Search Result
Results for "
dipeptide
" in MedChemExpress (MCE) Product Catalog:
2
Biochemical Assay Reagents
7
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-127090
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MDP
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p38 MAPK
NOD-like Receptor (NLR)
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Inflammation/Immunology
Cancer
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Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist .
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- HY-P2386
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-
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- HY-P0102
-
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mAChR
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Neurological Disease
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Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a mAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate can induce muscle relaxation .
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-
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- HY-P2395
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-
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- HY-P2404
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-
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- HY-W009486
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Tyrosylalanine
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Others
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Others
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H-Tyr-Ala-OH (Tyrosylalanine) is a L-tyrosine- and L-alanine-containing dipeptide .
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-
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- HY-162159
-
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Others
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Others
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Ac-Cys-NHMe is a Cys dipeptide with thiol group .
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-
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- HY-W009592
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Others
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Others
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Glycyl-L-tyrosine is a dipeptide containing glycine and L-tyrosine .
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-
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- HY-124005
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Others
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Others
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Prolylisoleucine (Pro-Ile) is a dipeptide composed of Proline and Isoleucine .
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-
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- HY-138068
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Others
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Metabolic Disease
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L-Tryptophanylglycine (Trp-gly) is a dipeptide that can inhibit Ceronapril uptake by Caco-2 cells, with a Ki of 7.19 mM .
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-
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- HY-150013
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L-Methionyl-L-methionine
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Others
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Others
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H-Met-Met-OH (L-Methionyl-L-methionine) is a dipeptide composed of two methionine residues .
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-
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- HY-148217
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Others
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Others
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DB02307 is a dipeptide that contains a sequence of two alpha-amino acids joined by a peptide bond .
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-
-
- HY-148371
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-
-
- HY-120347
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KM-208
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Fungal
Antibiotic
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Infection
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Bacilysin is a dipeptide antibiotic that can be isolated from Bacillus species. Bacilysin inhibits GlcN6P synthase activity .
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-
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- HY-158307
-
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Cathepsin
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Others
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Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins. .
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-
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- HY-148495
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Amyloid-β
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Neurological Disease
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Carnosine conjugated hyalyronate is a hyaluronic acid derivative functionalized with the dipeptide carnosine (Carnosine, Car) and has the ability to resist Aβ amyloid aggregation. Carnosine conjugated hyalyronate dissolves amyloid fibrils and reduces Aβ-induced toxicity in vitro. The effectiveness of Carnosine conjugated hyalyronate against amyloid aggregation is directly proportional to the Carnosine loading. .
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-
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- HY-135627
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cyclo(L-Hyp-L-Ser)
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Endogenous Metabolite
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Others
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JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases .
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-
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- HY-113402
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γ-Glu-Cys
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Endogenous Metabolite
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Inflammation/Immunology
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Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels .
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- HY-118347
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Others
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Neurological Disease
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Aspartame acesulfame is a methyl ester of a dipeptide. Aspartame acesulfame can be used as a synthetic nonnutritive sweetener. Aspartame acesulfame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%) .
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- HY-W012159
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H-MET-SER-OH
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Angiotensin-converting Enzyme (ACE)
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Cardiovascular Disease
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Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension .
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- HY-W014102
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- HY-105215
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Neurokinin Receptor
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Inflammation/Immunology
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FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration .
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- HY-114883
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L-Homocarnosine; γ-Aminobutyryl-L-histidine
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GABA Receptor
Endogenous Metabolite
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Neurological Disease
Inflammation/Immunology
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Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects .Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .
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- HY-149832
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Proteasome
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Cancer
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Anticancer agent 114 is a potent and orally active dipeptide boronic acid ester proteasome inhibitor with an IC50 value of 2.2 nM. Anticancer agent 114 has antiproliferative activity against the RPMI-8226 cells. Anticancer agent 114 can be used in research of multiple myeloma .
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- HY-147097A
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Bacterial
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Infection
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EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
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- HY-W014102R
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Endogenous Metabolite
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Metabolic Disease
Inflammation/Immunology
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L-Alanyl-L-glutamine (Standard) is the analytical standard of L-Alanyl-L-glutamine. This product is intended for research and analytical applications. L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .
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- HY-N3796
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Echinuline
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NF-κB
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Inflammation/Immunology
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Echinulin (Echinuline) is a cyclic dipeptide carrying a triprenylated indole moiety. Echinulin contributes to the activation of T cell subsets, which leads to NF-κB activation.Echinulin exerts its immune roles by the NF-κB pathway.Echinulin has the potential to serve as a immunotherapeutic agent .
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- HY-101402
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Cyclo(histidyl-proline); Histidylproline diketopiperazine
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NF-κB
Endogenous Metabolite
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Neurological Disease
Inflammation/Immunology
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Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .
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- HY-P4497
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ERK
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Cancer
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Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB) .
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- HY-101402A
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Cyclo(histidyl-proline) TFA; Histidylproline diketopiperazine TFA
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NF-κB
Endogenous Metabolite
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Neurological Disease
Inflammation/Immunology
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Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .
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- HY-P5033
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Bacterial
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Cancer
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Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC50 values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems .
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- HY-13682
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MTP-PE; L-MTP-PE; CGP 19835
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NOD-like Receptor (NLR)
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Inflammation/Immunology
Cancer
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Mifamurtide (MTP-PE), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide has potential for use in rare disease and osteosarcoma research .
