PP18 

PP18 is a novel OXM-based dual GLP-1 and glucagon receptor agonist with EC₅₀ values of 0.487 nM target hGLP-1R and 0.188 nM target hGcgR^[1].

6168.83

C₂₆₉H₄₂₆N₇₄O₈₈S₂

Ala-Cys-Ala-Glu-Leu-Val-Asp-Asn-Ala-Val-Ala-Ile-Gly-Gly-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys(AEEA-AEEA-γGlu-C18 diacid)-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-Ala-Arg-Asn-Arg-Asn-Asn-Ile-Ala

ACAELVDNAVAIGGQGTFTSDYS-K(AEEA-AEEA-γGlu-C18 diacid)-YLDSRRAQDFVQWLMNTARNRNNIA

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)[C@H](CC)C)=O)CC(N)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCCNC(N)=N)=O)C)=O)[C@@H](C)O)=O)CC(N)=O)=O)CCSC)=O)CC(C)C)=O)CC1=CNC2=CC=CC=C12)=O)CCC(N)=O)=O)C(C)C)=O)CC3=CC=CC=C3)=O)CC(O)=O)=O)CCC(N)=O)=O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)CC4=CC=C(O)C=C4)=O)CCCCNC(COCCOCCNC(COCCOCCNC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCCCC(O)=O)=O)=O)=O)=O)=O)CO)=O)CC5=CC=C(O)C=C5)=O)CC(O)=O)=O)CO)=O)[C@@H](C)O)=O)CC6=CC=CC=C6)=O)[C@@H](C)O)=O)=O)CCC(N)=O)=O)=O)=O)[C@H](CC)C)=O)C)=O)C(C)C)=O)C)=O)CC(N)=O)=O)CC(O)=O)=O)C(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)C)=O)CS

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lei Zhao, et al. Design, screening and biological evaluation of novel fatty acid chain-modified oxyntomodulin-based derivatives with prolonged glucose-lowering ability and potent anti-obesity effects. Org Biomol Chem. 2019, 17, 33.  [Content Brief]