basis

By Targets:	Akt (1) Apoptosis (1) Autophagy (1) Bcl-2 Family (1) Biochemical Assay Reagents (5) Caspase (1) MMP (2) Nucleoside Antimetabolite/Analog (1) P-glycoprotein (1) p38 MAPK (1) PARP (1) Thymidylate Synthase (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W073196

*Gold(Ⅲ) chloride hydrate (48% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)	Biochemical Assay Reagents	Others
Gold(Ⅲ) chloride hydrate (48% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)) can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (48% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W073196A

*Gold(Ⅲ) chloride hydrate (50% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)	Biochemical Assay Reagents	Others
Gold(Ⅲ) chloride hydrate (50% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (50% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W073196B

*Gold(Ⅲ) chloride hydrate (52% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)	Biochemical Assay Reagents	Others
Gold(Ⅲ) chloride hydrate (52% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (52% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-Y1220D

Anhydrous potassium carbonate, 99.995% metals basis	Biochemical Assay Reagents	Others
Anhydrous potassium carbonate, 99.995% metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y0537C

Potassium chloride, ≥99.99% trace metals basis Potassium chloride, suitable for the extraction and solubilization of proteins	Biochemical Assay Reagents	Others
Potassium chloride, ≥99.99% trace metals basis is a biochemical assay reagent suitable for protein extraction and solubilization.

HY-139452

PFB-FDGlu	Others	Others
PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis .

HY-W540600

Thaumatins	Others	Others
Thaumatins is a protein, which can be purified from the fruit of Thaumatococcus daniellii Benth. Thaumatins is 100,000 times sweeter than sucrose on a molar basis .

HY-110046

CL-82198 hydrochloride	MMP	Others
CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE .

HY-100359

CL-82198 4 Publications Verification	MMP	Inflammation/Immunology Cancer
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs . CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression .

HY-16478

Trifluridine/tipiracil hydrochloride mixture 1 Publications Verification TAS-102; FTD/TPI	Nucleoside Antimetabolite/Analog Thymidylate Synthase	Cancer
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .

HY-W747548

12(S)-HEPE	Others	Inflammation/Immunology
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis	Cancer
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

Cat. No.	Product Name

HY-L136

Coagulation and Anti-coagulation Compound Library	971 compounds
Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation. Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process. MCE supplies a unique collection of 971 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Coagulation and Anti-coagulation Compound Library

971 compounds

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 971 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

Cat. No.	Product Name	Type

HY-W073196

*Gold(Ⅲ) chloride hydrate (48% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)	Biochemical Assay Reagents
Gold(Ⅲ) chloride hydrate (48% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (48% Au basis)) can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (48% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W073196A

*Gold(Ⅲ) chloride hydrate (50% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)	Biochemical Assay Reagents
Gold(Ⅲ) chloride hydrate (50% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (50% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (50% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-W073196B

*Gold(Ⅲ) chloride hydrate (52% Au basis)* Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)	Biochemical Assay Reagents
Gold(Ⅲ) chloride hydrate (52% Au basis) (Tetrachloroauric(Ⅲ) acid hydrate (52% Au basis)) is an organic intermediate that can be used to prepare gold nanoparticles. Gold(Ⅲ) chloride hydrate (52% Au basis) is a kind of biological materials or organic compounds that are widely used in life science research .

HY-ER013B

Sodium carbonate anhydrous, 99.999% trace metals basis Calcined soda 99.999% trace metals basis	Buffer Reagents
Sodium carbonate anhydrous, 99.999% trace metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y1220D

Anhydrous potassium carbonate, 99.995% metals basis	Biochemical Assay Reagents
Anhydrous potassium carbonate, 99.995% metals basis is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Y0537C

Potassium chloride, ≥99.99% trace metals basis Potassium chloride, suitable for the extraction and solubilization of proteins	Buffer Reagents
Potassium chloride, ≥99.99% trace metals basis is a biochemical assay reagent suitable for protein extraction and solubilization.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3584

Paris saponin VII 2 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Source classification Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-W540600

Thaumatins	Marantaceae Thaumatococcus daniellii (Benn.) Benth. Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Plants Disease Research Fields Sweeteners Food Research	Others
Thaumatins is a protein, which can be purified from the fruit of Thaumatococcus daniellii Benth. Thaumatins is 100,000 times sweeter than sucrose on a molar basis .

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