Search Result

Pathways Recommended:	NF-κB

Results for "

IκB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IKK (22) Akt (2) Antibiotic (1) Apoptosis (14) Aryl Hydrocarbon Receptor (1) Autophagy (4) Bacterial (5) Bcl-2 Family (1) Calcium Channel (1) Caspase (2) COX (4) Deubiquitinase (1) E1/E2/E3 Enzyme (2) Endogenous Metabolite (4) ERK (1) Ferroptosis (1) FGFR (1) Fungal (2) HIV (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (2) JNK (1) Leukotriene Receptor (1) LRRK2 (2) MAP3K (1) MEK (1) Mitophagy (1) MMP (1) NF-κB (34) NO Synthase (2) NOD-like Receptor (NLR) (1) p38 MAPK (2) Parasite (2) PARP (1) Phosphodiesterase (PDE) (4) PI3K (1) PKA (1) PPAR (1) Proteasome (4) PTEN (1) Reactive Oxygen Species (2) SARS-CoV (1) Sodium Channel (3) STAT (1) TNF Receptor (5) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (25) Cardiovascular Disease (4) Infection (3) Inflammation/Immunology (50) Metabolic Disease (4) Neurological Disease (7)

By Targets:

IKK (22)

Akt (2)

Antibiotic (1)

Apoptosis (14)

Aryl Hydrocarbon Receptor (1)

Autophagy (4)

Bacterial (5)

Bcl-2 Family (1)

Calcium Channel (1)

Caspase (2)

COX (4)

Deubiquitinase (1)

E1/E2/E3 Enzyme (2)

Endogenous Metabolite (4)

ERK (1)

Ferroptosis (1)

FGFR (1)

Fungal (2)

HIV (1)

Influenza Virus (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

JNK (1)

Leukotriene Receptor (1)

LRRK2 (2)

MAP3K (1)

MEK (1)

Mitophagy (1)

MMP (1)

NF-κB (34)

NO Synthase (2)

NOD-like Receptor (NLR) (1)

p38 MAPK (2)

Parasite (2)

PARP (1)

Phosphodiesterase (PDE) (4)

PI3K (1)

PKA (1)

PPAR (1)

Proteasome (4)

PTEN (1)

Reactive Oxygen Species (2)

SARS-CoV (1)

Sodium Channel (3)

STAT (1)

TNF Receptor (5)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (25)

Cardiovascular Disease (4)

Infection (3)

Inflammation/Immunology (50)

Metabolic Disease (4)

Neurological Disease (7)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: IKK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10257

BAY 11-7085 30+ Cited Publications BAY 11-7083	NF-κB Ferroptosis Apoptosis	Cancer
BAY 11-7085 (BAY 11-7083) is an inhibitor of *NF-κB* activation and phosphorylation of IκBα; it stabilizes IκBα with an IC₅₀ of 10 μM .

HY-N0694

Schisantherin A 1 Publications Verification Gomisin-C; Schizantherin-A; Wuweizi ester-A	NF-κB	Inflammation/Immunology
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits *p65-NF-κB* translocation into the nucleus by IκBα degradation.

HY-107593

PS-1145 dihydrochloride	IKK	Inflammation/Immunology
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC₅₀ value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats .

HY-139833

Anti-inflammatory agent 6	NF-κB IKK	Inflammation/Immunology
Anti-inflammatory agent 6 blocks the phosphorylation of I kappa b kinase α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65) which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-155998

NF-κB-IN-11	NF-κB	Inflammation/Immunology
NF-κB-IN-11 (Compound 3i) is a *NF-κB* inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay .

HY-N1987

Cucurbitacin IIb 1 Publications Verification	Apoptosis	Inflammation/Immunology
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-105661

IMD-0560

IKK Cancer

IMD-0560 is a novel IκB kinase β inhibitor.

IMD-0560	IKK	Cancer
IMD-0560 is a novel IκB kinase β inhibitor.

HY-136741

BOT-64	IKK	Inflammation/Immunology
BOT-64 is an inhibitory κB (IκB) kinase β (IKKβ) inhibitor with an IC₅₀ of 1 µM. BOT-64 blocks lipopolysaccharide-induced nuclear factor-κB activation and nuclear factor-κB-regulated inflammatory gene transcription .

HY-18008

PS-1145

2 Publications Verification

IKK Apoptosis Cancer

PS-1145 is an IκB kinase (IKK) inhibitor with an IC₅₀ of 88 nM.

PS-1145 2 Publications Verification	IKK Apoptosis	Cancer
PS-1145 is an IκB kinase (IKK) inhibitor with an IC₅₀ of 88 nM.

