palm11-PrRP31

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palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC₅₀=39±5 pM) and effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.

For research use only. We do not sell to patients.

palm11-PrRP31 Chemical Structure

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Description

palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC₅₀=39±5 pM) and effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction^[1].

Molecular Weight
4003.64

Formula
C₁₈₁H₂₈₉N₅₅O₄₆S

Sequence
Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-{Lys(N-γGlu(N-palm))}-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2

Sequence Shortening
SRTHRHSMEI-{Lys(N-γGlu(N-palm))}-TPDINPAWYASRGIRPVGRF-NH2

SMILES
O=C(CC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(O)=O)NCCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CO)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CC1=CNC=N1)=O)CCCNC(N)=N)=O)CC2=CNC=N2)=O)CO)=O)CCSC)=O)CCC(O)=O)=O)[C@H](CC)C)=O)C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CC6=CC=CC=C6)=O)CCCNC(N)=N)=O)=O)C(C)C)=O)CCC5)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)=O)CCCNC(N)=N)=O)CO)=O)C)=O)CC7=CC=C(O)C=C7)=O)CC8=CNC9=CC=CC=C89)=O)C)=O)CCC4)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(O)=O)=O)CCC3)=O)[C@@H](C)O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (258 KB) Handling Instructions (2659 KB)

References

[1]. Strnadová V, et al. Search for lipidized PrRP analogs with strong anorexigenic effect: in vitro and in vivo studies[J]. Neuropeptides, 2023, 98: 102319. [Content Brief]

[1]. Strnadová V, et al. Search for lipidized PrRP analogs with strong anorexigenic effect: in vitro and in vivo studies[J]. Neuropeptides, 2023, 98: 102319.

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palm11-PrRP31 Related Classifications

GPCR/G Protein

Neuropeptide FF Receptor

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

palm11-PrRP31Neuropeptide FF ReceptorDouble receptor agonistAppetite RegulationNervous systemGPR10NPFF-R2Inhibitorinhibitorinhibit

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50 mg		Get quote
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250 mg		Get quote
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Description	palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC₅₀=39±5 pM) and effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction^[1].
Molecular Weight	4003.64
Formula	C₁₈₁H₂₈₉N₅₅O₄₆S
Sequence	Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-{Lys(N-γGlu(N-palm))}-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
Sequence Shortening	SRTHRHSMEI-{Lys(N-γGlu(N-palm))}-TPDINPAWYASRGIRPVGRF-NH2
SMILES	O=C(CC[C@H](NC(CCCCCCCCCCCCCCC)=O)C(O)=O)NCCCC[C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CO)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)CC1=CNC=N1)=O)CCCNC(N)=N)=O)CC2=CNC=N2)=O)CO)=O)CCSC)=O)CCC(O)=O)=O)[C@H](CC)C)=O)C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N5[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N)=O)CC6=CC=CC=C6)=O)CCCNC(N)=N)=O)=O)C(C)C)=O)CCC5)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)=O)CCCNC(N)=N)=O)CO)=O)C)=O)CC7=CC=C(O)C=C7)=O)CC8=CNC9=CC=CC=C89)=O)C)=O)CCC4)=O)CC(N)=O)=O)[C@H](CC)C)=O)CC(O)=O)=O)CCC3)=O)[C@@H](C)O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (258 KB) Handling Instructions (2659 KB)
References	[1]. Strnadová V, et al. Search for lipidized PrRP analogs with strong anorexigenic effect: in vitro and in vivo studies[J]. Neuropeptides, 2023, 98: 102319. [Content Brief]

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palm11-PrRP31

palm11-PrRP31 Related Antibodies

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