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- HY-13682B
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MTP-PE sodium; L-MTP-PE sodium; CGP 19835 sodium
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NOD-like Receptor (NLR)
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Inflammation/Immunology
Cancer
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Mifamurtide sodium (MTP-PE sodium), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide sodium is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide sodium has potential for use in rare disease and osteosarcoma research .
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- HY-147097
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Bacterial
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Infection
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EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-13682C
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MTP-PE TFA; L-MTP-PE TFA; CGP 19835 TFA
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NOD-like Receptor (NLR)
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Inflammation/Immunology
Cancer
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Mifamurtide TFA (MTP-PE TFA), an analog of the muramyl dipeptide (MDP), is a nonspecific immunomodulator by stimulating the immune response activating macrophages and monocytes. Mifamurtide TFA is a specific ligand for NOD2 and acts as an insulin sensitizer. Mifamurtide TFA has potential for use in rare disease and osteosarcoma research .
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- HY-P1934A
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Fungal
IFNAR
Reactive Oxygen Species
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Infection
Inflammation/Immunology
Cancer
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Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
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- HY-135158
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Others
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Others
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Prolylvaline (Pro-Val) is a proline-valine dipeptide that can be used to bind fluorescein isothiocyanate (FITC). Prolylvaline has specific imprinting effects in Tetrahymena, inducing negative imprinting. Using protozoan organisms, proline dipeptides containing different partner amino acids can be distinguished from dipeptides with opposite amino acid positions .
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- HY-W016785
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-
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- HY-131109
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-
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- HY-113278
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-
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- HY-114788
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L-Lysyl-L-cysteine
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Others
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Others
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Lysylcysteine (L-Lysyl-L-cysteine) is a dipeptide composed of lysine and cysteine.
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- HY-P2396
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-
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- HY-P2400
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-
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- HY-P2405
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-
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- HY-P2390
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-
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- HY-P2393
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-
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- HY-P2398
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-
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- HY-P2409
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-
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- HY-P2410
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-
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- HY-P2385
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- HY-W048830
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- HY-42709
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- HY-W048825
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Amino Acid Derivatives
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Others
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Fmoc-Ala-Ala-OH (3) is a self-assemble fluorenylmethoxycarbonyl-dipeptide, which is a smaller amphiphilic building blocks consists dipeptides linked to fluore nylmethoxycarbonyl (Fmoc). Fmoc-Ala-Ala-OH can be used as scaffold materials in 3D cell culture .
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- HY-W016077
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- HY-P2389
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-
- HY-P2397
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- HY-P2399
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- HY-P2401
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- HY-P2403
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- HY-P2407
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- HY-P2408
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- HY-P2384
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- HY-P2388
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- HY-P2402
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- HY-P2411
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- HY-P2391
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- HY-P2412
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- HY-P2387
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- HY-128434
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- HY-P2394
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- HY-114729
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- HY-126487
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-
- HY-P4356
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- HY-P4280
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- HY-W554764
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- HY-126487A
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- HY-P4276
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Bacterial
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Infection
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Arg-Trp is a dipeptide composed of arginine and tryptophan, and analogues of Arg-Trp-octyl ester show antibacterial activity .
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- HY-P5299
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- HY-118265
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Others
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Others
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N-Acetylglutaminylglutamine amide is a dipeptide previously reported only in osmotically stressed Rhizobium meliloti and Pseudomonas fluorescens .
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- HY-P4431
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Amino Acid Derivatives
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Others
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H-Met-Asp-OH is a dipeptide containing methionine and aspartic acid, which can be used for the synthesis of polypeptides .
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- HY-P2073
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Bacterial
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Infection
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Cyclo(Δ-Ala-L-Val) is a cyclic dipeptide and a putative quinolone signal (QS) molecule produced by Pseudomonas aeruginosa .
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- HY-135203
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Biochemical Assay Reagents
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Others
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Cysteinylcysteine is a dipeptide consisting of two cysteine amino acids. Cysteinylcysteine forms complexes with transition metals for metalloprotein research. .
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- HY-P4288
-
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Amino Acid Derivatives
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Others
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Beta-Asp-His is a dipeptide containing aspartic acid and histidine, which can form amino acid derivatives by complexing with Zinc .
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- HY-P4253
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VEGFR
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Cardiovascular Disease
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Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .
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- HY-W013494
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-
- HY-12528
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-
- HY-W009602
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H-Phe-Ala-OH
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Others
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Others
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Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .
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- HY-10913A
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GAP-134 Hydrochloride; ZP 1609 Hydrochloride
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Gap Junction Protein
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Cardiovascular Disease
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Danegaptide Hydrochloride (GAP-134 Hydrochloride) is a potent, selective and orally active gap-junction modifier with an antiarrhythmic effect .
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- HY-10913
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-
- HY-139440
-
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Others
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Others
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DL-Leucyl-DL-phenylalanine is a dipeptide and can be used as a substrate to detecte two regions of dipeptidase staining on a gel in Drosophila simulans as well as in Drosophila melanogaster .
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- HY-P4553
-
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Amino Acid Derivatives
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Others
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H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .
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- HY-78932A
-
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ADC Linker
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Cancer
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Dap-NE hydrochloride is a dipeptide hydrochloride and a cleavable ADC Linker.Dap-NE hydrochloride can be used to connect Antibody and toxin molecules (Cytotoxin) to synthesize Antibody-Drug Conjugates (ADCs) .
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- HY-W007035
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-
- HY-10397A
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MX1013
2 Publications Verification
CV1013; Z-VD-FMK
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Caspase
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Cancer
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MX1013 is a potent, irreversible dipeptide caspase inhibitor vith antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50 of 30 nM .
