolite
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Metabolic Disease
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2-Ethyl-2-hydroxybutanoic acid (2-Ethyl-2-hydroxybutyric acid) is a hydroxy fatty acid. 2-Ethyl-2-hydroxybutanoic is a metabolite of DEHP (HY-B1945) .
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- HY-113147A
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Potassium Channel
Endogenous Metabolite
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Cardiovascular Disease
Metabolic Disease
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L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2 .
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- HY-113147B
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Endogenous Metabolite
Potassium Channel
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Cardiovascular Disease
Metabolic Disease
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L-Palmitoylcarnitine TFA, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine TFA inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2 .
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- HY-W011297
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Arachidonic acid methyl ester
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Others
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Metabolic Disease
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Methyl arachidonate (Arachidonic acid methyl ester) is a fatty acid methyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with methanol. Methyl arachidonate has activity of human blood serum metabolite .
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- HY-100978
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DL-Hexanoylcarnitine chloride
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Endogenous Metabolite
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Metabolic Disease
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(±)-Hexanoylcarnitine chloride is a fatty acid metabolite that breaks down fatty acids into energy that can be used by the body. (±)-Hexanoylcarnitine chloride also serves as a specific and easily detectable biomarker for rat skeletal muscle toxicity. Cerivastatin (HY-129458) and TMPD (HY-W012145) induce an increase in Hexanoylcarnitine in rats in a metabolomic analysis of the rectus femoris muscle. In type 2 diabetes, Hexanoylcarnitine is also significantly associated with and improves prediction of all-cause mortality. Hexanoylcarnitine is a biomarker for the identification of novel pathogenic pathways .
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- HY-139391
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Others
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Others
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(±)10(11)-DiHDPA is a fatty acid diol and a metabolite of epoxidized fatty acids (EpFAs) .
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- HY-113069
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Endogenous Metabolite
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Metabolic Disease
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Decanoylcarnitine is a fatty ester lipid and an acylcarnitine derivative, which is a metabolite associated with impaired fatty acid metabolism in the elderly population .
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- HY-N10288
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- HY-W270810
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Others
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Others
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Nurr1 agonist 8 (compound 111) is a Nurr1 agonist with an EC50 value of 0.09 μM .
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- HY-113367
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- HY-130319
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- HY-113085
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- HY-W005178
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Endogenous Metabolite
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Others
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Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome .
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- HY-W751418
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(Z)-2-tetracos-15-enamidoethanesulfonic acid
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FAAH
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Neurological Disease
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N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .
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- HY-113202
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- HY-113261
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- HY-113367S1
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Endogenous Metabolite
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Metabolic Disease
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Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-113367S
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Endogenous Metabolite
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Metabolic Disease
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Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-130060
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Others
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Cardiovascular Disease
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12(S)-HETrE is a fatty acid metabolite that inhibits platelet aggregation. 12(S)-HETrE can be used in thrombosis-related research .
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- HY-W018392
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MEHP; Phthalic acid mono-2-ethylhexyl ester
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Endogenous Metabolite
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Metabolic Disease
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Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .
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- HY-W018678
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Others
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Metabolic Disease
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8-Aminooctanoic acid is an omega-amino fatty acid that is octanoic acid which carries an amino group at position 8. 8-aminooctanoic acid has a role as a human metabolite .
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- HY-112540B
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Endogenous Metabolite
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Metabolic Disease
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Acetoacetic acid sodium is a metabolite of non-esterified fatty acids, involved in the development of human diabetes. Acetoacetic acid sodium induces oxidative stress to inhibit the assembly of very low density lipoprotein in bovine hepatocytes .
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- HY-126833B
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14:0 Coenzyme A
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Others
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Metabolic Disease
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Myristoyl coenzyme A triammonium (14:0 Coenzyme A) is a type of long-chain acyl-CoA, which is the activated form of long-chain fatty acids and serves as a crucial lipid metabolite .
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- HY-N0729
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Linoleic acid
Maximum Cited Publications
10 Publications Verification
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Endogenous Metabolite
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Cardiovascular Disease
Metabolic Disease
Cancer
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Linoleic acid is a common polyunsaturated (PUFA) found in plant-based oils, nuts and seeds. Linoleic acid is a part of membrane phospholipids, and functions as a structural component to maintain a certain level of membrane fluidity of the transdermal water barrier of the epidermis. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism .
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- HY-W011819
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Endogenous Metabolite
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Metabolic Disease
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Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions .
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- HY-113202S
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Endogenous Metabolite
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Neurological Disease
Metabolic Disease
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Stearoyl-L-carnitine-d3 is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is a human endogenous metabolite. Stearoylcarnitine acts as a metabolomics biomarker for early-onset-preeclampsia and late-onset-preeclampsia[1].
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- HY-126967A
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1-P-GPA
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Others
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Metabolic Disease
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1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA) is an endogenous metabolite. 1-Palmitoyl-sn-glycerol 3-phosphate can be used for the research of non‐alcoholic fatty liver disease .
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- HY-W337335
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1-P-GPA sodium salt
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Endogenous Metabolite
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Metabolic Disease
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1-Palmitoyl-sn-glycerol 3-phosphate (sodium salt) (1-P-GPA (sodium salt)) is an endogenous metabolite. 1-Palmitoyl-sn-glycerol 3-phosphate (sodium salt) can be used in the study of non-alcoholic fatty liver disease .
