2. NF-κB Immunology/Inflammation PROTAC
  3. NF-κB IRAK PROTACs
  4. LC-MI-3

LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) PROTAC degrader, with a DC50 of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-κB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin. (Blue: VHL ligand, Black: linker, Pink: CRBN ligand (HY-14658)).

For research use only. We do not sell to patients.

LC-MI-3 Chemical Structure

LC-MI-3 Chemical Structure

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LC-MI-3 Related Antibodies

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Description

LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) PROTAC degrader, with a DC50 of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-κB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin. (Blue: VHL ligand, Black: linker, Pink: CRBN ligand (HY-14658))[1].

Molecular Weight

744.75

Formula

C39H36N8O8
SMILES

O=C1N(C(C2=C1C=C(C=C2)C#CCOCCC(N3CCN(CC3)C4=CC=C(C(OC)=C4)NC(C5=CC=CC(C6=CC=NN6)=N5)=O)=O)=O)C7CCC(NC7=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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LC-MI-3 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-MI-3NF-κBIRAKPROTACsNuclear factor-κBNuclear factor-kappaBInterleukin-1 receptor associated kinaseIL-1R associated kinaseorally activeacute and chronic inflammatory skindegradationInhibitorinhibitorinhibit

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