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- HY-143686
-
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Biochemical Assay Reagents
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Cancer
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ImmTher is a liposome-encapsulated lipophilic disaccharide tripeptide derivative of muramyl dipeptide. ImmTher can up-regulate specific monocyte cytokine genes and activate monocyte-mediated tumoricidal activity .
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- HY-P4654
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-
- HY-122381
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Bacterial
Endogenous Metabolite
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Neurological Disease
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Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients .
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- HY-148690
-
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Bacterial
Fungal
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Infection
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L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections .
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- HY-W013494S
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-
- HY-105019A
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Melphalan flufenamide hydrochloride
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells .
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- HY-105019
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Melphalan flufenamide
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .
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- HY-134458A
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Lysyltyrosine TFA
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P2X Receptor
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Neurological Disease
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H-Lys-Tyr-OH TFA (Lysyltyrosine TFA) is a dipeptide composed of lysine and tyrosine. H-Lys-Tyr-OH TFA prevents neurological diseases or improves brain function by promoting the release of noradrenaline and tyrosine into the brain .
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- HY-P4257
-
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Angiotensin-converting Enzyme (ACE)
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Cardiovascular Disease
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L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues. L-Isoleucyl-L-arginine is a potent angiotensin-converting enzyme (ACE) inhibitor. L-Isoleucyl-L-arginine can be used for research of hypertension .
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- HY-B0361S1
-
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Isotope-Labeled Compounds
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Neurological Disease
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Aspartame-d5 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
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- HY-B0361S
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SC-18862-d3
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Isotope-Labeled Compounds
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Neurological Disease
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Aspartame-d3 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
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- HY-122767
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Muroctasin
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Interleukin Related
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Inflammation/Immunology
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Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and IL-6 in vitro .
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- HY-W008642S
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L-Leucyl-13C6,15N-L-leucine
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Isotope-Labeled Compounds
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Others
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(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .
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- HY-15242
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CP 424391
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GHSR
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Endocrinology
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Capromorelin (CP 424391) is a pyrazolinone-piperidine dipeptide. Capromorelin is an orally active and potent growth hormone secretagogue (GHS) (hGHS-R1a Ki=7 nM, rat pituicyte EC50=3 nM) .
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- HY-15575
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VcMMAE
Maximum Cited Publications
45 Publications Verification
MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE
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Drug-Linker Conjugates for ADC
Microtubule/Tubulin
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Cancer
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VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc).
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- HY-P3280
-
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Endogenous Metabolite
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Metabolic Disease
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γ-Glu-Gly, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids .
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- HY-W010162
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L-Alanyl-L-alanine; Ala-Ala
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Amino Acid Derivatives
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Others
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H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) is a nonpolar dipeptide that is absorbed by human intestinal Caco-2 cells. The transport of alanine (Ala), like proton/amino acid symport, can lead to cytoplasmic acidification .
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- HY-P3280A
-
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Endogenous Metabolite
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Metabolic Disease
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γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly TFA has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids .
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- HY-129905
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LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
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Endogenous Metabolite
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Inflammation/Immunology
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L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .
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- HY-129905A
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LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide
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Endogenous Metabolite
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Inflammation/Immunology
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L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .
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- HY-122529
-
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Bacterial
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Infection
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Almurtide (nor-MDP), a muramyl dipeptide derivative with anti-inflammatory and anti-tumor activity. Almurtide also shows protective effects against intraperitoneal Pseudomonas aeruginosa infection or intravenously Candida albicans infection in mice. Almurtide also inhibits the carcinogenic Friend leukemia virus .
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- HY-P4522
-
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Endogenous Metabolite
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Others
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Bz-Ala-Arg is a dipeptide. Bz-Ala-Arg is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg can be used to screen competitive inhibitors of these two enzymes .
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- HY-B0944
-
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Bacterial
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Inflammation/Immunology
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Pidotimod is an orally active dipeptide immunostimulant with immunomodulatory properties on the adaptive and the innate immune responses. Pidotimod increases macrophage activity and humoral immune functions. Pidotimod can be used for the research of chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchiectasis, and chronic idiopathic urticaria,et al .
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- HY-113354
-
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Endogenous Metabolite
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Neurological Disease
|
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .
|
-
- HY-P4439
-
|
Amino Acid Derivatives
|
Neurological Disease
|
H-Met-Val-OH is a dipeptide containing free N-terminal methionine. H-Met-Val-OH exhibits activity against cDNA expressing Flavin-containing monooxygenase (FMO) 1 and FMO3. H-Met-Val-OH has potential applications in the growth of neuritis .
|
-
- HY-P4554
-
|
Endogenous Metabolite
|
Metabolic Disease
|
H-Phe-Arg-OH is a dipeptide containing phenylalanine and arginine. H-Phe-Arg-OH can be separated from Bradykinin (HY-P0206) through Angiotensin-converting enzyme (ACE, HY-P2983). H-Phe-Arg-OH can be used for metabolic research .
|
-
- HY-122357
-
|
Adenylate Cyclase
|
Inflammation/Immunology
|
Bestim is a dipeptide, which exhibits high affinity to murine peritoneal macrophages, thymocytes, and plasma membranes isolated from these cells, with Kds of 3.1, 2.1, 18.6 and 16.7 nM, respectively. Bestim inhibits adenylate cyclase in the membranes of murine macrophages and thymocytes. Bestim exhibits immunomodulatory efficacy .
