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Results for "

Depressant

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Adrenergic Receptor (2) Apoptosis (3) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Calcium Channel (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Metabolite (2) Endogenous Metabolite (1) ERK (1) Fungal (1) Guanylate Cyclase (1) HDAC (1) Histamine Receptor (1) iGluR (1) Isotope-Labeled Compounds (1) mGluR (2) MMP (1) mTOR (1) NF-κB (2) P2X Receptor (1) Potassium Channel (2) Prostaglandin Receptor (1) PROTACs (3) Ras (2) Somatostatin Receptor (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (9) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (25)

By Targets:

5-HT Receptor (5)

Adrenergic Receptor (2)

Apoptosis (3)

Autophagy (1)

Bacterial (1)

Bcl-2 Family (1)

Calcium Channel (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug Metabolite (2)

Endogenous Metabolite (1)

ERK (1)

Fungal (1)

Guanylate Cyclase (1)

HDAC (1)

Histamine Receptor (1)

iGluR (1)

Isotope-Labeled Compounds (1)

mGluR (2)

MMP (1)

mTOR (1)

NF-κB (2)

P2X Receptor (1)

Potassium Channel (2)

Prostaglandin Receptor (1)

PROTACs (3)

Ras (2)

Somatostatin Receptor (1)

Xanthine Oxidase (2)

By Research Areas:

Cancer (9)

Cardiovascular Disease (4)

Infection (4)

Inflammation/Immunology (7)

Metabolic Disease (1)

Neurological Disease (25)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100662

Didesethyl chloroquine Bisdesethylchloroquine	Drug Metabolite	Cardiovascular Disease
Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant .

HY-106587A

Octoclothepin maleate salt Clorotepine maleate salt	Dopamine Receptor	Neurological Disease
Octoclothepin maleate salt, an orally active neuroleptic agent, is a dual SR-2A and D2DR inhibitor. Octoclothepin maleate salt reveals an intensive central depressant action in a series of observational and instrumental procedures in rodents .

HY-B0530

Azacyclonol 1 Publications Verification γ-pipradol	Histamine Receptor	Neurological Disease
Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations .

HY-W294348

Prenderol

2,2-Diethyl-1,3-propanediol
Others Neurological Disease

Prenderol is a potent central-nervous-system depressant. Prenderol has anticonvulsant activity .

Prenderol 2,2-Diethyl-1,3-propanediol	Others	Neurological Disease
Prenderol is a potent central-nervous-system depressant. Prenderol has anticonvulsant activity .

HY-N12121

Piperundecalidine	Others	Infection Inflammation/Immunology
Piperundecalidine is an amide alkaloids that can be purified from Piper longum L. Piperundecalidine shows various biological properties, such as anti-inammatory, analgesic, anti-amoebic, anti-depressant, hepatoprotective,etc. .

HY-N2109

Macranthoidin A	Others	Metabolic Disease
Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-148065

FMF-06-098-1	PROTACs	Cancer
FMF-06-098-1 is a multitargeted depressant. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .

HY-100662S

Didesethyl chloroquine-d4 Bisdesethylchloroquine-d₄	Isotope-Labeled Compounds Drug Metabolite	Cardiovascular Disease
Didesethyl chloroquine-d₄ is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].

HY-U00149

Drobuline hydrochloride

Others Cardiovascular Disease

Drobuline hydrochloride is an anti-arrhythmic agent with cardiac depressant.
HY-107956

Imipramine pamoate

Others Neurological Disease

Imipramine pamoate is a potent anti-depressant compound .
HY-B1594

Carbromal

Adalin; Adisomnol; Bromacetocarbamide
Others Neurological Disease

Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects .

Drobuline hydrochloride	Others	Cardiovascular Disease
Drobuline hydrochloride is an anti-arrhythmic agent with cardiac depressant.

Imipramine pamoate	Others	Neurological Disease
Imipramine pamoate is a potent anti-depressant compound .

Carbromal Adalin; Adisomnol; Bromacetocarbamide	Others	Neurological Disease
Carbromal (Adalin; Adisomnol) is a sedative with centrally depressant effects .