HY-162092

Multi-target Pt	NF-κB IKK	Cancer
Multi-target Pt (IV), an antitumor agent, suppresses the IKKβ phosphorylation, IκBα phosphorylation and NF-κB p65 phosphorylation and nuclear translocation, leading to blocked the NF-kB signal pathway .

HY-N0629

Maslinic acid 5+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	NF-κB Bacterial HIV Endogenous Metabolite	Inflammation/Immunology Cancer
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N8884

Coelonin	PTEN Akt NF-κB Interleukin Related TNF Receptor	Inflammation/Immunology
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits *NF-κB* activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-138284

Avenanthramide-C methyl ester	NF-κB	Inflammation/Immunology
Avenanthramide-C methyl ester is an anti-inflammatory agent and NF-κB inhibitor that inhibits the secretion of pro-inflammatory factors. Avenanthramide-C methyl ester inhibits NF-κB activation by inhibiting IKK and IκB phosphorylation and inhibiting proteasome activity .

HY-B0788A

LY2409881 trihydrochloride

2 Publications Verification

IKK Apoptosis Cancer

LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.
HY-B0788

LY2409881

IKK Cancer

LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

LY2409881 trihydrochloride 2 Publications Verification	IKK Apoptosis	Cancer
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

LY2409881	IKK	Cancer
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-110261

GS143	IKK E1/E2/E3 Enzyme NF-κB	Inflammation/Immunology
GS143 is a selective IκBα ubiquitination inhibitor with an IC₅₀ of 5.2 μM for SCF ^βTrCP1-mediated IκBα ubiquitylation. GS143 suppresses *NF-κB* activation and transcription of target genes and does not inhibit proteasome activity. GS143 has anti-asthma effect .

HY-13982

JSH-23 80+ Cited Publications	NF-κB	Metabolic Disease Inflammation/Immunology Cancer
JSH-23 is an *NF-κB* inhibitor which inhibits NF-κB transcriptional activity with an IC₅₀ of 7.1 μM in lipopolysaccharide (LPS)-stimulated macrophages RAW 264.7. JSH-23 inhibits nuclear translocation of NF-κB p65 without affecting IκBα degradation .

HY-147836

Akt/NF-κB/JNK-IN-1	Akt NF-κB JNK TNF Receptor COX	Inflammation/Immunology
Akt/NF-κB/JNK-IN-1 (Compound 2i) is an inhibitor of Akt, *NF-κB* and JNK signaling pathways. Akt/NF-κB/JNK-IN-1 inhibits nitric oxide production with an IC₅₀ of 3.15 μM. Akt/NF-κB/JNK-IN-1 shows anti-inflammatory activities .

HY-144765

NF-κB-IN-4	NF-κB Apoptosis	Neurological Disease Inflammation/Immunology
NF-κB-IN-4 (compound 17) is a potent and BBB-penetrated *NF-κB* pathway inhibitor with blood brain barrier (BBB) permeability. NF-κB-IN-4 exhibits potential anti-neuroinflammatory activity with low toxicity. NF-κB-IN-4 can block the activation and phosphorylation of IκBα, reduce expression of NLRP3, and thus inhibit NF-κB activation. NF-κB-IN-4 can be used for neuroinflammation related diseases research .

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	NF-κB SARS-CoV Influenza Virus Autophagy Parasite	Infection Inflammation/Immunology Cancer
Andrographolide is a *NF-κB* inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-N0847

Micheliolide 3 Publications Verification	NF-κB	Others
Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

HY-12383

Pelubiprofen	COX	Neurological Disease Inflammation/Immunology
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects .

HY-13453

BAY 11-7082 Maximum Cited Publications 281 Publications Verification BAY 11-7821	IKK Deubiquitinase Autophagy Apoptosis NF-κB	Inflammation/Immunology Cancer
BAY 11-7082 is an IκBα phosphorylation and *NF-κB* inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC₅₀=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells .

HY-162316

NF-κB-IN-15	NF-κB	Inflammation/Immunology
NF-κB-IN-15 (compound 14r) is a potent *NF-κB* inhibitor. NF-κB-IN-15 decreases the NO levels and inhibits the release of IL-6, TNF-α, and IL-1β in LPS (HY-D1056) -induced cells. NF-κB-IN-15 inhibits LPS-induced phosphorylation of p65 and degradation of IκBα. NF-κB-IN-15 shows anti-inflammatory activity has the potential for the research of acute lung injury (ALI) .

HY-N12604

Penicisteck acid F	NF-κB	Others
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a *NF-κB* inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .

HY-N0029

Forsythoside B 5 Publications Verification	TNF Receptor NF-κB	Inflammation/Immunology
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate *NF-κB*.

