Search Result
Results for "
Oxidizing
" in MedChemExpress (MCE) Product Catalog:
14
Biochemical Assay Reagents
11
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B2224
-
|
HIV
Endogenous Metabolite
|
Infection
Metabolic Disease
|
Thiamine disulfide, a vitamin B1 derivative, is an oxidized dimer of Thiamine. Thiamine disulfide is a potent HIV-1 inhibitor. Thiamine disulfide significantly depresses HIV-1 transactivator (Tat) activity .
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-
-
- HY-129457
-
FINO2
2 Publications Verification
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Ferroptosis
|
Cancer
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FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation .
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-
-
- HY-125365
-
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Bacterial
Reactive Oxygen Species
Antibiotic
|
Infection
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Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .
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-
-
- HY-125554
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-
-
- HY-149066
-
|
Bacterial
|
Infection
Cancer
|
Diaporthein B is one of the most highly oxidized pimarane diterpenes. Diaporthein B exhibits activity against M. tuberculosis, with a MIC of 3.1 μg/mL. Diaporthein B reveals IC50s of 1.5-3 μM against HCT 116 and LoVo colon cancer cells .
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-
-
- HY-B0840
-
|
Parasite
Oxidative Phosphorylation
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Metabolic Disease
|
Chlorfenapyr is a pyrrole insecticide. Chlorfenapyr has a mode of action: the mixed function oxidase oxidizes and removes the Nethoxymethyl group to form the active metabolite, CL 303268. Chlorfenapyr is used for termite control and crop protection against a variety of insect and mite pests .
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-
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- HY-Y1242
-
|
Biochemical Assay Reagents
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Others
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Choline hydroxide is a Choline hydrogen oxidized derivative and a strong organic base, can be used as the standard alkaline to adjust the pH of the medium. Choline is an orally active nutrient, serves as an important component of lecithin and sphingomyelin, promotes fat metabolism .
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-
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- HY-W127679
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Bis(tetrabutylammonium) (dichromate) [Oxidizing Reagent]
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Biochemical Assay Reagents
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Others
|
Bis(tetrabutylammonium) Dichromate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-D0844
-
L-Glutathione oxidized; GSSG; Oxiglutatione
|
Endogenous Metabolite
Reactive Oxygen Species
|
Metabolic Disease
|
Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .
|
-
-
- HY-150260
-
|
Bacterial
|
Infection
|
SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn(II)-thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance .
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-
-
- HY-D0844S
-
L-Glutathione oxidized-13C4,15N2; GSSG-13C4,15N2; Oxiglutatione-13C4,15N2
|
Endogenous Metabolite
Reactive Oxygen Species
|
Metabolic Disease
|
Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes[1][2].
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-
-
- HY-B0959
-
|
Bacterial
|
Infection
|
Chloramine-T is a titrimetric reagent, and an oxidizing agent. Chloramine-T is an oxidizing biocide .
|
-
-
- HY-NP013
-
Mouse ox-LDL
|
LDLR
|
Cardiovascular Disease
|
Oxidized low density lipoprotein (mouse) is an oxidized low density lipoprotein (LDL). Oxidized low density lipoprotein (mouse) induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration .
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-
-
- HY-137888A
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oATP trisodium salt
|
P2X Receptor
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis .
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-
-
- HY-113303
-
|
Endogenous Metabolite
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Neurological Disease
Cancer
|
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases .
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-
-
- HY-77839
-
-
-
- HY-15917S
-
DTT-d10
|
Isotope-Labeled Compounds
|
Others
|
DL-dithiothreitol-d10 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
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-
-
- HY-15917S2
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DTT-d6
|
Isotope-Labeled Compounds
|
Others
|
DL-dithiothreitol-d6 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
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-
-
- HY-15917S1
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DTTl-d10-1
|
Isotope-Labeled Compounds
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Others
|
DL-dithiothreitol-d10-1 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
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-
-
- HY-D1740
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DHTM Ros
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Fluorescent Dye
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Others
|
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.
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-
-
- HY-107260
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-
-
- HY-P99793
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MLDL1278A
|
LDLR
|
Inflammation/Immunology
|
Orticumab (MLDL1278A) is an antibody targeting to oxidized or malondialdehyde-modified lipoprotein (LDL). Orticumab specifically inhibits oxidized low-density lipoproteins (oxLDL). Orticumab involves in modulation of autoimmune responses against oxLDL, improves atherosclerosis in animal model. Orticumab also can be used for research of psoriasis improvement .
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-
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- HY-12590
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-
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- HY-101885
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Biotinamidocaproyl hydrazide; BACH; (+)-Biotinamidohexanoic Acid hydrazide; Biotin Aminocaproyl Hydrazide
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Biochemical Assay Reagents
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Others
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Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins.