HY-B0740

Cyclobenzaprine hydrochloride MK130 hydrochloride	5-HT Receptor	Neurological Disease
Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-N3295

Mesuaxanthone A

Others Inflammation/Immunology

Mesuaxanthone A is a xanthone with anti-inflammatory activities. Mesuaxanthone A shows typical CNS depressant effects .
HY-N3193

Neritaloside

Others Neurological Disease

Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect ^[2.

Mesuaxanthone A	Others	Inflammation/Immunology
Mesuaxanthone A is a xanthone with anti-inflammatory activities. Mesuaxanthone A shows typical CNS depressant effects .

Neritaloside	Others	Neurological Disease
Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect ^[2.

HY-106769A

Fluparoxan hydrochloride GR50360 hydrochloride	Adrenergic Receptor	Neurological Disease
Fluparoxan hydrochloride is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan hydrochloride is an anti-depressant agent .

HY-106769

Fluparoxan GR50360	Adrenergic Receptor	Neurological Disease
Fluparoxan is an orally active, selective and competitive alpha 2-adrenoceptor antagonist. Fluparoxan is an anti-depressant agent .

HY-B0740S

Cyclobenzaprine-d3 hydrochloride MK130-d₃ (hydrochloride)	5-HT Receptor	Neurological Disease
Cyclobenzaprine-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-155352

mGluR5 antagonist-1	mGluR	Others
mGluR5 antagonist-1 (compound 10) is a high-affinity mGluR5 antagonist, with an IC₅₀ value of 11.5 nM. mGluR5 antagonist-1 has *anti-depressant* effect .

HY-N7126

Citronellal	Potassium Channel	Neurological Disease
Citronellal is a monoterpenea from the essential oils in various aromatic species of plants, with depressant, and antinociceptive properties. Citronellal attenuates mechanical nociception, mediated in part by the NO-cGMP-ATP-sensitive K ^⁺ channel pathway .

HY-107790

5-Methoxyflavone	DNA/RNA Synthesis	Neurological Disease
5-Methoxyflavone, belonged to Flavonoid family, is a DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity. possess central nervous system (CNS) depressant effect mediated through the ionotropic GABA_A receptors.

HY-W012618

1-Phenyl-1-propanol	Others	Others
1-Phenyl-1-propanol is used as a chiral building block and synthetic intermediate in the pharmaceutical industries. 1-Phenyl-1-propanol is an intermediate of anti-depressant agent Fluoxetine .

HY-161236

KRAS ligand 4	Ras	Cancer
KRAS ligand 4 (Compound 2) is a bifunctional depressant based on SOS1. KRAS ligand 4 reduces the downstream signaling markers pERK and pS6 and shows anti-proliferative activity in multiple KRAS mutated cells .

HY-137516A

LC-2 epimer	PROTACs Ras	Cancer
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849 .

HY-109046

Tulrampator 1 Publications Verification CX-1632; S-47445	iGluR mTOR	Neurological Disease
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder .

HY-P1212

Cortistatin 14, human, rat CST-14, human, rat	Somatostatin Receptor	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

HY-106888

CS-722 Free base	Endogenous Metabolite	Neurological Disease
CS-722 Free base is a synthesized centrally acting muscle relaxant, and has a muscle relaxant activity and depressant effectson the spinal reflex . CS-722 Free base inhibits spontaneous inhibitory postsynaptic currents and excitatory postsynaptic currents in hippocampal cultures probably by an inhibition of both sodium and calcium currents .

HY-108669

AZ10606120 dihydrochloride 1 Publications Verification	P2X Receptor	Neurological Disease Cancer
AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC₅₀ of about 10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth .

HY-114846

Ro 22-9194	Prostaglandin Receptor	Cardiovascular Disease
Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action .

HY-117764

LSP4-2022	mGluR	Neurological Disease
LSP4-2022 is a potent and brain-penetrant mGlu4-selective orthosteric agonist, with an EC₅₀ of 0.11 μM. LSP4-2022 inhibits neurotransmission in cerebellar slices from wild-type but not mGlu4 receptor-knockout mice. LSP4-2022 shows pro-depressant activity .