HY-N1956

Rubiadin-1-methyl ether	NF-κB	Metabolic Disease
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65 .

HY-121471

Chrysoeriol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity.

HY-N3071

Picrasidine I	Apoptosis Reactive Oxygen Species	Inflammation/Immunology
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, *NF-κB* and ROS generation, and suppresses the expression of c-Fos and NFATc1 .

HY-158098

FGFR1 inhibitor-11	FGFR	Metabolic Disease
FGFR1 inhibitor-11 (compound 5g) binds to FGFR1, inactivation of its downstream ERK1/2 and IκBα/NF-κB signaling inhibited RANKL-induced osteoclastogenesis. FGFR1 inhibitor-11 has oral bioactivity .

HY-111172

Inotilone	MMP NF-κB	Cancer
Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways .

HY-N2270

Chicanine	p38 MAPK ERK IKK	Inflammation/Immunology
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .

HY-12383S

Pelubiprofen-13C,d3	Isotope-Labeled Compounds COX	Neurological Disease Inflammation/Immunology
Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

HY-156297

β5i-IN-1	Proteasome	Inflammation/Immunology
β5i-IN-1 is a potent and selective inhibitor of *β5i* with a IC₅₀ of 8.463 nM. β5i-IN-1 releases TNF-α and IL-6 and influences the transcriptional activity of *NF-κB*. β5i-IN-1 can be used in study idiopathic pulmonary fibrosis .

HY-153320

AZ-TAK1

MAP3K Cancer

AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines .

AZ-TAK1	MAP3K	Cancer
AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines .

HY-149331

TNF-α-IN-11	TNF Receptor Caspase NF-κB	Inflammation/Immunology
TNF-α-IN-11 (Compound 10) is a TNF-α inhibitor with a K_D value of 12.06 μM. TNF-α-IN-11 binds to TNF-α and blocks the activation of TNF-α-trigged caspase and *NF-κB* signaling pathway. TNF-α-IN-11 inhibits the phosphorylation of IκBα, as well as the nuclear translocation of NF κB p65. TNF-α-IN-11 can be used for research of TNF-α-mediated autoimmune diseases .

HY-118922

IW927	TNF Receptor	Inflammation/Immunology
IW927 is a potent small molecule antagonist that blocks the binding of TNF-α to TNFRc1 with an IC₅₀ value of 50 nM and disrupts TNFα-induced IκB phosphorylation with an IC₅₀ value of 600 nM .

HY-111193

Declopramide 3-Chloroprocainamide	NF-κB Apoptosis	Cancer
Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research .

HY-N0141

Parthenolide 20+ Cited Publications (-)-Parthenolide	NF-κB Autophagy Mitophagy Apoptosis	Cancer
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting *NF-κB* activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N0170

Indole-3-carbinol 5+ Cited Publications Indole-3-methanol	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite	Cancer
Indole-3-carbinol (I3C) inhibits *NF-κB* activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-N10768

1-Dehydro-[10]-gingerdione	IKK NF-κB	Inflammation/Immunology
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	p38 MAPK	Neurological Disease Inflammation/Immunology
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-13295S

Vinpocetine-d5	Isotope-Labeled Compounds Sodium Channel IKK Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

HY-149472

Anti-osteoporosis agent-4	NF-κB PI3K	Inflammation/Immunology
Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC₅₀ value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation .

HY-14180

PHA 408	IKK	Inflammation/Immunology
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation .

HY-13687

IKK 16 15+ Cited Publications	IKK LRRK2	Inflammation/Immunology
IKK 16 is a selective IκB kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC₅₀s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC₅₀ of 50 nM.

Cat. No.	Product Name	Target	Research Area

HY-P1489

OVA Peptide(257-264) 3 Publications Verification	Peptides	Inflammation/Immunology
OVA Peptide(257-264) is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1489A

OVA Peptide(257-264) TFA 3 Publications Verification	Peptides	Inflammation/Immunology
OVA Peptide(257-264) TFA is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb.

HY-P1489B

OVA Peptide(257-264) acetate salt	Peptides	Inflammation/Immunology
OVA Peptide(257-264) acetate salt is a class I (Kb)-restricted peptide epitope of OVA, an octameric peptide can be from ovalbumin presented by the class I MHC molecule, H-2Kb .

HY-P3715

OVA peptide	Peptides	Inflammation/Immunology
OVA peptide mainly exists in egg white, it is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC). OVA peptide has been widely studied in allergy research .