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-
-
- HY-101541
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Methyl docosahexaenoate; all cis-DHA methyl ester
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Others
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Neurological Disease
|
Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
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-
-
- HY-125859
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-
-
- HY-15917
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DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
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Biochemical Assay Reagents
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Others
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DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized.
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-
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- HY-113291
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-
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- HY-N10518
-
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Others
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Others
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Celloheptaose is an oligosaccharide, consisting of seven glucose residues. Celloheptaose is the substrate of Polysaccharide monooxygenases (PMOs), to generate oxidized cellulo-oligosaccharides .
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-
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- HY-113485
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Melanin
1 Publications Verification
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Endogenous Metabolite
|
Others
|
Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.
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-
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- HY-N11642
-
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Others
|
Others
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Ganodermacetal is a highly oxidized lanostane triterpene, that can be isolated from G. amboinense. Ganodermacetal shows a marked toxicity to brine shrimp larvae .
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- HY-29035
-
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Others
|
Others
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Dopamine acrylamide, a polyphenol derivative, can cross-link collagen mainly via noncovalent bonding under acidic-non-oxidized conditions .
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-
-
- HY-134154
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PAzePC; Azelaoyl PC; 1-Palmitoyl-2-Azelaoyl PC
|
Endogenous Metabolite
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Metabolic Disease
|
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC (Azelaoyl PC) is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.
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-
-
- HY-115666
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-
-
- HY-105935
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Cyanidin 3-rutinoside chloride; Cyanidin 3-O-rutinoside chloride; Sambucin chloride
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Others
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Others
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Keracyanin chloride (Cyanidin 3-rutinoside chloride), an anthocyanin, has antioxidant activity. Keracyanin chloride inhibits malonaldehyde formation in oxidized calf thymus DNA .
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-
-
- HY-126181
-
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Endogenous Metabolite
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Others
|
5-Formylcytosine is a modified base, which is oxidized from 5-methylcytosine. 5-Formylcytosine is a intermediate of in the active DNA demethylation .
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-
-
- HY-114695
-
-
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- HY-105840
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p-Toluenesulfondichloramide
|
Bacterial
|
Infection
|
Dichloramine-T is a strong oxidizer and disinfectant, with strong oxidation and sterilization. Dichloramine-T is also widely used in the medical and health field for disinfection and sterilization operations .
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-
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- HY-124355
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-
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- HY-D1301
-
|
Fluorescent Dye
Ferroptosis
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Metabolic Disease
Inflammation/Immunology
Cancer
|
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .
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- HY-D1055
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MitoSOX Red
Maximum Cited Publications
39 Publications Verification
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Fluorescent Dye
Reactive Oxygen Species
Mitochondrial Metabolism
|
Cancer
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MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red. Excitation/emission wavelength: 510/580 nm.
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- HY-113262
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-
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- HY-113325A
-
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Endogenous Metabolite
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Others
|
NADP sodium hydrate, a β-Nicotinamide adenine dinucleotide phosphate sodium salt, is a redox cofactor. NADP sodium hydrate is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH) .
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-
- HY-N1346
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Robinin
2 Publications Verification
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Toll-like Receptor (TLR)
Apoptosis
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Inflammation/Immunology
|
Robinin is a flavonoid that can be extracted from the leaves of purple cowpea, inhibiting TGF-β, TLR4/NF-κB and TLR2-PI3k-AKT signaling pathways. Robinin exerts anti-inflammatory and anti-tumor effects. The combination of Robinin and Methotrexate (HY-14519) reduces inflammation in experimental arthritis, Robinin can decrease the Doxorubicin (HY-15142A) induced cardiac toxicity effect .
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- HY-N8531
-
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Others
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Others
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4α-Methylcholesterol is a Cholesterol derivative. 4α-Methylcholesterol can oxidize 3-hydroxy steroid, with the apparent Km of 12.6 μM .
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-
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- HY-11000A
-
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Phosphatase
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Cancer
|
CaMKP inhibitor sodium (compound 5) is an inhibitor of Ca 2+/neutral protein-dependent protein concentration (CaMKP) and its nuclear type (CaMKP-N) (IC50: 6.4 μM, CaMKP; 6.6 μM, CaMKP-N). CaMKP is one type of Ser/Thr protein, which can be passed through to remove the oxidized oxidized protein (CaMK). CaMKP inhibitor sodium inhibits CaMKP mediated phospho-CaMKI hydrolysis, unaffectes protein phosphoric acid 2C (PP2C) and calcineurin (CaN) .
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-
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- HY-141636
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1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4)
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Others
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Cardiovascular Disease
|
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.
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- HY-131933
-
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Others
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Others
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DCP-Bio3 is a biotinylated probe that can detect labeled proteins in polyacrylamide gels. DCP-Bio3 can be used in research for the identification of oxidized and modified proteins .
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-
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- HY-W011690
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-
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- HY-137131
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DC-Cholesterol hydrochloride
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Amyloid-β
Liposome
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Neurological Disease
|
DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner .
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- HY-130576
-
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Apoptosis
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Cardiovascular Disease
|
POVPC is an oxidized phospholipid can be found in in oxidatively modified low density lipoprotein (oxLDL). POVPC inhibits VSMC growth in high serum condition. POVPC induces apoptosis in low serum condition .
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- HY-154857
-
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Others
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Cancer
|
1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine is a glycerophosphorylcholine, consisting of glycerol phosphate, choline and palmitic acid. It accumulates in vivo at sites of oxidative stress. 1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine may be a ligand of scavenger receptors class B, while oxidized phospholipids oxPC(CD36) are potent ligands of scavenger receptors class B (CD36 and SR-BI). Oxidized phospholipids (oxPLs) also play an important role in tumor apoptosis, may be elevated in malignant biliary strictures .
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- HY-129770
-
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Endogenous Metabolite
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Metabolic Disease
|
D-methionine sulfoxide is the D-isomer of Methionine sulfoxide. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins , which is easily oxidized during the course of storage or processing .
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- HY-129770A
-
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Others
|
Metabolic Disease
|
D-methionine sulfoxide hydrochloride is the D-isomer of Methionine sulfoxide hydrochloride. Methionine sulfoxide is an oxidation product of methionine. Methionine is the limiting amino acid in milk or leguminous proteins, which is easily oxidized during the course of storage or processing .
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- HY-17461A
-
Cortisone 21-acetate
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
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- HY-W012145
-
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Others
|
Metabolic Disease
|
TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases . TMPD dihydrochloride is also a complex IV substrate .
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- HY-W038786
-
|
Others
|
Others
|
2,4,6-Trimethylphenol is a probe compound shown to react mainly with organic matter ( 3DOM *). 2,4,6-Trimethylphenol is rapidly oxidized by singlet oxygen in aqueous solution .
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-
- HY-101541S
-
Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5
|
Isotope-Labeled Compounds
|
Neurological Disease
|
Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].
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- HY-W015777
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P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol
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Biochemical Assay Reagents
|
Others
|
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water .
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- HY-Y0531
-
1-Adamantanol
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Biochemical Assay Reagents
|
Others
|
1-Adamantanol is a cyclic molecule with a hydroxyl group that can be used as an intermediate in the synthesis of adamantane. 1-Adamantanol can be oxidized to 1,3-adamantanediol by the Streptomyces SA8 oxidation system .
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- HY-107469
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Pyridoxaldehyde
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Endogenous Metabolite
|
Metabolic Disease
|
Pyridoxal is one of the major forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine .
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-
- HY-139414
-
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Interleukin Related
p38 MAPK
ERK
Apoptosis
|
Inflammation/Immunology
|
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .
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-
- HY-132188
-
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Endogenous Metabolite
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Others
|
Manganese peroxidase is a heme protein that oxidizes Mn2+ to Mn3+. Manganese peroxidase catalyzes plant lignin de-polymerization. Manganese peroxidase can be used for the biodegradation of hazardous environmental contaminants, and especially for dye wastewater decolorization .
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- HY-17461
-
17-Hydroxy-11-dehydrocorticosterone; Kendall's compound E
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
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- HY-116722
-
-
- HY-W196803
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Propyl Disulfide; DPDS
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Others
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Others
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Dipropyl disulfide is oxidized to dipropyl thiosulfinate (DPDSO) by rat microsomes. Both flavincontaining monooxygenases (FMO) and cytochrome P450 enzymes (CYPs) are involved in dipropyl disulfide oxidation. Dipropyl disulfide forms two metabolites: propylglutathione sulfide conjugate and propylthiol .
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-
- HY-23999
-
|
LOX-1
|
Cardiovascular Disease
|
BI-0115 is a selective inhibitor of LOX-1 (IC50=5.4 µM) that blocks cellular uptake of oxLDL. BI-0115 binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain .
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-
- HY-N6773
-
|
HIV Protease
Fungal
|
Infection
|
Cytochalasin A is a cell-permeable fungal toxin that is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50=3 μM) and inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhydryl groups. Antibiotic and fungicidal activitives .
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-
- HY-W040307
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L-Saccharopine
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Endogenous Metabolite
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Metabolic Disease
|
Saccharopine (L-Saccharopine), a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine by the lysine-ketoglutarate reductase. Saccharopine is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine impairs development by disrupting mitochondrial homeostasis .
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- HY-W011690S
-
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Endogenous Metabolite
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Metabolic Disease
|
L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
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-
- HY-W040307B
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L-Saccharopine hydrochloride
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Endogenous Metabolite
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Metabolic Disease
|
Saccharopine (L-Saccharopine) hydrochloride, a lysine degradation intermediate, is a mitochondrial toxin. Lysine and α-ketoglutarate are converted into Saccharopine hydrochloride by the lysine-ketoglutarate reductase. Saccharopine hydrochloride is then oxidized to α-aminoapidate semialdehyde and glutamate by the saccharopine dehydrogenase. Saccharopine hydrochloride impairs development by disrupting mitochondrial homeostasis .