|
-
- HY-13718
-
H-Glu-Trp-OH; L-Glutamyl-L-tryptophan
|
VEGFR
HCV
Endogenous Metabolite
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
|
Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .
|
-
- HY-114883A
-
L-Homocarnosine TFA; γ-Aminobutyryl-L-histidine TFA
|
GABA Receptor
Endogenous Metabolite
|
Neurological Disease
|
Homocarnosine TFA is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine TFA is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects . Homocarnosine TFA has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation .
|
-
- HY-P4560
-
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
H-Pro-Phe-OH is a dipeptide containing proline and phenylalanine, which can serve as a substrate for prolinase. H-Pro-Phe-OH can also be used for polypeptide synthesis, where phenylalanine is an aromatic amino acid that can inhibit the activity of Angiotensin-converting enzyme (ACE, HY-P2983) .
|
-
- HY-15575S
-
MC-Val-Cit-PAB-MMAE-d8; mc-vc-PAB-MMAE-d8
|
Drug-Linker Conjugates for ADC
Microtubule/Tubulin
|
Cancer
|
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .
|
-
- HY-P4522A
-
|
Endogenous Metabolite
|
Others
|
Bz-Ala-Arg TFA is a dipeptide. Bz-Ala-Arg TFA is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg TFA can be used to screen competitive inhibitors of these two enzymes .
|
-
- HY-P4550
-
|
Endogenous Metabolite
|
Metabolic Disease
|
H-Hyp-Gly-OH is a dipeptide containing hydroxyproline and glycine. H-Hyp-Gly-OH promotes the growth of mouse primary fibroblasts on collagen gel. H-Hyp-Gly-OH has potential applications in improving skin by ingesting hydrolyzed collagen. H-Hyp-Gly-OH can be used for metabolic research .
|
-
- HY-P4531
-
|
Opioid Receptor
|
Neurological Disease
|
H-Ser-Tyr-OH is a dipeptide consisting of glutamic acid, glycine and histidine. H-Ser-Tyr-OH can form a copper(II) complex with copper ions to form a strong free radical scavenging activity. H-Ser-Tyr-OH also increases the intracellular uptake of the delta opioid receptor ligand deltorphin .
|
-
- HY-136555
-
GSK717
5 Publications Verification
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells .
|
-
- HY-100212
-
AG1776; KNI-764
|
HIV
HIV Protease
|
Infection
|
JE-2147 (AG1776) is a potent dipeptide protease inhibitor with a Ki of 0.33 nM for HIV-1 protease. JE-2147 has effective activities against a wide spectrum of HIV-1, HIV-2, simian immunodeficiency virus, and various clinical HIV-1 strains in vitro .
|
-
- HY-78931C
-
|
Others
|
Cancer
|
(S,S,R,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-78931E
-
|
Others
|
Cancer
|
(R,S,R,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-78931F
-
|
Others
|
Cancer
|
(R,S,S,S,R)-Boc-Dap-NE is an isomer of the dipeptide Boc-Dap-NE (HY-78931). Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.
|
-
- HY-113354S
-
|
Endogenous Metabolite
|
Neurological Disease
|
Anserine-d4 is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].
|
-
- HY-N10473
-
|
Bacterial
Fungal
|
Infection
|
Pulcherriminic acid is a cyclic dipeptide antimicrobial agent with high affinity for Fe 3+, found mainly in Bacillus and yeast. Pulcherriminic acid chelates iron ions through a non-enzymatic reaction to form the extracellular red pigment pulcherrimin, which competes for iron nutrition and thus achieves an antibacterial effect. Pulcherriminic acid has great applications in food, agriculture and medical industries .
|
-
- HY-147506
-
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .
|
-
- HY-B0944R
-
|
Bacterial
|
Inflammation/Immunology
|
Pidotimod (Standard) is the analytical standard of Pidotimod. This product is intended for research and analytical applications. Pidotimod is an orally active dipeptide immunostimulant with immunomodulatory properties on the adaptive and the innate immune responses. Pidotimod increases macrophage activity and humoral immune functions. Pidotimod can be used for the research of chronic bronchitis, chronic obstructive pulmonary disease (COPD), bronchiectasis, and chronic idiopathic urticaria,et al .
|
-
- HY-113354S1
-
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Anserine-d4 hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .
|
-
- HY-155782
-
|
RIP kinase
|
Inflammation/Immunology
|
Zharp2-1 is an oral effective RIPK2 inhibitor, highly associated with inflammatory bowel disease (IBD). Zharp2-1 blocker muramyl dipeptide (MDP) induces growth of mononuclear cells and induces inflammatory cell factor infection. Zharp2-1 attenuates MDP-induced small inguinal peritonitis, or ameliorates by DNBS-induced large inguinal conjunctivitis .
|
-
- HY-W395779
-
|
Filovirus
|
Infection
|
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM .
|
-
- HY-P4523
-
|
Endogenous Metabolite
|
Endocrinology
|
FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells .
|
-
- HY-101283
-
HCH6-1
3 Publications Verification
|
Formyl Peptide Receptor (FPR)
|
Inflammation/Immunology
|
HCH6-1 is a potent and competitive dipeptide antagonist of Formyl peptide receptor 1 (FPR1). HCH6-1 inhibits chemotaxis, superoxide anion generation, and elastase release in human neutrophils specifically activated by fMLF (an FPR1 agonist). HCH6-1 has protective effects against acute lung injury (ALI) in vivo and can be used for the research of FPR1-involved inflammatory lung diseases .
|
-
- HY-P4641
-
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice .
|
-
- HY-113402A
-
γ-Glutamylcysteine TFA
|
Interleukin Related
TNF Receptor
Endogenous Metabolite
|
Inflammation/Immunology
|
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes .
|
-
- HY-P99238
-
|
ADC Antibody
|
Inflammation/Immunology
Cancer
|
Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (C242, C242'). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (C242, C242') .
|
-
- HY-108743
-
|
Insulin Receptor
|
Endocrinology
|
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes .
|
-
- HY-108743R
-
|
Insulin Receptor
|
Endocrinology
|
Insulin degludec (Standard) is the analytical standard of Insulin degludec. This product is intended for research and analytical applications. Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-W010162
-
L-Alanyl-L-alanine; Ala-Ala
|
Biochemical Assay Reagents
|
H-Ala-Ala-OH (L-Alanyl-L-alanine; Ala-Ala) is a nonpolar dipeptide that is absorbed by human intestinal Caco-2 cells. The transport of alanine (Ala), like proton/amino acid symport, can lead to cytoplasmic acidification .
|
-
- HY-143686
-
|
Drug Delivery
|
ImmTher is a liposome-encapsulated lipophilic disaccharide tripeptide derivative of muramyl dipeptide. ImmTher can up-regulate specific monocyte cytokine genes and activate monocyte-mediated tumoricidal activity .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-118060
-
N-Valyltryptophan; Val-Trp
|
Peptides
|
Others
|
Dipeptide 2 (N-Valyltryptophan; Val-Trp) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
|
-
- HY-16959
-
|
Peptides
|
Others
|
CEP dipeptide 1 is a CEP dipeptide with potent angiogenic activity; mediators of age-related macular degeneration (AMD).
|
-
- HY-P0102
-
|
mAChR
|
Neurological Disease
|
Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a mAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate can induce muscle relaxation .
|
-
- HY-P5267
-
|
Peptides
|
Metabolic Disease
|
Palmitoyl dipeptide-7 is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
|
-
- HY-P0101A
-
|
Peptides
|
Others
|
Palmitoyl dipeptide-5 diaminohydroxybutyrate is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
|
-
- HY-P5218
-
|
Peptides
|
Others
|
Acetyl dipeptide-3 aminohexanoate is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
|
-
- HY-P5279
-
|
Peptides
|
Metabolic Disease
|
Palmitoyl dipeptide-7 is a bioactive peptide with anti-aging effects that has been reported for use as a cosmetic ingredient.
|
-
- HY-134017
-
Calmosensine
|
Peptides
|
Others
|
Acetyl dipeptide-1 cetyl ester (Calmosensine) is a bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient .
|
-
- HY-P2386
-
-
- HY-P2395
-
-
- HY-P2404
-
-
- HY-W008642
-
L-Leucyl-L-leucine
|
Peptides
|
Others
|
Leu-Leu-OH, a Leu derivative, is a dipeptide.
|
-
- HY-139468
-
-
- HY-135514
-
-
- HY-W212029
-
-
- HY-158307
-
|
Cathepsin
|
Others
|
Z-Arg-Arg-βNA acetate is a sensitive dipeptide substrate of the protease Cathepsin B and resistant to proteases H and L. Z-Arg-Arg-βNA acetate can serve as an important tool for distinguishing non-Cathepsin B type proteins. .
|
-
- HY-B0361
-
SC-18862
|
Peptides
|
Neurological Disease
|
Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener .
|
-
- HY-133026
-
N-Acetyl-L-carnosine
|
Peptides
|
Inflammation/Immunology
|
N-Acetylcarnosine, a natural histidine-containing dipeptide, is a source of pharmacological principal L-carnosine. N-Acetylcarnosine is a potent ophthalmic agent in human cataracts .
|
-
- HY-W012159
-
H-MET-SER-OH
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
Methionylserine (H-MET-SER-OH) is a methionine- and serine-containing dipeptide. Methionylserine binds to and translocation via intestinal di/tri-peptide transporter 1 (hPEPT1) with a Km value of 0.2 mM. Methionylserine inhibits ACE enzyme activity. Methionylserine can be used in the research of hypension .
|
-
- HY-W014102
-
-
- HY-W014102R
-
|
Endogenous Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
L-Alanyl-L-glutamine (Standard) is the analytical standard of L-Alanyl-L-glutamine. This product is intended for research and analytical applications. L-Alanyl-L-glutamine, a glutamine dipeptide, is benefit for the antioxidant system, attenuating inflammation, and may modulate the heat shock protein (HSP) response in catabolic situations .
|
-
- HY-P4497
-
|
ERK
|
Cancer
|
Prolylserine, a dipeptide, is an inhibitor of melanogenesis production in Mel-Ab cells. Prolylserine decreases expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, induces phorphosylation of ERK, but not cAMP response element binding protein (CREB) .
|
-
- HY-P5033
-
|
Bacterial
|
Cancer
|
Cyclo(Gly-His) is a liposome-encapsulated cyclic dipeptide with antimicrobial and anticancer activity. Cyclo(Gly-His) has cytotoxicity for HeLa and MCF-7 cell with IC50 values of 1.699 mM and 0.358 mM, respectively. Cyclo(Gly-His) can be used for the research of drug delivery systems .
|
-
- HY-P1934A
-
|
Fungal
IFNAR
Reactive Oxygen Species
|
Infection
Inflammation/Immunology
Cancer
|
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
|
-
- HY-P4666
-
|
Peptides
|
Others
|
Valylhistidine is a dipeptide consisting of valine and histidine (Val-His). Valylhistidine forms a dipeptide complex with Cu(II) that mimics superoxide dismutase, but lacks activity .
