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Mannose triflate is a glucose analog. Mannose triflate is a well-known precursor for 18F-FDG synthesis for PET applications. 18F-FDG is an imaging technique of cancer .
GDP-mannose pyrophosphorylase (ManC) (GDP-MP) is a cytoplasmic protein that catalyzes the formation of GDP-mannose. GDP-mannose pyrophosphorylase (ManC) is the precursor for the mannose residues in glycoconjugates, using mannose 1-phosphate and GTP as substrates .
Mannose 1-phosphate sodium is an endogenous metabolite. Mannose 1-phosphate sodium can be used to synthesize GDP-Man by the enzyme GDP-mannose pyrophosphorylase .
D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation .
D-Mannose-d is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
D-Mannose- 18O is the 18O labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-3 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-4 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-1 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-2 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-mannose-d7 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
D-Mannose- 13C-1 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-2 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-3 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-4 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-5 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C,d is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .
D-Mannose- 13C,d-2 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-mannose- 13C6,d7 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
α1-6 Mannosidase, Xanthomonas phaseoli is a highly specific exoglycosidase that removes unbranched α1-6 linked mannose residues from oligosaccharides .
M6 glycan (Man6), procainamide labelled (Mannose-6 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury .
Eltrombopag- 13C4 (SB-497115- 13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits cell growth of MCF-7, KB, NCI H187, and Vero cells with IC50 values of 8.4, 8.6, 4.2, and 48.9 µM, respectively. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM [1]sup>[2]sup>[3]sup>[4].
Hydroxystilbamidine, a dye capable of binding to both DNA and RNA, is a powerful inhibitor of cellular ribonucleases. Hydroxystilbamidine is a retrograde fluorescent tracer and a histochemical stain [1]sup .
Milbemycin A4 inhibits P-glycoprotein activity, and reverses multidrug resistance of tumor cells. Milbemycins are a family of macrolide antibiotics with insecticidal and acaricidal activity [1]sup>[2].
CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels [1]sup .
7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola roseasup>[1].
(S)-(−)-Perillyl alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity .
Drpitor1a is a potent Drp1 inhibitor. Drpitor1a inhibits mitochondrial ROS production, preventes mitochondrial fission, and improves right ventricular diastolic dysfunction during IR (ischemia reperfusion) injury. Drpitor1a has the potential for the research of lung cancer [1]sup .
Xanthan gum is a microbial polysaccharide produced by Xanthomonas campestris. The structure of xanthan gum is based on a cellulose backbone of β-(1-4)-linked glucose units with a trisaccharide side of mannose-glucuronic acid-mannose attached to every other glucose unit in the backbone chain. Some terminal mannose units are pyruvated and some internal mannose units are acetylated. Due to its unique rheology and gelling properties, it is widely used as a food additive, thickener and stabilizer in the food and petroleum industries.
PF-00835231 is a CoV-2 cysteine 3C-like protease (3CL pro) inhibitor, with IC50s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CL pro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2/COVID-19 [1]sup>[2].
Phosphomannose isomerase is the first enzyme involved in the biosynthesis pathway of GDP-Man. Phosphomannose isomerase catalyzes the conversion between fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P). Phosphomannose isomerase is important for cell wall synthesis and protein glycosylation. Phosphomannose isomerase is a potent antifungal target to curb the threats posed by A. flavus .
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellataLS.
D-Mannosamine hydrochloride is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells .
Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) [2].
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 celllines.
Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Antifungal agent 26, a Pradimicin A derivative, shows antifungal, antiviral, and antiparasitic activities through binding to d-mannose (Man)-containing glycans of pathogenic species .
Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research .
Glucosamine- 13C, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i
Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
Endo-β-N-acetylglucosaminidase F2 (Endo F2), a highly specific endoglycosidase, cleaves within the chitobiose core of asparagine-linked complex biantennary and high mannose oligosaccharides from glycoproteins and glycopeptides. Endo F2 cleaves biantennary glycans at a rate approximately 20 times greater than high mannose glycans. The activity of Endo F2 is identical on biantennary structures with and without core fucosylation. Endo F2 is not active on hybrid or tri- and tetra-antennary oligosaccharides .
Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 (Cys modified with M6Pn) (Compound 24) is a mannose-6-phosphate (M6Pn)-peptide conjugate capable of binding to targeted ligands of various proteins and successfully internalizing and degrading them through M6PR. Biotin-εNle-CKCKC-γAbu-CKCKCG-NH2 can be utilized in the research of lysosomal targeting chimeras (LYTACs) based on M6Pn .
