KISS1-305 

KISS1-305, the Metastin/Kisspeptin analog, is a prototype peptide and a chemical probe. KISS1-305 has suboptimal KISS1R agonistic activity, and resists plasma protease degradation^[1].

KISS1-305 (4 nmol/h; s.c.) shows suppression of pituitary-gonadal functions^[1].
KISS1-305 causes substantial elevations of plasma LH and testosterone, followed by abrupt reductions of both hormone levels. KISS1-305 also reduced genital organ weight more profoundly than leuprolide. In mechanistic studies, chronic KISS1-305 administration only transiently induced c-Fos expression in GnRH neurons, suggesting that GnRH-neural response was attenuated over time^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1165.30

C₅₆H₇₆N₁₆O₁₂

872717-97-0

{d-Try}-{d-Ala(Py)}-Asn-Ser-Phe-{Gly(aza)}-Leu-{Arg(Me)}-Phe-NH2

{d-Try}-{d-Ala(Py)}-NSF-{Gly(aza)}-L-{Arg(Me)}-F-NH2

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(NC)=N)NC([C@H](CC(C)C)NC(NNC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@@H](CC3=CC=NC=C3)NC([C@@H](CC4=CC=C(O)C=C4)N)=O)=O)=O)=O)=O)=O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Matsui H, et al.Chronic administration of the metastin/kisspeptin analog KISS1-305 or the investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function and depletes plasma testosterone in adult male rats.Endocrinology. 2012 Nov;153(11):5297-308.  [Content Brief]