|
-
- HY-P4274
-
|
Peptides
|
Others
|
Arginylmethionine is a dipeptide composed of arginine and methionine.
|
-
- HY-P5028
-
-
- HY-P5029
-
-
- HY-111659
-
|
Peptides
|
Others
|
His-Pro is a dipeptide consisting of histidyl and proline.
|
-
- HY-111659A
-
|
Peptides
|
Others
|
His-Pro hydrochloride is a dipeptide consisting of histidyl and proline.
|
-
- HY-131110
-
-
- HY-131111
-
-
- HY-131115
-
-
- HY-P4438
-
-
- HY-P4599
-
-
- HY-P5036
-
-
- HY-P4483
-
|
Peptides
|
Others
|
H-Pro-Arg-OH is a dipeptide composed of proline and arginine.
|
-
- HY-P2396
-
-
- HY-P2400
-
-
- HY-P2405
-
-
- HY-P2390
-
-
- HY-P2393
-
-
- HY-P2398
-
-
- HY-P2409
-
-
- HY-P2410
-
-
- HY-P2385
-
-
- HY-W048830
-
-
- HY-42709
-
-
- HY-W048825
-
|
Amino Acid Derivatives
|
Others
|
Fmoc-Ala-Ala-OH (3) is a self-assemble fluorenylmethoxycarbonyl-dipeptide, which is a smaller amphiphilic building blocks consists dipeptides linked to fluore nylmethoxycarbonyl (Fmoc). Fmoc-Ala-Ala-OH can be used as scaffold materials in 3D cell culture .
|
-
- HY-P2389
-
- HY-P2397
-
- HY-P2399
-
- HY-P2401
-
- HY-P2403
-
- HY-P2407
-
- HY-P2408
-
- HY-P2384
-
- HY-P2388
-
- HY-P2402
-
- HY-P2411
-
- HY-P2391
-
- HY-P2412
-
- HY-P2387
-
- HY-126584
-
Val-val
|
Peptides
|
Others
|
H-VAL-VAL-OH is a dipeptide of the amino acid valine, an essential amino acid .
|
- HY-128434
-
- HY-P2394
-
- HY-P5092
-
|
Peptides
|
Others
|
FA-Glu-Glu-OH is a dipeptide that can be used as an intermediate in peptide synthesis .
|
- HY-P4659
-
|
Peptides
|
Others
|
H-Val-Arg-OH is a dipeptide consisting of valine and arginine, used in biochemical research .
|
- HY-P4600
-
|
Peptides
|
Others
|
H-Ala-Arg-OH is an L-arginyl dipeptide that can be used as salt taste enhancer .
|
- HY-122794
-
Tyr-Leu
|
Peptides
|
Neurological Disease
|
Tyrosylleucine (Tyr-Leu, YL), an orally active dipeptide, exhibits a potent antidepressant-like activity .
|
- HY-P4356
-
- HY-P4280
-
- HY-122794A
-
Tyr-Leu TFA
|
Peptides
|
Neurological Disease
|
Tyrosylleucine (Tyr-Leu, YL) TFA, an orally active dipeptide, exhibits a potent antidepressant-like activity .
|
- HY-P4384
-
|
Peptides
|
Others
|
H-Leu-Ser-OH is a dipeptide formed from L-leucine and L-serine residues and is a metabolite .
|
- HY-P4276
-
|
Bacterial
|
Infection
|
Arg-Trp is a dipeptide composed of arginine and tryptophan, and analogues of Arg-Trp-octyl ester show antibacterial activity .
|
- HY-P5299
-
- HY-P4431
-
|
Amino Acid Derivatives
|
Others
|
H-Met-Asp-OH is a dipeptide containing methionine and aspartic acid, which can be used for the synthesis of polypeptides .
|
- HY-P4632
-
|
Peptides
|
Others
|
H-γ-Glu-Leu-OH is a dipeptide consisting of γ-glutamic acid and leucine, terminated by a hydroxyl group .
|
- HY-112173
-
- HY-P4288
-
|
Amino Acid Derivatives
|
Others
|
Beta-Asp-His is a dipeptide containing aspartic acid and histidine, which can form amino acid derivatives by complexing with Zinc .
|
- HY-P4253
-
|
VEGFR
|
Cardiovascular Disease
|
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .
|
- HY-W013494
-
- HY-P4511
-
|
Peptides
|
Infection
|
Serylleucine is a dipeptide. Serylleucine's core 1 o-glycosylated peptide (SLC1G) can be detected in urine as a metabolite and is a biomarker in TB studies .
|
- HY-P4658
-
|
Peptides
|
Others
|
H-Val-Ala-pNA is a substrate for the dipeptide aminopeptidase (DPAPase) of Streptococcus bovis. H-Val-Ala-pNA can be used to measure the activity of the protease .
|
- HY-P4553
-
|
Amino Acid Derivatives
|
Others
|
H-Met-Pro-OH is a dipeptide containing methionine and proline. H-Met-Pro-OH is a substrate for aminopeptidase P (APP) and skin fibroblast prolidase .
|
- HY-P4650
-
|
Peptides
|
Cardiovascular Disease
|
Tyrosylhistidine is a dipeptide consisting of tyrosine and histidine (Tyr-His). Tyrosylhistidine is an orally active antihypertensive peptide. Tyrosylhistidine reduces blood pressure in mice in a model of spontaneous hypertension .
|
- HY-P4654
-
- HY-P4559
-
|
Peptides
|
Others
|
H-Pro-Met-OH is a dipeptide containing proline and methionine, which can serve as a substrate for prolinase. H-Pro-Met-OH can also be used for the synthesis of polypeptides .
|
- HY-122381
-
|
Bacterial
Endogenous Metabolite
|
Neurological Disease
|
Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients .
|
- HY-148690
-
|
Bacterial
Fungal
|
Infection
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L18-MDP is a derivative of muramyl dipeptide, an antibacterial agent. L18-MDP has antibacterial activity and has potential applications in bacterial and fungal infections .