L-Serine1- 13C, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
Dulcite- 13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
D-Glucose- 18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].
Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia) .
(-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]
Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
Cyanine5 DBCO (DBCO-Cy5) is a low-toxicity azide reactive probe (NIR fluorescent dye), for imaging azide-labeled biomolecules via a copper-free "click-through" reaction. Cyanine5 DBCO has no apparent cytotoxicity or animal toxicity and shows no damage to the physiological functions of cells other than the target cells (azide-labeled cells). Cyanine5 DBCO can be used to label and track cells in vitro and in vivo (Ex=635 nm, Em=650-700 nm) [2].
Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
Mannose triflate is a glucose analog. Mannose triflate is a well-known precursor for 18F-FDG synthesis for PET applications. 18F-FDG is an imaging technique of cancer .
M3 glycan (Man3) (Mannose-3 N-linked oligosaccharide; Oligomannose 3 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M7 glycan (Man7) (Mannose-7 N-linked oligosaccharide; Oligomannose 7 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M8 glycan (Man8) (Mannose-8 N-linked oligosaccharide; Oligomannose 8 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M5 glycan (Man5) (Mannose-5 N-linked oligosaccharide; Oligomannose 5 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M6 glycan (Man6) (Mannose-6 N-linked oligosaccharide; Oligomannose 6 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M9 glycan (Man9) (Mannose-9 N-linked oligosaccharide; Oligomannose 9 glycan) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M6 glycan (Man6), procainamide labelled (Mannose-6 N-linked oligosaccharide, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M5 glycan (Man5), APTS labelled (Mannose-5 N-linked oligosaccharide, APTS labelled; Oligomannose 5 glycan, APTS labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M7 glycan (Man7), procainamide labelled (Mannose-7 N-linked oligosaccharide, procainamide labelled; Oligomannose 7 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M5 glycan (Man5), procainamide labelled (Mannose-5 N-linked oligosaccharide, procainamide labelled; Oligomannose 5 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M8 glycan (Man8), procainamide labelled (Mannose-8 N-linked oligosaccharide, procainamide labelled; Oligomannose 8 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M9 glycan (Man9), procainamide labelled (Mannose-9 N-linked oligosaccharide, procainamide labelled; Oligomannose 9 glycan, procainamide labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
Concanavalin A is a Ca 2+/Mn 2+-dependent and mannose/glucose-binding plant lectin that can be found in jack bean. Concanavalin A can induce programmed cell death. Concanavalin A can be used to induce acute hepatic injury .
M9 glycan (Man9), 2-AB labelled (Mannose-9 N-linked oligosaccharide, 2-AB labelled; Oligomannose 9 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M6 glycan (Man6), 2-AB labelled (Mannose-6 N-linked oligosaccharide, 2-AB labelled; Oligomannose 6 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M3 glycan (Man3), 2-AA labelled (Mannose-3 N-linked oligosaccharide, 2-AA labelled; Oligomannose 3 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M3 glycan (Man3), 2-AB labelled (Mannose-3 N-linked oligosaccharide, 2-AB labelled; Oligomannose 3 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M8 glycan (Man8), 2-AA labelled (Mannose-8 N-linked oligosaccharide, 2-AA labelled; Oligomannose 8 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M8 glycan (Man8), 2-AB labelled (Mannose-8 N-linked oligosaccharide, 2-AB labelled; Oligomannose 8 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M7 glycan (Man7), 2-AB labelled (Mannose-7 N-linked oligosaccharide, 2-AB labelled; Oligomannose 7 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M9 glycan (Man9), 2-AA labelled (Mannose-9 N-linked oligosaccharide, 2-AA labelled; Oligomannose 9 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M6 glycan (Man6), 2-AA labelled (Mannose-6 N-linked oligosaccharide, 2-AA labelled; Oligomannose 6 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M7 glycan (Man7), 2-AA labelled (Mannose-7 N-linked oligosaccharide, 2-AA labelled; Oligomannose 7 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M5 glycan (Man5), 2-AA labelled (Mannose-5 N-linked oligosaccharide, 2-AA labelled; Oligomannose 5 glycan, 2-AA labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
M5 glycan (Man5), 2-AB labelled (Mannose-5 N-linked oligosaccharide, 2-AB labelled; Oligomannose 5 glycan, 2-AB labelled) is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe 2+), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe 2+) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .
Xanthan gum is a microbial polysaccharide produced by Xanthomonas campestris. The structure of xanthan gum is based on a cellulose backbone of β-(1-4)-linked glucose units with a trisaccharide side of mannose-glucuronic acid-mannose attached to every other glucose unit in the backbone chain. Some terminal mannose units are pyruvated and some internal mannose units are acetylated. Due to its unique rheology and gelling properties, it is widely used as a food additive, thickener and stabilizer in the food and petroleum industries.
Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research .
D-Mannose is a C-2 superpolymer of glucose that occurs naturally in many plants and fruits. D-Mannose has anti-inflammatory and antitumor activity. D-Mannose plays an important role in immune regulation .
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM) .
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits cell growth of MCF-7, KB, NCI H187, and Vero cells with IC50 values of 8.4, 8.6, 4.2, and 48.9 µM, respectively. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 µM [1]sup>[2]sup>[3]sup>[4].
7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol is a cuminol glycoside. 7-[α-L-Arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]cuminol can be isolated from Rhodiola roseasup>[1].
(S)-(−)-Perillyl alcohol is a monoterpene found in lavender, inhibits farnesylation of Ras, upregulates the mannose-6-phosphate receptor and induces apoptosis. Anti-cancer activity .
Ethyl β-D-glucopyranoside (compound 10) is a kind of phenolic compound. Ethyl β-D-glucopyranoside can be isolated from ethanolic extract of Scabiosa stellataLS.
D-Mannosamine hydrochloride is a six-carbon glycoamine that is an amino derivative of D-mannose. D-mannoamine plays a variety of important biological roles in cells .
Isoiridogermanal can be isolated from the extract of rhizomes of Iris tectorum Maxim. Isoiridogermanal is cytotoxic with IC50 values of 11 μM and 23 μM against MCF-7 and C32 celllines.
C-type lectin domain-containing protein is a soluble mannose-binding protein in serum which belongs to the collectin family and is an important element in the innate immune system. C-type lectin domain-containing protein exerts mannose-binding, calcium-dependent protein binding and identical protein binding activity. MBL2/COLEC1 Protein, Mouse (HEK293) is the recombinant mouse-derived MBL2/COLEC1 protein, expressed by HEK293, with tag free. The total length of MBL2/COLEC1 Protein, Mouse (HEK293) is 226 a.a., with molecular weight of ~28.0 kDa.
The MBL2/COLEC1 protein is a calcium-dependent lectin in innate immune defense that activates the lectin complement pathway by binding to mannose, fucose, and N-acetylglucosamine on microorganisms. MBL2/COLEC1 Protein, Human (HEK293, His) is the recombinant human-derived MBL2/COLEC1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MBL2/COLEC1 Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~31.0 kDa.
The MRC2 protein may function as an endocytic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands via clathrin-mediated endocytosis and releases them in endosomes. MRC2 Protein, Canine (HEK293, His) is the recombinant canine-derived MRC2 protein, expressed by HEK293 , with C-His labeled tag. The total length of MRC2 Protein, Canine (HEK293, His) is 503 a.a., with molecular weight of 60-70 kDa.
MBL1, a calcium-dependent lectin, recognizes microbial moieties, activating the lectin complement pathway. It also binds apoptotic and necrotic cells, aiding uptake by macrophages. As a homotrimer, MBL1 forms higher oligomeric complexes in the endoplasmic reticulum. MBL1's interaction with MASP1 and MASP2 enhances its role in immune response modulation and cellular recognition. MBL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MBL1 protein, expressed by HEK293 , with N-His, N-6*His labeled tag. The total length of MBL1 Protein, Mouse (HEK293, His) is 219 a.a., with molecular weight of ~32 KDa.
MBL1 protein is a calcium-dependent lectin that participates in innate immunity by binding to mannose, fucose and N-acetylglucosamine on microorganisms and activating the lectin complement pathway. MBL1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived MBL1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of MBL1 Protein, Rat (HEK293, Fc) is 221 a.a., with molecular weight of ~56-60 kDa.
LMAN2 Protein, an intracellular lectin, interacts with N-acetyl-D-galactosamine and high-mannose type glycans. This protein is integral to the transport and sorting of glycoproteins with high mannose-type glycans within the early secretory pathway, contributing significantly to cellular processes. LMAN2 Protein, Human (HEK293, His) is the recombinant human-derived LMAN2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LMAN2 Protein, Human (HEK293, His) is 278 a.a., with molecular weight of ~34.8 kDa.