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- HY-116444A
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Na+/K+ ATPase
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Cardiovascular Disease
Inflammation/Immunology
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16-HETE is arachidonic acid metabolite through subterminal hydroxylation by cytochrome P-450. 16-HETE exhibits vasodilatory and PMN inhibitory effects and serves as biomarker for early stages of non-alcoholic fatty liver disease .
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- HY-115358
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Tetracosanoic acid monoethanolamide
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Endogenous Metabolite
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Metabolic Disease
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Lignoceroyl ethanolamide is a member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids. Whereas lignoceric acid has been detected at relatively high levels in rat cerebrospinal fluid, the specific role and relative importance of its ethanolamine metabolite have not been determined.
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- HY-W018392S
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MEHP-d4; Phthalic acid mono-2-ethylhexyl ester-d4
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Isotope-Labeled Compounds
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Metabolic Disease
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Mono-(2-ethylhexyl) phthalate-d4 is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .
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- HY-112948
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Endogenous Metabolite
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Metabolic Disease
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2-Methylbutyrylcarnitine is a fatty acid metabolite. 2-Methylbutyrylcarnitine is found mainly in the blood and urine of humans and animals and is produced through the pyruvate carboxylation pathway. 2-Methylbutyrylcarnitine exhibits high level in the plasma of subjects with steatohepatitis (NASH) and can be used as an indicator for the diagnosis of metabolic diseases .
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- HY-W011819S
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Endogenous Metabolite
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Metabolic Disease
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Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions[2].
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- HY-113111
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Endogenous Metabolite
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Inflammation/Immunology
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11,12-DiHETrE, an endogenous metabolite, is a Cytochrome P450 (P450) eicosanoid. 11,12-DiHETrE can be used for preterm labor research. 11,12-DiHETrE can be used as a single biomarker for differentiating NAFL (nonalcoholic fatty liver) from NASH (nonalcoholic steatohepatitis) .
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- HY-113147AS
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Potassium Channel
Endogenous Metabolite
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Cardiovascular Disease
Metabolic Disease
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L-Palmitoylcarnitine-d3 (hydrochloride) is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
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- HY-129764A
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17-trans-PGF3α
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Others
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Inflammation/Immunology
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(17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity .
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- HY-130502
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Cholesterol beta-epoxide
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Biochemical Assay Reagents
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Others
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Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue .
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- HY-113545
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9(R)-Hydroxyoctadecadienoic acid
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Endogenous Metabolite
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Metabolic Disease
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9(R)-HODE is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.
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- HY-115004
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Others
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Neurological Disease
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MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 (FAAH-1) that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability (14-21%) and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites .
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- HY-136410
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Endogenous Metabolite
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Metabolic Disease
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4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
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Cat. No. |
Product Name |
Type |
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- HY-130502
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Cholesterol beta-epoxide
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Biochemical Assay Reagents
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Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. Cholesterol 5beta,6beta-epoxide has been found in human fatty streaks and advanced atherosclerotic lesions, but not in normal aortic tissue .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-113367S
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Suberylglycine-d4 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-113367S1
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Suberylglycine-d2 is the deuterium labeled Suberylglycine. Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid[1][2].
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- HY-113202S
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Stearoyl-L-carnitine-d3 is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is a human endogenous metabolite. Stearoylcarnitine acts as a metabolomics biomarker for early-onset-preeclampsia and late-onset-preeclampsia[1].
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- HY-W018392S
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Mono-(2-ethylhexyl) phthalate-d4 is a deuterium labeled Mono-(2-ethylhexyl) phthalate (HY-W018392). Mono-(2-ethylhexyl) phthalate (MEHP) is a major bioactive metabolite of diethylhexyl phthalate (DEHP). Mono-(2-ethylhexyl) phthalate can promote fatty acid synthesis in hepatocytes by regulating the expression of relevant genes and proteins, contributing to non-alcoholic fatty liver disease (NAFLD) .
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- HY-W011819S
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Tetradecanedioic acid-d24 is the deuterium labeled Tetradecanedioic acid[1]. Tetradecanedioic acid is an endogenous metabolite and belongs to the class of organic compounds known as long-chain fatty acids. Tetradecanedioic acid can act as a candidate biomarker for organic anion-transporting polypeptide mediated agent-agent interactions[2].
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- HY-113147AS
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L-Palmitoylcarnitine-d3 (hydrochloride) is the deuterium labeled L-Palmitoylcarnitine hydrochloride. L-Palmitoylcarnitine hydrochloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2[1].
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Cat. No. |
Product Name |
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Classification |
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- HY-17639
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RX-10045
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Alkynes
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Navamepent is an analog of naturally occurring resolvin E1 (a major dietary omega-3 polyunsaturated fatty-acid metabolite) with potent anti-inflammatory and cell survival benefits. Navamepent is highly effective against dry eye and goblet cell loss thereby accelerating tear production. Also, Navamepent can reduce corneal inflammation, epithelial damage, and accelerate corneal tissue repair. In addition, Navamepent can inhibit the release of several key proinflammatory mediators from corneal epithelial cells. Navamepent is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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