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Results for "

bimatoprost

" in MedChemExpress (MCE) Product Catalog:

22

Inhibitors & Agonists

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0191
    Bimatoprost

    AGN 192024

    		 Prostaglandin Receptor Endocrinology
    Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
    <em>Bimatoprost</em>
  • HY-125774
    Bimatoprost acid

    17-Phenyl trinor PGF2α

    		 Prostaglandin Receptor Others
    Bimatoprost acid (17-Phenyl trinor PGF2α), the acid hydrolysis product of Bimatoprost (HY-B0191), is a potent agonist of prostaglandin FP receptor .
    <em>Bimatoprost</em> acid
  • HY-139419
    Bimatoprost grenod

    NCX 470

    		 Prostaglandin Receptor Neurological Disease
    Bimatoprost grenod (NCX 470) is a second-generation nitric oxide (NO)-donating prostaglandin analogue. Bimatoprost grenod effectively lowers intraocular pressure (IOP) in animal models of ocular hypertension and glaucoma by activating bimatoprost-mediated uveoscleral outflow and NO mediated conventional outflow. Bimatoprost grenod can be used for the research of cular hypertension and glaucoma .
    <em>Bimatoprost</em> grenod
  • HY-B0191B
    Bimatoprost methyl ester

    		Others Endocrinology
    Bimatoprost methyl ester is a proagent of Bimatoprost (HY-B0191) .
    <em>Bimatoprost</em> methyl ester
  • HY-B0191S1
    Bimatoprost-d4

    AGN 192024-d4

    		 Prostaglandin Receptor Endocrinology
    Bimatoprost-d4 is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension.
    <em>Bimatoprost</em>-d4
  • HY-B0191S
    Bimatoprost-d5

    AGN 192024 d5

    		 Prostaglandin Receptor Endocrinology
    Bimatoprost-d5 is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect[1][2].
    <em>Bimatoprost</em>-d5
  • HY-120467
    Bima SA

    bimatoprost serinol amide

    		 Prostaglandin Receptor Endocrinology
    Bima SA (Bimatoprost serinol amide) is a Prostaglandin analog and has the potential for the research of glaucoma .
    <em>Bima</em> SA
  • HY-125774S
    Bimatoprost acid-d4

    17-Phenyl trinor PGF2α-d4

    		 Isotope-Labeled Compounds Others
    Bimatoprost acid-d4 (17-Phenyl trinor PGF2α-d4) is the deuterium labeled Bimatoprost acid[1].
    <em>Bimatoprost</em> acid-d4
  • HY-149554
    17-Phenyl trinor Prostaglandin F2α dimethyl amide

    bimatoprost dimethyl amide

    		 Others Neurological Disease
    17-Phenyl trinor Prostaglandin F2α dimethyl amide (Bimatoprost dimethyl amide), a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) derivative, is a smooth muscle relaxant. 17-Phenyl trinor Prostaglandin F2α dimethyl amide has the potential for glaucoma research .
    17-Phenyl trinor Prostaglandin F2α dimethyl amide
  • HY-116161
    Bimatoprost isopropyl ester

    		Others Others
    15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC50 values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.
    <em>Bimatoprost</em> isopropyl ester
  • HY-B0191C
    N-Desethyl Bimatoprost

    		Drug Metabolite Others
    N-Desethyl Bimatoprost is a N-desethyl metabolite of Bimatoprost (HY-B0191) .
    N-Desethyl <em>Bimatoprost</em>
  • HY-132277
    15-Keto Bimatoprost

    		Others Endocrinology
    15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive .
    15-Keto <em>Bimatoprost</em>
  • HY-114867
    (15R)-Bimatoprost

    15(R)-17-phenyl trinor PGF2α ethyl amide

    		 Others Endocrinology
    (15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to treat glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15 .
    (15R)-<em>Bimatoprost</em>
  • HY-132277S
    15-Keto Bimatoprost-d5

    		Isotope-Labeled Compounds Others
    15-Keto Bimatoprost-d5 is the deuterium labeled 15-Keto Bimatoprost. 15-Keto Bimatoprost is a prostaglandin F2α (PGF2α) analog that can be used for the research of ocular hypotensive[1][2].
    15-Keto <em>Bimatoprost</em>-d5
  • HY-124241
    N-Cyclopropyl bimatoprost