HY-P5410

OVA-Q4 Peptide	Peptides	Others
OVA-Q4 Peptide is a biological active peptide. (Q4 Peptide (SIIQFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-P5411

OVA-T4 Peptide SIITFEKL, OVA (257-264) Variant	Peptides	Others
OVA-T4 Peptide (SIITFEKL, OVA (257-264) Variant) is a biological active peptide. (T4 peptide (SIITFEKL) is a variant of the agonist ovalbumin (OVA) peptide (257-264), SIINFEKL. OVA Peptide is a class I (Kb)-restricted peptide epitope of ovalbumin presented by the class I MHC (major histocompatibility complex) molecule, H-2Kb (class I genes of the mouse MHC).)

HY-P2494

OVA (55-62)

Peptides Inflammation/Immunology

OVA 55-62 is a fragmented peptide of OVA (ovalbumin) antigen and can bind to the mouse MHC class I molecule, H2-Kb .

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric proteasome inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P2527

Tyrosinase-related Protein 2 (TRP-2) (181-188)	Peptides	Inflammation/Immunology
Tyrosinase-related Protein 2 (TRP-2) (181-188) is a tyrosinase-related protein 2 (TRP-2)-derived peptide, corresponding to residues 180-188. Tyrosinase-related Protein 2 (TRP-2) (181-188) is the major reactive epitope within TRP-2 recognized by anti-B16 CTLs. Tyrosinase-related Protein 2 (TRP-2) (181-188) is a peptide conforming to the MHC class I H2-Kb binding motif .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0694

Schisantherin A 1 Publications Verification Gomisin-C; Schizantherin-A; Wuweizi ester-A	Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.	NF-κB
Schisantherin A is a dibenzocyclooctadiene lignan. Schisantherin A inhibits *p65-NF-κB* translocation into the nucleus by IκBα degradation.

HY-N1987

Cucurbitacin IIb 1 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Cucurbitaceae Plants Hemsleya amabilis Diels Inflammation/Immunology Disease Research Fields	Apoptosis
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of IκB and NF-κB (p65), blocks nuclear translocation of NF-κB (p65) and decreases mRNA levels of IκBα and TNF-α .

HY-N0629

Maslinic acid 5+ Cited Publications Crategolic acid; 2α-Hydroxyoleanolic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	NF-κB Bacterial HIV Endogenous Metabolite
Maslinic acid can inhibit the DNA-binding activity of NF-κB p65 and abolish the phosphorylation of IκB-α, which is required for p65 activation.

HY-N0191

Andrographolide 15+ Cited Publications Andrographis	Infection Structural Classification Andrographis paniculata (Burm. F.) Nees Acanthaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Inflammation/Immunology Disease Research Fields	NF-κB SARS-CoV Influenza Virus Autophagy Parasite
Andrographolide is a *NF-κB* inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.

HY-N8884

Coelonin	Structural Classification Appendicula reflexa Blume Orchidaceae Source classification Phenols Polyphenols Plants	PTEN Akt NF-κB Interleukin Related TNF Receptor
Coelonin is a dihydrophenanthrene with anti-inflammation activity. Coelonin inhibits LPS-induced PTEN phosphorylation. Coelonin inhibits *NF-κB* activation and p27Kip1 degradation by regulating the PI3K/AKT pathway negatively. Coelonin can inhibit IκBα phosphorylation and degradation and increases the expression of IκBα protein .

HY-N0847

Micheliolide 3 Publications Verification	Other Monoterpenes other families Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields	NF-κB
Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs).

HY-N12604

Penicisteck acid F	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	NF-κB
Penicisteck acid F (Compound 2) is a Marine derived tanzanic acid derivative that is a *NF-κB* inhibitor. Penicisteck acid F inhibits osteoclast expression by decreasing RANKL-induced IκBα degradation, NF-κB p65 nuclear translocation, NFATc1 activation and nuclear translocation, and related mRNA expression. Penicisteck acid F can be used in osteoporosis research .

HY-N0029

Forsythoside B 5 Publications Verification	Structural Classification Classification of Application Fields Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Inflammation/Immunology Disease Research Fields	TNF Receptor NF-κB
Forsythoside B is a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, a Chinese folk medicinal plant for treating inflammatory diseases and promoting blood circulation. Forsythoside B could inhibit TNF-alpha, IL-6, IκB and modulate *NF-κB*.

HY-N1956

Rubiadin-1-methyl ether	Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Rubiaceae Phenols Metabolic Disease Plants Disease Research Fields Rubia cordifolia L.	NF-κB
Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65 .

