PolyQ aggregation inhibitor C2-8 (Synonyms: Polyglutamine Aggregation inhibitor III)

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C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC₅₀s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.

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PolyQ aggregation inhibitor C2-8 Chemical Structure

CAS No. : 300670-16-0

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Description	C2-8 is an inhibitor of polyglutamine (polyQ) aggregation (IC₅₀s=25 and 0.05 μM for recombinant HDQ51 and in PC12 cells, respectively). It also inhibits polyQ aggregation in organotypic hippocampal slice cultures isolated from R6/2 transgenic mice and reduces neurodegeneration in a dose-dependent manner in a Drosophila model of Huntington's disease. C2-8 (100 and 200 mg/kg) reduces huntingtin aggregate size, reduces neuronal atrophy, and improves motor performance in a rotarod test in the R6/2 transgenic mouse model of Huntington's disease.
Molecular Weight	510.20
Formula	C₁₉H₁₄Br₂N₂O₃S
CAS No.	300670-16-0
SMILES	O=C(NC1=CC=C(Br)C=C1)C2=CC=CC(S(=O)(NC3=CC=C(Br)C=C3)=O)=C2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (265 KB) Handling Instructions (2659 KB)
References	[1]. Zhang, et al. A potent small molecule inhibits polyglutamine aggregation in Huntington’s disease neurons and suppresses neurodegeneration in vivo. Proc. Natl. Acad. Sci. USA 102(3), 892-897 (2005).

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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PolyQ aggregation inhibitor C2-8300670-16-0Polyglutamine Aggregation inhibitor IIIOthersInhibitorinhibitorinhibit

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PolyQ aggregation inhibitor C2-8 (Synonyms: Polyglutamine Aggregation inhibitor III)

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