Ru-TRZ2

Cat. No.: HY-162569: FAQs
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Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity.

For research use only. We do not sell to patients.

Ru-TRZ2 Chemical Structure

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Description

Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity^[1].

In Vitro

Ru-TRZ2 (72 h) induces necroptosis with IC₅₀s of 0.45, 0.24 µM for HCT116, HT29 cells, respectively^[1].
Ru-TRZ2 induces mitochondrial depolarization and apoptotic cell death in HT29 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:	HT29 cells
Concentration:	10 μM
Incubation Time:	24 h
Result:	Induced apoptosis and increased the expression of cleaved PARP.

In Vivo

Ru-TRZ2 (5 mg/kg; i.v.; every 2 days for 10 injections) shows anti-tumor activity in HT29 xenograft mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks, Male nude mice^[1]
Dosage:	5 mg/kg
Administration:	I.v.; every 2 days for 10 injections
Result:	Decreased the tumor weight in HT29 xenograft mice.

Molecular Weight

1092.98

Formula

C₄₅H₄₃F₆N₄O₇P₂RuS₂

SMILES

FC(F)(F)S(=O)([O-])=O.CN(C(CCC)=O)/N=N/C1=CC=C(C#[N][Ru+2]2([])[P](C3=CC=CC=C3)(C4=CC=CC=C4)CC[P]2(C5=CC=CC=C5)C6=CC=CC=C6)C=C1.FC(F)(F)S(=O)([O-])=O.C7CCCC7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gonçalves J, et al. Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors. Cell Death Discov. 2024 May 28;10(1):261. [Content Brief]

Ru-TRZ2 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ru-TRZ2ApoptosisNecroptosisnecroptosisapoptosisantitumorHT29 cellscleaved PARPInhibitorinhibitorinhibit

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