HY-121471

Chrysoeriol 1 Publications Verification	Structural Classification Classification of Application Fields Flavones Metabolic Disease Plants Phyllanthus Flavonoids Phenols Polyphenols Euphorbiaceae Brassicaceae Disease Research Fields Coronopus didymus	Endogenous Metabolite
Chrysoeriol is a kind of natural yellow ash, which can be used for heating plants Coronopus didymus. Chrysoeriol suppresses the JAK2/STAT3, IκB/p65, and NF-κB pathways, and has strong anti-inflammatory activity.

HY-N3071

Picrasidine I	Simaroubaceae Source classification Plants Quassia amaraL. Indole Alkaloids	Apoptosis Reactive Oxygen Species
Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, *NF-κB* and ROS generation, and suppresses the expression of c-Fos and NFATc1 .

HY-N2270

Chicanine	Structural Classification Monophenols Classification of Application Fields Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields	p38 MAPK ERK IKK
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .

HY-N0141

Parthenolide Maximum Cited Publications 24 Publications Verification (-)-Parthenolide	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi Disease Research Fields Cancer	NF-κB Autophagy Mitophagy Apoptosis
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting *NF-κB* activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-N10206

11-epi-Chaetomugilin I	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N0170

Indole-3-carbinol 5+ Cited Publications Indole-3-methanol	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	NF-κB Aryl Hydrocarbon Receptor E1/E2/E3 Enzyme Endogenous Metabolite
Indole-3-carbinol (I3C) inhibits *NF-κB* activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

HY-N10768

1-Dehydro-[10]-gingerdione	Structural Classification Monophenols Source classification Phenols Plants Zingiberaceae	IKK NF-κB
1-Dehydro-[10]-gingerdione directly inhibits IKKβ activity by targeting the activation loop of IKKβ, thus disrupting IKKβ-catalysed IκBα phosphorylation in macrophages stimulated with agonists. 1-Dehydro-[10]-gingerdione inhibits LPS (HY-D1056)-induced *NF-κB* transcriptional activity. 1-Dehydro-[10]-gingerdione has the potential for NF-κB-associated inflammation and autoimmune disorders research .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincaminate	Cardiovascular Disease Classification of Application Fields Neurological Disease Anti-aging Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N1818

Deoxysappanone B 3-Deoxysappanone B	Structural Classification Leguminosae Caesalpinia sappan L. Source classification Phenols Polyphenols Plants	p38 MAPK
Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage .

HY-N0613

Sauchinone 1 Publications Verification	Saururaceae Classification of Application Fields Saururus chinensis (Lour.) Baill. Terpenoids Source classification Diterpenoids Plants Disease Research Fields Inflammation/Immunology	NF-κB
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity .

HY-13295R

Vinpocetine (Standard)	Apocynaceae Alkaloids Piperidine Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Standard) is the analytical standard of Vinpocetine. This product is intended for research and analytical applications. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits *NF-κB*-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N0811

Anemarsaponin B	Structural Classification Liliaceae Classification of Application Fields Source classification Anemarrhena asphodeloides Bunge Plants Inflammation/Immunology Disease Research Fields Steroids	NO Synthase COX NF-κB MEK
Anemarsaponin B is a steroidal saponin. Anemarsaponin B decreases the protein and mRNA levels of iNOS and COX-2. Anemarsaponin B reduces the expressions and productions of pro-inflammatory cytokines, including TNF-a and IL-6. Anemarsaponin B inhibits the nuclear translocation of the p65 subunit of *NF-κB* by blocking the phosphorylation of IκBα. Anemarsaponin B also inhibits the phosphorylation of MAP kinase kinases 3/6 (MKK3/6) and mixed lineage kinase 3 (MLK3). Anti-inflammatory effect .

HY-N0510

Aristolochic acid A 5+ Cited Publications Aristolochic acid I; TR 1736	Alkaloids Structural Classification other families Aristolochia debilis Sieb. et Zucc. Classification of Application Fields Other Alkaloids Source classification Plants Aristolochiaceae Disease Research Fields Cancer	NF-κB
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and *NF-κB* activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Structural Classification Source classification Phenols Polyphenols Hypoxis angustifolia Lam. Plants Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-N6727

Gliotoxin Aspergillin	Structural Classification Anti-inflammation/Immunoregulatory Classification of Application Fields Source classification Antibacterial Disease Research Other Antibiotics Biological Pesticide Research Agricultural Research Infection Microorganisms Antibiotics Inflammation/Immunology Disease Research Fields	Apoptosis PKA NF-κB Bacterial Fungal Antibiotic
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible *NF-κB* activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .

HY-N0515

Ophiopogonin D	Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids	PPAR NF-κB Calcium Channel
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

Cat. No.	Product Name	Chemical Structure

HY-12383S

Pelubiprofen-13C,d3

Pelubiprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Pelubiprofen. Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

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