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coumarin derivative

" in MedChemExpress (MCE) Product Catalog:

47

Inhibitors & Agonists

10

Fluorescent Dye

16

Natural
Products

2

Isotope-Labeled Compounds

6

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0947
    (-)-Anomalin

    (-)-Praeruptorin B

    		 Others Inflammation/Immunology
    (-)-Anomalin ((-)-Praeruptorin B) is a coumarin derivative isolated from the root of Angelica anomala .
    (-)-Anomalin
  • HY-D0039
    3-Cyanoumbelliferone

    		Fluorescent Dye Others
    3-Cyanoumbelliferone is a coumarin derivative, acting as molecular probe and fluorescent dye. 3-Cyanoumbelliferone is also a macrophage migration inhibitory factor (MIF) tautomerase inhibitor with a Ki of 2.9 μM .
    3-Cyanoumbelliferone
  • HY-N8791
    Qianhucoumarin G

    		Others Others
    Qianhucoumarin G is a natural coumarin derivative found in Ligustici Radix .
    Qianhucoumarin G
  • HY-N11791
    Qianhucoumarin B

    		Others Others
    Qianhucoumarin B is a coumarin derivative. Qianhucoumarin B can be isolated from from the traditional Chinese medicine Qianhu, roots of Peucedanum praeruptorum .
    Qianhucoumarin B
  • HY-163397
    Antibacterial agent 196

    		Fungal Infection
    Antibacterial agent 196 (compound 6b) is a coumarin derivative containing oxime ether structure, and shows antifungal activity, with the EC50 of 0.46 μg/mL against Rhizoctonia solani .
    Antibacterial agent 196
  • HY-121930
    Coumarin 6H

    		Fluorescent Dye Inflammation/Immunology
    Coumarin 6H, a Coumarin (Coumarin (HY-N0709)) derivative, is a laser dye. The fluorescence emission of Coumarin 6H can be enhanced by hydrogen bonding interactions .
    Coumarin 6H
  • HY-A0145
    Phenprocoumon

    		Others Others
    Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
    Phenprocoumon
  • HY-156304
    Coumarin-C2-TCO

    		Fluorescent Dye Others
    Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-C2-TCO
  • HY-156303
    Coumarin-PEG2-TCO

    		Fluorescent Dye Others
    Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-PEG2-TCO
  • HY-156306
    Coumarin-PEG3-TCO

    		Fluorescent Dye Others
    Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
    Coumarin-PEG3-TCO
  • HY-156309
    Coumarin-PEG8-tetrazine

    		Fluorescent Dye Others
    Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Coumarin-PEG8-tetrazine
  • HY-N6657
    7-Hydroxy-4-methyl-8-nitrocoumarin

    		Others Cancer
    7-Hydroxy-4-methyl-8-nitrocoumarin is a coumarin derivative .
    7-Hydroxy-4-methyl-8-nitrocoumarin
  • HY-128410
    4-Phenyl-7,8-dihydroxycoumarin

    		Others Inflammation/Immunology
    4-Phenyl-7,8-dihydroxycoumarin is a coumarin derivative and can be used for bronchiectasiss research .
    4-Phenyl-7,8-dihydroxycoumarin
  • HY-109714
    3,4-Benzocoumarin

    		Others Inflammation/Immunology
    3,4-Benzocoumarin is a kind of the expanded structure of coumarin derivatives.Coumarin is a chemical compound in the benzopyrone chemical class that can be found in many natural species. Coumarins possess variety of biological activities and unique photophysical properties . 3,4-Benzocoumarin, a AOH‐like compound , has the sensibility of the antibody with an IC50 of 919.2 ng/mL .
    3,4-Benzocoumarin
  • HY-121770
    Rutarin

    		Others Others
    Rutarin is a Coumarin (HY-N0709) derivative, that can be isolated from the aerial parts of the plant Atalantta racemosa .
    Rutarin
  • HY-156305
    Coumarin-C2-exo-BCN

    		Fluorescent Dye Others
    Coumarin-C2-exoBCN is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-exoBCN contains the lyophilic bidentate macrocyclic ligand exo-BCN, which can further synthesize macrocyclic complexes. In click chemistry, exo-BCN can react with molecules containing azide groups to generate stable triazoles under catalyst-free conditions.
    Coumarin-C2-exo-BCN
  • HY-155095
    DNA polymerase-IN-4

    		Others Infection
    DNA polymerase-IN-4 (Compd 5c), a coumarin derivative, has antiretroviral activity with IC50 value of 134.22 μM .
    DNA polymerase-IN-4
  • HY-101887
    Calcein Blue
    1 Publications Verification