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- HY-W027446
-
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Endogenous Metabolite
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Metabolic Disease
|
Pyridoxal hydrochloride is the hydrochloride form of Pyridoxal (HY-107469). Pyridoxal is one of the major forms of vitamin B6. Pyridoxal is phosphorylated by pyridoxal kinase to Pyridoxal phosphate (HY-B1744). Pyridoxal is oxidized by the liver to 4-Pyridoxic acid (HY-113493) which is excreted in the urine .
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- HY-N0428
-
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Apoptosis
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Cancer
|
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .
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-
- HY-149502
-
8-Iso(15R)PGF2α; 15(R)-8-Iso-PGF2α
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Prostaglandin Receptor
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Metabolic Disease
|
8-Iso-15(R)-prostaglandin F2α (8-Iso(15R)PGF2α), a type of eicosanoid, is a oxidized metabolite of Prostaglandin F2α (PGF2α) .
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- HY-126726
-
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Biochemical Assay Reagents
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Others
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Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species that are cytotoxic and proatherogenic. Many of these species were recently isolated and purified from oxLDL and identified as phosphatidylcholine species containing fragmented oxidized short-chain fatty acid residues at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine or KOdiA-PC is one of the most potent CD36 ligands of the oxLDL species. KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle and may be one of the more important structural determinants of oxLDL.
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-
- HY-160637
-
-
- HY-W615108B
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NMNH, reduced form disodium
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Endogenous Metabolite
|
Cancer
|
β-Nicotinamide mononucleotide, reduced form disodium (β-NMN) is the oxidized form of NAD+ precursor and is a NAD+ enhancer. β-Nicotinamide mononucleotide, reduced form disodium can be reduced to dihydronicotinamide mononucleotide (NMNH). NMNH inhibits glycolysis, TCA cycle, and cell growth .
|
-
- HY-113325
-
NADP
4 Publications Verification
|
Endogenous Metabolite
|
Others
|
NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .
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-
- HY-17461AR
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Cortisone 21-acetate (Standard)
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone acetate (Standard) is the analytical standard of Cortisone acetate. This product is intended for research and analytical applications. Cortisone acetate (Cortisone 21-acetate), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acetate acts as an immunosuppressant and anti-inflammatory agent. Cortisone acetate can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
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-
- HY-W739812
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Finasteride carboxylic acid
|
Others
|
Cancer
|
Carboxy finasteride is a metabolite of the 5α-reductase inhibitor Finasteride (HY-13635). Finasteride is biotransformed by cytochrome P450 (CYP3A4) and is successively oxidized to Hydroxy finasteride and Carboxy finasteride. Carboxy finasteride is the major metabolite in urine, while Hydroxy finasteride is the major metabolite in plasma .
|
-
- HY-17461S2
-
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone-d7 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
|
-
- HY-17461S1
-
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
|
-
- HY-135895
-
-
- HY-B1386
-
|
Bacterial
Carbonic Anhydrase
Sodium Channel
|
Infection
|
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a Kd value of 1.45 µM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .
|
-
- HY-N0416
-
-
- HY-N1881
-
|
Lipoxygenase
Glucosidase
|
Others
|
4',5-Dihydroxyflavone is a soybean LOX-1 and yeast α-Glucosidase inhibitor, with an Ki of 102.6 μM for soybean LOX-1 and an IC50 of 66 μM for yeast α-glucosidase. LOX-1 isshort for Lectin-like oxidized low-density lipoprotein receptor-1.
|
-
- HY-17461S
-
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone- 13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
|
-
- HY-W001187
-
Tempo
2 Publications Verification
|
Mitochondrial Metabolism
DNA/RNA Synthesis
Reactive Oxygen Species
|
Cancer
|
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .
|
-
- HY-17461S3
-
17-Hydroxy-11-dehydrocorticosterone-d2; Kendall's compound E-d2
|
Isotope-Labeled Compounds
Glucocorticoid Receptor
Endogenous Metabolite
|
Endocrinology
|
Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].
|
-
- HY-B0445A
-
β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .
|
-
- HY-N10638
-
|
Reactive Oxygen Species
NF-κB
|
Inflammation/Immunology
|
N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity .
|
-
- HY-17461R
-
17-Hydroxy-11-dehydrocorticosterone(Standard); Kendall's compound E (Standard)
|
Glucocorticoid Receptor
Endogenous Metabolite
|
Inflammation/Immunology
Endocrinology
|
Cortisone (Standard) is the analytical standard of Cortisone. This product is intended for research and analytical applications. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations .
