2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (±)-Anatoxin A fumarate

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM).

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(±)-Anatoxin A fumarate Chemical Structure

(±)-Anatoxin A fumarate Chemical Structure

CAS No. : 1219922-30-1

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(±)-Anatoxin A fumarate Related Antibodies

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Description

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

IC50 & Target

Ki: 1.25 nM ( α4β2 receptor)
Ki: 1.84 μM ( α7 receptor)[1]
Molecular Weight

281.30

Formula

C14H19NO5
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

CC(C1=CCCC2CCC1N2)=O.O=C(O)/C=C/C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 14.07 mg/mL (50.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5549 mL 17.7746 mL 35.5492 mL
5 mM 0.7110 mL 3.5549 mL 7.1098 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5549 mL 17.7746 mL 35.5492 mL 88.8731 mL
5 mM 0.7110 mL 3.5549 mL 7.1098 mL 17.7746 mL
10 mM 0.3555 mL 1.7775 mL 3.5549 mL 8.8873 mL
15 mM 0.2370 mL 1.1850 mL 2.3699 mL 5.9249 mL
20 mM 0.1777 mL 0.8887 mL 1.7775 mL 4.4437 mL
25 mM 0.1422 mL 0.7110 mL 1.4220 mL 3.5549 mL
30 mM 0.1185 mL 0.5925 mL 1.1850 mL 2.9624 mL
40 mM 0.0889 mL 0.4444 mL 0.8887 mL 2.2218 mL
50 mM 0.0711 mL 0.3555 mL 0.7110 mL 1.7775 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(±)-Anatoxin A fumarate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Anatoxin A1219922-30-1nAChRNicotinic acetylcholine receptorscyanobacteriumα4β2-typeα7-typebrain membranestriatalsynaptosomeInhibitorinhibitorinhibit

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