MBL2/COLEC1 Protein, a calcium-dependent lectin, binds to mannose, fucose, and N-acetylglucosamine on microorganisms, activating the lectin complement pathway. It also binds to late apoptotic cells, apoptotic blebs, and necrotic cells, aiding their uptake by macrophages. MBL2 forms an oligomeric complex with homotrimers and interacts with MASP1, MASP2, MEP1A, and MEP1B. It plays a crucial role in immune defense, targeting microbial invaders and clearing apoptotic and necrotic cells. MBL2/COLEC1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MBL2/COLEC1 protein, expressed by HEK293 , with N-His labeled tag. The total length of MBL2/COLEC1 Protein, Mouse (HEK293, His) is 226 a.a., with molecular weight of ~26.3 KDa.
MBL2/COLEC1 Protein, a calcium-dependent lectin, binds to mannose, fucose, and N-acetylglucosamine on microorganisms, activating the lectin complement pathway. It also binds to late apoptotic cells, apoptotic blebs, and necrotic cells, aiding their uptake by macrophages. MBL2 forms an oligomeric complex with homotrimers and interacts with MASP1, MASP2, MEP1A, and MEP1B. It plays a crucial role in immune defense, targeting microbial invaders and clearing apoptotic and necrotic cells. MBL2/COLEC1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived MBL2/COLEC1 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of MBL2/COLEC1 Protein, Mouse (HEK293, Fc) is 226 a.a., with molecular weight of ~50.6 KDa.
The LMAN2L protein plays a critical role in cellular processes and may regulate the export of a specific subset of glycoproteins from the endoplasmic reticulum (ER). Its involvement in glycoprotein export suggests a regulatory function within the endoplasmic reticulum. LMAN2L Protein, Human (295a.a, HEK293, His) is the recombinant human-derived LMAN2L protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LMAN2L Protein, Human (295a.a, HEK293, His) is 295 a.a., with molecular weight of 30-40 kDa.
FimH Protein, pivotal in regulating length, mediates adhesion for type 1 fimbriae without being essential for fimbriae production. Positioned laterally in the fimbriae structure, FimH primarily binds to D-mannose. FimH integration into fimbriae involves collaborative action with FimF and FimG, emphasizing the coordinated molecular interplay essential for type 1 fimbriae assembly and function. FimH Protein, E.coli (P.pastoris, His) is the recombinant Virus-derived FimH protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of FimH Protein, E.coli (P.pastoris, His) is 279 a.a., with molecular weight (glycosylation form) of ~38 kDa.
The LMAN2L protein plays a critical role in cellular processes and may regulate the export of a specific subset of glycoproteins from the endoplasmic reticulum (ER). Its involvement in glycoprotein export suggests a regulatory function within the endoplasmic reticulum. LMAN2L Protein, Human (304a.a, HEK293, His) is the recombinant human-derived LMAN2L protein, expressed by HEK293 , with C-His labeled tag. The total length of LMAN2L Protein, Human (304a.a, HEK293, His) is 304 a.a., with molecular weight of ~32 KDa.
SNAP25 is a key t-SNARE in neurotransmitter release, regulating synaptic function and plasma membrane recycling. It cooperates with CENPF to affect vesicle docking and membrane fusion. SNAP25 Protein, Human (His) is the recombinant human-derived SNAP25 protein, expressed by E. coli , with N-His labeled tag. The total length of SNAP25 Protein, Human (His) is 206 a.a., with molecular weight of ~28 kDa.
MRC2 Protein potentially acts as an endocytotic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands through clathrin-mediated endocytosis, releasing them in endosomes. MRC2 may control PLAUR/PLAU levels in the plasminogen activation system, regulating cell surface protease activity. It contributes to cellular uptake, remodeling, and degradation of extracellular collagen matrices, influencing collagen turnover in cancer and tissue destructive diseases. MRC2 collaborates with matrix metalloproteinases, interacting with type I collagen, forming a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly engaging with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293, with C-His labeled tag. The total length of MRC2 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 65-75 kDa.
The POMGNT1 protein crucially directs O-mannosyl glycosylation, which adds N-acetylglucosamine to O-linked mannose residues on glycoproteins. It catalyzes GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr on α-dystroglycan and other O-mannosylated proteins, laying the foundation for subsequent carbohydrate addition. POMGNT1 Protein, Human (HEK293, His) is the recombinant human-derived POMGNT1 protein, expressed by HEK293 , with C-6*His labeled tag.
GDP-L-Fucose Synthase; GDP-4-Keto-6-Deoxy-D-Mannose-3; 5-Epimerase-4-Reductase; Protein FX; Red Cell NADP(H)-Binding Protein; Short-Chain Dehydrogenase/Reductase Family 4E Member 1; TSTA3; SDR4E1
The TSTA3 protein plays a key role in catalyzing the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose. The process involves successive epimerase and reductase reactions, ultimately leading to the biosynthesis of GDP-fucose. TSTA3 Protein, Human (His) is the recombinant human-derived TSTA3 protein, expressed by E. coli , with C-6*His labeled tag. The total length of TSTA3 Protein, Human (His) is 321 a.a., with molecular weight of ~40.0 kDa.
