2. Apoptosis
  3. MDM-2/p53
  4. RG7112D

RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels.

For research use only. We do not sell to patients.

RG7112D Chemical Structure

RG7112D Chemical Structure

CAS No. : 2360561-90-4

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RG7112D Related Antibodies

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Description

RG7112D is a potent MDM2 inhibitor with IC50s of 11 nM and >10000 nM and for MDM2-p53 and VHL-HIF1α by binding HTRF assay, respectively. RG7112D is coupled by an amide bond to VHL-Amine, resulting in a bi-functional molecule, YX-02-030. YX-02-03, a MDM2-PROTAC, potently inhibits MDM2-p53 binding (HTRF IC50=63nM). RG7112D can stabilize MDM2 protein and increase p53 protein levels[1].

Molecular Weight

665.65

Formula

C36H42Cl2N4O4
CAS No.
SMILES

O=C(CN1CCN(CC1)C(N2[C@](C3=CC=C(C=C3)Cl)([C@](C4=CC=C(C=C4)Cl)(N=C2C5=CC=C(C=C5OCC)C(C)(C)C)C)C)=O)O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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RG7112D Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG7112D2360561-90-4MDM-2/p53MDM2-p53VHL-HIF1αHTRFVHL-AmineYX-02-030MDM2-PROTACInhibitorinhibitorinhibit

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