2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Apoptosis Cytoskeleton
  3. Microtubule/Tubulin ADC Cytotoxin Apoptosis
  4. Monomethyl auristatin E

Monomethyl auristatin E  (Synonyms: MMAE; SGD-1010; Vedotin)

Cat. No.: HY-15162G
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Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor.

For research use only. We do not sell to patients.

Monomethyl auristatin E Chemical Structure

Monomethyl auristatin E Chemical Structure

CAS No. : 474645-27-7

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Top Publications Citing Use of Products

40 Publications Citing Use of MCE Monomethyl auristatin E

Proliferation Assay

    Monomethyl auristatin E purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Apr 21;6:24954.  [Abstract]

    LC-MS/MS analysis quantified the MMAE concentration in the tumors 3, 24, and 72 h after the administration of MMAE alone. The contents of MMAE in the tumor tissues 3, 24, and 72 h after administration are 1155 ± 609, 736 ± 319, and 413 ± 88 fmol/g (mean ± SD, N = 5 for each group), respectively.

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    Description

    Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor[1].

    Molecular Weight

    717.98

    Formula

    C39H67N5O7
    CAS No.
    SMILES

    CC(C)[C@H](NC)C(N[C@H](C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)C(C)C)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Monomethyl auristatin E Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Monomethyl auristatin E (GMP)474645-27-7MMAE (GMP) SGD-1010 (GMP) Vedotin (GMP)Microtubule/TubulinADC CytotoxinApoptosisADC PayloadGMPADCauxiliary reagentMMAEcancerInhibitorinhibitorinhibit

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