    		 Fluorescent Dye Others
    Calcein Blue, a membrane-impermeant fluorescent dye, is a coumarin derivative that contains an iminodiacetic acid structure. Calcein Blue is also a metallofluorochromic indicator .
    Calcein Blue
  • HY-Y1298
    Methyl acetylacetate
    1 Publications Verification

    Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl acetoacetate

    		 Endogenous Metabolite Metabolic Disease
    Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
    Methyl acetylacetate
  • HY-129605
    Ferulenol

    		Oxidative Phosphorylation Mitochondrial Metabolism Infection
    Ferulenol, a sesquiterpene prenylated coumarin derivative, specifically inhibits succinate ubiquinone reductase at the level of the ubiquinonecycle. Ferulenol shows good antimycobacterial activity and haemorrhagic action .
    Ferulenol
  • HY-149828
    MTHFD2-IN-4

    		Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    MTHFD2-IN-4, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 can be used in research of cancer .
    MTHFD2-IN-4
  • HY-149828A
    MTHFD2-IN-4 sodium

    		Methylenetetrahydrofolate Dehydrogenase (MTHFD) Cancer
    MTHFD2-IN-4 sodium, tricyclic coumarin derivative, is a potent MTHFD2 inhibitor. MTHFD2-IN-4 sodium can be used in research of cancer .
    MTHFD2-IN-4 sodium
  • HY-155094
    DNA polymerase-IN-3

    		DNA/RNA Synthesis Others
    DNA polymerase-IN-3 (Compd 5b) is a coumarin derivative that exhibits inhibitory activity against Taq DNA polymerase and can be used in proliferative disease research .
    DNA polymerase-IN-3
  • HY-N7650
    Dihydroseselin

    		Biochemical Assay Reagents Others
    Dihydroseselin is a derivative of 7-hydroxycoumarin (HY-N0573). 7-hydroxycoumarin, a natural product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent
    Dihydroseselin
  • HY-W027544
    MCA

    		Fluorescent Dye Others
    MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities .
    MCA
  • HY-N4102
    5,7-Dihydroxy-4-methylcoumarin

    		Fungal Bacterial Infection
    5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities .
    5,7-Dihydroxy-4-methylcoumarin
  • HY-N4288
    4-Methylesculetin

    		Glutathione Peroxidase Inflammation/Immunology Cancer
    4-Methylesculetin is an orally active natural coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level .
    4-Methylesculetin
  • HY-W014081
    Ethyl 3-coumarincarboxylate

    Ethyl 2-oxo-2H-chromene-3-carboxylate

    		 Others Others
    Ethyl 3-coumarincarboxylate is a coumarin derivative. Ethyl 3-coumarincarboxylate can be used as a pseudo-template to give a molecularly imprinted polymer (MIP) that has a fairly specific recognition capability for aflatoxins .
    Ethyl 3-coumarincarboxylate
  • HY-D0092
    7-Ethoxy-4-methylcoumarin

    		Cytochrome P450 Others
    7-Ethoxy-4-methylcoumarin is a coumarin derivative and can be used as a substrate probe of mammalian cytochromes P450 1A1, 2B4 and 2B6 .
    7-Ethoxy-4-methylcoumarin
  • HY-155092
    DNA polymerase-IN-2

    		DNA/RNA Synthesis Others
    DNA polymerase-IN-2 (Compd 3c), a coumarin derivative, exhibits inhibitory activity against Taq DNA polymerase with IC50 of 48.25 μM , which can be used in value-added disease research .
    DNA polymerase-IN-2
  • HY-Y1298R
    Methyl acetylacetate (Standard)

    Acetoacetate methyl ester (Standard); Methyl 3-oxobutanoate (Standard); Methyl acetoacetate (Standard)

    		 Endogenous Metabolite Metabolic Disease
    Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is a chemical reagent used in the synthesis of pharmaceuticals for the synthesis of α-substituted acetoacetate and cyclic compounds such as pyrazole, pyrimidine, and coumarin derivatives .
    Methyl acetylacetate (Standard)
  • HY-N12875
    Ailancoumarin E

    		Tyrosinase Others
    Ailancoumarin E (Compound 5) is a derivative of Coumarin (HY-N0709). Ailancoumarin E exhibits antifeedant activity toward Plutella xylostella, and inhibits growth of third instar larva. Ailancoumarin E inhibits tyrosinase with IC50 of 14.21 μM .
    Ailancoumarin E
  • HY-W030319
    Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate

    		Fluorescent Dye Others
    Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate, a natural coumarins derivative, is exploited for the synthesis of the switchable fluorescent substrates to be used in bacterial enzyme detection .
    Methyl 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetate
  • HY-146305
    α-Glucosidase-IN-4

    		Glucosidase Infection Cardiovascular Disease Others Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
    α-Glucosidase-IN-4 is a reversible and mixed type α-glucosidase inhibitor with an IC50 of 12.98 μM, a KI of 27.02 μM, and a KIS of 13.65 μM, respectively .
    α-Glucosidase-IN-4
  • HY-D1085
    AMCA-X SE

