2. TGF-beta/Smad
  3. TGF-β Receptor
  4. RepSox

RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor.

For research use only. We do not sell to patients.

RepSox Chemical Structure

RepSox Chemical Structure

CAS No. : 446859-33-2

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Based on 17 publication(s) in Google Scholar

Other Forms of RepSox:

RepSox Related Antibodies

Top Publications Citing Use of Products

    RepSox purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Jun 19;8(36):60159-60172.  [Abstract]

    SH-SY5Y (A) and HEK293 cells (B) are treated with 25 μM RepSox (Rep) in absence or presence of dPA or dPPA for 72 h, and the Western blotting results show that dPA or dPPA increases the expression in the presence of RepSox. RepSox does not cause significant alteration of furin protein compared to control. The expression of furin remains significantly increased after dPA or dPPA in the presence of RepSox.

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    Description

    RepSox (E-616452) (GMP) is a RepSox (HY-13012) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RepSox is a potent and selective TGF-β-RI/ALK5 inhibitor[1].

    IC50 & Target

    IC50: ALK5 autophosphorylation (4 nM)
    In Vitro

    RepSox (GMP) (10 μM) induces MEFs differentiating to chemically induced pluripotent stem cells (CiPSCs)[1].
    RepSox (GMP) (10 μM, in stage I-Stage III induction medium) induces hCiPS cells from HEFs[2].
    RepSox (GMP) together with Forskolin (HY-15371) increases the number of proliferative cells in MEFs expressing MyoD, confirmed by increased EdU incorporation[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    RepSox Related Antibodies
    Molecular Weight

    287.32

    Formula

    C17H13N5
    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    RepSox Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    RepSox (GMP)446859-33-2E-616452 (GMP) SJN 2511 (GMP)TGF-β ReceptorTransforming growth factor beta receptorsTGF-β ALK5autophosphorylationobesitymetabolictype 2 diabetesreprogramdifferentiatingpluripotent stem cellPSCInhibitorinhibitorinhibit

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