|
-
- HY-123016
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
9(S)-HODE cholesteryl ester is originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.2 9(S)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
|
-
- HY-123341
-
9-KODE
|
Endogenous Metabolite
|
Metabolic Disease
|
9-OxoODE results from oxidation of the allylic hydroxyl of either 9(S)- or 9(R)-HODE. Rabbit reticulocyte plasma and mitochondrial membranes contain both 9- and 13-oxoODEs, representing about 2% of the total linoleate residues in the membranes. Most of these oxidized linoleate residues are esterified to membrane lipids.
|
-
- HY-125394
-
|
Endogenous Metabolite
|
Cardiovascular Disease
|
9(R)-HODE cholesteryl ester is originally extracted from atherosclerotic lesions. It remains uncertain whether the oxidized fatty acid portion of the molecule results from enzymatic lipoxygenation or from random lipid peroxidation.2 9(R)-HODE cholesteryl ester can be used as a standard for analysis of chiral HODE cholesteryl esters.
|
-
- HY-F0002
-
Sodium NADP
|
Endogenous Metabolite
|
Others
|
NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .
|
-
- HY-D2041
-
|
Fluorescent Dye
|
Cancer
|
3-HTC is a chemical fluorescent probe. 3-HTC reacts reversibly with thiols and disulfides, and can be used to measure dynamic GSH/GSSH ratios in vitro as well as to monitor the reversible redox status of whole cell lysates (λmax: 448 nm in its reduced thiolate form, and a λmax 370-410 nm for the oxidized mixed disulfide) .
|
-
- HY-F0002A
-
Disodium NADP
|
Endogenous Metabolite
|
Others
|
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP +) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .
|
-
- HY-135416
-
|
Endogenous Metabolite
|
Infection
|
Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .
|
-
- HY-W038786S
-
|
Isotope-Labeled Compounds
|
Others
|
2,4,6-Trimethylphenol-d11 is the deuterium labeled 2,4,6-Trimethylphenol[1]. 2,4,6-Trimethylphenol is a probe compound shown to react mainly with organic matter (3DOM*). 2,4,6-Trimethylphenol is rapidly oxidized by singlet oxygen in aqueous solution[2][3].
|
-
- HY-156081
-
|
Keap1-Nrf2
Apoptosis
|
Metabolic Disease
|
Nrf2 activator-9 (compound D-36) is an Nrf2 activator that inhibits oxidized low-density lipoprotein (oxLDL) and high glucose (HG)-induced apoptosis in HUVEC cells. Nrf2 activator-9 inhibits oxLDL and HG-induced vascular endothelial cell (VEC) injury and can effectively prevent and treat atherosclerosis .
|
-
- HY-W247098
-
DHR 6G
|
Reactive Oxygen Species
|
Cancer
|
Dihydrorhodamine 6G (DHR 6G) is the reduced form of Rhodamine 6G, which is used as fluorescent mitochondrial dye. It is nonfluorescent, but it readily enters most of the cells and is oxidized by oxidative species or by cellular redox systems to the fluorescent rhodamine 6G that accumulates in mitochondrial membranes. Dihydrorhodamine 6G is useful for detecting reactive oxygen species (ROS) including superoxide .
|
-
- HY-N5132
-
|
Others
|
Others
|
(-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .
|
-
- HY-W015788
-
Styrene Glycol
|
Others
|
Others
|
1-Phenylethane-1,2-diol is a typical benzyl diol compound. 1-Phenylethane-1,2-diol can be oxidized to hydroxyl ketone (2-hydroxy-1-phenylethan-1-one) selectively with variety of catalysts, including organocatalysts, metal complexes, non-noble metal oxides, bimetallics .
|
-
- HY-126833
-
|
Endogenous Metabolite
|
Infection
Cancer
|
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.
|
-
- HY-153812
-
AST070
|
Others
|
Metabolic Disease
|
AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration .
|
-
- HY-P2833
-
GSH-Px; EC 1.11.1.9
|
Glutathione Peroxidase
|
Others
|
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H2O. Glutathione Peroxidase is an effective antioxidant against oxidative stress .
|
-
- HY-126003
-
|
Aldehyde Dehydrogenase (ALDH)
|
Cancer
|
ALDH1A1-IN-2 is a potent inhibitor of aldehyde dehydrogenase 1a1 (aldh1a1). Aldehyde dehydrogenases (ALDH) constitute a family of enzymes that play a critical role in oxidizing various cytotoxic xenogenic and biogenic aldehydes. ALDH1A1-IN-2 has the potential for the research of cancer, inflammation, or obesity (extracted from patent WO2019089626A1, compound 295) .
|
-
- HY-157084
-
|
ROS Kinase
Bacterial
|
Infection
|
HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb .
|
-
- HY-126833A
-
|
Endogenous Metabolite
|
Infection
Cancer
|
Myristoyl coenzyme A lithium is lithium-labeled myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.