    		Prostaglandin Receptor Inflammation/Immunology
    N-Cyclopropyl bimatoprost (Formula II), a prostaglandin analog, can be used in the study of epithelial-related conditions .
    N-Cyclopropyl <em>bimatoprost</em>
  • HY-124243
    N-Cyclopropyl methyl bimatoprost

    17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide

    		 Prostaglandin Receptor Others
    N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .
    N-Cyclopropyl methyl <em>bimatoprost</em>
  • HY-B0191A
    5,6-trans-Bimatoprost

    5,6-trans-AGN 192024

    		 Others Endocrinology Cancer
    5,6-trans-Bimatoprost is the isomer of Bimatoprost (HY-B0191), and can be used as an experimental control. Bimatoprost is a prostaglandin analogue that can be used in studies of ocular hypertension and glaucoma and also has anti-fat formation effects.
    5,6-trans-<em>Bimatoprost</em>
  • HY-139121
    15(R)-17-Phenyl trinor Prostaglandin F2α

    15-epi bimatoprost free acid; 15(R)-bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α

    		 Prostaglandin Receptor Endocrinology
    17-phenyl trinor Prostaglandin F2α (17-phenyl trinor PGF2α) N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive agent. Investigations in our lab have shown that 17-phenyl trinor PGF2α ethyl amide is converted by an amidase enzymatic activity in the human cornea to yield the corresponding free acid, with a conversion rate of about 25 μg/cornea/24 hr. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist. 15(R)-17-phenyl trinor PGF2α is the 15-epi, or “unnatural” isomer of this active free acid metabolite. It has much diminished FP receptor-mediated activity, which is generally 1.5 to 2 logs less than the 15(S)-isomer. In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity.
    15(R)-17-Phenyl trinor Prostaglandin F2α
  • HY-116161A
    17-Phenyl trinor PGF2α isopropyl ester

    		Prostaglandin Receptor Endocrinology
    17-phenyl trinor PGF2α N-ethyl amide is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name Bimatoprost.1 The N-ethyl amide prostaglandin prodrugs are converted to the active free acid more slowly than the analogous prostaglandin ester prodrugs such as latanoprost.2 This product is the isopropyl ester of the free acid prostaglandin which corresponds to Bimatoprost. The free acid, 17-phenyl trinor PGF2α, is a potent FP receptor agonist.3 In human and animal models of glaucoma, FP receptor agonist activity corresponds very closely with intraocular hypotensive activity. The 17-phenyl trinor PGF2α isopropyl ester derivative is examined for IOP-lowering activity during the development of latanoprost.4 At the dose of 3 μg/eye in the monkey, 17-phenyl trinor PGF2α isopropyl ester is the most potent analog tested in reducing IOP, lowering the IOP 1.3 mm Hg below the level achieved by latanoprost. However, this derivative is also significantly more irritating to the eye than latanoprost.
    17-Phenyl trinor PGF2α isopropyl ester
  • HY-118599
    Prostaglandin F2α ethyl amide

    		Others Others
    Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) .
    Prostaglandin F2α ethyl amide
  • HY-113778
    15-keto-17-phenyl trinor Prostaglandin F2α

    15-keto-17-phenyl trinor PGF2α

    		 Prostaglandin Receptor Endocrinology
    Bimatoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.1 Oxidation of the C-15 hydroxyl group and amide hydrolysis of Bimatoprost produces 15-keto-17-phenyl trinor PGF2α. 15-keto-17-phenyl trinor PGF2α is a potential metabolite of bimatoprost when administered to animals. 15-keto PG analogs are potential minor impurities in commercial preparations of their corresponding bulk drug compounds. Although much less potent that the parent compound, 15-keto PGs still retain the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.2 15-keto Latanoprost (15-keto-17-phenyl-13,14-dihydro trinor PGF2α isopropyl ester) is a miotic in the normal cat eye, causing an 8 mm reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type PGs; for example, PGF2α will produce this degree of miosis at a dose of less than 1 μg/eye.
    15-keto-17-phenyl trinor Prostaglandin F2α
  • HY-124219
    17-Phenoxy trinor prostaglandin F2α ethyl amide

    17-Phenoxy trinor PGF2α ethyl amide

    		 Prostaglandin Receptor Others
    17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .
    17-Phenoxy trinor prostaglandin F2α ethyl amide

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