Daphne oleoides,Natural products,NMR spectroscopy,Structural elucidation

By Targets:	Akt (2) AMPK (1) Apoptosis (1) Autophagy (1) Bacterial (1) Bcl-2 Family (1) Bcr-Abl (1) Caspase (1) DNA Stain (2) EGFR (2) Eukaryotic Initiation Factor (eIF) (1) HIV (1) Liposome (1) mGluR (2) mTOR (2) Neuropeptide FF Receptor (1) Parasite (2) PARP (1) PKA (1) PKC (1) Reactive Oxygen Species (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (3) Neurological Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N9900

Demethyldaphnoretin-7-O-glucoside Demethyldaphnoretin-7-O-β-D-glucopyranoside	Others	Others
Demethyldaphnoretin-7-O-β-Dglucopyranoside (Demethyldaphnoretin-7-O-glucoside)(compound 1) is a natural product isolated from the ethyl acetate fraction of the roots of Daphne oleoides .

HY-N12596

Uralenol-3-methyl ether

Others Others

Uralenol-3-methyl ether is a flavonol which can be extracted from Daphne giraldii .
HY-N12678

Daphnepedunin A

HIV Infection

Daphnepedunin A is a terpenoid and can be isolated from Daphne pedunculata. Daphnepedunin A has activity against HIV with an IC₅₀ value of 107 nM .
HY-N10961

Daphnodorin B

Others Cancer

Daphnodorin B is a flavonoid. Daphnodorin B can be isolated from the roots of Daphne genkwa. Daphnodorin B can be used for the research of tumor .
HY-133181

Triumbelletin

Others Others

Triumbelletin is a tricoumarin rhamnopyranoside that can be found in Daphne mezereum .

Uralenol-3-methyl ether	Others	Others
Uralenol-3-methyl ether is a flavonol which can be extracted from Daphne giraldii .

Daphnepedunin A	HIV	Infection
Daphnepedunin A is a terpenoid and can be isolated from Daphne pedunculata. Daphnepedunin A has activity against HIV with an IC₅₀ value of 107 nM .

Daphnodorin B	Others	Cancer
Daphnodorin B is a flavonoid. Daphnodorin B can be isolated from the roots of Daphne genkwa. Daphnodorin B can be used for the research of tumor .

Triumbelletin	Others	Others
Triumbelletin is a tricoumarin rhamnopyranoside that can be found in Daphne mezereum .

HY-N3832

Epinortrachelogenin (-)-Epinortrachelogenin	Others	Others
Epinortrachelogenin ((-)-Epinortrachelogenin) is a natural lignan found in the plateau medicinal plant Daphne acutiloba Rehd .

HY-145922

ChemR23 ligand-1

Others Inflammation/Immunology

ChemR23 ligand-1 is a chemical probe that contributes to the elucidation and analysis of the functions of ChemR23.
HY-128000

ML095

CID-25067483
Others Others

ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP .

ChemR23 ligand-1	Others	Inflammation/Immunology
ChemR23 ligand-1 is a chemical probe that contributes to the elucidation and analysis of the functions of ChemR23.

ML095 CID-25067483	Others	Others
ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP .

HY-D1408

DMTr-4'-Me-U-CED-TBDMS phosphoramidite DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite	DNA Stain	Cardiovascular Disease
DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-D1409

DMTr-4'-F-U-CED-TBDMS phosphoramidite DMTr-4'-F-uridine-CED-TBDMS phosphoramidite	DNA Stain	Cardiovascular Disease
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-N7225

Yuanhuacine Gnidilatidin	Others	Cancer
Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active .

HY-127067

Yuanhuadin	Akt EGFR mTOR	Inflammation/Immunology Cancer
Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion .

HY-N7252

Daphnin	Bacterial	Infection
Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever .

HY-N1438

Hydroxygenkwanin 7-O-Methylluteolin	Others	Cancer
Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect .

HY-15517B

KN-92 hydrochloride 5 Publications Verification	Others	Cancer
KN-92 hydrochloride is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 hydrochloride is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93 .

