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Results for "

PX-20606

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100443A
    trans-PX20606
    1 Publications Verification

    trans-PX-102

    		 FXR Autophagy Metabolic Disease
    PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively .
    trans-<em>PX20606</em>
  • HY-100443
    PX20606

    PX-102

    		 FXR Cancer
    PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy .
    <em>PX20606</em>
  • HY-100443B
    (-)-PX20606 (trans isomer)

    (-)-PX-102 (trans isomer); (-)-PX-104

    		 FXR Autophagy Metabolic Disease
    (-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 and 29 nM for FXR in FRET and M1H assay, respectively.
    (-)-<em>PX20606</em> (trans isomer)

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