2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK
  4. PROTAC IRAK4 degrader-11

PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 96.25% and the DC50 of 2.29 nM in HEK293 cells(Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker；Pink: IRAK4 inhibitor).

For research use only. We do not sell to patients.

PROTAC IRAK4 degrader-11 Chemical Structure

PROTAC IRAK4 degrader-11 Chemical Structure

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PROTAC IRAK4 degrader-11 Related Antibodies

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Description

PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 96.25% and the DC50 of 2.29 nM in HEK293 cells(Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker；Pink: IRAK4 inhibitor)[1].

Molecular Weight

798.81

Formula

C41H41F3N8O6
SMILES

O=C(C1=CC=CC([C@@H]2CC2(F)F)=N1)NC3=CN4C=C(C5CCN(CC6CN(C6)C7=CC=C8C(N(C9C(NC(CC9)=O)=O)C(C8=C7)=O)=O)CC5)N=C4C(F)=C3C(C)(C)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC IRAK4 degrader-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK4 degrader-11PROTACsIRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseHEK293Inhibitorinhibitorinhibit

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