HY-145887

BCR-ABL1-IN-1	Bcr-Abl	Neurological Disease
BCR-ABL1-IN-1 is a potent, orally active, and specific inhibitor of ABL kinase. BCR-ABL1-IN-1 has potential for elucidating the role of ABL kinases in the brain in non-clinical studies .

HY-103111

MMPIP hydrochloride	mGluR	Neurological Disease
MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .

HY-107503

MMPIP	mGluR	Neurological Disease
MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .

HY-15517

KN-92	Others	Cancer
KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor .

HY-15517A

KN-92 phosphate 5 Publications Verification	Others	Cancer
KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 phosphate is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor .

HY-118667

Dehydroergosterol	Liposome	Others
Dehydroergosterolis a naturally occurring fluorescent sterol analog (Ex/Em=325/375 nm), which mimics the properties of cholesterol in cell membranes. DehydroergosterolEasily conjugated by cholesterol-binding proteins for real-time imaging in live cells. DehydroergosterolThe sterol environment and intracellular sterol transport in vivo can be probed/elucidated in real time .

HY-33838

eIF4A3-IN-8	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4A3-IN-8 is a selective ATP-competitive eukaryotic initiation factor 4A3 (eIF4A3) inhibitor. eIF4A3-IN-8 can serve as a valuable chemical probe to elucidate the detailed function of eIF4A3 and EJC (exon junction complex) .

HY-P10379

palm-PrRP31	Neuropeptide FF Receptor	Others Neurological Disease
palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC₅₀=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .

HY-N12210

Notrilobolide	Parasite	Others
Notrilobolide is an alkaloid with insecticidal properties isolated from sweet potatoes. Notrilobolide has an inhibitory effect on the larval development of pests such as Tribolium Castaneum, affecting the digestion and reproduction of insects by inhibiting the fecundity of pests .

HY-N0281

Daphnetin 3 Publications Verification 7,8-Dihydroxycoumarin	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite	Inflammation/Immunology Cancer
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

Cat. No.	Product Name	Type

HY-D1408

DMTr-4'-Me-U-CED-TBDMS phosphoramidite DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite	Oligonucleotide Labeling
DMTr-4'-Me-U-CED-TBDMS phosphoramidite (DMTr-4'-Methyluridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-Me-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

HY-D1409

DMTr-4'-F-U-CED-TBDMS phosphoramidite DMTr-4'-F-uridine-CED-TBDMS phosphoramidite	Oligonucleotide Labeling
DMTr-4'-F-U-CED-TBDMS phosphoramidite (DMTr-4'-F-uridine-CED-TBDMS phosphoramidite), a dye reagent for oligonucleotide labeling, can be used for the research of applications in RNA therapeutics, RNA aptamers, and ribozymes for elucidating RNA structure. DMTr-4'-F-U-CED-TBDMS phosphoramidite represents a probe with wide utility for elucidation of RNA structure .

Cat. No.	Product Name	Type

HY-118667

Dehydroergosterol	Biochemical Assay Reagents
Dehydroergosterolis a naturally occurring fluorescent sterol analog (Ex/Em=325/375 nm), which mimics the properties of cholesterol in cell membranes. DehydroergosterolEasily conjugated by cholesterol-binding proteins for real-time imaging in live cells. DehydroergosterolThe sterol environment and intracellular sterol transport in vivo can be probed/elucidated in real time .

Cat. No.	Product Name	Target	Research Area

HY-P10379

palm-PrRP31	Neuropeptide FF Receptor	Others Neurological Disease
palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC₅₀=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9900

Demethyldaphnoretin-7-O-glucoside Demethyldaphnoretin-7-O-β-D-glucopyranoside	Structural Classification Daphne oleoides Schreb. Thymelaeaceae Source classification Coumarins Phenylpropanoids Plants	Others
Demethyldaphnoretin-7-O-β-Dglucopyranoside (Demethyldaphnoretin-7-O-glucoside)(compound 1) is a natural product isolated from the ethyl acetate fraction of the roots of Daphne oleoides .

