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Results for "

cooling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (2) Drug Metabolite (1) GABA Receptor (1) Isotope-Labeled Compounds (2) TRP Channel (4)
By Research Areas:	Cancer (3) Inflammation/Immunology (2) Neurological Disease (6)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130074

FEMA 4809	TRP Channel	Neurological Disease
FEMA 4809 is a TRPM8 receptor agonist (EC₅₀=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception .

HY-11062

Icilin AG-3-5	TRP Channel	Neurological Disease Inflammation/Immunology
Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC₅₀=1.4 μM). Icilin is a “super-cooling agent” . Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response .

HY-108449

Acoltremon WS-12; AR-15512; AVX-012	TRP Channel	Cancer
Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research .

HY-116813

ZK 93423

GABA Receptor Neurological Disease

ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents .

ZK 93423	GABA Receptor	Neurological Disease
ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents .

HY-N1369S

Menthol-d4	Isotope-Labeled Compounds Calcium Channel	Neurological Disease
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes[1].

HY-N1369

Menthol 4 Publications Verification	Calcium Channel	Neurological Disease Cancer
Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-N9484S

Menthofuran-13C2	Drug Metabolite Isotope-Labeled Compounds	Others
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1369

Menthol 4 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	Calcium Channel
Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-N8264

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

Cat. No.	Product Name	Chemical Structure

HY-N1369S

Menthol-d4
Menthol-d₄ is the deuterium labeled Menthol. Menthol is a natural analgesic compound. Menthol could cause a feeling of coolness due to stimulation of ‘cold’ receptors by inhibiting Ca++ currents of neuronal membranes[1].

HY-N9484S

Menthofuran-13C2
Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

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