D-Mannose-d is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 18O is the 18O labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-3 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-4 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-1 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose-d-2 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-mannose-d7 is the deuterium labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-1 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-2 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-3 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-4 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C-5 is the 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C,d is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-Mannose- 13C,d-2 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
D-mannose- 13C6,d7 is the deuterium and 13C labeled D-Mannose. D-Mannose is a carbohydrate, which plays an important role in human metabolism, especially in the glycosylationof specific prote[1][2].
Eltrombopag- 13C4 (SB-497115- 13C4) is 13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .
Glucosamine- 13C, 15N (hydrochloride) is the 13C and 15N labeled Glucosamine hydrochloride. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, i
Pyrazinamide- 13C, 15N is 15N and 13C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.
L-Serine1- 13C, 15N is the 13C- and 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
Dulcite- 13C is the 13C labeled Dulcite. Dulcite is a sugar alcohol with a slightly sweet taste which is a metabolic breakdown product of galact[1][2].
Trifluridine- 13C, 15N2 is the 13C and 15N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].
D-Glucose- 13C is the 13C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1].
D-Glucose- 18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
Dutasteride- 13C, 15N,d is 15N and deuterated labeled Dutasteride (HY-13613). Dutasteride (GG745) is a potent inhibitor of both 5α-reductase isozymes. Dutasteride may possess off-target effects on the androgen receptor (AR) due to its structural similarity to DHT .
Droxidopa- 13C2, 15N (hydrochloride) is deuterium labeled Droxidopa. Droxidopa(L-DOPS), the mixture of Droxidopa (w/w80%) and Pharmaceutical starch (w/w20%), acts as a proagent to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); Droxidopa(L-DOPS) is capable of crossing the protective blood–brain barrier[1][2].
Acetaminophen- 13C2, 15N is the 13C and 15N labeled Acetaminophen[1]. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM;is a widely used antipyretic and analgesic agent[2][3][4]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[5].
PSI-6206-d1, 13C, 15N2 is 15N and 13C labeled PSI-6206 (HY-15236). PSI-6206 (RO 2433) is the deaminated derivative of PSI-6130, which is a potent and selective inhibitor of HCV NS5B polymerase. PSI-6206 low potently inhibits HCV replicon with EC90 of >100 μM.
(-)-Fucose- 13C is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[1]
Fmoc-Gly-OH- 13C2, 15N is a 15N-labeled and 13C-labled Crystal Violet. Crystal violet (Basic Violet 3) is a triarylmethane dye. Crystal Violet (Gentian Violet) has antiviral effects against H1N1 and also has prominent bactericidal activities.
Mannose Receptor; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage Mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage Mannose receptor 1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage Mannose receptor 1-like protein 1.
WB, ELISA, FC
Human
MRC1 Antibody is an unconjugated, approximately 160 kDa, rabbit-derived, anti-MRC1 polyclonal antibody. MRC1 Antibody can be used for: WB, ELISA, Flow-Cyt expriments in human, and predicted: mouse, rat, chicken, dog, pig, cow, horse, sheep, guinea pig background without labeling.
Mannose Phosphate Isomerase Antibody (YA1085) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA1085), targeting Mannose Phosphate Isomerase, with a predicted molecular weight of 47 kDa (observed band size: 47 kDa). Mannose Phosphate Isomerase Antibody (YA1085) can be used for WB, ICC/IF experiment in human, rat background.
IGF2R Antibody (YA1499) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1499), targeting IGF2R, with a predicted molecular weight of 274 kDa (observed band size: 274 kDa). IGF2R Antibody (YA1499) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.
Synaptosomal-associated protein 25; SNAP-25; super protein; sup; Synaptosomal-associated 25 kDa protein; SNAP25; SNAP
WB, ICC/IF, IP
Human, Mouse, Rat
SNAP25 Antibody (YA1412) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1412), targeting SNAP25, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). SNAP25 Antibody (YA1412) can be used for WB, ICC/IF, IP experiment in human, mouse, rat background.
Cyanine3 azide chloride, an analog of Cy3 azide, is a potent green fluorescent dye. Cyanine3 azide chloride uses click chemistry coupled with Alkyne-labeled proteins. Cyanine3 azide chloride can be detected by fluorometers, imagers, and microscopes. (λex=684 nm, λem=710 nm) [1]sup >. Cyanine3 azide (chloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.