|
-
- HY-154635
-
|
Biochemical Assay Reagents
|
Others
|
Oxidized paraffin (calcium) can be used as an excipient, such as ointment base, hardening agent. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
|
-
- HY-15932
-
TOOS sodium salt
|
Biochemical Assay Reagents
|
Others
|
TOOS (TOOS sodium salt) is a highly water-soluble aniline derivative widely used in diagnostics and biological experiments. TOOS can be combined with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) to form a chromogenic system to measure oxidase activity. In the MBTH-TOOS chromogenic system, MBTH is catalytically oxidized to produce (-NH) free radicals, which react with TOOS to form colorless compounds. Furthermore, the colorless compound undergoes a disproportionation reaction to produce a blue-violet quinoid compound .
|
-
- HY-135416A
-
|
Endogenous Metabolite
|
Infection
|
Streptolysin O (≥1000000 units/mg) is a ≥1000000 units/mg Streptolysin O (HY-135416). Streptolysin O, a group A streptococcal toxin, is a well-characterized oxygen-labile prototype of a cholesterol-binding bacterial exotoxin. Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .
|
-
- HY-145491
-
|
ERK
NF-κB
|
Inflammation/Immunology
|
Resolvin D5 is a prolytic mediator (SPM) with anti-inflammatory activity derived from oxidized lipids DHA. Resolvin D5 inhibits Th17 cell differentiation and promotes regulatory T cell differentiation, and inhibits CD4+ T cell proliferation. Resolvin D5 attenuates osteoclast differentiation and interferes with osteoclastogenesis. Resolvin D5 also regulates ERK phosphorylation and nuclear translocation of NF-kappaB. Resolvin D5 could be used in rheumatoid arthritis research .
|
-
- HY-143243
-
|
Apoptosis
NF-κB
Keap1-Nrf2
Reactive Oxygen Species
|
Cardiovascular Disease
|
Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway .
|
-
- HY-W018324
-
5hmC
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development .
|
-
- HY-W750595
-
|
Others
|
Cancer
|
6-(L-1,2,3-Trihydroxybutyl)-pterin is a derivative of L-biopterin (HY-102015) and is the oxidized form of tetrahydro-L-biopterin (BH4) as well as D-biopterin. Co-ingestion of 6-(L-1,2,3-Trihydroxybutyl)-pterin (0.5%) with the carcinogen 4-dimethylaminoazobenzene reduces the incidence of 4-dimethylaminoazobenzene-induced liver tumors in rats. 6-(L-1,2,3-Trihydroxybutyl)-pterin has been used as an internal standard for the LC-MS quantification of biopterin and neopterin in rat plasma.
|
-
- HY-N11009
-
|
EBV
|
Infection
|
11-Oxomogroside II A1 (compound 7) is an oxidized cucurbitin. It can be isolated from the ethanol extract of Rohanberry fruit. 11-Oxomogroside II A1 inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). 11-Oxomogroside II A1 also weakly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor .
|
-
- HY-145538
-
5'-Deoxyguanylic acid disodium hydrate
|
DNA/RNA Synthesis
|
Others
|
2'-Deoxyguanosine 5'-monophosphate (5'-Deoxyguanylic acid; dGMP) disodium hydrate is an oxidizable target of the photosensitizer pterin (PT) and can be used to evaluate the photosensitizing properties of biopterins (such as Bip, Fop and Cap) . Pterin causes a photosensitive reaction of dGMP under UV-A radiation, causing damage to DNA molecules. There are two main mechanisms for the photosensitive oxidation of purine nucleotides by pterin in vitro: one is the hydrogen abstraction reaction of electron transfer from dGMP to the triplet excited state of pterin (type I mechanism), and the other is the interaction between dGMP and pterin. The reaction produces singlet molecular oxygen (1O2) (Type II mechanism) .
|
-
- HY-136410
-
|
Endogenous Metabolite
|
Metabolic Disease
|
4-hydroxy Nonenal Mercapturic Acid (4-HNE) is generated by the peroxidation of common ω-6 polyunsaturated fatty acids (PUFAs) such as linoleic acid, DGLA, and arachidonic acid. 4-hydroxy Nonenal Mercapturic Acid is rapidly cleared from plasma and enters the enterohepatic circulation in rats as a glutathione conjugate. Approximately two-thirds of 4-hydroxy Nonenal Mercapturic Acid is excreted in the urine within 48 hours, primarily as mercapturic acid conjugates. Approximately half of the metabolites are C-1 aldehydes of 4-hydroxy Nonenal Mercapturic Acid that are reduced to alcohols. The remainder are C-1 aldehydes or have been oxidized to C-1 carboxylic acids. These aldehydes and carboxylic acids can also form gamma-lactols and gamma-lactones, respectively, resulting in at least four or five final urinary metabolites of 4-HNE in vivo.