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- HY-P4558
-
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Peptides
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Others
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H-Pro-Lys-OH is a dipeptide containing proline and lysine, which can serve as a substrate for iminodipeptidase (prolinase). H-Pro-Lys-OH can also be used for the synthesis of polypeptides .
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- HY-P4313
-
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Peptides
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Others
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Asp-Val is a dipeptide formed from L-alpha-aspartyl and L-valine residues. Asp-Val has a role as a metabolite. Asp-Val can be isolated from an enzymatic hydrolysate of food proteins .
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- HY-105019
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Melphalan flufenamide
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DNA Alkylator/Crosslinker
Apoptosis
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Cancer
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Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .
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- HY-116486
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Phevalin
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Peptides
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Infection
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Aureusimine B (Phevalin) is a cyclic dipeptide. Aureusimine B can be produced by Staphylococcus aureus biofilms. Aureusimine B may be exploited as potential biomarker and/or therapeutic target for chronic, S. aureus biofilm-based infections .
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- HY-P4257
-
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Angiotensin-converting Enzyme (ACE)
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Cardiovascular Disease
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L-Isoleucyl-L-arginine is a dipeptide formed from L-isoleucine and L-arginine residues. L-Isoleucyl-L-arginine is a potent angiotensin-converting enzyme (ACE) inhibitor. L-Isoleucyl-L-arginine can be used for research of hypertension .
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- HY-122767
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Muroctasin
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Interleukin Related
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Inflammation/Immunology
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Romurtide (Muroctasin), a synthetic muramyl dipeptide derivative, is a cytokines inducer. Romurtide can increase peripheral neutrophils and monocytes in vivo and enhance production of colony-stimulating factors (CSFs), IL-1 and IL-6 in vitro .
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- HY-P4569
-
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Peptides
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Others
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H-Ser-Pro-OH is a dipeptide containing serine and proline, which can serve as a substrate for prolinase I (PD I) and PD II. H-Ser-Pro-OH can also be used for the synthesis of polypeptide .
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- HY-117110
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H-Arg-Pro-OH
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Peptides
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Metabolic Disease
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Arginylproline (H-Arg-Pro-OH) is a dipeptide consisted of arginine and proline. Arginylproline reduces intracellular triglyceride (TG) levels stimulated by Oleic acid (HY-N1446), through the peptide transporter 1 (PepT1) pathway .
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- HY-P3280
-
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Endogenous Metabolite
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Metabolic Disease
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γ-Glu-Gly, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids .
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- HY-P3280A
-
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Endogenous Metabolite
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Metabolic Disease
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γ-Glu-Gly TFA, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly TFA has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids .
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- HY-P4716
-
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Peptides
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Inflammation/Immunology
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Boc-D-Trp(For)-OH, containing the amino acid tryptophan, is synthesized by the ammonolysis of Boc-protected D-alanine, followed by cyclization to form a dipeptide with ninhydrin. Boc-D-Trp(For)-OH has pharmacological properties, including inhibition of growth hormone release, induction of sleep and antiinflammatory .
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- HY-P4522
-
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Endogenous Metabolite
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Others
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Bz-Ala-Arg is a dipeptide. Bz-Ala-Arg is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg can be used to screen competitive inhibitors of these two enzymes .
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- HY-P4439
-
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Amino Acid Derivatives
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Neurological Disease
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H-Met-Val-OH is a dipeptide containing free N-terminal methionine. H-Met-Val-OH exhibits activity against cDNA expressing Flavin-containing monooxygenase (FMO) 1 and FMO3. H-Met-Val-OH has potential applications in the growth of neuritis .
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- HY-P4554
-
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Endogenous Metabolite
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Metabolic Disease
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H-Phe-Arg-OH is a dipeptide containing phenylalanine and arginine. H-Phe-Arg-OH can be separated from Bradykinin (HY-P0206) through Angiotensin-converting enzyme (ACE, HY-P2983). H-Phe-Arg-OH can be used for metabolic research .
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- HY-P4566
-
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Peptides
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Others
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H-Pro-Val-OH is a deprotonation dipeptide containing proline, which can catalyze the Michael addition reaction of acetone to trans-β-nitrostyrene. H-Pro Val OH can also serve as a substrate for fibroblast enzymes and prolinase, and has potential applications in biochemical analysis .
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- HY-122357
-
|
Adenylate Cyclase
|
Inflammation/Immunology
|
Bestim is a dipeptide, which exhibits high affinity to murine peritoneal macrophages, thymocytes, and plasma membranes isolated from these cells, with Kds of 3.1, 2.1, 18.6 and 16.7 nM, respectively. Bestim inhibits adenylate cyclase in the membranes of murine macrophages and thymocytes. Bestim exhibits immunomodulatory efficacy .
