2. Epigenetics Membrane Transporter/Ion Channel
  3. Histone Methyltransferase Potassium Channel
  4. PRMT5-IN-41

PRMT5-IN-41 (compound 130) is a potent and orally active PRMT5 inhibitor. PRMT5-IN-41 inhibits hERG ion channel with IC50 value of 1.36 µM.

For research use only. We do not sell to patients.

PRMT5-IN-41 Chemical Structure

PRMT5-IN-41 Chemical Structure

CAS No. : 3034034-32-4

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PRMT5-IN-41 Related Antibodies

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Description

PRMT5-IN-41 (compound 130) is a potent and orally active PRMT5 inhibitor. PRMT5-IN-41 inhibits hERG ion channel with IC50 value of 1.36 µM[1].

In Vitro

PRMT5-IN-41 (compound 130) (0-10000 nM) shows anti-priliferative activity with IC50 values of 5.8, 1291.6 µM for HCT116 MTAP(-/-), HCT116 WT cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRMT5-IN-41 Related Antibodies
In Vivo

PRMT5-IN-41 (3 mg/kg for i.v.; 10 mg/kg for p.o.) shows orally bioavailable with 77.5% and T1/2 value of 4.5, 3.34 h for IV and PO, respectively in ICR mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

477.39

Formula

C22H16F5N5O2
CAS No.
SMILES

CN([C@H]1C2=CC=C(C(F)(F)C(F)(F)F)C=C2OC1)C(C3=CC=C4N=C(N)C5=CN=CN5C4=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PRMT5-IN-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-413034034-32-4Histone MethyltransferasePotassium ChannelKcsAHEK293 cellsorally activeHCT116 cellsHCT116anti-priliferativeInhibitorinhibitorinhibit

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HY-163590
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