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D1301
-
|
Fluorescent Dyes/Probes
|
BODIPY 581/591 C11 is a BODIPY borofluoroprene derivative with good light stability and low fluorescence artifacts. BODIPY 581/591 C11 can be used for study lipid peroxidation and antioxidant properties in living cells, or detect ferroptosis by reaction with hydroxyl radicals. BODIPY 581/591 C11 is emitted at 591 nm (reduced prototype), or redshifted to 510 nm (oxidized type). The excitation wavelengths were 581 nm (reduced prototype) and 500 nm (oxidized type) .
|
-
- HY-D1055
-
|
Fluorescent Dyes/Probes
|
MitoSOX Red is a live cell fluorescent probe that specifically targets mitochondria and is cell membrane permeable. MitoSOX Red enters mitochondria and is oxidized by superoxide but not by other ROS or RNS generating systems. The oxidized MitoSOX Red then binds to nucleic acids in mitochondria/nucleus, producing strong red fluorescence. MitoSOX Red can be used as a fluorescent indicator to specifically detect superoxide. In addition, superoxide dismutase (SOD) can prevent the oxidation of MitoSOX Red. Excitation/emission wavelength: 510/580 nm.
|
-
- HY-D1740
-
DHTM Ros
|
Fluorescent Dyes/Probes
|
Dihydrotetramethylrosamine (DHTM Ros) is a fluorogenic substrate for peroxidase that oxidizes to fluorescent tetramethylrosamine chloride.
|
-
- HY-D2041
-
|
Fluorescent Dyes/Probes
|
3-HTC is a chemical fluorescent probe. 3-HTC reacts reversibly with thiols and disulfides, and can be used to measure dynamic GSH/GSSH ratios in vitro as well as to monitor the reversible redox status of whole cell lysates (λmax: 448 nm in its reduced thiolate form, and a λmax 370-410 nm for the oxidized mixed disulfide) .
|
Cat. No. |
Product Name |
Type |
-
- HY-101885
-
Biotinamidocaproyl hydrazide; BACH; (+)-Biotinamidohexanoic Acid hydrazide; Biotin Aminocaproyl Hydrazide
|
Biochemical Assay Reagents
|
Biotin LC hydrazide is a long chain protein modification reagent, which can transform periodate-oxidized glycoproteins.
|
-
- HY-125859
-
|
Biochemical Assay Reagents
|
Peroxidase, Horseradish actively involves in oxidizing reactive oxygen species, innate immunity, hormone biosynthesis and pathogenesis of several diseases .
|
-
- HY-15917
-
DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
|
Biochemical Assay Reagents
|
DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized.
|
-
- HY-W127679
-
Bis(tetrabutylammonium) (dichromate) [Oxidizing Reagent]
|
Biochemical Assay Reagents
|
Bis(tetrabutylammonium) Dichromate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-NP013
-
Mouse ox-LDL
|
Native Proteins
|
Oxidized low density lipoprotein (mouse) is an oxidized low density lipoprotein (LDL). Oxidized low density lipoprotein (mouse) induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration .
|
-
- HY-W110791
-
|
Biochemical Assay Reagents
|
Sodium diphenylamine-4-sulfonate is a oxidation-reduction titration indicator. Sodium diphenylamine-4-sulfonate shows a colourless reduced form and a red-violet oxidized form .
|
-
- HY-137131
-
DC-Cholesterol hydrochloride
|
Drug Delivery
|
DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner .
|
-
- HY-W015777
-
P-Methoxy-benzyl alcoho; (4-Methoxyphenyl)methanol
|
Biochemical Assay Reagents
|
4-Methoxybenzyl alcohol (P-Methoxy-benzyl alcohol; (4-Methoxyphenyl)methanol) is a Benzyl alcohol (HY-B0892) derivative, which is photocatalytically oxidized into p-anisaldehyde (PAA) in water .
|
-
- HY-Y0531
-
1-Adamantanol
|
Biochemical Assay Reagents
|
1-Adamantanol is a cyclic molecule with a hydroxyl group that can be used as an intermediate in the synthesis of adamantane. 1-Adamantanol can be oxidized to 1,3-adamantanediol by the Streptomyces SA8 oxidation system .
|
-
- HY-139414
-
|
Biochemical Assay Reagents
|
Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis .
|
-
- HY-126726
-
|
Biochemical Assay Reagents
|
Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species that are cytotoxic and proatherogenic. Many of these species were recently isolated and purified from oxLDL and identified as phosphatidylcholine species containing fragmented oxidized short-chain fatty acid residues at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine or KOdiA-PC is one of the most potent CD36 ligands of the oxLDL species. KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle and may be one of the more important structural determinants of oxLDL.
|
-
- HY-B0445A
-
β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium
|
Biochemical Assay Reagents
|
NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .
|
-
- HY-126833
-
|
Biochemical Assay Reagents
|
Myristoyl coenzyme A is a myristoylated coenzyme A (CoA). Myristoylation is an essential process in viruses and is generally controlled by N-myristoyltransferase (NMT). And NMT is more active in colon epithelial tumors than in normal cells. Reduced Ccoenzyme A (CoA) is known to be a key regulator of NMT activity, whereas oxidized CoA does not allow NMT to promote myristoylation. Myristoyl coenzyme A blocks the demyristoylation process and has potential anticancer and antiviral mechanisms.
