2. Cell Cycle/DNA Damage Cytoskeleton
  3. PAK
  4. NVS-PAK1-C

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).

For research use only. We do not sell to patients.

NVS-PAK1-C Chemical Structure

NVS-PAK1-C Chemical Structure

CAS No. : 2250019-95-3

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1 mg USD 120 In-stock
5 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

NVS-PAK1-C Related Antibodies

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Description

NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1].

IC50 & Target[1]

PAK1

0.007 μM (Kd)

PAK2

0.4 μM (Kd)

PAK1

5 nM (IC50)

PAK2

270 nM (IC50)

In Vitro

NVS-PAK1-1 potently inhibits autophosphorylation of PAK1 (S144) at 0.25 µM in the Su86.86 cell line and MEK S289 phosphorylation with an IC50=0.21 µM in Su86.86 cells in which PAK2 is downregulated[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NVS-PAK1-C Related Antibodies
Molecular Weight

465.90

Formula

C22H23ClF3N5O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C4=CC=C(Cl)C=C42)CC1)N(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (107.32 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1464 mL 10.7319 mL 21.4638 mL
5 mM 0.4293 mL 2.1464 mL 4.2928 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1464 mL 10.7319 mL 21.4638 mL 53.6596 mL
5 mM 0.4293 mL 2.1464 mL 4.2928 mL 10.7319 mL
10 mM 0.2146 mL 1.0732 mL 2.1464 mL 5.3660 mL
15 mM 0.1431 mL 0.7155 mL 1.4309 mL 3.5773 mL
20 mM 0.1073 mL 0.5366 mL 1.0732 mL 2.6830 mL
25 mM 0.0859 mL 0.4293 mL 0.8586 mL 2.1464 mL
30 mM 0.0715 mL 0.3577 mL 0.7155 mL 1.7887 mL
40 mM 0.0537 mL 0.2683 mL 0.5366 mL 1.3415 mL
50 mM 0.0429 mL 0.2146 mL 0.4293 mL 1.0732 mL
60 mM 0.0358 mL 0.1789 mL 0.3577 mL 0.8943 mL
80 mM 0.0268 mL 0.1341 mL 0.2683 mL 0.6707 mL
100 mM 0.0215 mL 0.1073 mL 0.2146 mL 0.5366 mL
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NVS-PAK1-C Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVS-PAK1-C2250019-95-3PAKp21 activated kinasesPAK1Su86.86dephosphorylatedphosphorylatedprobeATP-competitiveInhibitorinhibitorinhibit

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