HY-N12596

Uralenol-3-methyl ether	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Others
Uralenol-3-methyl ether is a flavonol which can be extracted from Daphne giraldii .

HY-N12678

Daphnepedunin A	Structural Classification Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Daphne pedunculata H. F. Zhou ex C. Y. Chang	HIV
Daphnepedunin A is a terpenoid and can be isolated from Daphne pedunculata. Daphnepedunin A has activity against HIV with an IC₅₀ value of 107 nM .

HY-N10961

Daphnodorin B	Structural Classification Flavonols Flavonoids Thymelaeaceae Source classification Plants Daphne genkwa Sieb. et Zucc.	Others
Daphnodorin B is a flavonoid. Daphnodorin B can be isolated from the roots of Daphne genkwa. Daphnodorin B can be used for the research of tumor .

HY-133181

Triumbelletin	Structural Classification Thymelaeaceae Source classification Coumarins Phenylpropanoids Plants Daphne mezereum L.	Others
Triumbelletin is a tricoumarin rhamnopyranoside that can be found in Daphne mezereum .

HY-N3832

Epinortrachelogenin (-)-Epinortrachelogenin	Structural Classification Daphne acutiloba Rehd. Thymelaeaceae Source classification Lignans Phenylpropanoids Plants	Others
Epinortrachelogenin ((-)-Epinortrachelogenin) is a natural lignan found in the plateau medicinal plant Daphne acutiloba Rehd .

HY-N7225

Yuanhuacine Gnidilatidin	Classification of Application Fields Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Disease Research Fields Daphne genkwa Sieb. et Zucc. Cancer	Others
Yuanhuacine (Gnidilatidin), a daphnane diterpenoid from the flowers of Daphne genkwa with extensive anti-tumor activity. Yuanhuacine is a DNA-damaging agent with orally active .

HY-127067

Yuanhuadin	Structural Classification Terpenoids Thymelaeaceae Source classification Diterpenoids Plants Daphne genkwa Sieb. et Zucc.	Akt EGFR mTOR
Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion .

HY-N7252

Daphnin	Infection Monophenols other families Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields	Bacterial
Daphnin is one of the major coumarin bioactive components with antibacterial activity. Daphnin is isolated from the whole herb of Daphne odora (Thunb.), which is a folk medicine in China for the relief of fever .

HY-N1438

Hydroxygenkwanin 7-O-Methylluteolin	Structural Classification Flavonoids Classification of Application Fields Flavones Thymelaeaceae Source classification Phenols Polyphenols Plants Daphne genkwa Sieb. et Zucc. Disease Research Fields Cancer	Others
Hydroxygenkwanin (7-O-Methylluteolin), a natural flavonoid compound, is one of the main components of Lilac Daphne. Hydroxygenkwanin has anti-oxidant ability, anti-glioma ability and anticancer effect .

HY-118667

Dehydroergosterol	Microorganisms Source classification	Liposome
Dehydroergosterolis a naturally occurring fluorescent sterol analog (Ex/Em=325/375 nm), which mimics the properties of cholesterol in cell membranes. DehydroergosterolEasily conjugated by cholesterol-binding proteins for real-time imaging in live cells. DehydroergosterolThe sterol environment and intracellular sterol transport in vivo can be probed/elucidated in real time .

HY-N12210

Notrilobolide	Structural Classification Natural Products Source classification Plants Umbelliferae	Parasite
Notrilobolide is an alkaloid with insecticidal properties isolated from sweet potatoes. Notrilobolide has an inhibitory effect on the larval development of pests such as Tribolium Castaneum, affecting the digestion and reproduction of insects by inhibiting the fecundity of pests .

HY-N0281

Daphnetin 3 Publications Verification 7,8-Dihydroxycoumarin	Classification of Application Fields Daphne Thymelaeaceae Source classification Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species Caspase Bcl-2 Family PARP Parasite
Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC₅₀s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Daphne oleoides,Natural products,NMR spectroscopy,Structural elucidation

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Natural
Products