HY-B0900

Anethole 1 Publications Verification Anise camphor; p-Propenylanisole; Isoestragole	Apoptosis Fungal Bacterial MMP NF-κB	Infection Neurological Disease Inflammation/Immunology Cancer
Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer .

HY-B0219

Allopurinol 5 Publications Verification	Xanthine Oxidase	Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-B0219A

Allopurinol sodium 5 Publications Verification	Xanthine Oxidase	Infection Neurological Disease Inflammation/Immunology Cancer
Allopurinol sodium is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol sodium can be used in the research of hyperuricemia and gout. Allopurinol sodium decreases the expression of HIF-1α and HIF-2α protein. Allopurinol sodium shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-148038

5-HT3 antagonist 5	5-HT Receptor	Neurological Disease
5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT₃ receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT₃ agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice .

HY-102064

SR 57227A 1 Publications Verification	5-HT Receptor	Neurological Disease
SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC₅₀) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects .

HY-155182

HDAC-IN-62	HDAC Autophagy	Neurological Disease Inflammation/Immunology
HDAC-IN-62 (Compound 5) a HDAC inhibitor, with IC₅₀s of 0.78, 1.0, 1.2? μM for HDAC6/8/11 respectively. HDAC-IN-62 inhibits-induced microglial activation by the initiation of autophagy, and inhibits nitric oxide production. HDAC-IN-62 has anti-inflammatory and anti-depressant effects. HDAC-IN-62 inhibits microglial activation in mouse brain .

HY-153356

MRT-2359	Apoptosis	Cancer
MRT-2359 is a potent, orally active and selective GSPT1 depressant (IC₅₀: >30 nM and <300 nM) that specifically induces apoptosis dependent on protein translation. MRT-2359 exhibits significant and preferred anti-proliferative activity in a variety of cancer cell lines, especially MYC-driven cell lines, such as non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) with high expression of N-Myc or L-Myc. MRT-2359 inhibits the growth of drug-resistant NSCLC and SCLC cells, making it suitable for cancer research .

HY-161410

WH244	PROTACs Apoptosis Bcl-2 Family	Cancer
WH244 is a second generation BCL-2 and BCL-xL dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of BCL-2 and BCL-xL proteins (BCL-xL: DC₅₀=0.6 nM, BCL-2: DC₅₀=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415); Blue: E3 ligase ligand (HY-112078); Black: linker) .

HY-147377

N-Salicyloyltryptamine	Calcium Channel ERK Potassium Channel Guanylate Cyclase NF-κB	Neurological Disease Inflammation/Immunology
N-Salicyloyltryptamine acts on voltage-dependent Na ⁺, Ca ²⁺, and K ⁺ ion channels inhibitor. N-Salicyloyltryptamine inhibits K ⁺ currents with an IC₅₀ value of 34.6 μM (I_to). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect ^- .

HY-103117

S 32212 hydrochloride	5-HT Receptor	Neurological Disease
S 32212 is an inverse agonist of the serotonin (5-HT) receptor subtypes 5-HT2CINI and 5-HT2CVSV (Kis=6.6 and 8.9 nM, respectively). It is also an antagonist of the 5-HT2A receptor and the α2B-adrenergic receptor (Ki=5.8 nM for both). S 32212 is greater than 70-fold selective for these receptors in a panel of 80 receptors, enzymes, and ion channels. S 32212 reduces binding of GTPγS to Gαq and decreases the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2CINI receptors (EC₅₀s=38 and 18.6 nM, respectively) and in CHO cells expressing 5-HT2CVSV receptors (EC₅₀s=38 and 18.6 nM, respectively). S 32212 (2.5 mg/kg) decreases head twitching, penile erections, and drug discrimination induced by 5-HT receptor agonists in mice and rats. It reduces immobility time in the forced swim test and decreases marble burying in mice and rats when administered at doses of 10 and 40 mg/kg, indicating anti-depressant-like and anxiolytic activities.

Cortistatin 14, human, rat CST-14, human, rat	Somatostatin Receptor	Neurological Disease
Cortistatin 14, human, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus .

Cat. No.	Product Name	Category	Target	Chemical Structure