2. Autophagy
  3. ULK Mitophagy
  4. NZ-66

NZ-66 is a UNC-51-like kinase 1 (ULK1) targeting chimera, which is used to achieve proximity-induced and ULK1-dependent degradation of mitochondria. NZ-66 induces mitophagy. NZ-66 is potential for attenuating neurodegenerative disorders.

For research use only. We do not sell to patients.

NZ-66 Chemical Structure

NZ-66 Chemical Structure

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NZ-66 Related Antibodies

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Description

NZ-66 is a UNC-51-like kinase 1 (ULK1) targeting chimera, which is used to achieve proximity-induced and ULK1-dependent degradation of mitochondria. NZ-66 induces mitophagy. NZ-66 is potential for attenuating neurodegenerative disorders[1].

IC50 & Target

ULK1

 

Molecular Weight

960.87

Formula

C48H40F8N8O5
SMILES

O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)C3=CC=C(OCC4=CN(CCCCCCNC(C(C5=C(C6=CC=CC=C6)NC7=C5C=CC=C7)=O)=O)N=N4)C=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NZ-66 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NZ-66NZ66NZ 66ULKMitophagyUnc-51 like kinaseMitochondrial Autophagymitophagyneurodegenerative disorderneuroprotectiveInhibitorinhibitorinhibit

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