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  3. Phenylbutazone(diphenyl-d10)

Phenylbutazone(diphenyl-d10) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

For research use only. We do not sell to patients.

Phenylbutazone(diphenyl-d<sub>10</sub>) Chemical Structure

Phenylbutazone(diphenyl-d10) Chemical Structure

CAS No. : 1219794-69-0

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1 mg USD 200 In-stock
5 mg USD 450 In-stock
10 mg USD 800 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Phenylbutazone(diphenyl-d10) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

318.44

Formula

C19H10D10N2O2

CAS No.
Unlabeled CAS

50-33-9

Appearance

Solid

Color

White to off-white

SMILES

O=C1N(N(C(=O)C1CCCC)C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H])C3=C(C(=C(C(=C3[2H])[2H])[2H])[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (314.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : ≥ 100 mg/mL (314.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.67 mg/mL (2.10 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.10 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1403 mL 15.7015 mL 31.4031 mL
5 mM 0.6281 mL 3.1403 mL 6.2806 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O / DMSO / DMSO 1 mM 3.1403 mL 15.7015 mL 31.4031 mL 78.5077 mL
DMSO / DMSO 5 mM 0.6281 mL 3.1403 mL 6.2806 mL 15.7015 mL
10 mM 0.3140 mL 1.5702 mL 3.1403 mL 7.8508 mL
15 mM 0.2094 mL 1.0468 mL 2.0935 mL 5.2338 mL
20 mM 0.1570 mL 0.7851 mL 1.5702 mL 3.9254 mL
25 mM 0.1256 mL 0.6281 mL 1.2561 mL 3.1403 mL
30 mM 0.1047 mL 0.5234 mL 1.0468 mL 2.6169 mL
40 mM 0.0785 mL 0.3925 mL 0.7851 mL 1.9627 mL
50 mM 0.0628 mL 0.3140 mL 0.6281 mL 1.5702 mL
60 mM 0.0523 mL 0.2617 mL 0.5234 mL 1.3085 mL
80 mM 0.0393 mL 0.1963 mL 0.3925 mL 0.9813 mL
100 mM 0.0314 mL 0.1570 mL 0.3140 mL 0.7851 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Phenylbutazone(diphenyl-d10)
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HY-B0230S
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