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- HY-13718
-
H-Glu-Trp-OH; L-Glutamyl-L-tryptophan
|
VEGFR
HCV
Endogenous Metabolite
|
Infection
Cardiovascular Disease
Inflammation/Immunology
Cancer
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Oglufanide (H-Glu-Trp-OH) is a dipeptide immunomodulator isolated from calf thymus. Oglufanide inhibits vascular endothelial growth factor (VEGF). Oglufanide can stimulate the immune response to hepatitic C virus (HCV) and intracellular bacterial infections. Oglufanide shows antitumor and anti-angiogenesis activities .
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- HY-P4560
-
|
Angiotensin-converting Enzyme (ACE)
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Cardiovascular Disease
|
H-Pro-Phe-OH is a dipeptide containing proline and phenylalanine, which can serve as a substrate for prolinase. H-Pro-Phe-OH can also be used for polypeptide synthesis, where phenylalanine is an aromatic amino acid that can inhibit the activity of Angiotensin-converting enzyme (ACE, HY-P2983) .
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- HY-P4522A
-
|
Endogenous Metabolite
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Others
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Bz-Ala-Arg TFA is a dipeptide. Bz-Ala-Arg TFA is also a spectrophotometric substrate (0.4 M pyridine formate, pH 4.25) of human pancreatic carboxypeptidase B and plasma carboxypeptidase N. Bz-Ala-Arg TFA can be used to screen competitive inhibitors of these two enzymes .
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- HY-P4550
-
|
Endogenous Metabolite
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Metabolic Disease
|
H-Hyp-Gly-OH is a dipeptide containing hydroxyproline and glycine. H-Hyp-Gly-OH promotes the growth of mouse primary fibroblasts on collagen gel. H-Hyp-Gly-OH has potential applications in improving skin by ingesting hydrolyzed collagen. H-Hyp-Gly-OH can be used for metabolic research .
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- HY-P4531
-
|
Opioid Receptor
|
Neurological Disease
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H-Ser-Tyr-OH is a dipeptide consisting of glutamic acid, glycine and histidine. H-Ser-Tyr-OH can form a copper(II) complex with copper ions to form a strong free radical scavenging activity. H-Ser-Tyr-OH also increases the intracellular uptake of the delta opioid receptor ligand deltorphin .
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- HY-P4523
-
|
Endogenous Metabolite
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Endocrinology
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FA-Ala-Arg is a dipeptide with furylacryloyl group. FA-Ala-Arg breaks down to produce arginine. While cell-surface Carboxypeptidase-D (CPD) also increases intracellular Arg, which is converted to nitric oxide (NO). FA-Ala-Arg enhances NO production in MCF-7 cells. FA-Ala-Arg also increases the cell survival of prolactin (PRL)-treated cells, PRL regulates CPD mRNA levels in cells .
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- HY-P4641
-
|
Angiotensin-converting Enzyme (ACE)
|
Cardiovascular Disease
|
H-Trp-Phe-OH is a dipeptide consisting of tryptophan and phenylalanine (Trp-Phe). H-Trp-Phe-OH is also an antihypertensive peptide with inhibitory activity on angiotensin-converting enzyme (ACE), dose-dependently increases NO levels, and decreases endothelin-1 (ET-1) levels. H-Trp-Phe-OH (2 mg/kg; subcutaneous injection; 6 injections over 3 days) causes an increase in ovarian weight in female mice .
|
- HY-108743
-
|
Insulin Receptor
|
Endocrinology
|
Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes .
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- HY-108743R
-
|
Insulin Receptor
|
Endocrinology
|
Insulin degludec (Standard) is the analytical standard of Insulin degludec. This product is intended for research and analytical applications. Insulin degludec is an ultra-long-acting form of insulin used for the research of hyperglycemia caused by type 1 and type 2 dabetes. Insulin degludec shows binding efficiency with an IC50 value of 19.59 nM for insulin receptor. Insulin degludec can be used for the research of type 1 and type 2 diabetes .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99238
-
|
ADC Antibody
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Inflammation/Immunology
Cancer
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Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (C242, C242'). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (C242, C242') .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W013494S
-
|
L-Carnosine-d4 is the deuterium labeled L-Carnosine. L-Carnosine is a dipeptide of the amino acids beta-alanine and histidine and has the potential to suppress many of the biochemical changes that accompany aging.
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-
-
- HY-B0361S1
-
|
Aspartame-d5 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
|
-
-
- HY-B0361S
-
|
Aspartame-d3 is the deuterium labeled Aspartame. Aspartame (SC-18862) is a methyl ester of a dipeptide. Aspartame can be used as a synthetic nonnutritive sweetener. Aspartame is composed of phenylalanine (50%), aspartic acid (40%) and methanol (10%)[1][2].
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-
-
- HY-W008642S
-
|
(Leu-13C6,15N)-Leu-OH TFA is a C13 and N15 labeled Leu-Leu-OH TFA. Leu-Leu-OH, a Leu derivative, is a dipeptide .
|
-
-
- HY-15575S
-
|
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .
|
-
-
- HY-113354S
-
|
Anserine-d4 is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].
|
-
-
- HY-113354S1
-
|
Anserine-d4 hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .
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-
Cat. No. |
Product Name |
|
Classification |
-
- HY-147097A
-
|
|
Alkynes
|
EDA-DA is a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. EDA-DA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .
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-
- HY-147097
-
|
|
Alkynes
|
EDA-DA, a N-terminally tagged dipeptide probe, can be used to label Peptidoglycan (PG) of bacteria. Peptidoglycan (PG), an essential structure in the cell walls of the vast majority of bacteria, is critical for division and maintaining cell shape and hydrostatic pressure . EDA-DA is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
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