2. Anti-infection
  3. Bacterial
  4. KKL-40

KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells.

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KKL-40 Chemical Structure

KKL-40 Chemical Structure

CAS No. : 865285-47-8

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10 mg USD 175 In-stock
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KKL-40 Related Antibodies

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Description

KKL-40 is a small molecule inhibitor that targets the trans-transcription process and is effective against methicillin-sensitive and -resistant Staphylococcus aureus (S. aureus) as well as other Gram-positive pathogens including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. KKL-40 synergizes with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not synergize with other antibiotics such as daptomycin, kanamycin, or erythromycin. Trans-transcription is an extreme form of recoding, and KKL-40 inhibits trans-transcription but is nontoxic to HeLa cells[1].

Molecular Weight

351.26

Formula

C16H9F4N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NN=C(C2=CC=C(F)C=C2)O1)C3=CC=CC(C(F)(F)F)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (71.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8469 mL 14.2345 mL 28.4689 mL
5 mM 0.5694 mL 2.8469 mL 5.6938 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8469 mL 14.2345 mL 28.4689 mL 71.1723 mL
5 mM 0.5694 mL 2.8469 mL 5.6938 mL 14.2345 mL
10 mM 0.2847 mL 1.4234 mL 2.8469 mL 7.1172 mL
15 mM 0.1898 mL 0.9490 mL 1.8979 mL 4.7448 mL
20 mM 0.1423 mL 0.7117 mL 1.4234 mL 3.5586 mL
25 mM 0.1139 mL 0.5694 mL 1.1388 mL 2.8469 mL
30 mM 0.0949 mL 0.4745 mL 0.9490 mL 2.3724 mL
40 mM 0.0712 mL 0.3559 mL 0.7117 mL 1.7793 mL
50 mM 0.0569 mL 0.2847 mL 0.5694 mL 1.4234 mL
60 mM 0.0474 mL 0.2372 mL 0.4745 mL 1.1862 mL
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KKL-40 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KKL-40865285-47-8KKL40KKL 40BacterialInhibitorinhibitorinhibit

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