    		Fluorescent Dye Others
    AMCA-X-SE is a coumarin derivative that generates fixed blue fluorescence and an NHS-activated ester that forms stable amide bonds with primary amine groups. It is used as a reactive dye for labeling amino groups of peptides, proteins, and oligonucleotides. Maximum excitation/emission wavelength: 354/442 nm .
    AMCA-X SE
  • HY-N9630
    Qianhucoumarin C

    		Others Others
    Qianhucoumarin C is a coumarin derivative, which can be isolated from the roots of Peucedanum praeruptorum. Qianhuoumarin C has been studied for potential medicinal properties, including anti-inflammatory, antioxidant and anticancer effects. Qianhucoumarin C is an important ingredient in a variety of industrial processes, especially in the production of pharmaceuticals and herbal medicines .
    Qianhucoumarin C
  • HY-N4286
    4-Methyldaphnetin

    		Apoptosis Cancer
    4-Methyldaphnetin is a precursor in the synthesis of derivatives of 4-methyl coumarin. 4-Methyldaphnetin has potent, selective anti-proliferative and apoptosis-inducing effects on several cancer cell lines. 4-Methyldaphnetin possesses radical scavenging property and strongly inhibits membrane lipid peroxidation .
    4-Methyldaphnetin
  • HY-N8618
    Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol

    		Others Others
    Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol was identified as one of the phenolic compounds isolated from Canadian maple syrup (MS-BuOH). It exhibited antioxidant properties along with other phenolic compounds and coumarins isolated from the syrup. These compounds showed varying degrees of antioxidant activity, with phenolic derivatives and coumarins showing superior activity, more so than lignans and flavonoids. This study marks the first time that 16 of the 23 phenolic compounds, including Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol, have been identified in maple syrup .
    Erythro-guaiacylglycerol-β-O-4'-dihydroconiferyl alcohol
  • HY-D0128
    4-Methylherniarin

    7-Methoxy-4-methylcoumarin

    		 Bacterial Infection
    4-Methylherniarin (7-Methoxy-4-methylcoumarin) is a coumarin derivative and fluorescent label, has an antimicrobial activitiy against both gram positive and gram negative bacterial stains. 4-Methylherniarin displays good activity against B. subtilis and S.sonnei with IC50 values of 11.76 μg/ml and 13.47 μg/ml .
    4-Methylherniarin
  • HY-N6856
    4-Hydroxycoumarin

    		Bacterial Endogenous Metabolite Infection
    4-Hydroxycoumarin is an orally active coumarin derivative, one of the most versatile heterocyclic scaffolds, often used in the synthesis of various organic compounds. 4-Hydroxycoumarin possesses both electrophilic and nucleophilic properties. 4-Hydroxycoumarin is an HIV protease inhibitor and tyrosine kinase inhibitor. 4-Hydroxycoumarin has anti-inflammatory, antibacterial and anti-tumor effects .
    4-Hydroxycoumarin
  • HY-W027544S
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3

    7-Methoxy-d3-2-oxo-2H-1-benzopyran-4-acetic acid; 7-Methoxy-d3-2H-chromen-2-one-4-acetic acid

    		 Isotope-Labeled Compounds Others
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3].
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d3
  • HY-163457
    Antileishmanial agent-27

    		Aminoacyl-tRNA Synthetase Parasite Infection
    Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC50 values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .
    Antileishmanial agent-27
  • HY-76779
    4-(Chloromethyl)-7-hydroxycoumarin

    		Others Cancer
    4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII .
    4-(Chloromethyl)-7-hydroxycoumarin
  • HY-157992
    LM-021

    		Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species Neurological Disease Inflammation/Immunology
    LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of caspase 1 activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research .
    LM-021
  • HY-158402
    Anti-inflammatory agent 84

    		Bacterial Fungal Infection Inflammation/Immunology
    Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
    Anti-inflammatory agent 84
  • HY-N0281
    Daphnetin
    3 Publications Verification

    7,8-Dihydroxycoumarin

    		 EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite Inflammation/Immunology Cancer
    Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
    Daphnetin
  • HY-W027544S1
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6

    5-(Dimethyl-d6-amino)-N-(prop-2-ynyl)naphthalene-1-sulfonamide

    		 Isotope-Labeled Compounds Others
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is the deuterium labeled MCA[1]. MCA is a coumarin derivative. MCA quantitates platelet-activating factor by high-performance liquid chromatography with fluorescent detection. MCA can modify FRET peptide substrates for analyzing protease activities[2][3]. (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (7-Methoxy-2-oxo-2H-chromen-4-yl)-acetic acid-d6

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