|
-
- HY-15932
-
TOOS sodium salt
|
Biochemical Assay Reagents
|
TOOS (TOOS sodium salt) is a highly water-soluble aniline derivative widely used in diagnostics and biological experiments. TOOS can be combined with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) to form a chromogenic system to measure oxidase activity. In the MBTH-TOOS chromogenic system, MBTH is catalytically oxidized to produce (-NH) free radicals, which react with TOOS to form colorless compounds. Furthermore, the colorless compound undergoes a disproportionation reaction to produce a blue-violet quinoid compound .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-D0844
-
L-Glutathione oxidized; GSSG; Oxiglutatione
|
Endogenous Metabolite
Reactive Oxygen Species
|
Metabolic Disease
|
Glutathione oxidized (L-Glutathione oxidized) is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes .
|
-
- HY-12590
-
-
- HY-139093
-
|
Peptides
|
Others
|
Paracetamol-cysteine is a Paracetamol-cysteine Paracetamol protein adduct (PPA) and is formed when paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .
|
-
- HY-K2006
-
1 Publications Verification
|
Sensitive ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems.
|
-
- HY-K2005
-
1 Publications Verification
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High Sensitivity ECL Kit enables low picogram detection of antigen by oxidizing luminol in the presence of HRP and peroxide. This reaction produces a prolonged chemiluminescence which can be visualized on X-ray film or digital imaging systems.
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- HY-K0311
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MCE GSH/GSSG Assay Kit is suitable for the quantitative determination of reduced and oxidized glutathione (GSH/GSSG) in whole blood, plasma, serum, urine, and tissue and cell extracts.
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- HY-K1501
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MCE NADP+/NADPH Assay Kit (WST-8) is a colorimetric assay that conveniently detects the oxidized (NADP+) and reduced (NADPH) forms of coenzyme Ⅱ within cells, tissues, and other samples.
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- HY-K0313
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MCE NAD+/NADH Assay Kit (WST-8) is a colorimetric assay that conveniently detects the oxidized (NAD+) and reduced (NADH) forms of coenzyme Ⅰ within cells, tissues, and other samples.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99793
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MLDL1278A
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LDLR
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Inflammation/Immunology
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Orticumab (MLDL1278A) is an antibody targeting to oxidized or malondialdehyde-modified lipoprotein (LDL). Orticumab specifically inhibits oxidized low-density lipoproteins (oxLDL). Orticumab involves in modulation of autoimmune responses against oxLDL, improves atherosclerosis in animal model. Orticumab also can be used for research of psoriasis improvement .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
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- HY-D0844S
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1 Publications Verification
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Glutathione oxidized- 13C4, 15N2 is the 13C and 15N labeled Glutathione oxidized (HY-D0844). Glutathione oxidized is produced by the oxidation of glutathione. Detoxification of reactive oxygen species is accompanied by production of glutathione oxidized. Glutathione oxidized can be used for the research of sickle cells and erythrocytes[1][2].
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- HY-15917S2
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DL-dithiothreitol-d6 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
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- HY-15917S
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DL-dithiothreitol-d10 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
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- HY-15917S1
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DL-dithiothreitol-d10-1 is the deuterium labeled DL-dithiothreitol[1]. DL-dithiothreitol (DTT) is a reducing agent. DL-dithiothreitol forms a stable six-membered ring with an internal disulfide bond once oxidized[2].
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- HY-101541S
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Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].
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- HY-W011690S
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L-Homocystine-d8 is the deuterium labeled L-Homocystine. L-Homocystine is the oxidized member of the L-homocysteine. Homocysteine is a pro-thrombotic factor, vasodilation impairing agent, pro-inflammatory factor and endoplasmatic reticulum-stress inducer used to study cardiovascular disease mechanisms.
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- HY-17461S2
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Cortisone-d7 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
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- HY-17461S1
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Cortisone-d8 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
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- HY-17461S
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Cortisone- 13C3 is the 13C-labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4].
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- HY-17461S3
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Cortisone-d2 is the deuterium labeled Cortisone. Cortisone (17-Hydroxy-11-dehydrocorticosterone), an oxidized metabolite of Cortisol (a Glucocorticoid). Cortisone acts as an immunosuppressant and anti-inflammatory agent. Cortisone can partially intervene in binding of Glucocorticoid to Glucocorticoid-receptor at high concentrations[1][3][4][5].
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- HY-W038786S
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2,4,6-Trimethylphenol-d11 is the deuterium labeled 2,4,6-Trimethylphenol[1]. 2,4,6-Trimethylphenol is a probe compound shown to react mainly with organic matter (3DOM*). 2,4,6-Trimethylphenol is rapidly oxidized by singlet oxygen in aqueous solution[2][3].
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