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Sortilin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurotensin Receptor (6)
By Research Areas:	Cancer (2) Metabolic Disease (1) Neurological Disease (4)

7

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Recombinant Proteins

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Sortilin antagonist 1	Neurotensin Receptor	Neurological Disease
Sortilin antagonist 1 (compound 44) is a *sortilin* antagonist with an IC₅₀ value of 20 nM for inhibiting Neurotensin (NTS) binds to sortilin. Neurotensin is a sortilin ligand. Sortilin antagonist 1 can be used for the research of neurological disease .

SORT-PGRN interaction inhibitor 1	Neurotensin Receptor	Neurological Disease
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC₅₀ of 2 μM .

Latozinemab AL001	Neurotensin Receptor	Cancer
Latozinemab (AL001) is a recombinant human *anti-Sortilin* monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research .

AF40431	Neurotensin Receptor	Neurological Disease
AF40431, the first reported small-molecule ligand of sortilin, has an IC₅₀ of 4.4 µM and a K_d of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin .

HY-12802

AF38469

5+ Cited Publications

Neurotensin Receptor Neurological Disease

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC₅₀ value of 330 nM.
HY-139668

VGD071

Neurotensin Receptor Cancer

VGD071, a sortilin-targeting compound, is a promising candidate for future studies using mouse breast cancer models.

3-Sulfo-taurocholic Acid Disodium Salt 3-Sulfocholyl Taurine; TCA3S	Others	Metabolic Disease
3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine; TCA3S) is a metabolite of the conjugated bile acid taurocholic acid. Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL.

Cat. No.	Product Name	Target	Research Area

Latozinemab AL001	Neurotensin Receptor	Cancer
Latozinemab (AL001) is a recombinant human *anti-Sortilin* monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research .

Cat. No.	Compare	Product Name	Species	Source

	Sortilin/SORT1 Protein, Human (HEK293, His) Sortilin; SORT1; 100 kDa NT receptor; Glycoprotein 95; Gp95; Gp95LDLCQ6; Neurotensin receptor 3; NT3NTR3; Ntr3; Sortilin 1;	Human	HEK293
	The Sortilin/SORT1 protein acts as a sorting receptor in the Golgi apparatus and as a clearance receptor on the cell surface. It plays a crucial role in protein transport to lysosomes, independent of M6PR. Sortilin/SORT1 Protein, Human (HEK293, His) is the recombinant human-derived Sortilin/SORT1 protein, expressed by HEK293 , with C-His labeled tag.

Cat. No.	Compare	Product Name	Application	Reactivity

	Sortilin Antibody (YA3243) 100 kDa NT receptor; Glycoprotein 95; Gp95; LDLCQ6; Neurotensin receptor 3; NT3; NTR3; SORT 1; Sortilin 1	WB, IHC-P	Human, Rat
	Sortilin Antibody (YA3243) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA3243), targeting Sortilin, with a predicted molecular weight of 92 kDa (observed band size: 92 kDa). Sortilin Antibody (YA3243) can be used for WB, IHC-P experiment in human, rat background.

	SorLA Antibody (YA2310) SORL1; C11orf32; Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; LDLR relative with 11 ligand-binding repeats; LR11; SorLA-1; Sorting protein-related receptor containing LDLR class A repe	WB, IHC-P	Human, Mouse, Rat
	SorLA Antibody (YA2310) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2310), targeting SorLA, with a predicted molecular weight of 248 kDa (observed band size: 270 kDa). SorLA Antibody (YA2310) can be used for WB, IHC-P experiment in human, mouse, rat background.

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