2. NF-κB
  3. NF-κB
  4. Ro 106-9920

Ro 106-9920 is a potent inhibitor of NF-kappaB. Ro 106-9920 has the potential for the research of tumor and cancer diseases.

For research use only. We do not sell to patients.

Ro 106-9920 Chemical Structure

Ro 106-9920 Chemical Structure

CAS No. : 62645-28-7

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1 mg USD 310 In-stock
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10 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Ro 106-9920 is a potent inhibitor of NF-kappaB. Ro 106-9920 has the potential for the research of tumor and cancer diseases[1].

IC50 & Target

NF-kappaB[1]
Molecular Weight

245.26

Formula

C10H7N5OS
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=CC=C1)C2=NN3N=NN=C3C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (81.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0773 mL 20.3865 mL 40.7731 mL
5 mM 0.8155 mL 4.0773 mL 8.1546 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (248 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0773 mL 20.3865 mL 40.7731 mL 101.9326 mL
5 mM 0.8155 mL 4.0773 mL 8.1546 mL 20.3865 mL
10 mM 0.4077 mL 2.0387 mL 4.0773 mL 10.1933 mL
15 mM 0.2718 mL 1.3591 mL 2.7182 mL 6.7955 mL
20 mM 0.2039 mL 1.0193 mL 2.0387 mL 5.0966 mL
25 mM 0.1631 mL 0.8155 mL 1.6309 mL 4.0773 mL
30 mM 0.1359 mL 0.6796 mL 1.3591 mL 3.3978 mL
40 mM 0.1019 mL 0.5097 mL 1.0193 mL 2.5483 mL
50 mM 0.0815 mL 0.4077 mL 0.8155 mL 2.0387 mL
60 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6989 mL
80 mM 0.0510 mL 0.2548 mL 0.5097 mL 1.2742 mL
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Ro 106-9920 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 106-992062645-28-7NF-κBNuclear factor-κBNuclear factor-kappaBNF-kappaBtumorcancerInhibitorinhibitorinhibit

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