2. PROTAC JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. PROTACs EGFR FAK
  4. PROTAC EGFR degrader 11

PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.

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PROTAC EGFR degrader 11 Chemical Structure

PROTAC EGFR degrader 11 Chemical Structure

CAS No. : 3034244-71-5

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PROTAC EGFR degrader 11 Related Antibodies

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Description

PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.

IC50 & Target

CRBN-DDB1

36 nM (Ki)

Molecular Weight

991.61

Formula

C49H64ClFN10O7S
CAS No.
SMILES

O=C1C(C2=C(F)C=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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PROTAC EGFR degrader 11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EGFR degrader 113034244-71-5PROTAC EGFR degrader11PROTAC EGFR degrader-11PROTACsEGFRFAKEpidermal growth factor receptorErbB-1HER1PTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseH1975HCC827BaF3Inhibitorinhibitorinhibit

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